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ARVO Annual Meeting Abstract June 2024

Polygenic risk is associated with differential treatment response to SLT and medical therapy in treatment-naive glaucoma

Jamie E Craig; Antonia Kolovos; Thi Thi Nguyen; Joshua Schmidt; Stuart L Graham; Alex W Hewitt; Owen Siggs; Stuart MacGregor; Mark Hassall

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1012.

ARVO Annual Meeting Abstract June 2024

Polygenic prediction of keratoconus and its measures: cross-sectional and longitudinal analyses in community-based young adults

Samantha Sze-Yee Lee; Santiago Diaz Torres; Weixiong He; Elsie Chan; Elaine Chong; Puya Gharahkhani; Stuart MacGregor; Gareth Lingham; David A Mackey

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2852.

ARVO Annual Meeting Abstract June 2024

Sleep Apnoea Syndrome Correlated with Progression of Normal Tension Glaucoma

Ella Claire Berry; Henry Marshall; Mark Hassall; Antonia Kolovos; Joshua Schmidt; Sean Mullany; Stewart Lake; Anna Galanopoulos; John Landers; Paul Healey; Stuart L Graham; Alex W Hewitt; Stuart MacGregor; Robert Casson; Owen Siggs; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2766.

ARVO Annual Meeting Abstract June 2024

High glaucoma polygenic risk is strongly associated with development of glaucoma in patients with pseudoexfoliation syndrome

Antonia Kolovos; Ayub Qassim; Mark Hassall; Weixiong He; Henry Marshall; Stuart L Graham; Robert James Casson; Richard A Mills; Stewart Lake; Alex W Hewitt; Kathryn Burdon; Joshua Schmidt; Stuart MacGregor; Emmanuelle Souzeau; Owen Siggs; Jamie Craig

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4058.

Glaucoma June 2024

Assessing the Efficacy of Synthetic Optic Disc Images for Detecting Glaucomatous Optic Neuropathy Using Deep Learning

PDF

Abadh K. Chaurasia; Stuart MacGregor; Jamie E. Craig; David A. Mackey; Alex W. Hewitt
TAGS: datasets, glaucoma, optic disk, optic nerve disorders, deep learning, training
Trans. Vis. Sci. Tech.. 2024; 13(6):1. https://doi.org/10.1167/tvst.13.6.1

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2023

Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study

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Ella C. Berry; Henry N. Marshall; Sean Mullany; Santiago Diaz Torres; Joshua Schmidt; Daniel Thomson; Lachlan S. W. Knight; Georgina L. Hollitt; Ayub Qassim; Bronwyn Ridge; Angela Schulz; Mark M. Hassall; Thi Thi Nguyen; Stewart Lake; Richard A. Mills; Ashish Agar; Anna Galanopoulos; John Landers; Paul R. Healey; Stuart L. Graham; Alex W. Hewitt; Stuart MacGregor; Robert J. Casson; Owen M. Siggs; Jamie E. Craig
TAGS: cohort studies, physical activity, biobanks
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):11. https://doi.org/10.1167/iovs.64.3.11

Includes: Supplemental Content

Glaucoma February 2023

Genetic Associations Between Smoking- and Glaucoma-Related Traits

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Jessica H. Tran; Kelsey V. Stuart; Victor de Vries; Joëlle E. Vergroesen; Clara C. Cousins; Pirro G. Hysi; Ron Do; Ghislain Rocheleau; Jae H. Kang; Janey L. Wiggs; Stuart MacGregor; Anthony P. Khawaja; David A. Mackey; Caroline C. W. Klaver; Wishal D. Ramdas; Louis R. Pasquale; for the UK Biobank Eye and Vision Consortium, and for the International Glaucoma Genetics Consortium
TAGS: genetics, glaucoma, smoking
Trans. Vis. Sci. Tech.. 2023; 12(2):20. https://doi.org/10.1167/tvst.12.2.20

Includes: Supplemental Content

Glaucoma October 2022

Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals

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Georgina L. Hollitt; Owen M. Siggs; Bronwyn Ridge; Miriam C. Keane; David A. Mackey; Stuart MacGregor; Alex W. Hewitt; Jamie E. Craig; Emmanuelle Souzeau
TAGS: genetic risk, glaucoma, attitude
Trans. Vis. Sci. Tech.. 2022; 11(10):38. https://doi.org/10.1167/tvst.11.10.38

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Integrating genetics and metabolomics data reveals putative mechanisms for age-related macular degeneration

Xikun Han; Ines Lains; Jun Li; Qibin Qi; Bing Yu; Jessica Lasky-Su; Joan W Miller; Frank Hu; Walter Willett; Stuart MacGregor; Deeba Husain; Liming Liang

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):0003.

ARVO Annual Meeting Abstract June 2022

Genetic correlations between smoking- and glaucoma-related traits

Jessica H. Tran; Kelsey V. Stuart; Clara Cousins; Pirro G Hysi; Anthony P Khawaja; Ron Do; Shantanu Bafna; Jae Kang; Jiali Wang; Stuart MacGregor; Janey L Wiggs; Louis R Pasquale

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1133.

ARVO Annual Meeting Abstract June 2022

The APOE E4 allele is associated with faster rates of mGCIPL thinning in the PROGRESSA cohort

Sean Mullany; Henry Marshall; Emmanuelle Souzeau; Mark Hassall; Ashish Agar; Anna Galanopoulos; John Landers; Paul Mitchell; Paul Healey; Stuart L Graham; Alex W Hewitt; Stuart MacGregor; Puya Gharahkhani; Robert Casson; Owen Siggs; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1658 – A0153.

