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Biochemistry and Molecular Biology December 2023

Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

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Marlies Gijs; Tuneille I. Adelaar; Daphne P. C. Vergouwen; Nienke Visser; Mor M. Dickman; Robin C. I. Ollivier; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts
TAGS: allergic conjunctivitis, keratoconus, proteins, proteome
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):9. https://doi.org/10.1167/iovs.64.15.9

Includes: Supplemental Content

Articles October 2021

In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study

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Marlies Gijs; Judith M. J. Veugen; Petra F. G. Wolffs; Paul H. M. Savelkoul; Jeanette Tas; Bas C. T. van Bussel; Martijn D. de Kruif; Ronald M. A. Henry; Carroll A. B. Webers; Mor M. Dickman; Rudy M. M. A. Nuijts
TAGS: cohort studies, conjunctiva, covid-19, nasopharynx, cytokine
Trans. Vis. Sci. Tech.. 2021; 10(12):32. https://doi.org/10.1167/tvst.10.12.32

Includes: Supplemental Content

Clinical Trials December 2020

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

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Christian J. F. Bertens; Suryan L. Dunker; Aylvin J. A. A. Dias; Frank J. H. M. van den Biggelaar; Rudy M. M. A. Nuijts; Marlies Gijs

Trans. Vis. Sci. Tech.. 2020; 9(13):35. https://doi.org/10.1167/tvst.9.13.35

Includes: Supplemental Content

Articles September 2020

Enzymatic Digestion of Porcine Corneas Cross-linked by Hypo- and Hyperosmolar Formulations of Riboflavin/ultraviolet A or WST11/Near-Infrared Light

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Jurriaan Brekelmans; Judith Veugen; Koen Rieff; Mor M. Dickman; Alexa Goz; Petra Wolffs; Alexander Brandis; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts; Avigdor Scherz; Arie L. Marcovich
TAGS: cornea, corneal collagen cross-linking, digestion, hyperosmolality, riboflavin, suidae, body weight, chromophore
Trans. Vis. Sci. Tech.. 2020; 9(10):4. https://doi.org/10.1167/tvst.9.10.4

Articles May 2020

Decreased Riboflavin Impregnation Time Does Not Increase the Risk for Endothelial Phototoxicity During Corneal Cross-Linking

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Arie L. Marcovich; Jurriaan Brekelmans; Alexander Brandis; Ilan Samish; Iddo Pinkas; Dina Preise; Keren Sasson; Ilan Feine; Alexandra Goz; Mor M. Dickman; Rudy M. M. A. Nuijts; Avigdor Scherz
TAGS: cornea, corneal collagen cross-linking, endothelium, mass or substance concentration per volume, phototoxicity, process of absorption, riboflavin, toxic effect, anterior chamber of eye, ultraviolet a radiation
Trans. Vis. Sci. Tech.. 2020; 9(6):4. https://doi.org/10.1167/tvst.9.6.4

Includes: Supplemental Content

Articles December 2019

Validation of Computerized Quantification of Ocular Redness

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Ekaterina Sirazitdinova; Marlies Gijs; Christian J. F. Bertens; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts; Thomas M. Deserno
TAGS: automation, color, conjunctiva, eye, machine learning, reliability, sclera, software, pixel, frequency distribution
Trans. Vis. Sci. Tech.. 2019; 8(6):31. https://doi.org/10.1167/tvst.8.6.31

Includes: Supplemental Content

Cornea June 2019

Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye

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Pooja Khamar; Archana Padmanabhan Nair; Rohit Shetty; Tanuja Vaidya; Murali Subramani; Murugeswari Ponnalagu; Kamesh Dhamodaran; Sharon D'souza; Anuprita Ghosh; Natasha Pahuja; Rashmi Deshmukh; Prerna Ahuja; Kanchan Sainani; Rudy M. M. A. Nuijts; Debashish Das; Arkasubhra Ghosh; Swaminathan Sethu
TAGS: cornea, dendritic cells, dry eye syndromes, pain perception, signs and symptoms, vitamin d
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2532-2542. https://doi.org/10.1167/iovs.19-26914

Includes: Supplemental Content

Cornea November 2018

In Vivo Prediction of Air-Puff Induced Corneal Deformation Using LASIK, SMILE, and PRK Finite Element Simulations

