Biochemistry and Molecular Biology

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Cornea & External Disease September 2024

Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study

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Yuan Chang; Tianze Huang; Shan Yang; Ying Li; Di Chen
TAGS: atopic dermatitis, keratoconus, mendelian randomization analysis, genome-wide association study, datasets
Trans. Vis. Sci. Tech.. 2024; 13(9):13. https://doi.org/10.1167/tvst.13.9.13

Includes: Supplemental Content

Cornea September 2024

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing

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Rajnish Kumar; Ratnakar Tripathi; Nishant R. Sinha; Rajiv R. Mohan
TAGS: cornea, genes, rna-seq, wound healing, proteins, rna, polymerase chain reaction, myofibroblasts
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):13. https://doi.org/10.1167/iovs.65.11.13

Includes: Supplemental Content

Retina September 2024

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia

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Ying Ling; Yao Wang; Jingjing Ye; Changlin Luan; Ailing Bi; Yu Gu; Xuefeng Shi
TAGS: dopamine, eye, myopia, retina, sutures, amacrine cells, retinal ganglion cells, vesicular monoamine transporter 2, melanopsin, pituitary adenylate cyclase activating polypeptide
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):8. https://doi.org/10.1167/iovs.65.11.8

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2024

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi J. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du
TAGS: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars, induced pluripotent stem cells, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):5. https://doi.org/10.1167/iovs.65.11.5

Includes: Supplemental Content

Artificial Intelligence September 2024

Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method

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Najung Kim; Minsub Lee; Hyewon Chung; Hyung Chan Kim; Hyungwoo Lee
TAGS: age-related macular degeneration, anti-vascular endothelial growth factor therapy, cohort studies, diagnostic imaging, drug loading dose, injections, machine learning, visual acuity, treatment protocols, eye
Trans. Vis. Sci. Tech.. 2024; 13(9):3. https://doi.org/10.1167/tvst.13.9.3

Includes: Supplemental Content

Retinal Cell Biology September 2024

Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway

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Furong Gao; Mengwen Li; Lilin Zhu; Jiao Li; Jie Xu; Song Jia; Qingjian Ou; Caixia Jin; Haibin Tian; Juan Wang; Jingying Xu; Wei Xu; Guo-Tong Xu; Lixia Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, epithelial to mesenchymal transition, phosphoinositide 3-kinase, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):1. https://doi.org/10.1167/iovs.65.11.1

Includes: Supplemental Content

Cornea August 2024

The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease

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Kazuki Asai; Hyung Keun Lee; Shinri Sato; Eisuke Shimizu; Jaehun Jung; Takahiro Okazaki; Mamoru Ogawa; Shigeto Shimmura; Kazuo Tsubota; Yoko Ogawa; Kazuno Negishi; Masatoshi Hirayama
TAGS: cornea, graft-versus-host disease, mice, necroptosis, proteins, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):38. https://doi.org/10.1167/iovs.65.10.38

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2024

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

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Chen Hou; Qi Wan; Lirong Xiao; Qing Xiao; Meixia Zhang; Naihong Yan
TAGS: heme oxygenase (decyclizing), intraocular melanoma, neoplasms, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):37. https://doi.org/10.1167/iovs.65.10.37

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2024

Agonism of β3-Adrenoceptors Inhibits Pathological Retinal Angiogenesis in the Model of Oxygen-Induced Retinopathy

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Alberto Melecchi; Alessio Canovai; Rosario Amato; Massimo Dal Monte; Luca Filippi; Paola Bagnoli; Maurizio Cammalleri
TAGS: adrenergic receptor, angiogenesis, astrocytes, did not receive therapy or drug, hypoxia, mice, oxygen, proteins, retina, retinal diseases
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):34. https://doi.org/10.1167/iovs.65.10.34

Includes: Supplemental Content

Glaucoma August 2024

Comparison of SNCG and NEFH Promoter–Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma

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Nuala O'Neill; Miranda Meng; Brahim Chaqour; Kimberly Dine; Neha Sarabu; Jennifer C. Pham; Kenneth S. Shindler; Ahmara G. Ross
TAGS: glaucoma, mice, spatial vectors, enhancer of transcription, genes, cytomegalovirus
Trans. Vis. Sci. Tech.. 2024; 13(8):37. https://doi.org/10.1167/tvst.13.8.37

Retina August 2024

Retinal Penetrating Adeno-Associated Virus

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Binit Kumar; Manish Mishra; Siobhan Cashman; Rajendra Kumar-Singh
TAGS: adeno-associated virus, capsid, green fluorescent proteins, injections, intravitreal injections, mice, oxidative stress, peptides, photoreceptors, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):30. https://doi.org/10.1167/iovs.65.10.30

Includes: Multimedia, Supplemental Content

Retinal Cell Biology August 2024

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons

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Jie Meng; Xiu Mei Yang; Oliver Scheer; Johannes Lange; Heidi Müller; Susanne Bürger; Sven Rothemund; Ruaa Younis; Jan D. Unterlauft; Wolfram Eichler
TAGS: vegfr-1, vascular endothelial growth factor receptors, retinal neurons, pigment, placenta growth factor, vascular endothelial growth factor a, epithelium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):27. https://doi.org/10.1167/iovs.65.10.27

