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ARVO Annual Meeting Abstract June 2024

Assessment of the Orbit™ Subretinal Delivery System (OSDS™) and prototypes in Adult and Juvenile Canine Eyes

Jennifer Caroline Kwok; Alexa Gray; Yu Sato; Sam Reichenbacker; Tom Meyer; Kirsten Stoner; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3779.

ARVO Annual Meeting Abstract June 2024

A canine model for ABCA4 Stargardt disease: in-vivo phenotypic characterization and natural disease history

Valerie L. Dufour; Artur V Cideciyan; Jennifer Kwork; Alexa Gray; Yu Sato; Kyle Quigley; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4739.

ARVO Annual Meeting Abstract June 2024

Clinical characterization of canine cone-rod dystrophy with early foveo-macular degeneration

Gustavo D Aguirre; Valerie L. Dufour; Leonardo Murgiano; Jennifer Caroline Kwok; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4734.

ARVO Annual Meeting Abstract June 2024

Frameshift variant in the Cirneco dell’Etna dog with syndromic retinopathy and tremors

Leonardo Murgiano; Jessica K Niggel; Leontine Benedicenti; Arianna Bionda; Matteo Cortellari; Paola Crepaldi; Geoffrey K Aguirre; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4683.

ARVO Annual Meeting Abstract June 2024

Ultrastructure expansion microscopy for characterization of the canine photoreceptor sensory cilium

Kei Takahashi; Raghavi Sudharsan; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5578.

ARVO Annual Meeting Abstract June 2024

Development of OPGx-BEST1 AAV gene therapy for the treatment of bestrophinopathies

Mayur Choudhary; Alexa Gray; Yu Sato; Jennifer Caroline Kwok; Vik Arora; Benjamin R Yerxa; Artur V Cideciyan; Gustavo D Aguirre; William A Beltran; Ashwath Jayagopal

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5335.

ARVO Annual Meeting Abstract June 2024

Adaptive glial cell and gene expression alterations in retinas of treated and untreated RPE65 mutant dogs

Tatyana Appelbaum; Evelyn Santana; David Smith; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5322.

ARVO Annual Meeting Abstract June 2024

Identification of photoreceptor-specific promoters for gene therapy at advanced stages of retinal degeneration

Raghavi Sudharsan; Leonardo Murgiano; Aditi Ahuja; Yu Sato; Jennifer Caroline Kwok; Morgan Sedorovitz; Gustavo D Aguirre; Leah Byrne; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5315.

ARVO Annual Meeting Abstract June 2024

Novel octadecane-poly(ethylene glycol)-octadecane hydrogel as a delivery agent for retinal gene therapies

James Westbay; Daniel Bigley; Morgan DiLeo; Leah Byrne; Jose Alain Sahel; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6094.

Neuro-ophthalmology January 2024

Cone-Driven, Geniculocortical Responses in Canine Models of Outer Retinal Disease

PDF

Huseyin O. Taskin; Jacqueline Wivel; Gustavo D. Aguirre; William A. Beltran; Geoffrey K. Aguirre
TAGS: functional magnetic resonance imaging, retinal cone, retinal diseases, pupil reaction, rod photoreceptors, retinitis pigmentosa, visual cortex
Trans. Vis. Sci. Tech.. 2024; 13(1):18. https://doi.org/10.1167/tvst.13.1.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Structural and functional assessment after subretinal transplantation of human iPSC-derived photoreceptor precursors in a canine model of end stage retinal degeneration

William A Beltran; Ana Ripolles-Garcia; Yu Sato; Alexandra Gray; John H Wolfe; Agustin Luz-Madrigal; Michael J Philipps; David M Gamm; Geoffrey K Aguirre; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):766.

ARVO Annual Meeting Abstract June 2023

The landscape of the RPGR exon ORF15–haplotype diversity in human populations

Tatyana Appelbaum; Leonardo Murgiano; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2795.

