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Artificial Intelligence September 2024

Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

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Coen de Vente; Philippe Valmaggia; Carel B. Hoyng; Frank G. Holz; Mohammad M. Islam; Caroline C. W. Klaver; Camiel J. F. Boon; Steffen Schmitz-Valckenberg; Adnan Tufail; Marlene Saßmannshausen; Clara I. Sánchez; on behalf of the MACUSTAR Consortium
TAGS: datasets, deep learning, eye, retinal atrophy, retinal pigment epithelium, biological markers, cohort studies, training
Trans. Vis. Sci. Tech.. 2024; 13(9):11. https://doi.org/10.1167/tvst.13.9.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Comparison between OCT B-Scan and En Face Imaging for the Diagnosis of Early Macular Atrophy in Age-Related Macular Degeneration

Omer Trivizki; Yuxuan Cheng; Monika Fleckenstein; Steffen Schmitz-Valckenberg; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4829.

ARVO Annual Meeting Abstract June 2024

Geographic atrophy secondary to age-related macular degeneration: Significance of lesion location and functional determinants to vision-related quality of life

Eliza Eliza Broadbent; Sandrine H. Künzel; Philipp Möller; Moritz Linder; Lukas Goerdt; Joanna Czauderna; Steffen Schmitz-Valckenberg; Frank G Holz; Maximilian Pfau; Monika Fleckenstein

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5973.

ARVO Annual Meeting Abstract June 2024

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Lukas Schloesser; Jan Henrik Terheyden; Charlotte Behning; Hannah Klinkhammer; Davide Garzone; Marlene Sassmannshausen; Steffen Schmitz-Valckenberg; Carel C B Hoyng; Clarisa Sanchez; Ulrich F O Luhmann; Klaus-Peter Moll; Sergio Leal; Matthias Schmid; Frank G Holz; Robert Finger

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):378.

ARVO Annual Meeting Abstract June 2024

Patient-tailored fundus-controlled perimetry testing in intermediate and early atrophic age-related macular degeneration

Steffen Schmitz-Valckenberg; Petrus Chang; Monika Fleckenstein; Frank G Holz; Zhichao Wu; Robyn H Guymer; Liang Liu; Hao Chen; Maximilian Pfau

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2794.

ARVO Annual Meeting Abstract June 2024

Clinical Manifestation of Macular Neovascularization in Age-related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5), on Chromosome 10 (ARMS2/HTRA1) or Both

Brian Solinsky; Steffen Schmitz-Valckenberg; Moussa A Zouache; Whitney Brinkley; Christian Pappas; Jill Hageman; Monika Fleckenstein; Gregory S Hageman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2788.

ARVO Annual Meeting Abstract June 2024

Association of Ellipsoid Zone Reflectivity and Choriocapillaris Flow in Age-Related Macular Degeneration: a MACUSTAR study report

Yannick N. Liermann; Ben Isselmann; Marlene Sassmannshausen; Sandrine H. Künzel; Ulrich F O Luhmann; Sergio Leal; Matthias Schmid; Robert Finger; Steffen Schmitz-Valckenberg; Frank G Holz; Charlotte Behning; Sarah Thiele

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2315.

ARVO Annual Meeting Abstract June 2024

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Tobias Peters; Katarina Stingl; Wolfgang Klein; Mario G Fsadni; Nils Meland; Patty P.A. Dhooge; Camiel Boon; Andrew Lotery; Maurizio Battaglia Parodi; Philipp Herrmann; Frank G Holz; Steffen Schmitz-Valckenberg; Philipp Möller; Carel C B Hoyng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2205.

ARVO Annual Meeting Abstract June 2024

Validating a Confirmatory Structure-Function Model Prognostic of Progression of Intermediate AMD: MACUSTAR Study Primary Endpoint Analysis

Charlotte Behning; Jan Henrik Terheyden; Robert Finger; Hannah M P Dunbar; Marlene Sassmannshausen; Adnan Tufail; David P. Crabb; Alison M Binns; Zhichao Wu; Robyn H Guymer; Nadia Zakaria; Sergio Leal; Steffen Schmitz-Valckenberg; Ulrich F O Luhmann; Matthias Schmid; Frank G Holz

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4314.

