Biochemistry and Molecular Biology

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Glaucoma August 2019

Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells

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Vidhya R. Rao; Jonathan D. Lautz; Simon Kaja; Eileen M. Foecking; Emőke Lukács; Evan B. Stubbs, Jr
TAGS: antioxidants, attenuation, mitochondria, signal transduction, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3613-3624. doi: 10.1167/iovs.19-27542

Article August 2019

Age effects on sensorimotor predictions: What drives increased tactile suppression during reaching?

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Lena Klever; Dimitris Voudouris; Katja Fiehler; Jutta Billino
TAGS: adult, aging, elderly, executive functioning, memory, attenuation
Journal of Vision. 2019; 19(9):9. doi: 10.1167/19.9.9

Editorial August 2019

Reviewers

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TAGS: christianity, reading (activity), cataract-alopecia-sclerodactyly syndrome, congenital absence of limb, fexofenadine, hematoma of pinna, immune reconstitution inflammatory syndrome, microangiopathic hemolytic anemia, silver, vacterl association with hydrocephalus, zein, vision
Journal of Vision. 2019; 19(9):r. doi: 10.1167/19.9.r

Editorial August 2019

Reviewers

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TAGS: acoustic evoked brain stem potentials, arthritis, juvenile rheumatoid, aves, betula, burns, chewing, christianity, cluster headache, enzyme-linked immunosorbent assay, esters, french, glycogen storage disease type iv, happiness, hematoma of pinna, hida scan, horns, human leukocyte antigens, hurricane katrina, hypertension, ilex, immune reconstitution inflammatory syndrome, iris, laparoscopic uterosacral nerve ablation, local area networks, magnetic endoscopic imaging, monoamine oxidase, morale, mosses, netherlands, nongovernmental organizations, no-observed-effect level, ophthalmology, potassium hydroxide, pstpip1 gene, pyogenic sterile arthritis, pyoderma gangrenosum, and acne, quality, radiation therapy, adaptive, reading (activity), rod photoreceptors, rosales, salmon, science, simian-human immunodeficiency virus, stepp trial, superfund amendments and reauthorization act, tai ji, tau proteins, tolnaftate, vorinostat
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3414-3420. doi: 10.1167/iovs.19-28020

Cornea August 2019

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

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Uri Simcha Soiberman; Ahmed Elsayed Mahmoud Shehata; Michelle Xiaoyi Lu; Tempest Young; Yassine J. Daoud; Shukti Chakravarti; Albert S. Jun; James William Foster
TAGS: keratoconus, phenotype, regulation, small molecule, stress response, fibroblasts, proteins, cell count, collagen synthesis, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3422-3431. doi: 10.1167/iovs.19-27151

Includes: Supplemental Content

Physiology and Pharmacology August 2019

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

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Caitriona O'Leary; Mary K. McGahon; Sadaf Ashraf; Jennifer McNaughten; Thomas Friedel; Patrizia Cincolà; Peter Barabas; Jose A. Fernandez; Alan W. Stitt; J. Graham McGeown; Tim M. Curtis
TAGS: angiogenesis, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3297-3309. doi: 10.1167/iovs.18-26344

Includes: Multimedia, Supplemental Content

Article July 2019

Evaluating the performance of the staircase and quick Change Detection methods in measuring perceptual learning

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Pan Zhang; Yukai Zhao; Barbara Anne Dosher; Zhong-Lin Lu
TAGS: learning, precision, stairs, transfer technique, perceptual learning
Journal of Vision. 2019; 19(7):14. doi: 10.1167/19.7.14

Includes: Supplemental Content

Retina July 2019

Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy

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Katherine Sumarriva; Karan Uppal; Chunyu Ma; David J. Herren; Yating Wang; Isaac M. Chocron; Cassandra Warden; Sabrina L. Mitchell; L. Goodwin Burgess; Megan P. Goodale; Melissa P. Osborn; Allison J. Ferreira; Janice C. Law; Edward F. Cherney; Dean P. Jones; Milam A. Brantley, Jr
TAGS: arginine, carnitine, diabetic retinopathy, metabolites, nonproliferative diabetic retinopathy, diabetes mellitus
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3119-3126. doi: 10.1167/iovs.19-27321

Includes: Supplemental Content

Retinal Cell Biology July 2019

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

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Yi Liao; Houjian Zhang; Danxue He; Yan Wang; Binxiang Cai; Jingmeng Chen; Jianxing Ma; Zuguo Liu; Yalin Wu
TAGS: caspase-1, inflammasomes, nlr family, pyrin domain-containing 3 protein, retinal pigment epithelium, cell death, interleukin-18
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3034-3045. doi: 10.1167/iovs.18-26360

Includes: Supplemental Content

Cornea July 2019

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

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Aurelie Dos Santos; Alis Balayan; Martha L. Funderburgh; John Ngo; James L. Funderburgh; Sophie X. Deng
TAGS: keratocytes, stem cell, mesenchymal, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3013-3023. doi: 10.1167/iovs.19-27008