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Mathew Francis; Pooja Khamar; Rohit Shetty; Kanchan Sainani; Rudy M. M. A. Nuijts; Bart Haex; Abhijit Sinha Roy
TAGS: cornea, keratomileusis, laser in situ, postoperative care, preoperative care, surgical ocular refractive procedure, eye, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5320-5328. https://doi.org/10.1167/iovs.18-2470

Cornea November 2017

Corneal Biomechanical Changes and Tissue Remodeling After SMILE and LASIK

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Rohit Shetty; Mathew Francis; Rushad Shroff; Natasha Pahuja; Pooja Khamar; Molleti Girrish; Rudy M. M. A. Nuijts; Abhijit Sinha Roy
TAGS: biophysics, cornea, keratomileusis, laser in situ, tissue remodeling, eye
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5703-5712. https://doi.org/10.1167/iovs.17-22864

Cornea August 2017

Long-Term Biomechanical and Histologic Results of WST-D/NIR Corneal Stiffening in Rabbits, Up to 8 Months Follow-up

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Jurriaan Brekelmans; Alexandra Goz; Mor M. Dickman; Alexander Brandis; Xiaomeng Sui; H. Daniel Wagner; Rudy M. M. A. Nuijts; Avigdor Scherz; Arie L. Marcovich
TAGS: cornea, follow-up, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4089-4095. https://doi.org/10.1167/iovs.17-22108

Cornea October 2016

Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus

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Natasha Pahuja; Nimisha R. Kumar; Rushad Shroff; Rohit Shetty; Rudy M. M. A. Nuijts; Anuprita Ghosh; Abhijit Sinha-Roy; Shyam S. Chaurasia; Rajiv R. Mohan; Arkasubhra Ghosh
TAGS: cornea, gene expression, genes, keratoconus, retinal cone, extracellular matrix, gelatinase b, tumor necrosis factors, interleukin-6, tissue-inhibitor of metalloproteinase-1
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5372-5382. https://doi.org/10.1167/iovs.16-19677

Includes: Supplemental Content

Cornea February 2015

Elevated Expression of Matrix Metalloproteinase-9 and Inflammatory Cytokines in Keratoconus Patients Is Inhibited by Cyclosporine A

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Rohit Shetty; Anuprita Ghosh; Rayne R. Lim; Murali Subramani; Krina Mihir; Reshma A. R; Ashwini Ranganath; Sriharsha Nagaraj; Rudy M. M. A. Nuijts; Roger Beuerman; Reshma Shetty; Debashish Das; Shyam S. Chaurasia; Abhijit Sinha-Roy; Arkasubhra Ghosh
TAGS: cyclosporine, cytokine, gelatinase b, keratoconus, corneal epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2015; 56(2):738-750. https://doi.org/10.1167/iovs.14-14831

Includes: Supplemental Content

Cornea August 2014

Repeatability and Agreement of Three Scheimpflug-Based Imaging Systems for Measuring Anterior Segment Parameters in Keratoconus

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Rohit Shetty; Vishal Arora; Chaitra Jayadev; Rudy M. M. A. Nuijts; Mukesh Kumar; Narendra K. Puttaiah; Mathew Kurian Kummelil
TAGS: diagnostic imaging, keratoconus, cornea, keratometry
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5263-5268. https://doi.org/10.1167/iovs.14-15055

Cornea August 2014

Surface Metrology and 3-Dimensional Confocal Profiling of Femtosecond Laser and Mechanically Dissected Ultrathin Endothelial Lamellae

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Mor M. Dickman; Marc P. F. H. L. van Maris; Friso W. van Marion; Yvonne Schuchard; Petra Steijger-Vermaat; Frank J. H. M. van den Biggelaar; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts
TAGS: cornea, endothelium, femtosecond pulsed lasers, tissue dissection, reconstructive surgical procedures, microscopy, confocal, optics
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5183-5190. https://doi.org/10.1167/iovs.14-14309

Cornea April 2012

Vector Analysis of Corneal and Refractive Astigmatism Changes Following Toric Pseudophakic and Toric Phakic IOL Implantation

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Nienke Visser; Tos T. J. M. Berendschot; Noël J. C. Bauer; Rudy M. M. A. Nuijts
TAGS: astigmatism, cornea, implantation procedure, spatial vectors, postoperative care, eye
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):1865-1873. https://doi.org/10.1167/iovs.11-8868

