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ARVO Annual Meeting Abstract June 2024

Islets of Langerhans transplantation into the eye anterior chamber improves retinal ganglion cell function and visual behaviors in glaucoma

Sana El Hajji; Clara Gobault; Yukihiro Shiga; Nicolas Belforte; Melanie Ethier; Isaac Alejandro Vidal Paredes; Florence Dotigny; Vincent Poitout; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):701.

ARVO Annual Meeting Abstract June 2024

Restoration of Blood-Retinal Barrier Integrity Prevents Neurodegeneration in Glaucoma

Isaac Alejandro Vidal Paredes; Jorge Luis Cueva Vargas; Nicolas Belforte; Yukihiro Shiga; Florence Dotigny; Heberto Quintero; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):393.

ARVO Annual Meeting Abstract June 2024

Chemogenetic-induced retinal ganglion cell excitation reveals IP3R-dependent dysregulation of calcium dynamics linked to neuronal metabolic stress in glaucoma

Yukihiro Shiga; Jorge Luis Cueva Vargas; Sana El Hajji; Nicolas Belforte; Florence Dotigny; Heberto Quintero; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3253.

ARVO Annual Meeting Abstract June 2023

Calcium clearance deficits linked to endoplasmic reticulum stress are signature features of early retinal ganglion cell damage in glaucoma

Yukihiro Shiga; Aline Giselle Rangel Olguin; Sana El Hajji; Nicolas Belforte; Heberto Quintero; Florence Dotigny; Luis Alarcon-Martinez; Arjun Krishnaswamy; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):482.

ARVO Annual Meeting Abstract June 2023

A crosstalk between mTORC1 and mTORC2 is required for full retinal ganglion cell regeneration mediated by insulin

Sana El Hajji; Yukihiro Shiga; Nicolas Belforte; Yves Carpentier Solorio; Olivier Tastet; Philippe D'Onofrio; Florence Dotigny; Alexandre Prat; Brad Fortune; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2839.

ARVO Annual Meeting Abstract June 2023

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Takeshi Iwata; Yang Pan; Akiko Suga; Itaru Kimura; Chojiro Kimura; Yuriko Minegishi; Mao Nakayama; Kazutoshi Yoshitake; Megumi Yamamoto; Fumihiko Mabuchi; Mitsuko Takamoto; Yukihiro Shiga; Makoto Araie; Kenji Kashiwagi; Makoto Aihara; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4354.

ARVO Annual Meeting Abstract June 2022

Restoration of mitochondrial axonal transport by adaptor supplementation prevents neurodegeneration and rescues visual function in glaucoma

Heberto Quintero; Yukihiro Shiga; Nicolas A Belforte; Luis Alarcon-Martinez; Sana El Hajji; Deborah Villafranca-Baughman; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):12.

ARVO Annual Meeting Abstract June 2022

Autophagy Dysfunction Represses mTORC1 Signaling Resulting in Neurodegeneration of Retinal Ganglion Cells in Glaucoma

Kang-Chieh Huang; Cátia Gomes; Yukihiro Shiga; Kirstin VanderWall; Sailee Sham Lavekar; Clarisse Fligor; Jade Harkin; Adriana Di Polo; Jason S Meyer

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1475.

ARVO Annual Meeting Abstract June 2022

Insulin promotes RGC dendrite regeneration through ribosomal protein S6 kinase activation leading to restoration of neuronal function in glaucoma

Sana El Hajji; Nicolas A Belforte; Yukihiro Shiga; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1137.

ARVO Annual Meeting Abstract June 2022

Light-evoked RGC calcium dynamics are altered in glaucoma: live imaging evidence of abnormal calcium clearance

Yukihiro Shiga; Aline Giselle Rangel Olguin; Luis Alarcon-Martinez; Nicolas A Belforte; Heberto Quintero; Deborah Villafranca-Baughman; Florence Dotigny; Arjun Krishnaswamy; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1850.

ARVO Annual Meeting Abstract June 2021

Live two-photon calcium imaging in retinal ganglion cells: characterization of early changes in a mouse glaucoma model.

Yukihiro Shiga; Luis Alarcon-Martinez; Nicolas Belforte; Heberto Quintero; Deborah Villafranca-Baughman; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2344.

ARVO Annual Meeting Abstract June 2021

Pericyte dysfunction promotes neurovascular deficits in glaucoma

Luis Alarcon-Martinez; Yukihiro Shiga; Nicolas Belforte; Deborah Villafranca-Baughman; Jorge Cueva Vargas; Heberto Quintero; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1864.

ARVO Annual Meeting Abstract June 2020

Live two-photon calcium imaging in retinal ganglion cells: characterization of early changes in a mouse glaucoma model.

Yukihiro Shiga; Luis Alarcon-Martinez; Nicolas Belforte; Deborah Villafranca-Baughman; Florence Dotigny; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1437.

