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Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract July 2024

Imaging and photomodulation of lamina cribrosa (LC) microstructure

Po-Yi Lee; Miriam Kunz; Susannah Waxman; Hannah Schilpp; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PP0014.

ARVO Annual Meeting Abstract June 2024

IOP-induced strains in individual in situ collagenous lamina cribrosa astrocytes are heterogenous

Susannah Waxman; Bingrui Wang; Sofia Lusvardi; Ian Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4878.

ARVO Annual Meeting Abstract June 2024

Axons passing through small LC pores suffer larger IOP-induced distortions than those through large pores

Bingrui Wang; Susannah Waxman; Sofia Lusvardi; Yuankai Lu; Yingzhe Han; Ashley Ray Linton; Tian Qi; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1205.

ARVO Imaging in the Eye Conference Abstract June 2023

High-resolution dual-modality imaging for collagen fibers and blood vessels in lamina cribrosa (LC) beams

Po-Yi Lee; Susannah Waxman; Hannah Schilpp; Nathan Naylor; Callen Wallace; Simon Watkins; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2023; 64(9):PP0022.

ARVO Annual Meeting Abstract June 2023

Astrocyte morphological differences between collagenous and glial lamina

Ian A Sigal; Susannah Waxman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3782.

ARVO Annual Meeting Abstract June 2023

More peripapillary sclera (PPS) collagen fibers straighten than lamina cribrosa (LC) fibers before reaching 10% bundle stretch

Po-Yi Lee; Gosia Fryc; John Gnalian; Yi Hua; Susannah Waxman; Fuqiang Zhong; Bin Yang; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):59.

ARVO Annual Meeting Abstract June 2023

Astrocyte Branch Tortuosity as a Mechanism to Withstand IOP-related Insult

Susannah Waxman; Bingrui Wang; Brad Fortune; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1314.

ARVO Annual Meeting Abstract June 2022

The lamina cribrosa vascular network is heavily interconnected with that of adjacent regions, not just the periphery, likely improving perfusion resilience

Ian A Sigal; Po-Yi Lee; Marissa Quinn; Susannah Waxman; Andrew P Voorhees; Bin Yang; Tatjana C Jakobs; Joseph Rizzo; Brad Fortune; Yi Hua

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4031 – A0416.

ARVO Annual Meeting Abstract June 2022

Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling

Susannah Waxman; Marissa Quinn; Cara Donahue; Siamak Salavatian; Aman Mahajan; Louis Falo; Daniel Sun; Ian Sigal

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3097.

Glaucoma November 2020

So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult

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Andrew P. Voorhees; Yi Hua; Bryn L. Brazile; Bingrui Wang; Susannah Waxman; Joel S. Schuman; Ian A. Sigal

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):15. https://doi.org/10.1167/iovs.61.13.15

Glaucoma October 2020

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

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Bryn L. Brazile; Bin Yang; Susannah Waxman; Po Lam; Andrew P. Voorhees; Yi Hua; Ralitsa T. Loewen; Nils A. Loewen; Joseph F. Rizzo, III; Tatjana Jakobs; Ian A. Sigal
TAGS: blood capillaries, cribriform plate, intraocular pressure, vasculature, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(12):2. https://doi.org/10.1167/iovs.61.12.2

Articles September 2020

Ripasudil in a Model of Pigmentary Glaucoma

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Chao Wang; Yalong Dang; Susannah Waxman; Ying Hong; Priyal Shah; Ralitsa T. Loewen; Xiaobo Xia; Nils A. Loewen
TAGS: glaucoma, pigmentary, pigment, intraocular pressure, phagocytosis, actins, stress fibers, eye
Trans. Vis. Sci. Tech.. 2020; 9(10):27. https://doi.org/10.1167/tvst.9.10.27

Glaucoma October 2018

Structure–Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide

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Susannah Waxman; Chao Wang; Yalong Dang; Ying Hong; Hamed Esfandiari; Priyal Shah; Kira L. Lathrop; Ralitsa T. Loewen; Nils A. Loewen
TAGS: endothelin-1, ng-nitroarginine methyl ester, nitric oxide, spectral domain-optical coherence tomography, suidae, eye, deet, perfusion, dilatation, pathologic
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4886-4895. https://doi.org/10.1167/iovs.18-24943

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Incorporation of survey data from ophthalmologists and first responders in the development of a novel, point-of-injury treatment for ocular trauma

Michael A Washington; Katherine Duncan; Susannah Waxman; Nils A Loewen; Jenny Y Yu; Morgan V Fedorchak

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):111.

Glaucoma May 2018

High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes

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Susannah Waxman; Ralitsa T. Loewen; Yalong Dang; Simon C. Watkins; Alan M. Watson; Nils A. Loewen
TAGS: eye, microscopy, confocal, reconstructive surgical procedures, lectin, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2371-2380. https://doi.org/10.1167/iovs.17-23075

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2017

An ex vivo pigment dispersion glaucoma perfusion model

Yalong Dang; Susannah Waxman; Ralitsa Loewen; Adrianna Jensen; CHAO WANG; Ming Sun; Nils Loewen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3147.

ARVO Annual Meeting Abstract June 2017

Freeze-thaw Decellularization with Preserved Trabecular Meshwork Scaffold in an Ex Vivo Eye Perfusion Model

Susannah Waxman; Yalong Dang; Ralitsa Loewen; Chao Wang; Adrianna Jensen; Nils Loewen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3469.

ARVO Annual Meeting Abstract June 2017

Rapid learning curve assessment in an ex vivo training system for microincisional glaucoma surgery

CHAO WANG; Yalong Dang; Susannah Waxman; Hardik Parikh; Igor I Bussel; Ralitsa Loewen; Xiaobo Xia; Kira L Lathrop; Richard Anthony Bilonick; Nils Loewen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4929.

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Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

Imaging and photomodulation of lamina cribrosa (LC) microstructure

IOP-induced strains in individual in situ collagenous lamina cribrosa astrocytes are heterogenous

Axons passing through small LC pores suffer larger IOP-induced distortions than those through large pores

High-resolution dual-modality imaging for collagen fibers and blood vessels in lamina cribrosa (LC) beams

Astrocyte morphological differences between collagenous and glial lamina

More peripapillary sclera (PPS) collagen fibers straighten than lamina cribrosa (LC) fibers before reaching 10% bundle stretch

Astrocyte Branch Tortuosity as a Mechanism to Withstand IOP-related Insult

The lamina cribrosa vascular network is heavily interconnected with that of adjacent regions, not just the periphery, likely improving perfusion resilience

Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling

So-Called Lamina Cribrosa Defects May Mitigate IOP-Induced Neural Tissue Insult

Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases

Ripasudil in a Model of Pigmentary Glaucoma

Structure–Function Changes of the Porcine Distal Outflow Tract in Response to Nitric Oxide

Incorporation of survey data from ophthalmologists and first responders in the development of a novel, point-of-injury treatment for ocular trauma

High-Resolution, Three-Dimensional Reconstruction of the Outflow Tract Demonstrates Segmental Differences in Cleared Eyes

An ex vivo pigment dispersion glaucoma perfusion model

Freeze-thaw Decellularization with Preserved Trabecular Meshwork Scaffold in an Ex Vivo Eye Perfusion Model

Rapid learning curve assessment in an ex vivo training system for microincisional glaucoma surgery

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