Includes: Supplemental Content

Retina August 2024

Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology

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Rami A. Shahror; Esraa Shosha; Marco H. Ji; Carol A. Morris; Melissa Wild; Bushra Zaman; Christian D. Mitchell; Pedro Tetelbom; Yuet-Kin Leung; Paul H. Phillips; Ahmed A. Sallam; Abdelrahman Y. Fouda
TAGS: aqueous humor, central retinal artery occlusion, hypertension, proteins, pathophysiology, clusterin, enzyme-linked immunosorbent assay
Trans. Vis. Sci. Tech.. 2024; 13(8):30. https://doi.org/10.1167/tvst.13.8.30

Includes: Supplemental Content

Retina August 2024

Molecular Responses of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration: Integrative Insights From Multi-Omics and Clinical Imaging

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Xuenan Zhuang; Miaoling Li; Lan Mi; Xiongze Zhang; Jiaxin Pu; Guiqin He; Liang Zhang; Honghua Yu; Liwei Yao; Hui Chen; Yuying Ji; Chengguo Zuo; Yongyue Su; Yuhong Gan; Xinlei Hao; Yining Zhang; Xuelin Chen; Feng Wen
TAGS: anti-vascular endothelial growth factor therapy, exudative age-related macular degeneration, molecule, diagnostic imaging, hypertension, metabolites, metabolomics, multiomics, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):24. https://doi.org/10.1167/iovs.65.10.24

Includes: Supplemental Content

Letters to the Editor August 2024

Causal Association Between Lipid-Lowering Drugs and Glaucoma: A Drug-Targeted Mendelian Randomization Study

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Yaqiong Liu; Tao Li
TAGS: antilipemic agents, glaucoma, lipid-lowering therapy, mendelian randomization analysis
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):23. https://doi.org/10.1167/iovs.65.10.23

Includes: Supplemental Content

Glaucoma August 2024

Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

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Sijie Zhao; Qing Dai; Zixuan Rao; Juan Li; Aiqin Wang; Ziqing Gao; Yuchen Fan
TAGS: biological markers, open-angle glaucoma, mendelian randomization analysis, genes, bioinformatics, optic nerve, dna methylation
Trans. Vis. Sci. Tech.. 2024; 13(8):21. https://doi.org/10.1167/tvst.13.8.21

Includes: Supplemental Content

Retina August 2024

Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa

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Yan Tao; Masatoshi Fukushima; Sakurako Shimokawa; Huanyu Zhao; Ayako Okita; Kohta Fujiwara; Atsunobu Takeda; Shizuo Mukai; Koh-Hei Sonoda; Yusuke Murakami
TAGS: aqueous humor, chemokines, cytokine, molecule, retinitis pigmentosa, interleukin-23, interleukin-8
Trans. Vis. Sci. Tech.. 2024; 13(8):18. https://doi.org/10.1167/tvst.13.8.18

Includes: Supplemental Content

Methods August 2024

Genetic Influence of Oily Fish Intake on Age-Related Macular Degeneration Risk: A Two-Sample Mendelian Randomization Analysis

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Miaoran Gao; Jian Zhou; Jingru Zhao; Zihao Liu; Xianke Luo; Changlu Yang; Xinning Yu; Mengdan Tang; Jiamei Zhu; Xiaoling Yan
TAGS: age-related macular degeneration, fatty fish, genetics, mendelian randomization analysis, instrumental variables
Trans. Vis. Sci. Tech.. 2024; 13(8):14. https://doi.org/10.1167/tvst.13.8.14

Includes: Supplemental Content

Genetics August 2024

Identification of Potential Drug Targets for Myopia Through Mendelian Randomization

PDF

Yimin Qin; Chengcheng Lei; Tianfeng Lin; Xiaotong Han; Decai Wang
TAGS: drug delivery systems, genes, mendelian randomization analysis, myopia, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):13. https://doi.org/10.1167/iovs.65.10.13

Includes: Supplemental Content

Retina August 2024

Identification of the Metabolic Signature of Aging Retina

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Wan Mu; Xiaoyan Han; Ming Tong; Shuai Ben; Mudi Yao; Ya Zhao; Jiao Xia; Ling Ren; Chang Huang; Duo Li; Xiumiao Li; Qin Jiang; Biao Yan
TAGS: aging, metabolites, retina
Trans. Vis. Sci. Tech.. 2024; 13(8):8. https://doi.org/10.1167/tvst.13.8.8

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Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method

Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway

The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

Agonism of β3-Adrenoceptors Inhibits Pathological Retinal Angiogenesis in the Model of Oxygen-Induced Retinopathy

Comparison of SNCG and NEFH Promoter–Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma

Retinal Penetrating Adeno-Associated Virus

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons

Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology

Molecular Responses of Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration: Integrative Insights From Multi-Omics and Clinical Imaging

Causal Association Between Lipid-Lowering Drugs and Glaucoma: A Drug-Targeted Mendelian Randomization Study

Identification of Optic Nerve–Related Biomarkers in Primary Open-Angle Glaucoma Based on Comprehensive Bioinformatics and Mendelian Randomization

Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa

Genetic Influence of Oily Fish Intake on Age-Related Macular Degeneration Risk: A Two-Sample Mendelian Randomization Analysis

Identification of Potential Drug Targets for Myopia Through Mendelian Randomization

Identification of the Metabolic Signature of Aging Retina

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