External Eye Disease

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Cornea & External Disease April 2025

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

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Xiang Cao; Zijiao Xu; Boyang Zhang; Qingyu Li; Zhixin Jiang; Xiaoyong Yuan
TAGS: allergic conjunctivitis, biological markers, mendelian randomization analysis, modified barium swallow, proteins
Trans. Vis. Sci. Tech.. 2025; 14(4):12. https://doi.org/10.1167/tvst.14.4.12

Includes: Supplemental Content

Clinical Trials February 2025

A Single-Center Sham and Active-Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis

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Kevin E. Houston; Shrinivas Pundlik; Prerana Shivshanker; Alex R. Bowers; Sarah LaRosa; Mara Robinson; James Chodosh; Lynn Brandes; Patrick Lee; Eleftherios I. Paschalis
TAGS: eyelid ptosis, prostheses, safety, adverse event
Trans. Vis. Sci. Tech.. 2025; 14(2):15. https://doi.org/10.1167/tvst.14.2.15

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit January 2025

A Novel Rabbit Model of Meibomian Gland Dysfunction–Induced Dry Eye

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Annabelle Gallois-Bernos; Lichun Zhong; Mingqi Bai; Caroline A. Blackie
TAGS: cautery, developmental stages, dry eye syndromes, meibomian gland dysfunction, oryctolagus cuniculus, eye, tear film finding, meibomian gland
Trans. Vis. Sci. Tech.. 2025; 14(1):28. https://doi.org/10.1167/tvst.14.1.28

Cornea & External Disease November 2024

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

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Hao-Yu Wang; Dan Shen; Meng-Ying Qi; Chen Qiao; Lan Ke; Mingwu Wang; Qing-Yan Zeng
TAGS: blepharitis, eyelid, mites, ocular surfaces, eyelid margin, follow-up
Trans. Vis. Sci. Tech.. 2024; 13(11):22. https://doi.org/10.1167/tvst.13.11.22

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Cornea & External Disease October 2024

Key Clinical and Histopathological Features of a Pterygium-Like Induced Lesion in a Rabbit Model

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Carlos A. Rodríguez-Barrientos; Gloria Regina Ayala-Villegas; Jorge E. Valdez-García; Judith Zavala
TAGS: histopathology tests, oryctolagus cuniculus, pterygium
Trans. Vis. Sci. Tech.. 2024; 13(10):1. https://doi.org/10.1167/tvst.13.10.1

Cornea & External Disease September 2024

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

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Ángel Nava-Castañeda; Lilia Garnica-Hayashi; Noé Santiago-Rea; Edric González-Mondragón; Beatriz Buentello-Volante; Fátima Sofía Magaña-Guerrero; Yonathan Garfias
TAGS: conjunctiva, mucins, pterygium, transplantation, transplantation, autologous, follow-up, amnion, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2024; 13(9):10. https://doi.org/10.1167/tvst.13.9.10

Cornea & External Disease August 2024

Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression

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Benjamin Blautain; Ghislaine Rabut; Bénédicte Dupas; Luisa Riancho; Hong Liang; Jade Luzu; Antoine Labbé; Jean-Sébastien Garrigue; Françoise Brignole-Baudouin; Christophe Baudouin; Karima Kessal
TAGS: dry eye syndromes, hla-dr antigens, microscopy, confocal, conjunctiva, signs and symptoms
Trans. Vis. Sci. Tech.. 2024; 13(8):39. https://doi.org/10.1167/tvst.13.8.39

Includes: Supplemental Content

Cornea & External Disease July 2024

Tear Fluid Progranulin as a Noninvasive Biomarker for the Monitoring of Corneal Innervation Changes in Patients With Type 2 Diabetes Mellitus

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Tianyi Zhou; Zhiwei Dou; Yuchen Cai; Dongqing Zhu; Yao Fu
TAGS: biological markers, cornea, diabetes mellitus, diabetes mellitus, type 2, grn gene, nerve supply, neurons, progranulins, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(7):9. https://doi.org/10.1167/tvst.13.7.9

Artificial Intelligence June 2024

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

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Chun-Hsiao Yeh; Andrew D. Graham; Stella X. Yu; Meng C. Lin
TAGS: artificial intelligence, datasets, dreams, dry eye syndromes, eyelid, masks, tarsal plate, learning
Trans. Vis. Sci. Tech.. 2024; 13(6):16. https://doi.org/10.1167/tvst.13.6.16

Cornea & External Disease May 2024

Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model

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Chih-Chien Hsu; Hao-Kai Chuang; Yu-Jer Hsiao; Pin-Hsuan Chiang; Szu-Wen Chen; Wei-Ting Luo; Yi-Ping Yang; Ping-Hsing Tsai; Shih-Jen Chen; Ai-Ru Hsieh; Shih-Hwa Chiou
TAGS: dry eye syndromes, genome, genome-wide association study, polygenic risk score
Trans. Vis. Sci. Tech.. 2024; 13(5):13. https://doi.org/10.1167/tvst.13.5.13

Includes: Supplemental Content

Letters to the Editor March 2024

Concerns About a Dog Model of Dry Eye Disease

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Ron Ofri; Nicholas J. Millichamp; Charlotte Keller; Gillian J. McLellan; András M. Komáromy; David Morton; Màrian Matas; Tammy M. Michau; Sarah Coall; Jane Sansom; Brian C Leonard
TAGS: dog, domestic, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(3):28. https://doi.org/10.1167/tvst.13.3.28