Glaucoma April 2011

Reproducibility of Anterior Chamber Angle Measurements with Anterior Segment Optical Coherence Tomography

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Annelie N. Tan; Loes D. C. Sauren; John de Brabander; Tos T. J. M. Berendschot; Valéria Lima Passos; Carroll A. B. Webers; Rudy M. M. A. Nuijts; Henny J. M. Beckers
TAGS: anterior chamber of eye, optical coherence tomography, software, significance
Invest. Ophthalmol. Vis. Sci.. 2011; 52(5):2095-2099. https://doi.org/10.1167/iovs.10-5872

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics March 2011

Evaluation of the Comparability and Repeatability of Four Wavefront Aberrometers

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Nienke Visser; Tos T. J. M. Berendschot; Frenne Verbakel; Annelie N. Tan; John de Brabander; Rudy M. M. A. Nuijts
TAGS: astigmatism, cornea, eye, interobserver variation, pupil, coma, pupil size, retinoscopy
Invest. Ophthalmol. Vis. Sci.. 2011; 52(3):1302-1311. https://doi.org/10.1167/iovs.10-5841

Cornea February 2010

Model to Predict Endothelial Cell Loss after Iris-Fixated Phakic Intraocular Lens Implantation

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Muriël Doors; Tos T. J. M. Berendschot; Carroll A. B. Webers; Rudy M. M. A. Nuijts
TAGS: endothelial cells, implantation procedure, intraocular lens implantation procedure, iris fixation, preoperative care, follow-up, eye, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2010; 51(2):811-815. https://doi.org/10.1167/iovs.09-3981

Physiology and Pharmacology October 2005

The Influence of Intraocular Pressure on the Transscleral Diffusion of High-Molecular-Weight Compounds

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Lars P. J. Cruysberg; Rudy M. M. A. Nuijts; Dayle H. Geroski; Jake A. Gilbert; Fred Hendrikse; Henry F. Edelhauser
TAGS: body weight, diffusion, fluorescein-5-isothiocyanate, intraocular pressure, permeability, sclera, weight (force), dextran, albumins, pressure-physical agent
Invest. Ophthalmol. Vis. Sci.. 2005; 46(10):3790-3794. https://doi.org/10.1167/iovs.04-1414

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Tear Fluid Inflammatory Proteome Analysis Highlights Similarities Between Keratoconus and Allergic Conjunctivitis

In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

Enzymatic Digestion of Porcine Corneas Cross-linked by Hypo- and Hyperosmolar Formulations of Riboflavin/ultraviolet A or WST11/Near-Infrared Light

Decreased Riboflavin Impregnation Time Does Not Increase the Risk for Endothelial Phototoxicity During Corneal Cross-Linking

Validation of Computerized Quantification of Ocular Redness

Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye

In Vivo Prediction of Air-Puff Induced Corneal Deformation Using LASIK, SMILE, and PRK Finite Element Simulations

Corneal Biomechanical Changes and Tissue Remodeling After SMILE and LASIK

Long-Term Biomechanical and Histologic Results of WST-D/NIR Corneal Stiffening in Rabbits, Up to 8 Months Follow-up

Differential Molecular Expression of Extracellular Matrix and Inflammatory Genes at the Corneal Cone Apex Drives Focal Weakening in Keratoconus

Elevated Expression of Matrix Metalloproteinase-9 and Inflammatory Cytokines in Keratoconus Patients Is Inhibited by Cyclosporine A

Repeatability and Agreement of Three Scheimpflug-Based Imaging Systems for Measuring Anterior Segment Parameters in Keratoconus

Surface Metrology and 3-Dimensional Confocal Profiling of Femtosecond Laser and Mechanically Dissected Ultrathin Endothelial Lamellae

Vector Analysis of Corneal and Refractive Astigmatism Changes Following Toric Pseudophakic and Toric Phakic IOL Implantation

Reproducibility of Anterior Chamber Angle Measurements with Anterior Segment Optical Coherence Tomography

Evaluation of the Comparability and Repeatability of Four Wavefront Aberrometers

Model to Predict Endothelial Cell Loss after Iris-Fixated Phakic Intraocular Lens Implantation

The Influence of Intraocular Pressure on the Transscleral Diffusion of High-Molecular-Weight Compounds

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