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Retina March 2022

Evaluation of Local Rod and Cone Function in Stargardt Disease

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Krunoslav Stingl; Carel Hoyng; Melanie Kempf; Susanne Kohl; Ronja Jung; Giulia Righetti; Laura Kühlewein; Lisa Pohl; Friederike Kortüm; Carina Kelbsch; Barbara Wilhelm; Tobias Peters; Katarina Stingl; on behalf of the SORAPRAZAN consortium
TAGS: cardiac progenitor cells, pupil reaction, retinal cone, rod photoreceptors, stargardt's disease, constriction procedure
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):6. doi: https://doi.org/10.1167/iovs.63.3.6

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles May 2020

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity

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Carina Kelbsch; Jakob Lange; Helmut Wilhelm; Barbara Wilhelm; Tobias Peters; Melanie Kempf; Laura Kuehlewein; Krunoslav Stingl
TAGS: constriction procedure, exudative age-related macular degeneration, pupil, pupil constriction, pupil reaction
Trans. Vis. Sci. Tech.. 2020; 9(6):5. doi: https://doi.org/10.1167/tvst.9.6.5

Articles December 2019

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

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Krunoslav T. Stingl; Laura Kuehlewein; Nicole Weisschuh; Saskia Biskup; Frans P. M. Cremers; M. Imran Khan; Carina Kelbsch; Tobias Peters; Marius Ueffing; Barbara Wilhelm; Eberhart Zrenner; Katarina Stingl
TAGS: eye, illness length, mutation, pupil reaction, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2019; 8(6):45. doi: https://doi.org/10.1167/tvst.8.6.45

Articles November 2019

Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

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Carina Kelbsch; Katarina Stingl; Melanie Kempf; Torsten Strasser; Ronja Jung; Laura Kuehlewein; Helmut Wilhelm; Tobias Peters; Barbara Wilhelm; Krunoslav Stingl
TAGS: constriction procedure, gaze, pupil, pupil reaction, retinal cone, rod photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(6):19. doi: https://doi.org/10.1167/tvst.8.6.19

ARVO Annual Meeting Abstract July 2019

Systemic and intraocular administration of the liposomal formulation of the cyclic GMP analogue CN03: An exploratory safety and tolerability study in non-human primates

Francois Paquet-Durand; Tobias Peters; Pieter Gaillard; Nicolaas Schipper; Torsten Strasser; Frank Schwede; Valeria Marigo; Per A R Ekstrom; Christer Säfholm

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):257. doi:

ARVO Annual Meeting Abstract July 2019

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

G. Alex Ochakovski; Ahmad Zhour; Laura Kuehlewein; Susanne Kohl; Andrea Rindtorff; Karl Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Stylianos Michalakis; Martin Biel; Bernd Wissinger; Tobias Peters; Barbara Wilhelm; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2921. doi:

ARVO Annual Meeting Abstract July 2019

Designing a clinical trial to evaluate the safety and efficacy of oral soraprazan in Stargardt Disease

Carel C B Hoyng; Andrew Lotery; Katarina Stingl; Camiel Boon; Maurizio Parodi; Patty Dhooge; Tobias Peters; Wolfgang Klein; Mario G Fsadni; Hans Müller; Oliver Jungmann

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5704. doi:

ARVO Annual Meeting Abstract July 2019

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Tobias Peters; Krunoslav Stingl; Karl Ulrich Bartz-Schmidt; Laura Kuehlewein; Carina Kelbsch; Melanie Kempf; Eberhart Zrenner; Barbara Wilhelm; Katarina Stingl

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1829. doi:

ARVO Annual Meeting Abstract July 2019

Objective Measurement of Functional Defects in Age-related Macular Degeneration by Pupil Campimetry

Carina Kelbsch; Jakob Lange; Helmut Wilhelm; Barbara Wilhelm; Tobias Peters; Melanie Kempf; Laura Kuehlewein; Krunoslav Stingl

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2295. doi:

ARVO Annual Meeting Abstract July 2019

Pupil campimetry: An objective measurement of local rod and/or cone function by pupillary response

