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ARVO Annual Meeting Abstract June 2023

Single-cell transcriptomics of the murine cornea reveals novel age driven changes in gene expression, cell identity composition, and limbal trajectory

Raneesh Ramarapu; Sangwan Park; Nayeli Echeverria; Michelle Ferneding; Sophie M Le; Monica Ardon; Vijay Krishna Raghunathan; Crystal D Rogers; Brian Leonard; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3145.

Cornea April 2023

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

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Brian C. Leonard; Sangwan Park; Soohyun Kim; Laura J. Young; Iman Jalilian; Krista Cosert; Xunzhi Zhang; Jessica M. Skeie; Hanna Shevalye; Nayeli Echeverria; Vanessa Rozo; Xin Gong; Chao Xing; Christopher J. Murphy; Mark A. Greiner; V. Vinod Mootha; Vijay Krishna Raghunathan; Sara M. Thomasy
TAGS: cornea, endothelium, hereditary corneal dystrophy, mice, signs and symptoms, proteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):22. https://doi.org/10.1167/iovs.64.4.22

Includes: Supplemental Content

Glaucoma August 2020

Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways

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Felix Yemanyi; Janice Vranka; Vijay Krishna Raghunathan
TAGS: extracellular matrix, proteins, signal pathway, signal transduction, signal transduction pathways, trabecular meshwork, culture media, serum-free, cytoplasm, culture media
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):41. https://doi.org/10.1167/iovs.61.10.41

Includes: Supplemental Content

Articles May 2020

Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma

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Soohyun Kim; Iman Jalilian; Sara M. Thomasy; Morgan A. W. Bowman; Vijay Krishna Raghunathan; Yeonju Song; Cynthia A. Reinhart-King; Christopher J. Murphy
TAGS: cornea, corneal stroma, hyaluronidase, injections, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2020; 9(6):21. https://doi.org/10.1167/tvst.9.6.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Corneal biomechanics following intrastromal injection of hyaluronidase

Soohyun Kim; Iman Jalilian; Vijay Krishna Raghunathan; Sara M Thomasy; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):524.

ARVO Annual Meeting Abstract July 2018

Biophysical properties of the corneal stroma influence apoptosis of fibroblasts

Iman Jalilian; Amanda Robinson; Vijay Krishna Raghunathan; Jasmyne Sermeno; SANTOSHI MUPPALA; Sara M Thomasy; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4369.

Biochemistry and Molecular Biology January 2018

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

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Janice A. Vranka; Julia A. Staverosky; Ashok P. Reddy; Phillip A. Wilmarth; Larry L. David; Ted S. Acott; Paul Russell; Vijay Krishna Raghunathan
TAGS: biomechanics, body tissue, fluid flow, heart failure, muscle rigidity, pressure-physical agent, proteins, proteomics, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):246-259. https://doi.org/10.1167/iovs.17-22759

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Characterization of the cornea in the YAP -/+ mouse

Soohyun Kim; Sara M Thomasy; Vijay Krishna Raghunathan; Paul G FitzGerald; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1418.

ARVO Annual Meeting Abstract June 2017

TGFß INDUCED KFM TRNASFORMATION IN HUMAN CORNEAL FIBROBLASTS IS MODULATED BY YAP AND TAZ

SANTOSHI MUPPALA; Yeonju Song; Eva Rewinski; Vijay Krishna Raghunathan; Iman Jalilian; Sara M Thomasy; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1419.

ARVO Annual Meeting Abstract June 2017

Biomechanics of an in vitro model of Descemet’s membrane in health and disease

Sara M Thomasy; Vijay Krishna Raghunathan; Maryam Ali; Iman Jalilian; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1461.

ARVO Annual Meeting Abstract June 2017

Effects of the heat shock protein inhibitor, 17AAG, on corneal stromal haze using an in vivo rabbit phototherapeutic keratectomy model

Sydney Garrison Edwards; Philip Kass; Maryam Ali; Ariana Marangakis; Vijay Krishna Raghunathan; Christopher J Murphy; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3908.

Cornea December 2015

Effect of Stratification on Surface Properties of Corneal Epithelial Cells

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Bernardo Yáñez-Soto; Brian C. Leonard; Vijay Krishna Raghunathan; Nicholas L. Abbott; Christopher J. Murphy
TAGS: cell culture techniques, corneal epithelial cells, corneal epithelium, dry eye syndromes, engineering, hysteresis, mucins, stratification, surface properties, heterogeneity
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8340-8348. https://doi.org/10.1167/iovs.15-17468

Includes: Supplemental Content

Glaucoma July 2015

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix

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Vijay Krishna Raghunathan; Joshua T. Morgan; Shin Ae Park; Darren Weber; Brett S. Phinney; Christopher J. Murphy; Paul Russell
TAGS: cytoskeleton, dexamethasone, proteins, trabecular meshwork, oryctolagus cuniculus, actins, biophysics, genes, morphology, ethanol
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4447-4459. https://doi.org/10.1167/iovs.15-16739

Includes: Supplemental Content

Cornea August 2013

Substratum Compliance Modulates Corneal Fibroblast to Myofibroblast Transformation

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Britta Dreier; Sara M. Thomasy; Rima Mendonsa; Vijay Krishna Raghunathan; Paul Russell; Christopher J. Murphy
TAGS: cell transformation, cornea, fibroblasts, myofibroblasts, oryctolagus cuniculus, gel, proteins, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5901-5907. https://doi.org/10.1167/iovs.12-11575

Glaucoma January 2013

Role of Substratum Stiffness in Modulating Genes Associated with Extracellular Matrix and Mechanotransducers YAP and TAZ

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Vijay Krishna Raghunathan; Joshua T. Morgan; Britta Dreier; Christopher M. Reilly; Sara M. Thomasy; Joshua A. Wood; Irene Ly; Binh C. Tuyen; Marissa Hughbanks; Christopher J. Murphy; Paul Russell
TAGS: extracellular matrix, genes, mechanotransduction, cellular, proteins, trabecular meshwork, glaucoma, donors, patient isolation
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):378-386. https://doi.org/10.1167/iovs.12-11007

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Single-cell transcriptomics of the murine cornea reveals novel age driven changes in gene expression, cell identity composition, and limbal trajectory

Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways

Intrastromal Injection of Hyaluronidase Alters the Structural and Biomechanical Properties of the Corneal Stroma

Corneal biomechanics following intrastromal injection of hyaluronidase

Biophysical properties of the corneal stroma influence apoptosis of fibroblasts

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

Characterization of the cornea in the YAP -/+ mouse

TGFß INDUCED KFM TRNASFORMATION IN HUMAN CORNEAL FIBROBLASTS IS MODULATED BY YAP AND TAZ

Biomechanics of an in vitro model of Descemet’s membrane in health and disease

Effects of the heat shock protein inhibitor, 17AAG, on corneal stromal haze using an in vivo rabbit phototherapeutic keratectomy model

Effect of Stratification on Surface Properties of Corneal Epithelial Cells

Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix

Substratum Compliance Modulates Corneal Fibroblast to Myofibroblast Transformation

Role of Substratum Stiffness in Modulating Genes Associated with Extracellular Matrix and Mechanotransducers YAP and TAZ

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