ARVO Annual Meeting Abstract June 2024

Prognostic value of structural biomarkers for disease progression in intermediate age-related macular degeneration: a MACUSTAR study report

Marlene Sassmannshausen; Sarah Thiele; Jan Henrik Terheyden; Ulrich F O Luhmann; Sergio Leal; Matthias Schmid; Robert Finger; Frank G Holz; Steffen Schmitz-Valckenberg; Charlotte Behning

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5684.

Retina April 2024

Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years

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Marlene Saßmannshausen; Senem Döngelci; Marc Vaisband; Leon von der Emde; Kenneth R. Sloan; Jan Hasenauer; Frank G. Holz; Steffen Schmitz-Valckenberg; Thomas Ach
TAGS: age-related macular degeneration, biological markers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):45. https://doi.org/10.1167/iovs.65.4.45

Includes: Supplemental Content

Retina July 2023

Geographic Atrophy Segmentation Using Multimodal Deep Learning

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Theodore Spaide; Jiaxiang Jiang; Jasmine Patil; Neha Anegondi; Verena Steffen; Michael G. Kawczynski; Elizabeth M. Newton; Christina Rabe; Simon S. Gao; Aaron Y. Lee; Frank G. Holz; SriniVas Sadda; Steffen Schmitz-Valckenberg; Daniela Ferrara
TAGS: atrophy, datasets, deep learning, screening, training, diagnostic imaging
Trans. Vis. Sci. Tech.. 2023; 12(7):10. https://doi.org/10.1167/tvst.12.7.10

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Initial Manifestation of Complete Retinal Pigment Epithelium and Outer Retinal Atrophy (cRORA) in Age-related Macular Degeneration: Associations With Genetic Risk Profile

Steffen Schmitz-Valckenberg; Monika Fleckenstein; Christian Pappas; Jill Hageman; Moussa A Zouache; Gregory S Hageman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):918.

ARVO Annual Meeting Abstract June 2023

Retest variability of quantitative fundus autofluorescence and its determinants in age-related macular degeneration: A MACUSTAR study report

Leon Alexander von der Emde; Merten Mallwitz; Steffen Schmitz-Valckenberg; Marlene Sassmannshausen; Kenneth R Sloan; Marc Vaisband; Jan Henrik Terheyden; Robert Patrick Finger; Frank G Holz; Thomas Ach

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1057.

ARVO Annual Meeting Abstract June 2023

Functional, Anatomical and Patient-Reported Baseline Characteristics of the MACUSTAR Study

Robert Patrick Finger; Jan H. Terheyden; Hannah M P Dunbar; Charlotte Behning; Matthias Schmid; Adnan Tufail; David Crabb; Klaus Peter Moll; Ulrich F O Luhmann; Steffen Schmitz-Valckenberg; Sergio Leal; Frank G Holz

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1751.

ARVO Annual Meeting Abstract June 2023

Association of age-related macular degeneration (AMD) retinal biomarkers with AMD polygenic risk scores in the MACUSTAR study cohort

Jan Henrik Terheyden; Charlotte Behning; Marlene Sassmannshausen; sarah thiele; Steffen Schmitz-Valckenberg; Adnan Tufail; Carel C B Hoyng; Matthias Schmid; Ulrich F O Luhmann; Klaus Peter Moll; Sergio Leal; Frank G Holz; Robert P Finger

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2150.

ARVO Annual Meeting Abstract June 2023

Functional characterization of the relative ellipsoid zone reflectivity in age-related macular degeneration.

Yannick Liermann; Marlene Sassmannshausen; Charlotte Behning; Leonie Weinhold; Matthias Schmid; Ben Isselmann; Hannah M P Dunbar; Alison Binns; Ulrich F O Luhmann; Stephen Poor; Robert P Finger; Steffen Schmitz-Valckenberg; Frank G Holz; Maximilian Pfau; Chi D Luu; sarah thiele

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2145.