ARVO Annual Meeting Abstract June 2022

Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts

Ella Claire Berry; Henry Marshall; Sean Mullany; Santiago Diaz Torres; Joshua Schmidt; Daniel Thomson; Mark Hassall; Stewart R Lake; Richard A Mills; John Landers; Stuart MacGregor; Robert Casson; Owen Siggs; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3490.

ARVO Annual Meeting Abstract June 2022

High polygenic risk is associated with earlier treatment initiation and escalation in glaucoma suspects

Henry Marshall; Xikun Han; Sean Mullany; Georgie Hollitt; Ella Claire Berry; Lachlan Knight; Richard A Mills; John Landers; Paul Healey; Alex W Hewitt; Stuart L Graham; Robert Casson; Stuart MacGregor; Owen Siggs; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4018 – A0360.

ARVO Annual Meeting Abstract June 2022

A polygenic risk score predicts functional progression in early primary open-angle glaucoma

Owen Siggs; Ayub Qassim; Xikun Han; Henry Marshall; Sean Mullany; Emmanuelle Souzeau; Anna Galanopoulos; Ashish Agar; John Landers; Robert Casson; Alex W Hewitt; Paul Healey; Stuart L Graham; Stuart MacGregor; Jamie Craig

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4011 – A0353.

Glaucoma January 2022

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

PDF

Nathan Ingold; Adrian I. Campos; Xikun Han; Jue-Sheng Ong; Puya Gharahkhani; David A. Mackey; Miguel E. Rentería; Matthew H. Law; Stuart MacGregor
TAGS: disease susceptibility, glaucoma, obstructive sleep apnea, sleep apnea syndromes, genetic risk
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):25. https://doi.org/10.1167/iovs.63.1.25

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Combining glaucoma and correlated risk factors dramatically expands gene discovery for glaucoma

Stuart MacGregor; Xikun Han; Puya Gharahkhani; Maciej Trzaskowski; Jamie E Craig; Alex W Hewitt; David A Mackey; Janey L Wiggs; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1512.

ARVO Annual Meeting Abstract June 2021

Hypercholestolaemia predicts disease progression in primary open-angle glaucoma

Henry Marshall; Sean Mullany; Ayub Qassim; Xikun Han; Mark Hassall; Thi Nguyen; Paul R Healey; Ashish Agar; Alex W Hewitt; Stuart MacGregor; Stuart L Graham; Robert Casson; Owen Siggs; Jamie E Craig

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2365.

ARVO Annual Meeting Abstract June 2021

Cost-effectiveness of polygenic risk profiling for primary open-angle glaucoma in the United Kingdom and Australia

Qinqin Liu; John Davis; Xikun Han; David A Mackey; Stuart MacGregor; Jamie E Craig; Lei Si; Alex W Hewitt

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2649.

Special Issue April 2021

IMI 2021 Yearly Digest

PDF

Monica Jong; Jost B. Jonas; James S. Wolffsohn; David A. Berntsen; Pauline Cho; Danielle Clarkson-Townsend; Daniel I. Flitcroft; Kate L. Gifford; Annechien E. G. Haarman; Machelle T. Pardue; Kathryn Richdale; Padmaja Sankaridurg; Milly S. Tedja; Christine F. Wildsoet; Joan E. Bailey-Wilson; Jeremy A. Guggenheim; Christopher J. Hammond; Jaakko Kaprio; Stuart MacGregor; David A. Mackey; Anthony M. Musolf; Caroline C. W. Klaver; Virginie J. M. Verhoeven; Veronique Vitart; Earl L. Smith, III
TAGS: myopia
Invest. Ophthalmol. Vis. Sci.. 2021; 62(5):7. https://doi.org/10.1167/iovs.62.5.7

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Janey Wiggs; Puya Gharahkhani; Eric Jorgenson; Pirro G Hysi; Anthony Khawaja; Sarah Pendergrass; Xikun Han; David Mackey; Christopher Hammond; Michael A Hauser; Louis R Pasquale; Caroline Klaver; Michiaki Kubo; Tin Aung; Jamie E Craig; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1890.

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Polygenic risk is associated with differential treatment response to SLT and medical therapy in treatment-naive glaucoma

Polygenic prediction of keratoconus and its measures: cross-sectional and longitudinal analyses in community-based young adults

Sleep Apnoea Syndrome Correlated with Progression of Normal Tension Glaucoma

High glaucoma polygenic risk is strongly associated with development of glaucoma in patients with pseudoexfoliation syndrome

Assessing the Efficacy of Synthetic Optic Disc Images for Detecting Glaucomatous Optic Neuropathy Using Deep Learning

Physical Activity Is Associated With Macular Thickness: A Multi-Cohort Observational Study

Genetic Associations Between Smoking- and Glaucoma-Related Traits

Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals

Integrating genetics and metabolomics data reveals putative mechanisms for age-related macular degeneration

Genetic correlations between smoking- and glaucoma-related traits

The APOE E4 allele is associated with faster rates of mGCIPL thinning in the PROGRESSA cohort

Greater physical activity is associated with neuroretinal thinning in glaucomatous and normative cohorts

High polygenic risk is associated with earlier treatment initiation and escalation in glaucoma suspects

A polygenic risk score predicts functional progression in early primary open-angle glaucoma

Is Genetic Risk for Sleep Apnea Causally Linked With Glaucoma Susceptibility?

Combining glaucoma and correlated risk factors dramatically expands gene discovery for glaucoma

Hypercholestolaemia predicts disease progression in primary open-angle glaucoma

Cost-effectiveness of polygenic risk profiling for primary open-angle glaucoma in the United Kingdom and Australia

IMI 2021 Yearly Digest

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

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