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ARVO Annual Meeting Abstract July 2019

Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients with Dry Eye Disease: Results of a Randomized Clinical Trial

Christine Mun; Sapna Tibrewal; Anna Ahn; Azucena Lopez; Nour Atassi; Bayasgalan Surenkhuu; Morgan Buwick; Hirali Shah; Shivali Shukla; Jessica Mun; Anubhav Pradeep; Illangovan Raju; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6759.

Clinical Trials May 2019

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain
TAGS: deoxyribonucleases, dry eye syndromes, eyedrops, placebos, deoxyribonuclease i
Trans. Vis. Sci. Tech.. 2019; 8(3):10. https://doi.org/10.1167/tvst.8.3.10

ARVO Annual Meeting Abstract June 2017

Evaluation of computer-based image analysis for retinopathy of prematurity screening

Sapna Tibrewal; Peng Tian; Dharanish Kedarisetti; Jayashree Kalpathy-Cramer; Stratis Ioannidis; Deniz Erdogmus; J. Peter Campbell; Robison Vernon Paul Chan; Michael F Chiang

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5539.

Cornea September 2015

Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study

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Joelle A. Hallak; Sapna Tibrewal; Neil Mohindra; Xiaoyi Gao; Sandeep Jain
TAGS: brain-derived neurotrophic factor, deoxyribonuclease i, depressive disorders, dry eye syndromes, genes, polymorphism, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5990-5996. https://doi.org/10.1167/iovs.15-17036

ARVO Annual Meeting Abstract June 2015

Depressive Symptoms in Dry Eye Disease Patients: A Case-Control Study using the Beck Depression Inventory

Joelle Hallak; Sapna Tibrewal; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):312.

ARVO Annual Meeting Abstract June 2015

Forced Differentiation of Corneal Stromal Cell Spheroids Yields Cells with Tissue-Resident Keratocyte Characteristics

Eunjae Kim; Yong-Soo Byun; Sapna Tibrewal; Joy Sarkar; Yair Ivanir; Anubhav Pradeep; Wesley Jun; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4916.

Cornea December 2014

Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease

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Sapna Tibrewal; Yair Ivanir; Joy Sarkar; Neema Nayeb-Hashemi; Charles S. Bouchard; Eunjae Kim; Sandeep Jain
TAGS: dry eye syndromes, hyperosmolality, hyperosmolar hyperglycemia, neutrophil extracellular traps, neutrophils, stress, international organization for standardization
Invest. Ophthalmol. Vis. Sci.. 2014; 55(12):7961-7969. https://doi.org/10.1167/iovs.14-15332

ARVO Annual Meeting Abstract April 2014

Non-self extracellular DNA (eDNA) may potentiate inflammation and severity of dry eyes in patients with chronic ocular Graft-Versus-Host Disease (GVHD)

Sapna Tibrewal; Joy Sarkar; Sarmad Hassan Jassim; Yair Ivanir; Eunjae Kim; Yong Soo Byun; Rama Wahood; Shweta Chaudhary; Kaele Leonard; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2008.

ARVO Annual Meeting Abstract April 2014

Neutrophil Extracellular Traps accumulate on ocular surface of Dry Eye Disease patients: Potential for a new therapeutic strategy using DNase I eye drops

Yair Ivanir; Sapna Tibrewal; Joy Sarkar; Eunjae Kim; Sarmad Hassan Jassim; Snehal Sonawane; Yong-Soo Byun; Rama Wahood; Lauren Schneider; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3685.

ARVO Annual Meeting Abstract April 2014

Neuroregenerative and Immunosuppressive actions of Myeloid-derived Suppressor Cells (MDSCs) in the Cornea

Joy Sarkar; Eunjae Kim; Shweta Chaudhary; Yong Soo Byun; Sapna Tibrewal; Yair Ivanir; Rama Wahood; Neil Mohindra; Kaele Leonard; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4721.

ARVO Annual Meeting Abstract April 2014

Stemness Transcription Factor Nanog is Expressed During Spheroid Culture of Corneal Stromal Cells

Yong Soo Byun; Eunjae Kim; Sapna Tibrewal; Yair Ivanir; Rama Wahood; Kaele Leonard; Sarmad Hassan Jassim; Shweta Chaudhary; Joy Sarkar; Sandeep Jain

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5133.

