Biochemistry and Molecular Biology

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Articles February 2021

Genome-Wide Association Studies-Based Machine Learning for Prediction of Age-Related Macular Degeneration Risk

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Qi Yan; Yale Jiang; Heng Huang; Anand Swaroop; Emily Y. Chew; Daniel E. Weeks; Wei Chen; Ying Ding
TAGS: age-related macular degeneration, genome, genome-wide association study, machine learning, single nucleotide polymorphism, datasets, genotype
Trans. Vis. Sci. Tech.. 2021; 10(2):29. doi: https://doi.org/10.1167/tvst.10.2.29

Includes: Supplemental Content

Articles February 2021

Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy

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Michelle R. Tamplin; Kimberly A. Broadhurst; Anthony H. Vitale; Ryuya Hashimoto; Randy H. Kardon; Isabella M. Grumbach
TAGS: hypertension, lasers, mice, vascular flow, angiotensin ii, infusion procedures
Trans. Vis. Sci. Tech.. 2021; 10(2):16. doi: https://doi.org/10.1167/tvst.10.2.16

Includes: Supplemental Content

Articles October 2020

Laser Capture Microdissection-Based RNA Microsequencing Reveals Optic Nerve Crush-Related Early mRNA Alterations in Retinal Ganglion Cell Layer

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Dongyan Pan; Mengqiao Xu; Xin Chang; Mao Xia; Yibin Fang; Yinghua Fu; Wei Shen; Yue Wang; Xiaodong Sun
TAGS: lasers, microdissection, optic nerve, rna, rna, messenger, retinal ganglion cells, genes, sequence analysis, rna
Trans. Vis. Sci. Tech.. 2020; 9(11):30. doi: https://doi.org/10.1167/tvst.9.11.30

Includes: Supplemental Content

Articles October 2020

Corneal Biomechanics After Intrastromal Ring Surgery: Optomechanical In Silico Assessment

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Miguel Ángel Ariza-Gracia; Julio Flecha-Lescún; Philippe Büchler; Begoña Calvo
TAGS: cornea, implants, surgical procedures, operative, biomechanics, implantation procedure
Trans. Vis. Sci. Tech.. 2020; 9(11):26. doi: https://doi.org/10.1167/tvst.9.11.26

Includes: Supplemental Content

Articles October 2020

Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport

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Neel D. Pasricha; Alex J. Smith; Marc H. Levin; Julie M. Schallhorn; Alan S. Verkman
TAGS: chlorides, cystic fibrosis transmembrane conductance regulator, ion transport, perfusion, epithelial sodium channel, safety, isoproterenol, cornea, epithelium
Trans. Vis. Sci. Tech.. 2020; 9(11):20. doi: https://doi.org/10.1167/tvst.9.11.20

Includes: Multimedia, Supplemental Content

Articles October 2020

Protein Composition of the Subretinal Fluid Suggests Selective Diffusion of Vitreous Proteins in Retinal Detachment

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Ebbe Toftgaard Poulsen; Xhevat Lumi; Anders K. Hansen; Jan J. Enghild; Goran Petrovski
TAGS: proteins, vitreous body, retinal detachment, proteomics
Trans. Vis. Sci. Tech.. 2020; 9(11):16. doi: https://doi.org/10.1167/tvst.9.11.16

Includes: Supplemental Content

Articles September 2020

Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients

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Ashley Polski; Liya Xu; Rishvanth K. Prabakar; Jonathan W. Kim; Rachana Shah; Rima Jubran; Peter Kuhn; David Cobrinik; James Hicks; Jesse L. Berry
TAGS: aqueous humor, cell-free dna, neoplasms, retinoblastoma, hypertension
Trans. Vis. Sci. Tech.. 2020; 9(10):30. doi: https://doi.org/10.1167/tvst.9.10.30

Includes: Supplemental Content

Articles September 2020

Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery

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Sebastian Freidank; Alfred Vogel; Norbert Linz
TAGS: 5-lipoxygenase-activating protein, cornea, lasers, surgical flaps, surgical ocular refractive procedure, tissue dissection, vortex formation, optics
Trans. Vis. Sci. Tech.. 2020; 9(10):22. doi: https://doi.org/10.1167/tvst.9.10.22

