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Articles June 2020

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

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Hongman Song; Yong Zeng; Sheik Pran Babu Sardar Pasha; Ronald A. Bush; Camasamudram Vijayasarathy; Haohua Qian; Lisa Wei; Henry E. Wiley; Zhijian Wu; Paul A. Sieving
TAGS: eye, retina, spatial vectors, transfer technique, oryctolagus cuniculus, mice, fibroblast growth factor 2, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(7):28. https://doi.org/10.1167/tvst.9.7.28

ARVO Annual Meeting Abstract July 2019

Rescue of mouse RPGR function in vivo using CRISPR/Cas9 gene editing

Jessica Gumerson; Amal Alsufyani; Wenhan Yu; Xun Sun; Jingqi Lei; Zhijian Wu; Lijin Dong; Tiansen Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3409.

ARVO Annual Meeting Abstract July 2018

RPGR gene editing with CRISPR-Cas 9 system in Retinal degeneration 9 (Rd9) mice to correct a disease mutation and phenotype

Amal Alsufyani; Wenhan Yu; Jessica Gumerson; Lijin Dong; Zhijian Wu; Tiansen Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):41.

ARVO Annual Meeting Abstract July 2018

Interleukin-34 provide neuroprotection to the neural retina in a mouse model of experimental autoimmune uveoretinitis

Mary J Mattapallil; Yingyos Jittayasothorn; Zhijian Wu; H Nida Nida Sen; Rachel R Caspi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2535.

ARVO Annual Meeting Abstract July 2018

Use of a novel Rpgr -null mouse line allows rapid efficacy evaluation of gene augmentation therapy

Zhijian Wu; Myung Kuk Joe; Wenhan Yu; Suja Hiriyanna

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4528.

ARVO Annual Meeting Abstract July 2018

Repeat Administration of AAV8 Vector in the Mouse Eye Results in Transgene Expression

Lisa Lining Wei; Yong Zeng; Suja Hiriyanna; Zhijian Wu; Paul Sieving; Ronald A Bush

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5656.

ARVO Annual Meeting Abstract June 2017

A CEP290 C-terminal protein fragment rescues retinal degeneration in a mouse model of Leber Congenital Amaurosis

Suddhasil Mookherjee; Wenhan Yu; Suja Hiriyanna; Yasaman Ataeijannati; Tiansen Li; Anand Swaroop; Zhijian Wu

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1572.

ARVO Annual Meeting Abstract June 2017

C-terminal phosphorylation of mouse melanopsin regulates the kinetics of a subset of melanopsin mediated behaviors in mice

Preethi Somasundaram; Glenn Wyrick; Diego Baltimore Fernandez; Alireza Ghahari; Cindy Pinhal; Melissa Simmonds-Richardson; Alan Rupp; Lihong Cui; Zhijian Wu; Lane Brown; Tudor C. Badea; Samer Hattar; Phyllis Robinson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4129.

ARVO Annual Meeting Abstract September 2016

An AAV2 vector encoding prolactin reverses blood retinal barrier pathology when administered intravitreally to diabetic rats

Nundehui Diaz-Lezama; Zhijian Wu; Elva Adan-Castro; Bibiana Moreno-Carranza; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):758.

ARVO Annual Meeting Abstract September 2016

In vivo reprogramming of rods to cone-like cells by Nrl -knockdown using AAV-delivered CRISPR-Cas9 rescues retinal degeneration

Wenhan Yu; Suddhasil Mookherjee; Jung-Woong Kim; Suja Hiriyanna; Yasaman Ataeijannati; Xun Sun; Lijin Dong; Tiansen Li; Anand Swaroop; Zhijian Wu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract September 2016

The function of ARL3 in mouse photoreceptors

Christin Hanke-Gogokhia; Zhijian Wu; Jeanne M Frederick; Houbin Zhang; Wolfgang Baehr

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

Articles July 2016

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

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Yong Zeng; Ronald S. Petralia; Camasamudram Vijayasarathy; Zhijian Wu; Suja Hiriyanna; Hongman Song; Ya-Xian Wang; Paul A. Sieving; Ronald A. Bush
TAGS: gene therapy, mice, retina, diagnostic imaging, mice, knockout
Invest. Ophthalmol. Vis. Sci.. 2016; 57(9):OCT277-OCT287. https://doi.org/10.1167/iovs.15-18920

Includes: Supplemental Content

Retinal Cell Biology May 2016

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

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Hongman Song; Camasamudram Vijayasarathy; Yong Zeng; Dario Marangoni; Ronald A. Bush; Zhijian Wu; Paul A. Sieving
TAGS: mice, nadph oxidases, photoreceptors, retina, rod photoreceptors, superoxides, tissue degeneration, injections, proteins, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2864-2875. https://doi.org/10.1167/iovs.15-18974

ARVO Annual Meeting Abstract June 2015

Gene therapy rescues cone function and viability in Rp2 knockout mice over a broad vector dose range and a wide therapeutic time window

Suddhasil Mookherjee; Suja Hiriyanna; Kayleigh Kaneshiro; Haohua Qian; Tiansen Li; Hemant Khanna; Peter Colosi; Anand Swaroop; Zhijian Wu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2063.