Includes: Supplemental Content

Articles July 2019

Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape

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Henry B. Wallace; James McKelvie; Colin R. Green; Stuti L. Misra
TAGS: cornea, visual accommodation, biomechanics, shape
Trans. Vis. Sci. Tech.. 2019; 8(4):5. doi: 10.1167/tvst.8.4.5

Biochemistry and Molecular Biology July 2019

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

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Feng He; Ralph M. Nichols; Lavanya Kailasam; Theodore G. Wensel; Melina A. Agosto
TAGS: biopharmaceutics classification system, phosphatidylinositols, phosphotransferases, retinal bipolar cells, tissue degeneration, mice, tissue membrane, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2861-2874. doi: 10.1167/iovs.19-26586

Includes: Supplemental Content

Articles June 2019

Age-Related Loss of Human Vitreal Viscoelasticity

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André Schulz; Silke Wahl; Annekatrin Rickmann; Jannine Ludwig; Boris V. Stanzel; Hagen von Briesen; Peter Szurman
TAGS: viscoelasticity, vitreous body
Trans. Vis. Sci. Tech.. 2019; 8(3):56. doi: 10.1167/tvst.8.3.56

Includes: Supplemental Content

Anatomy and Pathology/Oncology June 2019

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

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Ikram El Zaoui; Maya Bucher; Donata Rimoldi; Michael Nicolas; Gurkan Kaya; Rosanna Pescini Gobert; Nicola Bedoni; Ann Schalenbourg; Ezziat Sakina; Leonidas Zografos; Serge Leyvraz; Nicolo Riggi; Carlo Rivolta; Alexandre P. Moulin
TAGS: 1-phosphatidylinositol 3-kinase, malignant melanoma of conjunctiva, mitogen-activated protein kinases, molecular targeted therapy, mtor serine-threonine kinases, phosphoinositide 3-kinase, braf gene, proto-oncogene proteins c-akt, melanoma, mutation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2764-2772. doi: 10.1167/iovs.18-26508

Includes: Supplemental Content

Retina June 2019

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

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Matthew M. Harper; Adam Hedberg-Buenz; Judith Herlein; Eric E. Abrahamson; Michael G. Anderson; Markus H. Kuehn; Randy H. Kardon; Pieter Poolman; Milos D. Ikonomovic
TAGS: alzheimer's disease, amyloidosis, basic local alignment search tool, mice, nerve degeneration, traumatic brain injuries, optic nerve, brain, retina, blast injuries, pupil light reflex
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2716-2725. doi: 10.1167/iovs.18-26353

Biochemistry and Molecular Biology June 2019

Modulation of cPKCγ on Synapsin-Ia/b–Specific Phosphorylation Sites in the Developing Visual Cortex of Mice

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Tao Fu; Jing Wang; Yichao Ding; Yunxia Zhang; Song Han; Junfa Li
TAGS: mice, synapsins, visual cortex, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2676-2684. doi: 10.1167/iovs.19-26675

Retina June 2019

Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

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Yousif Subhi; Marie Krogh Nielsen; Christopher Rue Molbech; Akio Oishi; Amardeep Singh; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: cytokine, exudative age-related macular degeneration, helper-inducer t-lymphocytes, interleukin-33, phenotype, plasma, polypoidal choroidal vasculopathy, regulatory t-lymphocytes, flow cytometry, immunology, interleukin-4
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2583-2590. doi: 10.1167/iovs.19-26882

Includes: Supplemental Content

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria, organelles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. doi: 10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics, clinical trial protocol document, body temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: 10.1167/tvst.8.3.40

Glaucoma June 2019

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

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Judith Kouassi Nzoughet; Juan Manuel Chao de la Barca; Khadidja Guehlouz; Stéphanie Leruez; Laurent Coulbault; Stéphane Allouche; Cinzia Bocca; Jeanne Muller; Patrizia Amati-Bonneau; Philippe Gohier; Dominique Bonneau; Gilles Simard; Dan Milea; Guy Lenaers; Vincent Procaccio; Pascal Reynier
TAGS: cohort studies, glaucoma, niacinamide, open-angle glaucoma, pellagra, plasma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2509-2514. doi: 10.1167/iovs.19-27099

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Mitochondrial-Targeted Antioxidants Attenuate TGF-β2 Signaling in Human Trabecular Meshwork Cells

Age effects on sensorimotor predictions: What drives increased tactile suppression during reaching?

Reviewers

Reviewers

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

Evaluating the performance of the staircase and quick Change Detection methods in measuring perceptual learning

Arginine and Carnitine Metabolites Are Altered in Diabetic Retinopathy

Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All- trans Retinal

Differentiation Capacity of Human Mesenchymal Stem Cells into Keratocyte Lineage

Corneal Curvature: the Influence of Corneal Accommodation and Biomechanics on Corneal Shape

Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells

Age-Related Loss of Human Vitreal Viscoelasticity

Conjunctival Melanoma Targeted Therapy: MAPK and PI3K/mTOR Pathways Inhibition

Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease

Modulation of cPKCγ on Synapsin-Ia/b–Specific Phosphorylation Sites in the Developing Visual Cortex of Mice

Polypoidal Choroidal Vasculopathy Associate With Diminished Regulatory T Cells That Are Polarized Into a T Helper 2-Like Phenotype

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

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