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Retina April 2023

Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes

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Yvonne Adu-Agyeiwaah; Cristiano P. Vieira; Bright Asare-Bediako; Sergio Li Calzi; Mariana DuPont; Jason Floyd; Sanford Boye; Vince Chiodo; Julia V. Busik; Maria B. Grant
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, intravitreal injections, mice, retina, blood capillaries, inflammation, hypoxia
Trans. Vis. Sci. Tech.. 2023; 12(4):20. https://doi.org/10.1167/tvst.12.4.20

Includes: Supplemental Content

Glaucoma November 2022

AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension

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Mi-Hyun Nam; Rooban B. Nahomi; Mina B. Pantcheva; Armaan Dhillon; Vince A. Chiodo; W. Clay Smith; Ram H. Nagaraj
TAGS: axonal transport, glaucoma, mice, ocular hypertension, eye, injections, wounds and injuries, intraocular pressure
Trans. Vis. Sci. Tech.. 2022; 11(11):8. https://doi.org/10.1167/tvst.11.11.8

Includes: Supplemental Content

Glaucoma February 2022

Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration

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Rafael Lani-Louzada; Camila Marra; Mariana Santana Dias; Victor Guedes de Araújo; Carla Andreia Abreu; Vinícius Toledo Ribas; Daniel Adesse; Silvana Allodi; Vince Chiodo; William Hauswirth; Hilda Petrs-Silva; Rafael Linden
TAGS: gene therapy, glaucoma, intravitreal injections, nerve degeneration, optic nerve, protein overexpression, tissue degeneration, transcription factor, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):5. https://doi.org/10.1167/iovs.63.2.5

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

Frank M Dyka; Vince A. Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2464.

ARVO Annual Meeting Abstract July 2019

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

Frank M Dyka; Laurie L Molday; Vince A Chiodo; Robert S Molday; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3402.

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522.

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002.

ARVO Annual Meeting Abstract June 2017

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Alejandra Bosco; Sarah Anderson; Kevin T Breen; Cesar O Romero; Michael R Steele; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Stephen Tomlinson; Monica L Vetter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2957.

ARVO Annual Meeting Abstract June 2017

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Nermin Kady; Xuwen Liu; Todd Lydic; Segey Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William Hauswirth; Maria B Grant; David Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4034.

ARVO Annual Meeting Abstract June 2017

Adeno-associated virus dual vector-mediated gene therapy for ABCA4 Stargardt Disease

Frank M Dyka; Vince A Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4497.

ARVO Annual Meeting Abstract June 2017

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Laurence Mireille Occelli; Paige A Winkler; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4508.

ARVO Annual Meeting Abstract June 2017

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Christine Harman; Kristin Koehl; Annie Oh; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Shannon Elizabeth Boye; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4611.

ARVO Annual Meeting Abstract September 2016

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Rachel Michelle Stupay; Astra Dinculescu; Seok-Hong Min; Sanford L. Boye; Vince Chiodo Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1167.

ARVO Annual Meeting Abstract September 2016

Gene augmentation therapy in a large animal model of CNGB1 retinitis pigmentosa

Simon M Petersen-Jones; Laurence Mireille Occelli; Paige Winkler; Vince Chiodo Chiodo; Sanford L. Boye; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

Retina October 2015

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

PDF

Astra Dinculescu; Seok-Hong Min; Frank M. Dyka; Wen-Tao Deng; Rachel M. Stupay; Vince Chiodo; W. Clay Smith; William W. Hauswirth
TAGS: antibodies, eye, immunohistochemistry, injections, mice, photoreceptors, proteins, retinal pigment epithelium, spatial vectors, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6971-6980. https://doi.org/10.1167/iovs.15-17166

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

William W Hauswirth; Rachel M Stupay; Ping Zhu; Wen-Tao Deng; Vince Chiodo; Sanford L Boye; Qiuhong Li; Astra Dinculescu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3630.

ARVO Annual Meeting Abstract June 2015

Clarin-1 expression in the inner retina: implications for gene therapy

Astra Dinculescu; Rachel M Stupay; Seok-Hong Min; Sanford L Boye; Vince Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3632.

ARVO Annual Meeting Abstract June 2015

In Vivo Gene Augmentation in the ADAMTS10 -Mutant Canine Trabecular Meshwork (TM) with Y444F-Capsid Mutant, Single-Stranded AAV2

Christine Harman; Annie Oh; Kristin L Koehl; Sanford L Boye; Vince Chiodo; Jiayan Huang; Gui-Shuang Ying; Shannon Elizabeth Boye; William W Hauswirth; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3648.

ARVO Annual Meeting Abstract June 2015

Overexpression of hELOVL4 prevents diabetes-induced blood-retinal barrier breakdown through an increase in very long chain ceramides

Nermin Kady; Xuwen Liu; Todd Lydic; Sergey Seregin; Andrea Amalfitano; Vince Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4292.

ARVO Annual Meeting Abstract June 2015

Phosphatase and Tensin Homolog (PTEN) Knockout in Retinal Ganglion Cells (RGCs) Rescues Optic Neuritis in Experimental Autoimmune Encephalomyelitis (EAE) Mice

Venu Talla; Vince Chiodo; Vittorio Porciatti; Sanford L Boye; William W Hauswirth; John Guy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5531.

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Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes

AAV2-Mediated Expression of HspB1 in RGCs Prevents Somal Damage and Axonal Transport Deficits in a Mouse Model of Ocular Hypertension

Neuroprotective Gene Therapy by Overexpression of the Transcription Factor MAX in Rat Models of Glaucomatous Neurodegeneration

Serotype dependent Adeno-Associated Virus Hybrid Vector mediated gene therapy for Stargardt Disease

Dual Adeno-Associated Virus Vector mediated gene therapy for autosomal recessive Stargardt Disease

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Adeno-associated virus dual vector-mediated gene therapy for ABCA4 Stargardt Disease

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Gene augmentation therapy in a large animal model of CNGB1 retinitis pigmentosa

Pathological Effects of Mutant C1QTNF5 (S163R) Expression in Murine Retinal Pigment Epithelium

Localization of Clarin-1 in Photoreceptor Cells and Optimized AAV Gene Delivery of Clarin-1 to the Mouse Retina

Clarin-1 expression in the inner retina: implications for gene therapy

In Vivo Gene Augmentation in the ADAMTS10 -Mutant Canine Trabecular Meshwork (TM) with Y444F-Capsid Mutant, Single-Stranded AAV2

Overexpression of hELOVL4 prevents diabetes-induced blood-retinal barrier breakdown through an increase in very long chain ceramides

Phosphatase and Tensin Homolog (PTEN) Knockout in Retinal Ganglion Cells (RGCs) Rescues Optic Neuritis in Experimental Autoimmune Encephalomyelitis (EAE) Mice

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