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Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li
TAGS: cornea, lacrimal gland, nerve injuries, neurons, rhythm, circadian rhythms, nerve supply, mice, wounds and injuries, sensory nerves
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):40. https://doi.org/10.1167/iovs.66.4.40

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Refractive Intervention February 2025

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model

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Zhihao Jiang; Wenjia Yan; Haili Fang; Chang Liu; Zhaotian Zhang; Zhiquan Li; Yantao Wei; Yao Ni
TAGS: choroid, dopamine, eye, myopia, oryctolagus cuniculus, refraction
Trans. Vis. Sci. Tech.. 2025; 14(2):18. https://doi.org/10.1167/tvst.14.2.18

Includes: Supplemental Content

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

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Shenzhen Huang; Wenxiao Zhang; Mengru Ba; Shuting Xuan; Duliurui Huang; Di Qi; Xiaoting Pei; Dingli Lu; Zhijie Li
TAGS: circadian rhythm disorders, circadian rhythms, jet lag syndrome, mice, gene expression, rhythm, genes, cell proliferation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):12. https://doi.org/10.1167/iovs.66.1.12

Includes: Supplemental Content

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Retina November 2024

Choroidal Thickness and Visual Acuity in High Myopia Without Myopic Maculopathy: Insights From a Chinese Population Study

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Yueye Wang; Decai Wang; Qiuxia Yin; Jiayong Li; Zhixi Li; Mingguang He
TAGS: macular disorders, myopia, population studies, vision, visual acuity, chinese (other dialects), chinese people
Trans. Vis. Sci. Tech.. 2024; 13(11):9. https://doi.org/10.1167/tvst.13.11.9

Includes: Supplemental Content

Retinal Cell Biology October 2024

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

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Mei-Ling Gao; Tong-Yu Wang; Xin Lin; Chun Tang; Mengyao Li; Zhan-Pei Bai; Zhi-Cong Liu; Li-Jun Chen; Qing-Ran Kong; Shao-Hui Pan; Shan-Shan Zeng; Ya Guo; Jian-Qi Cai; Xiu-Feng Huang; Jun Zhang
TAGS: foreign medical graduates, microglia, organoids, coculture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):19. https://doi.org/10.1167/iovs.65.12.19

Includes: Supplemental Content

Glaucoma October 2024

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony

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Jian Wu; Ruyue Li; Sirui Zhu; Kezhe Chen; Caixia Lin; Jiaxin Tian; Lijie Pan; Hongyi Liu; Xu Jia; Ziyu Yu; Zhidong Li; Yingting Zhu; Wei Liu; Chenlong Yang; Chiwai Wong; Ningli Wang; Yehong Zhuo; for the Non-Human Primate Eye Study Group
TAGS: glaucoma, macaca fascicularis, retinal nerve fiber layer, eye, cercopithecidae, intraocular pressure
Trans. Vis. Sci. Tech.. 2024; 13(10):6. https://doi.org/10.1167/tvst.13.10.6

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

Multiple identified items can be simulatenously tested against the target templates in memory in the hybrid visual and memory search

Yujie Zheng; Jiafei Lou; Zhi Li

Journal of Vision. 2024; 24(10):340. https://doi.org/10.1167/jov.24.10.340

Clinical and Epidemiologic Research August 2024

Choroidal Vascularity and Axial Length Elongation in Highly Myopic Children: A 2-Year Longitudinal Investigation

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Meng Xuan; Decai Wang; Ou Xiao; Xinxing Guo; Jian Zhang; Qiuxia Yin; Wei Wang; Mingguang He; Zhixi Li
TAGS: cardiovascular imaging, child, cortical blindness, choroid, myopia, risk factors, ophthalmic examination and evaluation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):7. https://doi.org/10.1167/iovs.65.10.7

ARVO Annual Meeting Abstract June 2024

Development of a Canine Glaucoma Model with Intermittent, Controlled Intraocular Pressure Elevations

Shin Ae Park; Manbok Jeong; Hyerim Ra; Levi Smith; Sunjun Jung; Lisa Hoard; Julie Zhi Ying Li; Nicolas Tovar; Oluwabunmi Ojo; Christine Harman; Dodd Sledge; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4066.

