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ARVO Annual Meeting Abstract June 2022

Impaired Cathepsin D evidenced in iPSC-derived RPE cells of STGD1 patients

Eunice Sze Yin Ng; Jane Hu; Katherine Frei; Zhichun Jiang; Michael B Gorin; Anna Matynia; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3894 – A0096. doi:

Articles March 2022

Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients

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Anna Matynia; Jun Wang; Sangbae Kim; Yumei Li; Anupama Dimashkie; Zhichun Jiang; Jane Hu; Samuel P. Strom; Roxana A. Radu; Rui Chen; Michael B. Gorin
TAGS: abca4 gene, proteins, retinal pigment cell, stargardt's disease, pathogenicity, idiopathic pneumonia syndrome, alleles
Trans. Vis. Sci. Tech.. 2022; 11(3):33. doi: https://doi.org/10.1167/tvst.11.3.33

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Membrane attack complex induces RPE cell death in Stargardt Disease

Roxana A Radu; Nermin Kady; Michael B Gorin; Anna Matynia; Jane G Hu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2994. doi:

ARVO Annual Meeting Abstract June 2021

Deciphering the role of Rab28 in cone vision and outer segment phagocytosis

Ailis Moran; Stephen P Carter; Joanna J Kaylor; Roxana A Radu; Alicia Gómez Sánchez; Gabriel H Travis; Oliver E. Blacque; Breandan N Kennedy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2978. doi:

ARVO Annual Meeting Abstract June 2021

The D167A mutation in PDEA greatly depresses PDE expression but produces sensitive (though slower) rod responses and remarkably slow degeneration

Ala Morshedian; Gabriela Sendek; Sze Yin Ng; Kimberly Boyd; Annia Abtout; Jürgen Reingruber; Nikolai Artemyev; Roxana A Radu; Mingyao Liu; Gordon L Fain

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3149. doi:

ARVO Annual Meeting Abstract June 2021

Cathepsin D deficiency in RPE cells mediates Stargardt Disease pathogenesis

Eunice Sze Yin Ng; Jane G Hu; Zhichun Jiang; Michael B Gorin; Anna Matynia; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3113. doi:

ARVO Annual Meeting Abstract June 2021

MeCP2-mediated mitochondrial impairment evidenced in Stargardt disease

Arpita R. Dave; Eunice Sze Yin Ng; Zhichun Jiang; Jane G Hu; Michael B Gorin; Anna Matynia; Linsey Stiles; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):269. doi:

Retinal Cell Biology July 2020

Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions

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Vera L. Bonilha; Brent A. Bell; Jane Hu; Caroline Milliner; Gayle J. Pauer; Stephanie A. Hagstrom; Roxana A. Radu; Joe G. Hollyfield
TAGS: atrophy, diagnostic imaging, donors, eye, granules, histology, inflammation, scanning laser ophthalmoscopy, body tissue, retina
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):15. doi: https://doi.org/10.1167/iovs.61.8.15

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Complement Dysregulation is Evidenced in iPSC-derived RPE Cells from Stargardt Disease patients

Jane Hu; Nermin Kady; Ashley Macabasco; Michael B Gorin; Anna Matynia; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1507. doi:

ARVO Annual Meeting Abstract July 2019

RGR opsin and RDH10 in Müller Cells Affect Light Dependent Synthesis of Chromophore Precursor for Cone Pigment Regeneration

Gabriel H Travis; Avian Tsan; Jeremy D Cook; Ala Morshedian; Lilly Yuan; Eunice Ng; Tongzhou Xu; Roxana A Radu; Gordon L Fain; Joanna J. Kaylor

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2341. doi:

ARVO Annual Meeting Abstract July 2019

Retinoid recycling is impaired in Stargardt iPSC-derived RPE

Roxana A Radu; Nermin Kady; Jane Hu; Jacqueline Pei; Marcia Lloyd; Dean Bok; Michael B Gorin; Saravanan Karumbayaram; Anna Matynia

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2343. doi:

ARVO Annual Meeting Abstract July 2019

Reduced expression of “normal” ABCA4 alleles in iPS-derived RPE cells from Stargardt Disease patients

Anna Matynia; Saravanan Karumbayaram; Samuel Strom; Jane Hu; Nermin Kady; Roxana A Radu; Michael B Gorin

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):388. doi:

ARVO Annual Meeting Abstract July 2018

Characterization of Stargardt iPSC-derived RPE cells

Nermin Kady; Anna Matynia; Saravanan Karumbayaram; Jane Hu; Marcia Lloyd; Dean Bok; Michael B Gorin; Roxana A. Radu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3045. doi:

