Biochemistry and Molecular Biology

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Editorial July 2021

Data Science in Translational Vision Science and Technology

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Marco A. Zarbin; Aaron Y. Lee; Pearse A. Keane; Michael F. Chiang
TAGS: data science, technology, vision
Trans. Vis. Sci. Tech.. 2021; 10(8):20. doi: https://doi.org/10.1167/tvst.10.8.20

Biochemistry and Molecular Biology July 2021

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy

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Juanjuan Zhang; Yanchun Ji; Jie Chen; Man Xu; Guoping Wang; Xiaorui Ci; Bing Lin; Jun Q. Mo; Xiangtian Zhou; Min-Xin Guan
TAGS: apoptosis, cell lines, mitochondria, mutation, optic atrophy, hereditary, leber, mitochondrial membranes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):38. doi: https://doi.org/10.1167/iovs.62.9.38

Includes: Supplemental Content

Retina July 2021

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

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Ahmed M. Abu El-Asrar; Mohd Imtiaz Nawaz; Ajmal Ahmad; Mohammad Mairaj Siddiquei; Eef Allegaert; Priscilla W. Gikandi; Gert De Hertogh; Ghislain Opdenakker
TAGS: angiogenesis, biological markers, diabetes mellitus, endothelial cells, enzyme-linked immunosorbent assay, inflammation, proliferative diabetic retinopathy, rats, retina, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):32. doi: https://doi.org/10.1167/iovs.62.9.32

Retina July 2021

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

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Han Han; Xiao Zhao; Mengyu Liao; Yinting Song; Caiyun You; Xue Dong; Xueli Yang; Xiaohong Wang; Bo Huang; Mei Du; Hua Yan
TAGS: epithelial to mesenchymal transition, eye, factor x, fibrosis, mice, ocular trauma, oryctolagus cuniculus, receptor, par-1, retinal pigment cell, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):29. doi: https://doi.org/10.1167/iovs.62.9.29

Includes: Supplemental Content

Retinal Cell Biology July 2021

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

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Xiaoling Shi; Nuo Dong; Qi Qiu; Shanhua Li; Jiaxing Zhang
TAGS: hypoxia, wounds and injuries, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):25. doi: https://doi.org/10.1167/iovs.62.9.25

Articles July 2021

Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy

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Louise A. Mesentier-Louro; Laurel Stell; Yan Yan; Artis A. Montague; Vinicio de Jesus Perez; Yaping Joyce Liao
TAGS: inflammation, nonarteritic anterior ischemic optic neuropathy, optic neuropathy, ischemic
Trans. Vis. Sci. Tech.. 2021; 10(8):17. doi: https://doi.org/10.1167/tvst.10.8.17

Includes: Supplemental Content

Physiology and Pharmacology July 2021

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated

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Zhen Liu; Yanghui Xiu; Fangfang Qiu; Zhenzhen Zhu; Rongrong Zong; Xiangtian Zhou; Jianhong An; Qiongsi Wang; Peter S Reinach; Wei Li; Wensheng Chen; Zuguo Liu
TAGS: myopia, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):21. doi: https://doi.org/10.1167/iovs.62.9.21

Articles July 2021

Comparison of Clinical and Biomechanical Outcomes of Small Incision Lenticule Extraction With 120- and 140-µm Cap Thickness

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Ikhyun Jun; David Sung Yong Kang; Cynthia J. Roberts; Hun Lee; Seung Ki Jean; Eung Kweon Kim; Kyoung Yul Seo; Tae-im Kim
TAGS: cornea, eye, postoperative care, refraction, visual acuity, surgical procedures, operative, safety, biomechanics, treatment outcome, nomogram
Trans. Vis. Sci. Tech.. 2021; 10(8):15. doi: https://doi.org/10.1167/tvst.10.8.15

Articles July 2021

Electrophysiologic and Morphologic Strain Differences in a Low-Dose NaIO 3 -Induced Retinal Pigment Epithelium Damage Model

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Nan Zhang; Xian Zhang; Preston E. Girardot; Micah A. Chrenek; Jana T. Sellers; Ying Li; Yong-Kyu Kim; Vivian R. Summers; Salma Ferdous; Debresha A. Shelton; Jeffrey H. Boatright; John M. Nickerson
TAGS: diagnostic imaging, electroretinography, injections, mice, mice, inbred c57bl, retinal pigment epithelium, painful bladder syndrome, retinal pigment cell, fluorescent antibody technique
Trans. Vis. Sci. Tech.. 2021; 10(8):10. doi: https://doi.org/10.1167/tvst.10.8.10

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2021

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

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Bo Young Chun; Jong-Heon Kim; Youn-Kwan Jung; Yoon Seok Choi; Gunwoo Kim; Tomoko Yonezawa; Kyoungho Suk
TAGS: astrocytes, autoimmunity, mice, optic nerve, optic neuritis, plasma
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):8. doi: https://doi.org/10.1167/iovs.62.9.8