Articles September 2020

Quantifying Sample Collection and Processing Impacts on Fiber-Based Tear Fluid Chemical Analysis

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Anis Barmada; Scott A. Shippy
TAGS: amines, chemical analysis, phenolsulfonphthalein, specimen collection, volume, electrophoresis, capillary, buffers, small molecule
Trans. Vis. Sci. Tech.. 2020; 9(10):23. doi: https://doi.org/10.1167/tvst.9.10.23

Articles September 2020

Semi-Automated Approach for Retinal Tissue Differentiation

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Evgenii Kegeles; Tatiana Perepelkina; Petr Baranov
TAGS: body tissue, liquids, organoids, mice, retinal ganglion cells, fluorescence, stem cells
Trans. Vis. Sci. Tech.. 2020; 9(10):24. doi: https://doi.org/10.1167/tvst.9.10.24

Includes: Supplemental Content

Articles September 2020

Increased Aqueous Humor GDF15 Is Associated with Worse Visual Field Loss in Pseudoexfoliative Glaucoma Patients

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Jonathan B. Lin; Arsham Sheybani; Andrea Santeford; Alicia De Maria; Rajendra S. Apte
TAGS: aqueous humor, blindness, glaucoma, growth differentiation factor 15, hypertension, open-angle glaucoma
Trans. Vis. Sci. Tech.. 2020; 9(10):16. doi: https://doi.org/10.1167/tvst.9.10.16

Articles September 2020

Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration

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Anne M. Lynch; Brandie D. Wagner; Alan G. Palestine; Nebojsa Janjic; Jennifer L. Patnaik; Marc T. Mathias; Frank S. Siringo; Naresh Mandava
TAGS: age-related macular degeneration, biological markers, plasma, proteins, proteomics, reticular pseudodrusen
Trans. Vis. Sci. Tech.. 2020; 9(10):12. doi: https://doi.org/10.1167/tvst.9.10.12

Includes: Supplemental Content

Articles September 2020

Enzymatic Digestion of Porcine Corneas Cross-linked by Hypo- and Hyperosmolar Formulations of Riboflavin/ultraviolet A or WST11/Near-Infrared Light

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Jurriaan Brekelmans; Judith Veugen; Koen Rieff; Mor M. Dickman; Alexa Goz; Petra Wolffs; Alexander Brandis; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts; Avigdor Scherz; Arie L. Marcovich
TAGS: cornea, corneal collagen cross-linking, digestion, hyperosmolality, riboflavin, suidae, body weight, chromophore
Trans. Vis. Sci. Tech.. 2020; 9(10):4. doi: https://doi.org/10.1167/tvst.9.10.4

Special Issue August 2020

Predicting Thioflavin Fluorescence of Retinal Amyloid Deposits Associated With Alzheimer's Disease from Their Polarimetric Properties

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Yunyi Qiu; Tao Jin; Erik Mason; Melanie C. W. Campbell
TAGS: alzheimer's disease, amyloid, fluorescence, machine learning, datasets, retina
Trans. Vis. Sci. Tech.. 2020; 9(2):47. doi: https://doi.org/10.1167/tvst.9.2.47

Articles August 2020

Establishment and Characterization of a Unilateral UV-Induced Photoreceptor Degeneration Model in the C57Bl/6J Mouse

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Anna-Marina   van der Meer; Tanja Berger; Frank Müller; Ann Christina Foldenauer; Sandra Johnen; Peter Walter
TAGS: eye, mice, mice, inbred c57bl, photoreceptors, retina, spectral domain-optical coherence tomography, tissue degeneration, ultraviolet rays, did not receive therapy or drug, electroretinography
Trans. Vis. Sci. Tech.. 2020; 9(9):21. doi: https://doi.org/10.1167/tvst.9.9.21

Includes: Supplemental Content

Letters to the Editor August 2020

International Retinal Laser Society Guidelines For Subthreshold Laser Treatment

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Jan E. E. Keunen; Maurizio Battaglia-Parodi; Stela Vujosevic; Jeffrey K. Luttrull
TAGS: guidelines, laser therapy, lasers, societies
Trans. Vis. Sci. Tech.. 2020; 9(9):15. doi: https://doi.org/10.1167/tvst.9.9.15

