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Articles June 2020

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

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Hongman Song; Yong Zeng; Sheik Pran Babu Sardar Pasha; Ronald A. Bush; Camasamudram Vijayasarathy; Haohua Qian; Lisa Wei; Henry E. Wiley; Zhijian Wu; Paul A. Sieving
TAGS: eye, retina, spatial vectors, transfer technique, oryctolagus cuniculus, mice, fibroblast growth factor 2, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(7):28. https://doi.org/10.1167/tvst.9.7.28

Retina August 2019

Cone ERG Changes During Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions

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Ronald A. Bush; Atsuhiro Tanikawa; Yong Zeng; Paul A. Sieving

Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3680-3688. https://doi.org/10.1167/iovs.19-27242

ARVO Annual Meeting Abstract July 2019

The role of constitutively active RAC1 in rod out segment formation in mouse rhodopsin-null rods

Hongman Song; Yong Zeng; Ronald A Bush; Ronald S Petralia; Ya Xian Wang; Robert N Fariss; Camasamudram Vijaysarathy; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):570.

ARVO Annual Meeting Abstract July 2018

Repeat Administration of AAV8 Vector in the Mouse Eye Results in Transgene Expression

Lisa Lining Wei; Yong Zeng; Suja Hiriyanna; Zhijian Wu; Paul Sieving; Ronald A Bush

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5656.

Retina March 2017

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome

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Dario Marangoni; Zeng Yong; Sten Kjellström; Camasamudram Vijayasarathy; Paul A. Sieving; Ronald A. Bush
TAGS: gene therapy, light intensity, mice, x-linked retinoschisis, electroretinography, pathology
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1656-1664. https://doi.org/10.1167/iovs.16-21016

Articles July 2016

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

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Yong Zeng; Ronald S. Petralia; Camasamudram Vijayasarathy; Zhijian Wu; Suja Hiriyanna; Hongman Song; Ya-Xian Wang; Paul A. Sieving; Ronald A. Bush
TAGS: gene therapy, mice, retina, diagnostic imaging, mice, knockout
Invest. Ophthalmol. Vis. Sci.. 2016; 57(9):OCT277-OCT287. https://doi.org/10.1167/iovs.15-18920

Includes: Supplemental Content

Retinal Cell Biology May 2016

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

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Hongman Song; Camasamudram Vijayasarathy; Yong Zeng; Dario Marangoni; Ronald A. Bush; Zhijian Wu; Paul A. Sieving
TAGS: mice, nadph oxidases, photoreceptors, retina, rod photoreceptors, superoxides, tissue degeneration, injections, proteins, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2864-2875. https://doi.org/10.1167/iovs.15-18974

Retina October 2015

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3 −/− Mouse Model of Achromatopsia

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Dario Marangoni; Camasamudram Vijayasarathy; Ronald A. Bush; Lisa L. Wei; Rong Wen; Paul A. Sieving
TAGS: ciliary neurotrophic factor, mice, retinal cone, electroretinography, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6810-6822. https://doi.org/10.1167/iovs.15-16866

ARVO Annual Meeting Abstract June 2015

Intravitreal CNTF transiently improves residual cone function in CNGB3 −/− mouse

Dario Marangoni; Camasamudram Vijayasarathy; Ronald A Bush; Lisa Wei; Rong Wen; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):479.

ARVO Annual Meeting Abstract June 2015

Constitutively Active RAC1 Causes Photoreceptor Degeneration through NADPH Oxidase-Mediated Oxidative Stress

Hongman Song; Ronald A Bush; Yong Zeng; Camasamudram Vijayasarathy; Dario Marangoni; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5451.

Retina October 2014

CNGB3 -Achromatopsia Clinical Trial With CNTF: Diminished Rod Pathway Responses With No Evidence of Improvement in Cone Function

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Wadih M. Zein; Brett G. Jeffrey; Henry E. Wiley; Amy E. Turriff; Santa J. Tumminia; Weng Tao; Ronald A. Bush; Dario Marangoni; Rong Wen; Lisa L. Wei; Paul A. Sieving
TAGS: achromatopsia, ciliary neurotrophic factor, retinal cone, rod photoreceptors, implants, eye, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6301-6308. https://doi.org/10.1167/iovs.14-14860

Includes: Supplemental Content

Retinal Cell Biology April 2014

Transgenic Expression of Constitutively Active RAC1 Disrupts Mouse Rod Morphogenesis

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Hongman Song; Ronald A. Bush; Camasamudram Vijayasarathy; Robert N. Fariss; Sten Kjellstrom; Paul A. Sieving
TAGS: animals, transgenic, mice, morphogenesis, photoreceptors, retina, rod photoreceptors, rhodopsin, polarity, proteins, antibodies
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2659-2668. https://doi.org/10.1167/iovs.13-13649

Retina November 2011

X-Linked Retinoschisis: RS1 Mutation Severity and Age Affect the ERG Phenotype in a Cohort of 68 Affected Male Subjects

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Kristen Bowles; Catherine Cukras; Amy Turriff; Yuri Sergeev; Susan Vitale; Ronald A. Bush; Paul A. Sieving
TAGS: cohort studies, electroretinography, mutation, phenotype, x-linked retinoschisis, eye, proteins
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):9250-9256. https://doi.org/10.1167/iovs.11-8115

ARVO Annual Meeting Abstract April 2011

Rs1 Knockout Mice Show Altered Transducin Translocation But Not Arrestin In Response To Light At Early Age

Lucia Ziccardi; Camasamudram Vijayasarathy; Robert N. Fariss; Maria M. Campos; Ronald A. Bush; Paul A. Sieving

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2667.