Includes: Supplemental Content

Editorial July 2021

Reviewers

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TAGS: christianity, reading (activity), superfund amendments and reauthorization act, watt, barrett's esophagus, brill's disease, gold, sennosides, silver, vacterl association with hydrocephalus
Journal of Vision. 2021; 21(7):1. doi: https://doi.org/10.1167/jov.21.7.1

Editorial July 2021

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2021; 10(8):3. doi: https://doi.org/10.1167/tvst.10.8.3

Cornea July 2021

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

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Runpu Li; Yingxin Qu; Xiaoqi Li; Ye Tao; Qinghua Yang; Junyi Wang; Yumei Diao; Qian Li; Yifan Fang; Yifei Huang; Liqiang Wang
TAGS: chronic exertional compartment syndrome, cornea, oryctolagus cuniculus, hepatorenal syndrome, wounds and injuries, hrs trial, hydrogen, endothelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):2. doi: https://doi.org/10.1167/iovs.62.9.2

Articles June 2021

Growth Modeling for Quantitative, Spatially Resolved Geographic Atrophy Lesion Kinetics

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Eric M. Moult; Yunchan Hwang; Yingying Shi; Liang Wang; Siyu Chen; Nadia K. Waheed; Giovanni Gregori; Philip J. Rosenfeld; James G. Fujimoto
TAGS: atrophy, eye, growth rate, kinetics
Trans. Vis. Sci. Tech.. 2021; 10(7):26. doi: https://doi.org/10.1167/tvst.10.7.26

Includes: Supplemental Content

Glaucoma June 2021

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma

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Wouter H. G. Hubens; Julian Krauskopf; Henny J. M. Beckers; Jos C. S. Kleinjans; Carroll A. B. Webers; Theo G. M. F. Gorgels
TAGS: glaucoma, hypertension, micrornas, open-angle glaucoma, plasma, rna, small, aqueous humor, rna-seq, biological markers
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):24. doi: https://doi.org/10.1167/iovs.62.7.24

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2021

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations

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Xiaofen Jin; Juanjuan Zhang; Qiuzi Yi; Feilong Meng; Jialing Yu; Yanchun Ji; Jun Q. Mo; Yi Tong; Pingping Jiang; Min-Xin Guan
TAGS: mitochondria, mutation, optic atrophy, hereditary, leber, cell lines, proteins, western blotting
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):22. doi: https://doi.org/10.1167/iovs.62.7.22

Includes: Supplemental Content

Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. doi: https://doi.org/10.1167/iovs.62.7.21

Visual Neuroscience June 2021

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

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Ai-Ling Bi; Yue-Ying Zhang; Zhi-Yuan Lu; Hong-Ying Tang; Xiu-Yan Zhang; Zi-Han Zhang; Bo-Qin Li; Da-Dong Guo; Sheng Gong; Qian Li; Xing-Rong Wang; Xiu-Zhen Lu; Hong-Sheng Bi
TAGS: actins, rats, visual acuity, visual cortex, mitochondria, primary visual cortex
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):20. doi: https://doi.org/10.1167/iovs.62.7.20

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. doi: https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

Cornea June 2021

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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Evan D. Bogdan; Whitney L. Stuard; Rossella Titone; Danielle M. Robertson
TAGS: corneal epithelium, homeostasis, hyperosmolality, insulin-like growth factor binding protein 3, sodium chloride, stress, mosmol, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):11. doi: https://doi.org/10.1167/iovs.62.7.11

Includes: Supplemental Content

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Data Science in Translational Vision Science and Technology

Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy

CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy

Activated Blood Coagulation Factor X (FXa) Contributes to the Development of Traumatic PVR Through Promoting RPE Epithelial-Mesenchymal Transition

Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis

Immunoprofiling of Nonarteritic Anterior Ischemic Optic Neuropathy

Canonical Wnt Signaling Drives Myopia Development and Can Be Pharmacologically Modulated

Comparison of Clinical and Biomechanical Outcomes of Small Incision Lenticule Extraction With 120- and 140-µm Cap Thickness

Electrophysiologic and Morphologic Strain Differences in a Low-Dose NaIO 3 -Induced Retinal Pigment Epithelium Damage Model

Protective Role of Limitrin in Experimental Autoimmune Optic Neuritis

Reviewers

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway

Growth Modeling for Quantitative, Spatially Resolved Geographic Atrophy Lesion Kinetics

Small RNA Sequencing of Aqueous Humor and Plasma in Patients With Primary Open-Angle Glaucoma

Leber's Hereditary Optic Neuropathy Arising From the Synergy Between ND1 3635G>A Mutation and Mitochondrial YARS2 Mutations

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

Synaptosomal Actin Dynamics in the Developmental Visual Cortex Regulate Behavioral Visual Acuity in Rats

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium

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