ARVO Annual Meeting Abstract July 2018

Localization of ABCA4 in the Retinal Pigment Epithelium and its implications for Stargardt Disease

Tamara Lee Lenis; Sze Yin Ng; Jane Hu; Zhichun Jiang; Marcia Lloyd; Nicholas Esposito; Dean Bok; Silvia C Finnemann; Gabriel H Travis; Roxana A. Radu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4502. doi:

ARVO Annual Meeting Abstract July 2018

Complement C5 Inhibition as a Potential Treatment for Autosomal Recessive Stargardt Disease (STGD1): Design of a Clinical Trial Assessing a Novel Treatment and Primary Outcome Measure

Karl G Csaky; Dean Bok; Roxana A. Radu; Srinivas R. Sadda

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1569. doi:

ARVO Annual Meeting Abstract June 2017

Expression of ABCA4 in Retinal Pigment Epithelium cells and its implications for Stargardt disease

Tamara L Lenis; Shanta Sarfare; Jane Hu; Zhichun Jiang; Marcia Lloyd; Dean Bok; Gabriel H Travis; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):607. doi:

ARVO Annual Meeting Abstract June 2017

AAV-mediated delivery of ABCA4 to the photoreceptors of Abca4 -/- mice using an overlapping dual vector strategy

Michelle E McClements; Alun R Barnard; Mandeep S Singh; Zhichun Jiang; Peter Charbel Issa; Roxana A Radu; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4506. doi:

ARVO Annual Meeting Abstract September 2016

Liver x receptors (LXR) at the intersection of lipid metabolism and inflammation: implications for age-related macular degeneration (AMD)

Goldis Malek; Faryan Tayyari; Mayur Choudhary; Yiyi Wang; Zhichun Jiang; Steven Nusinowitz; Roxana A Radu; Peter Tontonoz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5011. doi:

ARVO Annual Meeting Abstract September 2016

Peropsin Effects Light-dependent Modulation of Retinyl Esters in the RPE

Jeremy D Cook; Eunice Ng; Marcia Lloyd; Shannan Eddington; Dean Bok; Hui Sun; Roxana A Radu; Gabriel H Travis

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1736. doi:

ARVO Annual Meeting Abstract September 2016

Elucidating the role of Retinal Pigment Epithelium (RPE)-specific ABCA4 in Stargardt disease

Tamara Lee Lenis; Zhichun Jiang; Shanta Sarfare; Andrew Le; Shannan Eddington; Dean Bok; Robert S Molday; Steven Nusinowitz; Michael Redmond; Gabriel H Travis; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3177. doi:

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Impaired Cathepsin D evidenced in iPSC-derived RPE cells of STGD1 patients

Assessing Variant Causality and Severity Using Retinal Pigment Epithelial Cells Derived from Stargardt Disease Patients

Membrane attack complex induces RPE cell death in Stargardt Disease

Deciphering the role of Rab28 in cone vision and outer segment phagocytosis

The D167A mutation in PDEA greatly depresses PDE expression but produces sensitive (though slower) rod responses and remarkably slow degeneration

Cathepsin D deficiency in RPE cells mediates Stargardt Disease pathogenesis

MeCP2-mediated mitochondrial impairment evidenced in Stargardt disease

Geographic Atrophy: Confocal Scanning Laser Ophthalmoscopy, Histology, and Inflammation in the Region of Expanding Lesions

Complement Dysregulation is Evidenced in iPSC-derived RPE Cells from Stargardt Disease patients

RGR opsin and RDH10 in Müller Cells Affect Light Dependent Synthesis of Chromophore Precursor for Cone Pigment Regeneration

Retinoid recycling is impaired in Stargardt iPSC-derived RPE

Reduced expression of “normal” ABCA4 alleles in iPS-derived RPE cells from Stargardt Disease patients

Characterization of Stargardt iPSC-derived RPE cells

Localization of ABCA4 in the Retinal Pigment Epithelium and its implications for Stargardt Disease

Complement C5 Inhibition as a Potential Treatment for Autosomal Recessive Stargardt Disease (STGD1): Design of a Clinical Trial Assessing a Novel Treatment and Primary Outcome Measure

Expression of ABCA4 in Retinal Pigment Epithelium cells and its implications for Stargardt disease

AAV-mediated delivery of ABCA4 to the photoreceptors of Abca4 -/- mice using an overlapping dual vector strategy

Liver x receptors (LXR) at the intersection of lipid metabolism and inflammation: implications for age-related macular degeneration (AMD)

Peropsin Effects Light-dependent Modulation of Retinyl Esters in the RPE

Elucidating the role of Retinal Pigment Epithelium (RPE)-specific ABCA4 in Stargardt disease

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