Articles August 2020

DS-7080a, a Selective Anti-ROBO4 Antibody, Shows Anti-Angiogenic Efficacy with Distinctly Different Profiles from Anti-VEGF Agents

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Yoshitaka Isumi; Shinko Hayashi; Tatsuya Inoue; Yasushi Yoshigae; Toshiyuki Sato; Jun Hasegawa; Toshinori Agatsuma
TAGS: angiogenesis, antibodies, anti-vascular endothelial growth factor therapy, choroidal neovascularization, lasers, eye, ranibizumab, macaca fascicularis
Trans. Vis. Sci. Tech.. 2020; 9(9):7. doi: https://doi.org/10.1167/tvst.9.9.7

Includes: Supplemental Content

Editorial July 2020

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2020; 9(8):r. doi: https://doi.org/10.1167/tvst.9.8.r

Articles July 2020

Expression Profiles of Inflammatory Cytokines in the Aqueous Humor of Children after Congenital Cataract Extraction

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Yinying Zhao; Xiaohui Deng; Pingjun Chang; Man Hu; Zhangliang Li; Fan Zhang; Xixia Ding; Yune Zhao
TAGS: cataract surgery, child, congenital cataract, cytokine, hypertension, eye, aqueous humor
Trans. Vis. Sci. Tech.. 2020; 9(8):3. doi: https://doi.org/10.1167/tvst.9.8.3

Articles July 2020

Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

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Kazuhisa Yamada; Hiroki Kaneko; Hideyuki Shimizu; Ayana Suzumura; Rina Namba; Kei Takayama; Seina Ito; Masataka Sugimoto; Hiroko Terasaki
TAGS: aging, rna, tissue degeneration, lamivudine, interleukin-18, retinal pigment cell, anti-inflammatory agents, retinal pigment epithelium
Trans. Vis. Sci. Tech.. 2020; 9(8):1. doi: https://doi.org/10.1167/tvst.9.8.1

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Genome-Wide Association Studies-Based Machine Learning for Prediction of Age-Related Macular Degeneration Risk

Longitudinal Testing of Retinal Blood Flow in a Mouse Model of Hypertension by Laser Speckle Flowgraphy

Laser Capture Microdissection-Based RNA Microsequencing Reveals Optic Nerve Crush-Related Early mRNA Alterations in Retinal Ganglion Cell Layer

Corneal Biomechanics After Intrastromal Ring Surgery: Optomechanical In Silico Assessment

Ocular Surface Potential Difference Measured in Human Subjects to Study Ocular Surface Ion Transport

Protein Composition of the Subretinal Fluid Suggests Selective Diffusion of Vitreous Proteins in Retinal Detachment

Cell-Free DNA Tumor Fraction in the Aqueous Humor Is Associated With Therapeutic Response in Retinoblastoma Patients

Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery

Quantifying Sample Collection and Processing Impacts on Fiber-Based Tear Fluid Chemical Analysis

Semi-Automated Approach for Retinal Tissue Differentiation

Increased Aqueous Humor GDF15 Is Associated with Worse Visual Field Loss in Pseudoexfoliative Glaucoma Patients

Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration

Enzymatic Digestion of Porcine Corneas Cross-linked by Hypo- and Hyperosmolar Formulations of Riboflavin/ultraviolet A or WST11/Near-Infrared Light

Predicting Thioflavin Fluorescence of Retinal Amyloid Deposits Associated With Alzheimer's Disease from Their Polarimetric Properties

Establishment and Characterization of a Unilateral UV-Induced Photoreceptor Degeneration Model in the C57Bl/6J Mouse

International Retinal Laser Society Guidelines For Subthreshold Laser Treatment

DS-7080a, a Selective Anti-ROBO4 Antibody, Shows Anti-Angiogenic Efficacy with Distinctly Different Profiles from Anti-VEGF Agents

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Expression Profiles of Inflammatory Cytokines in the Aqueous Humor of Children after Congenital Cataract Extraction

Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

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