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ARVO Annual Meeting Abstract June 2024

The corneal endothelial transcriptome of TAZ-deficient mice demonstrates extracellular matrix (ECM) dysregulation and oxidative stress

Sara Thomasy; Raneesh Ramarapu; Sangwan Park; Nayeli Echeverria; Vijaykrishna Raghunathan; C. Titus Brown; Brian Leonard

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2141.

ARVO Annual Meeting Abstract June 2024

The corneal epithelium demonstrates cell type specific expression of alpha and beta tubulin subtypes

Raneesh Ramarapu; Sangwan Park; Nayeli Echeverria; Vijaykrishna Raghunathan; Brian Leonard; Crystal D Rogers; Sara Thomasy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4458.

ARVO Annual Meeting Abstract June 2024

Endothelial response to ultraviolet A (UVA)-induced injury in a murine model of Fuchs’ endothelial corneal dystrophy (FECD)

Nayeli Echeverria; Maria Ai Huong, Tran Do; Weinong Song; Hannah Shevalye; Laura Jane Young; Michelle Ferneding; Ana Cláudia Santos Raposo; Sangwan Park; Jessica Marie Skeie; Mark A Greiner; Brian Leonard; Sara Thomasy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5792.

ARVO Annual Meeting Abstract June 2024

Mitochondrial and endoplasmic reticular stress identified in the corneal endothelium of TAZ-deficient mice

Sangwan Park; Nayeli Echeverria; Raneesh Ramarapu; Brian Leonard; Christopher J Murphy; Vijaykrishna Raghunathan; Sara Thomasy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4167.

Retina September 2023

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen

PDF

Yevgeniy Sazhnyev; Tzu-Ni Sin; Anthony Ma; Ellie Chang; Leon Huynh; Karolina Roszak; Sangwan Park; Kevin Choy; Sina Farsiu; Ala Moshiri; Sara M. Thomasy; Glenn Yiu
TAGS: aging, drusen, macaca mulatta
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):44. https://doi.org/10.1167/iovs.64.12.44

Includes: Supplemental Content

Retina June 2023

Chromatic Pupillometry as a Putative Screening Tool for Heritable Retinal Disease in Rhesus Macaques

PDF

Elyse M. Salpeter; Ala Moshiri; Michelle Ferneding; Monica J. Motta; Sangwan Park; Chrisoula Skouritakis; Sara M. Thomasy
TAGS: macaca mulatta, pupillometry, retinal diseases, screening, dark adaptation
Trans. Vis. Sci. Tech.. 2023; 12(6):13. https://doi.org/10.1167/tvst.12.6.13

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Multimodal corneal imaging to characterize a novel central stromal dystrophy in dog

Ana Cláudia Raposo; Sangwan Park; Sophie M Le; Michelle Ferneding; Elyse Salpeter; Bret Moore; Brian Leonard; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4037.

ARVO Annual Meeting Abstract June 2023

Chromatic Electroretinography in Non-human Primates with and without PDE6C-associated Achromatopsia

Monica Motta; Quentin Davis; Michelle Ferneding; Sangwan Park; Kira H Lin; Rui Chen; Jeffrey Rogers; Tim Stout; Sara M Thomasy; Ala Moshiri

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5228.

ARVO Annual Meeting Abstract June 2023

A WHRN mutation in nonhuman primates alters ocular biometric parameters but not retinal structure or function

Jaeho Shim; Sangwan Park; Karolina Roszak; Kira H Lin; Sophie M Le; Monica Motta; Michelle Ferneding; Jun Wang; Marguerite F Knipe; Tim Stout; Jeffrey Rogers; Rui Chen; Ala Moshiri; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4190.

ARVO Annual Meeting Abstract June 2023

Long-term safety and biocompatibility of a biodegradable, thermoresponsive aflibercept-loaded microsphere-hydrogel drug delivery system in nonhuman primates

Brett D Story; Sangwan Park; Karolina Roszak; Jaeho Shim; Monica Motta; Michelle Ferneding; Kayla M Rudeen; Glenn Yiu; William F Mieler; Sara M Thomasy; Jennifer J Kang-Mieler

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):737.

ARVO Annual Meeting Abstract June 2023

Investigation of a novel rabbit nonpolar lipid for the treatment of evaporative dry eye disease in a murine model

Brian Leonard; Erin Hisey; Sangwan Park; Daniel M Albert; Charles O’Neill; Christopher J Murphy; Thomas R Gadek; Jennifer Y Li; Sara M Thomasy; Atul N Parikh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):712.

ARVO Annual Meeting Abstract June 2023

Biophysical behaviors of meibum from mice with meibomian gland dysfunction

Erin Hisey; Tanner J Finney; Tonya L Kuhl; Daniel M Albert; Charles A O'Neill; Thomas R Gadek; Jennifer Y Li; Sangwan Park; Christopher J Murphy; Sara M Thomasy; Atul N Parikh; Brian Leonard

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):669.

ARVO Annual Meeting Abstract June 2023

Disease progression using multimodal corneal imaging in an early-onset murine model of FECD

Nayeli Echeverria; Sangwan Park; Jaeho Shim; Michelle Ferneding; Laura J Young; Jessica Skeie; Mark A Greiner; Sara M Thomasy; Brian Leonard

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):637.