Krunoslav Stingl; Tobias Peters; Torsten Strasser; Helmut Wilhelm; Barbara Wilhelm; Melanie Kempf; Katarina Stingl; Carina Kelbsch

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6461. doi:

ARVO Annual Meeting Abstract July 2018

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

M Dominik Fischer; Stylianos Michalakis; Barbara Wilhelm; Nadine Kahle; Tobias Peters; Karl Ulrich Bartz-Schmidt; Susanne Kohl; Mathias W Seeliger; Nicole Weisschuh; Ditta Zobor; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2982. doi:

ARVO Annual Meeting Abstract July 2018

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; Birgit Korbmacher; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2658. doi:

Retina April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

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Felix F. Reichel; Tobias Peters; Barbara Wilhelm; Martin Biel; Marius Ueffing; Bernd Wissinger; Karl U. Bartz-Schmidt; Reinhild Klein; Stylianos Michalakis; M. Dominik Fischer; for the RD-CURE Consortium

Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1910-1915. doi: https://doi.org/10.1167/iovs.17-22494

Includes: Supplemental Content

Retina November 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

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Immanuel P. Seitz; Stylianos Michalakis; Barbara Wilhelm; Felix F. Reichel; G. Alex Ochakovski; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger; Karl U. Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: cohort studies, disease vectors, dna, gene transfer techniques, genome, injections, primates, spatial vectors, body tissue, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5792-5801. doi: https://doi.org/10.1167/iovs.17-22473

Includes: Supplemental Content

Retina August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

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G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene therapy, injections, primates, safety, serotonin uptake inhibitors, retina, eye, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4155-4160. doi: https://doi.org/10.1167/iovs.17-22402

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Evaluation of electroretinography in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; birgit niggemann; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; Dominik M Fischer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4096. doi:

ARVO Annual Meeting Abstract June 2017

Non-inferiority of subretinal versus intravitreal injection regarding photoreceptor layer thickness

Guy Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4100. doi:

ARVO Annual Meeting Abstract June 2017

How do patients rate their subjective symptoms after CNGA3 gene therapy: First application of the instrument A3-PRO

Barbara Wilhelm; Andreas Koegel; Nadine Kahle; Tobias Peters; Stylianos Michalakis; Martin Biel; Mathias Seeliger; Eberhart Zrenner; Bernd Wissinger; Susanne Kohl; Marius Ueffing; Karl Ulrich Bartz-Schmidt; Dominik M Fischer; Ditta Zobor

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4678. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology February 2017

Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3 -Linked Achromatopsia

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Jolanta Lisowska; Lukasz Lisowski; Carina Kelbsch; Fumiatsu Maeda; Paul Richter; Susanne Kohl; Ditta Zobor; Torsten Strasser; Krunoslav Stingl; Eberhart Zrenner; Tobias Peters; Helmut Wilhelm; M. Dominik Fischer; Barbara Wilhelm; for the RD-CURE Consortium
TAGS: achromatopsia, gene therapy, pupil reaction, dark adaptation, retinal cone, light, lighting, rod photoreceptors, pupil, cornea
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1274-1282. doi: https://doi.org/10.1167/iovs.16-20505

Includes: Supplemental Content

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Evaluation of Local Rod and Cone Function in Stargardt Disease

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

Systemic and intraocular administration of the liposomal formulation of the cyclic GMP analogue CN03: An exploratory safety and tolerability study in non-human primates

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

Designing a clinical trial to evaluate the safety and efficacy of oral soraprazan in Stargardt Disease

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Objective Measurement of Functional Defects in Age-related Macular Degeneration by Pupil Campimetry

Pupil campimetry: An objective measurement of local rod and/or cone function by pupillary response

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

Evaluation of electroretinography in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Non-inferiority of subretinal versus intravitreal injection regarding photoreceptor layer thickness

How do patients rate their subjective symptoms after CNGA3 gene therapy: First application of the instrument A3-PRO

Development of a Chromatic Pupillography Protocol for the First Gene Therapy Trial in Patients With CNGA3 -Linked Achromatopsia

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