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Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Glaucoma June 2025

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

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Yumeng Zhang; Hanwen Huang; Huimin Zhong; Yang Zhang; Siqi He; Yanzhi Guo; Yiwei Wang; Ping Huang; Shouyue Huang; Yisheng Zhong
TAGS: aging, mice, older adult, signal transduction, retinal ganglion cells, western blotting, hypoxia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):8. https://doi.org/10.1167/iovs.66.6.8

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Immunology and Microbiology February 2025

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

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Jiamin Liu; Min Kang; Yuan Wei; Zijun Zhang; Jinding Pang; Qiankun Chen; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: genes, genome, keratitis, virulence, aspergillus flavus, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):42. https://doi.org/10.1167/iovs.66.2.42

Includes: Supplemental Content

Cornea & External Disease January 2025

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

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Yan Peng; Qiankun Chen; Yuan Wei; Leying Wang; Zijun Zhang; Zhenyu Wei; Jinding Pang; Bo Peng; Qingquan Shi; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Qingfeng Liang
TAGS: candida, keratitis, hyphae, plant spores, reproduction spores
Trans. Vis. Sci. Tech.. 2025; 14(1):23. https://doi.org/10.1167/tvst.14.1.23

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Early Antibiotic Use and Retinopathy of Prematurity: A Single-Center Retrospective Study

Jason Yang Zhang; Dimitra Skondra; Deborah S. Bondi; John Moir; Sarah Rodriguez

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1717.

ARVO Annual Meeting Abstract June 2024

Western diets and gut dysbiosis are implicated in choroidal transcriptional dysregulation and neovascularization

Rohan Nishant Shah; Bingqing Xie; Hugo Barba; Jason Xiao; Jason Yang Zhang; Betty Theriault; Eugene B Chang; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4987.

Immunology and Microbiology March 2024

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

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Xiaoyan Guo; Zijun Zhang; Qiankun Chen; Leying Wang; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: cornea, genes, keratitis, nocardia, family
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):26. https://doi.org/10.1167/iovs.65.3.26

Includes: Supplemental Content

Cornea & External Disease February 2024

Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations

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Jinding Pang; Zhenyu Wei; Leying Wang; Xiaoyan Guo; Qiankun Chen; Yuan Wei; Yan Peng; Zijun Zhang; Yuheng Zhang; Jiamin Liu; Zhen Cheng; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Xinxin Lu; Qingfeng Liang
TAGS: acanthamoeba, acanthamoeba keratitis, china, genotype, signs and symptoms
Trans. Vis. Sci. Tech.. 2024; 13(2):5. https://doi.org/10.1167/tvst.13.2.5

Includes: Supplemental Content

Cornea December 2023

Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b + Ly6G + Cells and Increasing the Viral Load in the Cornea

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Jing Feng; Lingling Yang; Lili Ran; Xia Qi; Xiaolei Wang; Yangyang Zhang; Zongzheng Zou; Ting Liu; Xiaochuan Wang; Yang Yu; Xiaodong Sun; Qingjun Zhou
TAGS: cornea, human herpesvirus 1, infections, keratitis, herpetic, macrophage-1 antigen, mice, symptom aggravating factors, viral load result
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):24. https://doi.org/10.1167/iovs.64.15.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Single-nuclei Multiomics Analysis of Human Organoids and Fetal Retina Reveals Developmental Transcriptional and Epigenetic Differences

Salma Ferdous; Zhen Zuo; Yang Zhang; Xinye Qian; Yumei Li; Xuesen Cheng; Jin Li; Alice Tian; Joseph Quinlan; Yourong Bao; Antonio Jacobo Lopez; Ala Moshiri; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1867.

ARVO Annual Meeting Abstract June 2023

Effects of Oral Metformin on Choroidal Neovascularization, RPE/Choroidal Transcriptome, and Gut Microbiota

Jason Yang Zhang; Jason Xiao; Bingqing Xie; Hugo Barba; Michael Boachie-Mensah; Urooba Nadeem; Melanie Spedale; Nicholas Dylla; Huaiying Lin; Mark D'Souza; Betty Theriault; Dinanath Sulakhe; Eugene B Chang; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2825.

ARVO Annual Meeting Abstract June 2023

Gut Microbiome Mediates Metformin’s Effects on Choroidal Neovascularization

Hugo Barba; Jason Yang Zhang; Jason Xiao; Bingqing Xie; Michael Boachie-Mensah; Urooba Nadeem; Melanie Spedale; Huaiying Lin; Mark D’Souza; Betty Theriault; Dinanath Sulakhe; Eugene B Chang; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3242.