ARVO Annual Meeting Abstract June 2015

Neuro and vasoprotective effects of vascular endothelial growth factor-B in Retinitis pigmentosa

Pachiappan Arjunan; Zhongshu Tang; Lijin Dong; Zhijian Wu; Pamela M Martin; Cutler W Christopher; Xuri Li

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3646.

ARVO Annual Meeting Abstract April 2014

Isoform Switch of RPGR During Photoreceptor Development

Xun Sun; Oleg V Bulgakov; Michael Adamian; Zhijian Wu; Tiansen Li

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2972.

ARVO Annual Meeting Abstract April 2014

Preclinical Development of AAV Vectors for the Treatment of X-linked Retinitis Pigmentosa Caused by RPGR Mutations

Zhijian Wu; Suja Hiriyanna; Haohua Qian; Suddhasil Mookherjee; Kayleigh Kaneshiro; Maria M Campos; Robert N Fariss; Tiansen Li; Anand Swaroop; Peter Colosi

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3305.

ARVO Annual Meeting Abstract April 2014

A Low Dose AAV Vector Administration Preserves Cone Function in an Rp2 Knockout Mouse Model for Retinitis Pigmentosa

Suddhasil Mookherjee; Peter Colosi; Suja Hiriyanna; Kayleigh Kaneshiro; Linjing Li; Haohua Qian; Tiansen Li; Hemant Khanna; Anand Swaroop; Zhijian Wu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3310.

ARVO Annual Meeting Abstract April 2014

Diabetes enhances the efficacy of adeno-associated virus vectors in rat retina

Nundehui Diaz-Lezama; Zhijian Wu; Elva Hortencia Adan-Castro; David Arredondo; Gonzalo Martínez de la Escalera; Stephanie Thebault; Peter Colosi; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3323.

ARVO Annual Meeting Abstract June 2013

Enhancement of AAV2-mediated retinal transduction in diabetic rats

Nundehui Díaz-Lezama; Zhijian Wu; Mayda Ramírez; Bibiana Moreno-Carranza; Gonzalo Martinez de la Escalera; Peter Colosi; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2716.

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Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

Rescue of mouse RPGR function in vivo using CRISPR/Cas9 gene editing

RPGR gene editing with CRISPR-Cas 9 system in Retinal degeneration 9 (Rd9) mice to correct a disease mutation and phenotype

Interleukin-34 provide neuroprotection to the neural retina in a mouse model of experimental autoimmune uveoretinitis

Use of a novel Rpgr -null mouse line allows rapid efficacy evaluation of gene augmentation therapy

Repeat Administration of AAV8 Vector in the Mouse Eye Results in Transgene Expression

A CEP290 C-terminal protein fragment rescues retinal degeneration in a mouse model of Leber Congenital Amaurosis

C-terminal phosphorylation of mouse melanopsin regulates the kinetics of a subset of melanopsin mediated behaviors in mice

An AAV2 vector encoding prolactin reverses blood retinal barrier pathology when administered intravitreally to diabetic rats

In vivo reprogramming of rods to cone-like cells by Nrl -knockdown using AAV-delivered CRISPR-Cas9 rescues retinal degeneration

The function of ARL3 in mouse photoreceptors

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice

Gene therapy rescues cone function and viability in Rp2 knockout mice over a broad vector dose range and a wide therapeutic time window

Neuro and vasoprotective effects of vascular endothelial growth factor-B in Retinitis pigmentosa

Isoform Switch of RPGR During Photoreceptor Development

Preclinical Development of AAV Vectors for the Treatment of X-linked Retinitis Pigmentosa Caused by RPGR Mutations

A Low Dose AAV Vector Administration Preserves Cone Function in an Rp2 Knockout Mouse Model for Retinitis Pigmentosa

Diabetes enhances the efficacy of adeno-associated virus vectors in rat retina

Enhancement of AAV2-mediated retinal transduction in diabetic rats

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