Biochemistry and Molecular Biology

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Cornea & External Disease June 2025

Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes

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Ruisi Xie; Yan Huo; Yutong Li; Zhengyuan Qu; Haohan Zou; Yan Wang
TAGS: biomechanics, cornea, eye, myopia, sclera
Trans. Vis. Sci. Tech.. 2025; 14(6):8. https://doi.org/10.1167/tvst.14.6.8

Includes: Supplemental Content

Retina May 2025

Perifoveal Choriocapillaris Flow Deficits Associated With Cerebrospinal Fluid Aβ 42 /tau in Presymptomatic Alzheimer's Disease

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Jane W. Chan; Giulia Corradetti; Xiaomeng Wu; Natalie Astraea; Xianghong Arakaki; Alfred N. Fonteh; Astrid M. Suchy-Dicey; SriniVas Sadda
TAGS: alzheimer's disease, biological markers, cerebrospinal fluid, fluid flow, tau proteins, chief complaint, cohort studies
Trans. Vis. Sci. Tech.. 2025; 14(5):27. https://doi.org/10.1167/tvst.14.5.27

Cornea & External Disease May 2025

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

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Yuke Huang; Jiejie Zhuang; Chang Liu; Shiji Liu; Huanhuan Ren; Qitong Zhang; Yan Li; Jin Qiu; Na Yu; Keming Yu; Xi Chen; Jing Zhuang
TAGS: genetics, keratoconus, obesity
Trans. Vis. Sci. Tech.. 2025; 14(5):20. https://doi.org/10.1167/tvst.14.5.20

Includes: Supplemental Content

Uveitis May 2025

Associations Between the Gut Microbiota and Its Related Metabolic Pathways and Uveitis: A Bidirectional Two-Sample Mendelian Randomization Study

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Maomei Luo; Zhen Xing; Yanhao Gou; Xianlin Yang; Xinran Zhang; Wei Yu; Hongbin Lv
TAGS: gastrointestinal microbiome, uveitis, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(5):15. https://doi.org/10.1167/tvst.14.5.15

Retina May 2025

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

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Chengming Chen; Yanyan Lan; Weiming Yan; Xiaohong Zhang; Tian Li; Jing Han
TAGS: age-related macular degeneration, metabolites, plasma, proteins, european continental ancestry group
Trans. Vis. Sci. Tech.. 2025; 14(5):8. https://doi.org/10.1167/tvst.14.5.8

Includes: Supplemental Content

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Retina May 2025

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

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Yaqi Bai; Yujia Xi; Chenwei Gui; Guohai Huang; Guohong Zhou
TAGS: diabetic retinopathy, genetics, mechanistic target of rapamycin complex 1, proteins
Trans. Vis. Sci. Tech.. 2025; 14(5):4. https://doi.org/10.1167/tvst.14.5.4

Includes: Supplemental Content

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Cornea & External Disease April 2025

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

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Xiru Yang; Xinyao Yu; Shan Gao; Pinghui Wei; Guoge Han
TAGS: extrinsic asthma, hypersensitivity, keratoconus, mendelian randomization analysis, atopic dermatitis, urticaria
Trans. Vis. Sci. Tech.. 2025; 14(4):14. https://doi.org/10.1167/tvst.14.4.14

Cornea & External Disease April 2025

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

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Xiang Cao; Zijiao Xu; Boyang Zhang; Qingyu Li; Zhixin Jiang; Xiaoyong Yuan
TAGS: allergic conjunctivitis, biological markers, mendelian randomization analysis, modified barium swallow, proteins
Trans. Vis. Sci. Tech.. 2025; 14(4):12. https://doi.org/10.1167/tvst.14.4.12

Includes: Supplemental Content

Glaucoma March 2025

Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization

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Dong Eun Kim; Do Young Park; Jong Chul Han
TAGS: aqueous humor, corneal neovascularization, mass or substance concentration per volume, oryctolagus cuniculus, vascular endothelial growth factor a, viscosity, choroidal neovascularization, copy number polymorphism, eye, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(3):9. https://doi.org/10.1167/tvst.14.3.9