ARVO Annual Meeting Abstract June 2023

Oral Metformin Reduces Choroidal Neoangiogenesis and Alters Microbiota-Derived Fecal Metabolites

Jason Xiao; Jason Yang Zhang; Bingqing Xie; Hugo Barba; Michael Boachie-Mensah; Urooba Nadeem; Melanie Spedale; Nicholas Dylla; Huaiying Lin; Ashley Sidebottom; Mark D’Souza; Betty Theriault; Dinanath Sulakhe; Eugene B Chang; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3021.

Immunology and Microbiology March 2023

Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis

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Xizhan Xu; Yuan Wei; Jinding Pang; Zhenyu Wei; Leying Wang; Qiankun Chen; Zhiqun Wang; Yang Zhang; Kexin Chen; Yan Peng; Zijun Zhang; Jiamin Liu; Yuheng Zhang; Zi-Bing Jin; Qingfeng Liang
TAGS: cornea, fungal keratitis, immune response, mice, mycoses, time factors, genes, infections, gene expression profiling
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):6. https://doi.org/10.1167/iovs.64.3.6

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Improving integration of transplanted human stem cell derived retinal ganglion cells

Erika Antuanette Aguzzi; Kevin Yang Zhang; Arumugam Nagalingam; Xiaoli Chang; Donald J Zack; Thomas Vincent Johnson

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1140.

ARVO Annual Meeting Abstract June 2022

Multiscale imaging of mouse corneal endothelial cell damage induced by elevated intraocular pressure

Junghun Kweon; Yang Zhang; Benjamin Samuel brenner; Raymond Fang; Cheng Sun; Jeffrey L Goldberg; Hao Zhang

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2741 – A0230.

ARVO Annual Meeting Abstract June 2022

Microbiome Metagenomics in High-Fat Diet-Fed Mice Reveals Altered Microbial Metabolic Pathways Related to AMD

Michael Boachie-Mensah; Huaiying Lin; Hugo Adrian Barba; Urooba Nadeem; Jason Yang Zhang; Asad Movahedan; Nini Deng; Jason Xiao; Eugene Chang; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):476 – A0013.

ARVO Annual Meeting Abstract June 2022

Anxiety and depression in patients treated for proliferative diabetic retinopathy.

Vikram Ponnusamy; Patrick Le; Yang Zhang

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):570 – A0135.

ARVO Annual Meeting Abstract June 2022

Multi-Omics Analysis Reveals Effects of High Fat Diet Induced Gut Dysbiosis on RPE/Choroidal Transcriptome and Microbiome-Transcriptome Associations

Jason Yang Zhang; Bingqing Xie; Asadolah Movahedan; Hugo Adrian Barba; Urooba Nadeem; Nini Deng; Mark D'Souza; Eugene Chang; Dinanath Sulakhe; Dimitra Skondra

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1174 – A0028.

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SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

Early Antibiotic Use and Retinopathy of Prematurity: A Single-Center Retrospective Study

Western diets and gut dysbiosis are implicated in choroidal transcriptional dysregulation and neovascularization

Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis

Acanthamoeba Keratitis in China: Genotypic and Clinical Correlations

Loss of TRPM8 Exacerbate Herpes Simplex Keratitis Infection in Mice by Promoting the Infiltration of CD11b + Ly6G + Cells and Increasing the Viral Load in the Cornea

Single-nuclei Multiomics Analysis of Human Organoids and Fetal Retina Reveals Developmental Transcriptional and Epigenetic Differences

Effects of Oral Metformin on Choroidal Neovascularization, RPE/Choroidal Transcriptome, and Gut Microbiota

Gut Microbiome Mediates Metformin’s Effects on Choroidal Neovascularization

Oral Metformin Reduces Choroidal Neoangiogenesis and Alters Microbiota-Derived Fecal Metabolites

Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in Fungal Keratitis

Improving integration of transplanted human stem cell derived retinal ganglion cells

Multiscale imaging of mouse corneal endothelial cell damage induced by elevated intraocular pressure

Microbiome Metagenomics in High-Fat Diet-Fed Mice Reveals Altered Microbial Metabolic Pathways Related to AMD

Anxiety and depression in patients treated for proliferative diabetic retinopathy.

Multi-Omics Analysis Reveals Effects of High Fat Diet Induced Gut Dysbiosis on RPE/Choroidal Transcriptome and Microbiome-Transcriptome Associations

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