ARVO Annual Meeting Abstract June 2023

Impact of subretinal AAV delivery on the transcriptomic inflammatory profile of the degenerating retina

Raghavi Sudharsan; Jennifer C Kwok; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3023.

Retina December 2022

Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations

PDF

Artur V. Cideciyan; Samuel G. Jacobson; Malgorzata Swider; Alexander Sumaroka; Rebecca Sheplock; Arun K. Krishnan; Alexandra V. Garafalo; Karina E. Guziewicz; Gustavo D. Aguirre; William A. Beltran; Elise Heon
TAGS: best1 gene, eye, mutation, photoreceptors, retina, retinal cone, rod photoreceptors, vitelliform dystrophy, fovea centralis, vision
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):12. https://doi.org/10.1167/iovs.63.13.12

Retina November 2022

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations

PDF

Ana Ripolles-Garcia; Yineng Chen; Yu Sato; Alexa Gray; Gui-Shuang Ying; Gustavo D. Aguirre; William A. Beltran
TAGS: retinal degeneration, retinal vasculature, dog, domestic, retinitis pigmentosa, diagnostic imaging, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):22. https://doi.org/10.1167/iovs.63.12.22

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2022

Triple drug immunosuppression for xenotransplantation of human photoreceptor precursor cells in the canine retina.

Ana Ripolles-Garcia; Natalia Dolgova; M. Joseph Phillips; Svetalana Savina; Allison Ludwig; Sara Stuedemann; John H Wolfe; Oliver Garden; David M Gamm; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):53 – A0026.

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454.

ARVO Annual Meeting Abstract June 2022

Disease-driven Prolactin Isoform Expression in Canine Inherited Retinopathies

Raghavi Sudharsan; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1964 – F0382.

ARVO Annual Meeting Abstract June 2022

Detection and characterization of circular RNAs hosted by RPGR exon ORF15.

Tatyana Appelbaum; Leonardo Murgiano; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3890 – A0092.

ARVO Annual Meeting Abstract June 2022

Surgical Procedure and Applicability of the Orbit Subretinal Delivery System (SDS)™ in the Normal Adult Canine Eye

Alexa P Gray; Yu Sato; Tom Meyer; Kirsten Stoner; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4118 – F0355.

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Assessment of the Orbit™ Subretinal Delivery System (OSDS™) and prototypes in Adult and Juvenile Canine Eyes

A canine model for ABCA4 Stargardt disease: in-vivo phenotypic characterization and natural disease history

Clinical characterization of canine cone-rod dystrophy with early foveo-macular degeneration

Frameshift variant in the Cirneco dell’Etna dog with syndromic retinopathy and tremors

Ultrastructure expansion microscopy for characterization of the canine photoreceptor sensory cilium

Development of OPGx-BEST1 AAV gene therapy for the treatment of bestrophinopathies

Adaptive glial cell and gene expression alterations in retinas of treated and untreated RPE65 mutant dogs

Identification of photoreceptor-specific promoters for gene therapy at advanced stages of retinal degeneration

Novel octadecane-poly(ethylene glycol)-octadecane hydrogel as a delivery agent for retinal gene therapies

Cone-Driven, Geniculocortical Responses in Canine Models of Outer Retinal Disease

Structural and functional assessment after subretinal transplantation of human iPSC-derived photoreceptor precursors in a canine model of end stage retinal degeneration

The landscape of the RPGR exon ORF15–haplotype diversity in human populations

Impact of subretinal AAV delivery on the transcriptomic inflammatory profile of the degenerating retina

Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations

Retinal Vascular Plexuses Are Unequally Affected in Canine Inherited Retinal Degenerations

Triple drug immunosuppression for xenotransplantation of human photoreceptor precursor cells in the canine retina.

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Disease-driven Prolactin Isoform Expression in Canine Inherited Retinopathies

Detection and characterization of circular RNAs hosted by RPGR exon ORF15.

Surgical Procedure and Applicability of the Orbit Subretinal Delivery System (SDS)™ in the Normal Adult Canine Eye

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