ARVO Annual Meeting Abstract June 2023

Genome-wide association study of corneal endothelial dystrophy in Boston terriers with the addition of formalin-fixed paraffin embedded tissue samples

Laura J Young; M Isabel Casanova; Danika L Bannasch; Sangwan Park; Nayeli Echeverria; Morgan AW Bowman; Alyssa L Hoehn; Connor Chang; Michelle Ferneding; Brian Leonard; Kathryn L Good; Jennifer Y Li; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2778.

ARVO Annual Meeting Abstract June 2023

Single-cell transcriptomics of the murine cornea reveals novel age driven changes in gene expression, cell identity composition, and limbal trajectory

Raneesh Ramarapu; Sangwan Park; Nayeli Echeverria; Michelle Ferneding; Sophie M Le; Monica Ardon; Vijay Krishna Raghunathan; Crystal D Rogers; Brian Leonard; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3145.

Cornea April 2023

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

PDF

Brian C. Leonard; Sangwan Park; Soohyun Kim; Laura J. Young; Iman Jalilian; Krista Cosert; Xunzhi Zhang; Jessica M. Skeie; Hanna Shevalye; Nayeli Echeverria; Vanessa Rozo; Xin Gong; Chao Xing; Christopher J. Murphy; Mark A. Greiner; V. Vinod Mootha; Vijay Krishna Raghunathan; Sara M. Thomasy
TAGS: cornea, endothelium, hereditary corneal dystrophy, mice, signs and symptoms, proteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):22. https://doi.org/10.1167/iovs.64.4.22

Includes: Supplemental Content

Retina January 2023

A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis

PDF

Tzu-Ni Sin; Sangbae Kim; Yumei Li; Jun Wang; Rui Chen; Sook Hyun Chung; Soohyun Kim; M. Isabel Casanova; Sangwan Park; Zeljka Smit-McBride; Ning Sun; Ori Pomerantz; Jeffrey A. Roberts; Bin Guan; Robert B. Hufnagel; Ala Moshiri; Sara M. Thomasy; Paul A. Sieving; Glenn Yiu
TAGS: myopic foveoschisis, primates, genes, macaca mulatta, photoreceptors, diagnostic imaging, eye, cell nucleus, proteins, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):18. https://doi.org/10.1167/iovs.64.1.18

Includes: Supplemental Content

Cornea & External Disease September 2022

Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques ( Macaca mulatta )

PDF

M. Isabel Casanova; Laura J. Young; Sangwan Park; Soohyun Kim; Karolina Roszak; Brian C. Leonard; Andrew Blandino; Monica J. Motta; Glenn Yiu; Jennifer Y. Li; Ala Moshiri; Sara M. Thomasy
TAGS: cornea, endothelial cells, macaca mulatta, body weight
Trans. Vis. Sci. Tech.. 2022; 11(9):23. https://doi.org/10.1167/tvst.11.9.23

Cornea & External Disease September 2022

Topical Ripasudil for the Treatment of Primary Corneal Endothelial Degeneration in Dogs

PDF

Sarah R. Michalak; Soohyun Kim; Sangwan Park; M. Isabel Casanova; Morgan A. W. Bowman; Michelle Ferneding; Brian C. Leonard; Kathryn L. Good; Jennifer Y. Li; Sara M. Thomasy
TAGS: cornea, dog, domestic, endothelium, eye, tissue degeneration, corneal edema, edema
Trans. Vis. Sci. Tech.. 2022; 11(9):2. https://doi.org/10.1167/tvst.11.9.2

ARVO Annual Meeting Abstract June 2022

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen

Yevgeniy Sazhnyev; Anthony Ma; Ellie Chang; Leon Huynh; Sangwan Park; Kevin Choy; Sina Farsiu; Ala Moshiri; Sara M Thomasy; Glenn Yiu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):485 – A0022.

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The corneal endothelial transcriptome of TAZ-deficient mice demonstrates extracellular matrix (ECM) dysregulation and oxidative stress

The corneal epithelium demonstrates cell type specific expression of alpha and beta tubulin subtypes

Endothelial response to ultraviolet A (UVA)-induced injury in a murine model of Fuchs’ endothelial corneal dystrophy (FECD)

Mitochondrial and endoplasmic reticular stress identified in the corneal endothelium of TAZ-deficient mice

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen

Chromatic Pupillometry as a Putative Screening Tool for Heritable Retinal Disease in Rhesus Macaques

Multimodal corneal imaging to characterize a novel central stromal dystrophy in dog

Chromatic Electroretinography in Non-human Primates with and without PDE6C-associated Achromatopsia

A WHRN mutation in nonhuman primates alters ocular biometric parameters but not retinal structure or function

Long-term safety and biocompatibility of a biodegradable, thermoresponsive aflibercept-loaded microsphere-hydrogel drug delivery system in nonhuman primates

Investigation of a novel rabbit nonpolar lipid for the treatment of evaporative dry eye disease in a murine model

Biophysical behaviors of meibum from mice with meibomian gland dysfunction

Disease progression using multimodal corneal imaging in an early-onset murine model of FECD

Genome-wide association study of corneal endothelial dystrophy in Boston terriers with the addition of formalin-fixed paraffin embedded tissue samples

Single-cell transcriptomics of the murine cornea reveals novel age driven changes in gene expression, cell identity composition, and limbal trajectory

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis

Normal Corneal Thickness and Endothelial Cell Density in Rhesus Macaques ( Macaca mulatta )

Topical Ripasudil for the Treatment of Primary Corneal Endothelial Degeneration in Dogs

Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen

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