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ARVO Annual Meeting Abstract June 2024

Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Martha Neuringer; Jonathan Stoddard; Rene Reynaga; Junghyun Ryu; Jon D Hennebold; Carol B Hanna; John V Brigande; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Elizabeth Boye; Renee Christine Ryals; Trevor J Mcgill; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4269.

ARVO Annual Meeting Abstract June 2024

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Rene Stephen Reynaga; Jonathan Stoddard; Lauren Renner; Hannah Woolard; Andreas K Lauer; Sanford L Boye; Shannon Elizabeth Boye; Steven Grey; Alison Weiss; Will Liguore; Trevor J Mcgill; Paul Yang; Renee Christine Ryals; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6088.

ARVO Annual Meeting Abstract June 2023

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Lauren Renner; Junghyun Ryu; Jon D Hennebold; Sanford L Boye; Carol Hanna; Fernanda Burch; Beth Kempton; Edward V Porsov; Rachel Spears; Benjamin Burwitz; Andreas K Lauer; David Wilson; Mark E Pennesi; Shannon Boye; John V Brigande; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):475.

ARVO Annual Meeting Abstract June 2023

Modification of rAAV capsid to improve retinal vascular endothelial tropism

Ramesh Periasamy; Dwani Patel; Sanford L Boye; Shannon E Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):768.

ARVO Annual Meeting Abstract June 2023

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Christine Nichols Kay; Paul Yang; Artur V Cideciyan; Allen Ho; Andreas K Lauer; Shannon E Boye; Sanford L Boye; Alejandro J Roman; Vivian Wu; Alexandra V Garafalo; Alexander Sumaroka; Laura P Pardon; Dan Yoon; Kenji P Fujita; Samuel Jacobson

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1914.

ARVO Annual Meeting Abstract June 2023

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Martha Neuringer; Junghyun Ryu; Jon D Hennebold; Carol Hanna; Fernanda Burch; Emily Mishler; Samuel Peterson; Betsy Ferguson; Rachel Spears; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Boye; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3854.

Retina April 2023

Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes

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Yvonne Adu-Agyeiwaah; Cristiano P. Vieira; Bright Asare-Bediako; Sergio Li Calzi; Mariana DuPont; Jason Floyd; Sanford Boye; Vince Chiodo; Julia V. Busik; Maria B. Grant
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, intravitreal injections, mice, retina, blood capillaries, inflammation, hypoxia
Trans. Vis. Sci. Tech.. 2023; 12(4):20. https://doi.org/10.1167/tvst.12.4.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Laterally Spreading AAV.SPR-hRS1 Vector for Treatment of XLRS

Linda Couto; Dana Elmore; James Peterson; Hangning Zhang; Laurence Ocelli; Ryan Boyd; Lauren Knupp; Sanford Boye; Shannon Boye

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2825 – A0341.

ARVO Annual Meeting Abstract June 2022

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Ramesh Periasamy; Dwani D Patel; Sanford L Boye; Shannon E Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):66 – A0039.

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454.

ARVO Annual Meeting Abstract June 2021

Four-year follow up of intraocular pressure (IOP) control in a canine model of open-angle glaucoma (OAG) treated with adeno-associated virus (AAV)-mediated modification of gene expression within the aqueous humor outflow pathways (AHOP)

Andras M Komaromy; Christine Harman; Kristin Koehl; Amanda Anderson; Sanford L Boye; Juan Pedro Steibel; Leandro Teixeira; Carol B Toris; Sayoko E Moroi; Shannon E Boye

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2783.

ARVO Annual Meeting Abstract June 2021

Development of rAAV capsid mutant vectors with improved tropism for retinal vascular endothelial.

Ramesh Periasamy; Dwani Patel; Shannon E Boye; Sanford L Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1468.

ARVO Annual Meeting Abstract June 2021

Gene therapy and gene-editing approaches to treat vision loss in a murine model of Acadian Usher syndrome

Katelyn N Robillard; Bhagwat V Alapure; Sanford L Boye; Shannon E Boye; Nicolas G Bazan; Jennifer J Lentz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1184.

ARVO Annual Meeting Abstract June 2020

Genetic strategies to treat vision loss in a murine model of Acadian Usher syndrome

Katelyn N Robillard; Sanford Boye; Shannon Boye; Nicolas G Bazan; Jennifer J Lentz

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2443.

ARVO Annual Meeting Abstract June 2020

Targeting Retinal Vascular Endothelial cells using rAAV Capsid Mutant Vectors

Ramesh Periasamy; Dwani Patel; Benyapa Khowpinitchai; Shannon Boye; Sanford Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4480.

ARVO Annual Meeting Abstract July 2019

Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Ryan F. Boyd; Joshua T Bartoe; Thomas S Vihtelic; James J Peterson; Hangning Zhang; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1330.

ARVO Annual Meeting Abstract July 2019

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Andras M Komaromy; Kristin L Koehl; Christine Harman; Sanford L Boye; Juan P. Steibel; Leandro B C Teixeira; Carol B Toris; Sayoko Eileen Moroi; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6470.

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002.

ARVO Annual Meeting Abstract July 2018

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

Kaitlyn Calabro; Sanford L Boye; Kevin Mccullough; Diego Fajardo; W Clay Smith; Christianne E Strang; Douglas C. Witherspoon; Dibyendu Chakraborty; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4535.

ARVO Annual Meeting Abstract July 2018

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Shreyasi Choudhury; Russell Mellen; Kevin Mccullough; James Peterson; Diego Fajardo; John Chiorini; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4536.

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Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Modification of rAAV capsid to improve retinal vascular endothelial tropism

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes

Laterally Spreading AAV.SPR-hRS1 Vector for Treatment of XLRS

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Four-year follow up of intraocular pressure (IOP) control in a canine model of open-angle glaucoma (OAG) treated with adeno-associated virus (AAV)-mediated modification of gene expression within the aqueous humor outflow pathways (AHOP)

Development of rAAV capsid mutant vectors with improved tropism for retinal vascular endothelial.

Gene therapy and gene-editing approaches to treat vision loss in a murine model of Acadian Usher syndrome

Genetic strategies to treat vision loss in a murine model of Acadian Usher syndrome

Targeting Retinal Vascular Endothelial cells using rAAV Capsid Mutant Vectors

Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

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