Cornea December 2013

Tear Fluid Extracellular DNA: Diagnostic and Therapeutic Implications in Dry Eye Disease

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Sapna Tibrewal; Joy Sarkar; Sarmad H. Jassim; Sonal Gandhi; Snehal Sonawane; Shweta Chaudhary; Yong-Soo Byun; Yair Ivanir; Joelle Hallak; John H. Horner; Martin Newcomb; Sandeep Jain
TAGS: dna, dry eye syndromes, dyes, eyedrops, fluorescence, signs and symptoms, deoxyribonuclease i
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):8051-8061. https://doi.org/10.1167/iovs.13-12844

Cornea September 2013

CD11b+GR1+ Myeloid Cells Secrete NGF and Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration

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Joy Sarkar; Shweta Chaudhary; Sarmad H. Jassim; Okan Ozturk; Wallace Chamon; Balaji Ganesh; Sapna Tibrewal; Sonal Gandhi; Yong-Soo Byun; Joelle Hallak; Dolores L. Mahmud; Nadim Mahmud; Damiano Rondelli; Sandeep Jain
TAGS: cornea, myeloid cells, neural development
Invest. Ophthalmol. Vis. Sci.. 2013; 54(9):5920-5936. https://doi.org/10.1167/iovs.13-12237

ARVO Annual Meeting Abstract June 2013

CD11b+GR1+ Myeloid Cells Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration

Sonal Gandhi; Joy Sarkar; Wallace Chamon; Shweta Chaudhary; Sapna Tibrewal; Yong-Soo Byun; Sarmad Jassim; Abhishek Sharma; Neil Mohindra; Sandeep Jain; Corneal Neurobiology Laboratory

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3884.

ARVO Annual Meeting Abstract June 2013

Semaphorin 7a actions on nerves and myeloid cells in the cornea promote nerve regeneration, thus linking neuronal and myeloid systems

Sarmad Jassim; Abed Namavari; Shweta Chaudhary; Sapna Tibrewal; Yong-Soo Byun; Sonal Gandhi; Neil Mohindra; Hyun Lee; Joy Sarkar; Sandeep Jain; Corneal Neurobiology Laboratory

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3885.

ARVO Annual Meeting Abstract June 2013

Reprogramming Genes Are Expressed during Spheroidal Culture of Corneal Stromal Cells

Yong-Soo Byun; Lisette Yco; Brittany Shaheen; Abhishek Sharma; Shweta Chaudhary; Sonal Gandhi; Sarmad Jassim; Joy Sarkar; Sapna Tibrewal; Sandeep Jain; Corneal Neurobiology Laboratory

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5251.

Cornea December 2012

Ocular Surface Extracellular DNA and Nuclease Activity Imbalance: A New Paradigm for Inflammation in Dry Eye Disease

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Snehal Sonawane; Vishakha Khanolkar; Abed Namavari; Shweta Chaudhary; Sonal Gandhi; Sapna Tibrewal; Sarmad H. Jassim; Brittany Shaheen; Joelle Hallak; John H. Horner; Martin Newcomb; Joy Sarkar; Sandeep Jain
TAGS: conjunctiva, deoxyribonuclease i, dna, dry eye syndromes, imbalance, inflammation, nuclease, leukocyte elastase, neutrophils
Invest. Ophthalmol. Vis. Sci.. 2012; 53(13):8253-8263. https://doi.org/10.1167/iovs.12-10430

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Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients with Dry Eye Disease: Results of a Randomized Clinical Trial

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

Evaluation of computer-based image analysis for retinopathy of prematurity screening

Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study

Depressive Symptoms in Dry Eye Disease Patients: A Case-Control Study using the Beck Depression Inventory

Forced Differentiation of Corneal Stromal Cell Spheroids Yields Cells with Tissue-Resident Keratocyte Characteristics

Hyperosmolar Stress Induces Neutrophil Extracellular Trap Formation: Implications for Dry Eye Disease

Non-self extracellular DNA (eDNA) may potentiate inflammation and severity of dry eyes in patients with chronic ocular Graft-Versus-Host Disease (GVHD)

Neutrophil Extracellular Traps accumulate on ocular surface of Dry Eye Disease patients: Potential for a new therapeutic strategy using DNase I eye drops

Neuroregenerative and Immunosuppressive actions of Myeloid-derived Suppressor Cells (MDSCs) in the Cornea

Stemness Transcription Factor Nanog is Expressed During Spheroid Culture of Corneal Stromal Cells

Tear Fluid Extracellular DNA: Diagnostic and Therapeutic Implications in Dry Eye Disease

CD11b+GR1+ Myeloid Cells Secrete NGF and Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration

CD11b+GR1+ Myeloid Cells Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration

Semaphorin 7a actions on nerves and myeloid cells in the cornea promote nerve regeneration, thus linking neuronal and myeloid systems

Reprogramming Genes Are Expressed during Spheroidal Culture of Corneal Stromal Cells

Ocular Surface Extracellular DNA and Nuclease Activity Imbalance: A New Paradigm for Inflammation in Dry Eye Disease

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