ARVO Annual Meeting Abstract July 2019

Evaluation of glaucoma diagnosis machine learning models based on color optical coherence tomography and color fundus images

Masahiro Akiba; Guangzhou An; Hideo yokota; Kazuko Omodaka; Kazuki Hashimoto; Satoru Tsuda; Yukihiro Shiga; naoko takada; tsutomu kikawa; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1298.

ARVO Annual Meeting Abstract July 2019

Prediction of glaucomatous visual field progression by genetic variants associated with primary open-angle glaucoma

Fumihiko Mabuchi; Yoichi Sakurada; Kenji Kashiwagi; Mitsuko Takamoto; Makoto Aihara; Takeshi Iwata; Kazuki Hashimoto; Kota Sato; Yukihiro Shiga; Koji Nishiguchi; Toru Nakazawa; Masato Akiyama; Kazuhide Kawase; Mineo Ozaki; Makoto Araie

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1601.

ARVO Annual Meeting Abstract July 2019

Genetic risk score is associated with retinal nerve fiber layer thickness and severe glaucoma in Japanese normal-tension glaucoma patients

Yukihiro Shiga; Kazuki Hashimoto; Kota Sato; Koji Nishiguchi; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1605.

ARVO Annual Meeting Abstract July 2019

Associations between clinical features and risk alleles in Japanese glaucoma susceptibility loci

Kazuki Hashimoto; Yukihiro Shiga; Koji Nishiguchi; Masahiro Miyake; Kenji Yamashiro; Yosuke Kawai; Masao Nagasaki; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1625.

ARVO Annual Meeting Abstract July 2019

The association between oxidative stress and corneal hysteresis in patients with glaucoma

Keiko Uchida; Noriko Himori; Hashimoto Kazuki; Maki Inoue-Yanagimachi; Naoki Kiyota; Marika Sato; Shigeto Maekawa; Yukihiro Shiga; Satoru Tsuda; Kazuko Omodaka; Toru Nakazawa

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5648.

Glaucoma June 2019

Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression

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Naoki Kiyota; Yukihiro Shiga; Masayuki Yasuda; Naoko Aizawa; Kazuko Omodaka; Satoru Tsuda; Hiroshi Kunikata; Toru Nakazawa
TAGS: glaucomatous visual field defect, optic disk, vascular flow, body tissue
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2650-2658. https://doi.org/10.1167/iovs.19-27230

Includes: Supplemental Content

Retinal Cell Biology August 2018

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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Kota Sato; Yukihiro Shiga; Yurika Nakagawa; Kosuke Fujita; Koji M. Nishiguchi; Hiroshi Tawarayama; Namie Murayama; Shigeto Maekawa; Takeshi Yabana; Kazuko Omodaka; Shota Katayama; Qiwei Feng; Satoru Tsuda; Toru Nakazawa
TAGS: mice, optic nerve, retina, optic nerve injuries
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3943-3951. https://doi.org/10.1167/iovs.18-23784

Includes: Supplemental Content

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Islets of Langerhans transplantation into the eye anterior chamber improves retinal ganglion cell function and visual behaviors in glaucoma

Restoration of Blood-Retinal Barrier Integrity Prevents Neurodegeneration in Glaucoma

Chemogenetic-induced retinal ganglion cell excitation reveals IP3R-dependent dysregulation of calcium dynamics linked to neuronal metabolic stress in glaucoma

Calcium clearance deficits linked to endoplasmic reticulum stress are signature features of early retinal ganglion cell damage in glaucoma

A crosstalk between mTORC1 and mTORC2 is required for full retinal ganglion cell regeneration mediated by insulin

METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma

Restoration of mitochondrial axonal transport by adaptor supplementation prevents neurodegeneration and rescues visual function in glaucoma

Autophagy Dysfunction Represses mTORC1 Signaling Resulting in Neurodegeneration of Retinal Ganglion Cells in Glaucoma

Insulin promotes RGC dendrite regeneration through ribosomal protein S6 kinase activation leading to restoration of neuronal function in glaucoma

Light-evoked RGC calcium dynamics are altered in glaucoma: live imaging evidence of abnormal calcium clearance

Live two-photon calcium imaging in retinal ganglion cells: characterization of early changes in a mouse glaucoma model.

Pericyte dysfunction promotes neurovascular deficits in glaucoma

Live two-photon calcium imaging in retinal ganglion cells: characterization of early changes in a mouse glaucoma model.

Evaluation of glaucoma diagnosis machine learning models based on color optical coherence tomography and color fundus images

Prediction of glaucomatous visual field progression by genetic variants associated with primary open-angle glaucoma

Genetic risk score is associated with retinal nerve fiber layer thickness and severe glaucoma in Japanese normal-tension glaucoma patients

Associations between clinical features and risk alleles in Japanese glaucoma susceptibility loci

The association between oxidative stress and corneal hysteresis in patients with glaucoma

Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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