ARVO Annual Meeting Abstract June 2024

Development and Validation of a Deep Learning Algorithm to Automate Detection of Referable Glaucoma in a Safety Net Teleretinal Program

Haroon Rasheed; Sreenidhi Iyengar; Van Nguyen; Zhiwei Li; Aniket Kumar; Aidan Lee; Andrew Duong; Brandon Wong; Jeffrey Gluckstein; Kendra Hong; Kent Nguyen; Rahul Dhodapkar; Carl Kesselman; Lauren Daskivich; Michael Pazzani; Benjamin Y. Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):372.

ARVO Annual Meeting Abstract June 2024

Eye shape deformity predicts myopic maculopathy progression among highly myopic participants：a 4-year longitudinal study

Cong Li; Ou Xiao; Zhixi Li; Mingguang He

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):136.

ARVO Annual Meeting Abstract June 2024

Efficient prevention of retinal degeneration in Pde6a mice by all-in-one AAV-mediated Nrl gene editing

Zhiquan Liu; Siyu Chen; Chien-Hui Lo; Qing Wang; Yang Sun

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1552.

ARVO Annual Meeting Abstract June 2024

Sensory Nerves Modulate Corneal Angiogenesis via Alpha-Melanocyte-Stimulating Hormone (α-MSH)

Jia Yin; Sheyda Najafi; Asmaa Zidan; Shuyan Zhu; Elsayed Elbasiony; Zhirong Lin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2922.

ARVO Annual Meeting Abstract June 2024

Activation of Hypoxia-inducible Factor 1 (HIF-1) Signaling in a Murine Model of Nitrogen Mustard Keratopathy

Asmaa Zidan; Zhirong Lin; Elsayed Elbasiony; Sheyda Najafi; Jia Yin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2797.

ARVO Annual Meeting Abstract June 2024

Gene Therapy for Glaucoma using CRISPR/Cas13d in mice

Siyu Chen; Zhiquan Liu; Chien-Hui Lo; Yang Sun

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3541.

ARVO Annual Meeting Abstract June 2024

Topical Application of Calcitonin Gene-related Peptide Ameliorates Corneal Epitheliopathy and Inflammatory Responses in Experimental Dry Eye

Zhirong Lin; Asmaa Zidan; Elsayed Elbasiony; Sheyda Najafi; Jia Yin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5754.

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Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

Choroidal Thickness and Visual Acuity in High Myopia Without Myopic Maculopathy: Insights From a Chinese Population Study

Retinal Organoid Microenvironment Enhanced Bioactivities of Microglia-Like Cells Derived From HiPSCs

Normative Profile of Retinal Nerve Fiber Layer Thickness and Lamina Cribrosa-Related Parameters in a Healthy Non-Glaucoma Cynomolgus Monkey Colony

Multiple identified items can be simulatenously tested against the target templates in memory in the hybrid visual and memory search

Choroidal Vascularity and Axial Length Elongation in Highly Myopic Children: A 2-Year Longitudinal Investigation

Development of a Canine Glaucoma Model with Intermittent, Controlled Intraocular Pressure Elevations

Development and Validation of a Deep Learning Algorithm to Automate Detection of Referable Glaucoma in a Safety Net Teleretinal Program

Eye shape deformity predicts myopic maculopathy progression among highly myopic participants：a 4-year longitudinal study

Efficient prevention of retinal degeneration in Pde6a mice by all-in-one AAV-mediated Nrl gene editing

Sensory Nerves Modulate Corneal Angiogenesis via Alpha-Melanocyte-Stimulating Hormone (α-MSH)

Activation of Hypoxia-inducible Factor 1 (HIF-1) Signaling in a Murine Model of Nitrogen Mustard Keratopathy

Gene Therapy for Glaucoma using CRISPR/Cas13d in mice

Topical Application of Calcitonin Gene-related Peptide Ameliorates Corneal Epitheliopathy and Inflammatory Responses in Experimental Dry Eye

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