Retina August 2009

Photoreceptor Protection by Adeno-Associated Virus–Mediated LEDGF Expression in the RCS Rat Model of Retinal Degeneration: Probing the Mechanism

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Dorit Raz-Prag; Yong Zeng; Paul A. Sieving; Ronald A. Bush
TAGS: adeno-associated virus, electroretinography, eye, photoreceptors, proteins, retina, retinal degeneration, tissue degeneration, stress, rats
Invest. Ophthalmol. Vis. Sci.. 2009; 50(8):3897-3906. https://doi.org/10.1167/iovs.08-3153

Retinal Cell Biology August 2008

Synaptic Pathology in Retinoschisis Knockout ( Rs1 −/ y ) Mouse Retina and Modification by rAAV- Rs1 Gene Delivery

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Yuichiro Takada; Camasamudram Vijayasarathy; Yong Zeng; Sten Kjellstrom; Ronald A. Bush; Paul A. Sieving
TAGS: genes, mice, retina, retinoschisis, proteins, photoreceptors, electroretinography, postsynaptic density protein-95, pathology
Invest. Ophthalmol. Vis. Sci.. 2008; 49(8):3677-3686. https://doi.org/10.1167/iovs.07-1071

Visual Neuroscience January 2008

Photopic ERG Negative Response from Amacrine Cell Signaling in RCS Rat Retinal Degeneration

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Shigeki Machida; Dorit Raz-Prag; Robert N. Fariss; Paul A. Sieving; Ronald A. Bush
TAGS: electroretinography, erg protein, human, rats, retinal degeneration, amacrine cells, tissue degeneration, signal transduction, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2008; 49(1):442-452. https://doi.org/10.1167/iovs.07-0291

Retina August 2007

Retinoschisin Gene Therapy and Natural History in the Rs1h -KO Mouse: Long-term Rescue from Retinal Degeneration

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Sten Kjellstrom; Ronald A. Bush; Yong Zeng; Yuichiro Takada; Paul A. Sieving
TAGS: electroretinography, mice, retinal degeneration, retina, natural history, gene therapy
Invest. Ophthalmol. Vis. Sci.. 2007; 48(8):3837-3845. https://doi.org/10.1167/iovs.07-0203

Biochemistry and Molecular Biology March 2007

Retinoschisin Is a Peripheral Membrane Protein with Affinity for Anionic Phospholipids and Affected by Divalent Cations

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Camasamudram Vijayasarathy; Yuichiro Takada; Yong Zeng; Ronald A. Bush; Paul A. Sieving
TAGS: divalent cations, membrane proteins, phospholipids, proteins, tissue membrane, lipids, affinity, photoreceptors, cell membrane
Invest. Ophthalmol. Vis. Sci.. 2007; 48(3):991-1000. https://doi.org/10.1167/iovs.06-0915

Retina October 2006

Elovl4 5-bp–Deletion Knock-in Mice Develop Progressive Photoreceptor Degeneration

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Vidyullatha Vasireddy; Monica M. Jablonski; Md Nawajes A. Mandal; Dorit Raz-Prag; Xiaofei F. Wang; Lesli Nizol; Alessandro Iannaccone; David C. Musch; Ronald A. Bush; Norman Salem, Jr; Paul A. Sieving; Radha Ayyagari
TAGS: fatty acids, mice, mice, knockin, photoreceptors, retina, tissue degeneration, genes, retinal cone, electroretinography, proteins
Invest. Ophthalmol. Vis. Sci.. 2006; 47(10):4558-4568. https://doi.org/10.1167/iovs.06-0353

Includes: Supplemental Content

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Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

Cone ERG Changes During Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions

The role of constitutively active RAC1 in rod out segment formation in mouse rhodopsin-null rods

Repeat Administration of AAV8 Vector in the Mouse Eye Results in Transgene Expression

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3 −/− Mouse Model of Achromatopsia

Intravitreal CNTF transiently improves residual cone function in CNGB3 −/− mouse

Constitutively Active RAC1 Causes Photoreceptor Degeneration through NADPH Oxidase-Mediated Oxidative Stress

CNGB3 -Achromatopsia Clinical Trial With CNTF: Diminished Rod Pathway Responses With No Evidence of Improvement in Cone Function

Transgenic Expression of Constitutively Active RAC1 Disrupts Mouse Rod Morphogenesis

X-Linked Retinoschisis: RS1 Mutation Severity and Age Affect the ERG Phenotype in a Cohort of 68 Affected Male Subjects

Rs1 Knockout Mice Show Altered Transducin Translocation But Not Arrestin In Response To Light At Early Age

Photoreceptor Protection by Adeno-Associated Virus–Mediated LEDGF Expression in the RCS Rat Model of Retinal Degeneration: Probing the Mechanism

Synaptic Pathology in Retinoschisis Knockout ( Rs1 −/ y ) Mouse Retina and Modification by rAAV- Rs1 Gene Delivery

Photopic ERG Negative Response from Amacrine Cell Signaling in RCS Rat Retinal Degeneration

Retinoschisin Gene Therapy and Natural History in the Rs1h -KO Mouse: Long-term Rescue from Retinal Degeneration

Retinoschisin Is a Peripheral Membrane Protein with Affinity for Anionic Phospholipids and Affected by Divalent Cations

Elovl4 5-bp–Deletion Knock-in Mice Develop Progressive Photoreceptor Degeneration

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