Letters to the Editor March 2024

Author Response: Concerns About a Dog Model of Dry Eye Disease

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Zhi-Zheng Li; Yan-Ping Zou; Hui Zhu; Wei-Zhen Zeng; Yi Ding; Jia-Zeng Su; Guang-Yan Yu
TAGS: dog, domestic, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(3):26. https://doi.org/10.1167/tvst.13.3.26

Clinical Trials March 2024

OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial

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Matt Trinh; Judy Nam; Meenakshi Kumar; Lisa Nivison-Smith
TAGS: vascular flow, eye, grip strength
Trans. Vis. Sci. Tech.. 2024; 13(3):22. https://doi.org/10.1167/tvst.13.3.22

Includes: Supplemental Content

Cornea & External Disease February 2024

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

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Filippo Bonelli; Fabiola Campestre; Romina Mayra Lasagni Vitar; Ibrahim Halil Demirsoy; Philippe Fonteyne; Giulio Ferrari
TAGS: aprepitant, cornea, pain, signs and symptoms, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(2):9. https://doi.org/10.1167/tvst.13.2.9

Includes: Supplemental Content

Public Health January 2024

Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits

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Qinyi Gu; Qinxiang Zheng; Xiaoyu Zhang; Lei Lin; Saiqing Li; Fangwei Chen; Xian Zhang; Lijing L. Yan; Wei Chen
TAGS: dry eye syndromes, health services, outpatients, trend
Trans. Vis. Sci. Tech.. 2024; 13(1):17. https://doi.org/10.1167/tvst.13.1.17

Includes: Supplemental Content

Cornea & External Disease December 2023

Noninvasive Imaging of Conjunctival Goblet Cells as a Method for Diagnosing Dry Eye Disease in an Experimental Mouse Model

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Jeongho Kim; Jungbin Lee; Seonghan Kim; Sook Hyun Yoon; Yeong Chae Jo; Ki Hean Kim; Hong Kyun Kim
TAGS: conjunctiva, diagnostic imaging, dry eye syndromes, goblet cells, mice, cyclosporine
Trans. Vis. Sci. Tech.. 2023; 12(12):22. https://doi.org/10.1167/tvst.12.12.22

Cornea & External Disease December 2023

Preliminary Application of a Continuous Functional Contrast Visual Acuity System in the Assessment of Visual Function in Dry Eye Patients

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Gui-Lian Shi; An-Peng Pan; Rui-Lin Hu; Yu-Qian Zhang; Yun-Jing Ma; A-Yong Yu
TAGS: dry eye syndromes, vision, visual acuity
Trans. Vis. Sci. Tech.. 2023; 12(12):6. https://doi.org/10.1167/tvst.12.12.6

Lacrimal Apparatus, Eyelids, Orbit December 2023

An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Reanimation in Severe Blepharoptosis II: Randomized Evaluation of Angular Translation

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Pooyan Tirandazi; Melanie Nadeau; Russell L. Woods; Eleftherios I. Paschalis; Kevin E. Houston
TAGS: eye, eyelid, eyelid ptosis, magnets, prostheses, fissure
Trans. Vis. Sci. Tech.. 2023; 12(12):1. https://doi.org/10.1167/tvst.12.12.1

Lens October 2023

Tear Film Stability Affects Visual Acuity After Implantations of Monofocal and Multifocal Intraocular Lenses: An Evaluation by Objective Scatter Index

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Hao Huang; Jianjun Yan; Bowen Li; Mansha Huang; Shuanglin Guo; Aifang Fan; Wei Liu
TAGS: implantation procedure, multifocal intraocular lenses, tear film finding, visual acuity, eye, dry eye syndromes
Trans. Vis. Sci. Tech.. 2023; 12(10):15. https://doi.org/10.1167/tvst.12.10.15

Includes: Supplemental Content

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Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

A Single-Center Sham and Active-Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis

A Novel Rabbit Model of Meibomian Gland Dysfunction–Induced Dry Eye

Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Key Clinical and Histopathological Features of a Pterygium-Like Induced Lesion in a Rabbit Model

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

Multimodal Approach in Dry Eye Disease Combining In Vivo Confocal Microscopy and HLA-DR Expression

Tear Fluid Progranulin as a Noninvasive Biomarker for the Monitoring of Corneal Innervation Changes in Patients With Type 2 Diabetes Mellitus

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model

Concerns About a Dog Model of Dry Eye Disease

Author Response: Concerns About a Dog Model of Dry Eye Disease

OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits

Noninvasive Imaging of Conjunctival Goblet Cells as a Method for Diagnosing Dry Eye Disease in an Experimental Mouse Model

Preliminary Application of a Continuous Functional Contrast Visual Acuity System in the Assessment of Visual Function in Dry Eye Patients

An Adjustable Magnetic Levator Prosthesis for Customizable Eyelid Reanimation in Severe Blepharoptosis II: Randomized Evaluation of Angular Translation

Tear Film Stability Affects Visual Acuity After Implantations of Monofocal and Multifocal Intraocular Lenses: An Evaluation by Objective Scatter Index

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