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Glaucoma February 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta
TAGS: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):24. https://doi.org/10.1167/tvst.14.2.24

Includes: Supplemental Content

Retina February 2025

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

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Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Yuto Hashimoto; Hana Yoshida; Hironori Takahashi; Yujiro Fujino; Kenichi Aizawa; Hidetoshi Kawashima; Yasuo Yanagi
TAGS: aflibercept, aqueous humor, bodily secretions, eyedrops, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):21. https://doi.org/10.1167/tvst.14.2.21

Includes: Supplemental Content

Public Health February 2025

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

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Dan-Lin Li; Min-Xin Liu; Ya-Jie Zheng; Yu Qin; Rong Ma; Gang Liang; Chen-Wei Pan
TAGS: biomechanics, cornea, young adult
Trans. Vis. Sci. Tech.. 2025; 14(2):19. https://doi.org/10.1167/tvst.14.2.19

Glaucoma February 2025

Objective Grading of Tonography Tracings for the Measurement of Outflow Facility

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Arthur J. Sit; Carol B. Toris; Vikas Gulati; Arash Kazemi; Jesse Gilbert; Shan Fan; David M. Reed; David O. Hodge; Sayoko E. Moroi
TAGS: aqueous humor, intraocular pressure, eye, bland-altman plot
Trans. Vis. Sci. Tech.. 2025; 14(2):10. https://doi.org/10.1167/tvst.14.2.10

Uveitis February 2025

Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study

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Huan Liu; Fuzhen Li; Feiyan Wang; Ziqing Hu; Liping Du; Jing Wei
TAGS: cytokine, iridocyclitis, genetics, proteins, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(2):6. https://doi.org/10.1167/tvst.14.2.6

Includes: Supplemental Content

Public Health February 2025

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

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Jianqi Chen; Xuhao Chen; Xu Cao; Xiaohua Zhuo; Yuwen Wen; Guitong Ye; Yuan Zhang; Jinan Zhan; Hongmei Tan; Yingting Zhu; Yehong Zhuo
TAGS: frailty, national health and nutrition examination survey, diabetic retinopathy, mendelian randomization analysis
Trans. Vis. Sci. Tech.. 2025; 14(2):2. https://doi.org/10.1167/tvst.14.2.2

Includes: Supplemental Content

Retina February 2025

Effect of the Sugar Present in the Culture Medium on the Preservation of Human RPE Cell Suspensions

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Shohei Kitahata; Hinako Ichikawa; Yuji Tanaka; Shin Tanaka; Tatsuya Inoue; Maiko Maruyama-Inoue; Kazuaki Kadonosono
TAGS: culture media, retinal pigment cell, sugars, fructose
Trans. Vis. Sci. Tech.. 2025; 14(2):1. https://doi.org/10.1167/tvst.14.2.1

Includes: Supplemental Content

Glaucoma January 2025

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

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Faycal Moujane; Chi Zhang; Robert Knight; John Y. Lee; Sophie X. Deng; Jie J. Zheng
TAGS: attenuation, cornea, extracellular vesicles, glaucoma, myoc gene, trabecular meshwork, culture media, conditioned, dexamethasone, genes, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(1):21. https://doi.org/10.1167/tvst.14.1.21

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Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes

Perifoveal Choriocapillaris Flow Deficits Associated With Cerebrospinal Fluid Aβ 42 /tau in Presymptomatic Alzheimer's Disease

Unraveling the Link Between Obesity and Keratoconus Risk Based on Genetic Evidence

Associations Between the Gut Microbiota and Its Related Metabolic Pathways and Uveitis: A Bidirectional Two-Sample Mendelian Randomization Study

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

Measurement of Aqueous Humor Viscosity in an Experimental Rabbit Model With Corneal Neovascularization

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

Objective Grading of Tonography Tracings for the Measurement of Outflow Facility

Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization

Effect of the Sugar Present in the Culture Medium on the Preservation of Human RPE Cell Suspensions

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

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