ARVO Annual Meeting Abstract June 2023

Structural biomarkers of abnormal dynamic and static rod function in the MACUSTAR baseline dataset

Alison Binns; Hannah M P Dunbar; David Crabb; Charlotte Behning; Jan H. Terheyden; Marlene Sassmannshausen; sarah thiele; Steffen Schmitz-Valckenberg; Bethany Elora Higgins; Stephen Poor; Robert Patrick Finger; Sergio Leal; Frank G Holz; Matthias Schmid; Ulrich F O Luhmann

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2763.

ARVO Annual Meeting Abstract June 2023

Evidence for association between impaired visual function and structurally defined sub-phenotypes in intermediate AMD – A MACUSTAR study report

Charlotte Behning; Hannah M P Dunbar; Marlene Sassmannshausen; sarah thiele; Alison Binns; Bethany Elora Higgins; Jan H. Terheyden; Adnan Tufail; Sergio Leal; Nadia Zakaria; Frank G Holz; Matthias Schmid; Robert P Finger; David Crabb; Steffen Schmitz-Valckenberg; Ulrich F O Luhmann

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2761.

ARVO Annual Meeting Abstract June 2023

Global versus localized association of reticular pseudodrusen with relative ellipsoid zone reflectivity in intermediate age-related macular degeneration

Sarah Thiele; Charlotte Behning; Yannick Liermann; Marlene Sassmannshausen; Leonie Weinhold; Ben Isselmann; Matthias Schmid; Robert P Finger; Steffen Schmitz-Valckenberg; Maximilian Pfau; Chi D Luu; Frank G Holz

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4326.

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Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

Comparison between OCT B-Scan and En Face Imaging for the Diagnosis of Early Macular Atrophy in Age-Related Macular Degeneration

Geographic atrophy secondary to age-related macular degeneration: Significance of lesion location and functional determinants to vision-related quality of life

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Patient-tailored fundus-controlled perimetry testing in intermediate and early atrophic age-related macular degeneration

Clinical Manifestation of Macular Neovascularization in Age-related Macular Degeneration Among Individuals Homozygous for Risk Alleles on Chromosome 1 (CFH-CFHR5), on Chromosome 10 (ARMS2/HTRA1) or Both

Association of Ellipsoid Zone Reflectivity and Choriocapillaris Flow in Age-Related Macular Degeneration: a MACUSTAR study report

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Validating a Confirmatory Structure-Function Model Prognostic of Progression of Intermediate AMD: MACUSTAR Study Primary Endpoint Analysis

Prognostic value of structural biomarkers for disease progression in intermediate age-related macular degeneration: a MACUSTAR study report

Spatially Resolved Association of Structural Biomarkers on Retinal Function in Non-Exudative Age-Related Macular Degeneration Over 4 Years

Geographic Atrophy Segmentation Using Multimodal Deep Learning

Initial Manifestation of Complete Retinal Pigment Epithelium and Outer Retinal Atrophy (cRORA) in Age-related Macular Degeneration: Associations With Genetic Risk Profile

Retest variability of quantitative fundus autofluorescence and its determinants in age-related macular degeneration: A MACUSTAR study report

Functional, Anatomical and Patient-Reported Baseline Characteristics of the MACUSTAR Study

Association of age-related macular degeneration (AMD) retinal biomarkers with AMD polygenic risk scores in the MACUSTAR study cohort

Functional characterization of the relative ellipsoid zone reflectivity in age-related macular degeneration.

Structural biomarkers of abnormal dynamic and static rod function in the MACUSTAR baseline dataset

Evidence for association between impaired visual function and structurally defined sub-phenotypes in intermediate AMD – A MACUSTAR study report

Global versus localized association of reticular pseudodrusen with relative ellipsoid zone reflectivity in intermediate age-related macular degeneration

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