Eye Anatomy and Disorders

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Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

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Francesca Giovannetti; Paola Pontecorvi; Francesca Megiorni; Marta Armentano; Ludovico Alisi; Enrico Romano; Cinzia Marchese; Alessandro Lambiase; Alice Bruscolini
TAGS: dry eye syndromes, micrornas, peeling skin syndrome, systemic scleroderma, sjogren's syndrome, bioinformatics, eye, conjunctiva, molecular profiling
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):80. https://doi.org/10.1167/iovs.66.4.80

Editorial April 2025

Supporting Effective Peer Review at Investigative Ophthalmology & Visual Science

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Abigail T. Fahim; Joseph Carroll
TAGS: ophthalmology, peer review
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):79. https://doi.org/10.1167/iovs.66.4.79

Article April 2025

Distinctive pupil and microsaccade-rate signatures in self-recognition

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Lisa Schwetlick; Hendrik Graupner; Olaf Dimigen; Ralf Engbert
TAGS: face, pupil, pupil size, dilatation, pathologic, peer group, pupil reaction
Journal of Vision. 2025; 25(4):16. https://doi.org/10.1167/jov.25.4.16

Includes: Supplemental Content

Article April 2025

Gaze behavioral patterns during table tennis forehand rallies

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Ryosuke Shinkai; Shintaro Ando; Yuki Nonaka; Tomohiro Kizuka; Seiji Ono
TAGS: gaze, tennis
Journal of Vision. 2025; 25(4):15. https://doi.org/10.1167/jov.25.4.15

Physiology and Pharmacology April 2025

Segmental Uveoscleral Outflow and its Relationship With Trabecular Outflow in Monkey Eyes

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Hoi-Lam Li; Su Yu; Shan Fan; Carol B. Toris; Haiyan Gong
TAGS: cercopithecidae, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):78. https://doi.org/10.1167/iovs.66.4.78

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

Multiterminal En Plaque Motor Endplates in Extraocular Muscles Are Conserved Across Vertebrate Species

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Jing-Xia Liu; Abraha Kahsay; Nils Dennhag; Jonas von Hofsten; Fatima Pedrosa Domellöf
TAGS: mice, motor endplate, muscle of orbit, neuromuscular junction, vertebrates, zebrafish, oryctolagus cuniculus, antibodies, muscle
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):77. https://doi.org/10.1167/iovs.66.4.77

Includes: Supplemental Content

Physiology and Pharmacology April 2025

A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow

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Jennifer H. Tweedy; Mariia Dvoriashyna; Jessica R. Crawshaw; Darryl R. Overby; Rodolfo Repetto; Paul A. Roberts; Tamsin A. Spelman; Peter S. Stewart; Alexander J. E. Foss
TAGS: albumins, body tissue, chief complaint, fluid flow, intraocular pressure, sclera, unit of flow rate, sensitivity analysis, choroid, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):75. https://doi.org/10.1167/iovs.66.4.75

Includes: Supplemental Content

Retina April 2025

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

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Biying Chen; Jianing Qiu; Yongan Meng; Youling Liang; Dan Liu; Yuqian Hu; Zhishang Meng; Jing Luo
TAGS: anti-vascular endothelial growth factor therapy, central retinal vein, macular edema, optical coherence tomography, radiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):74. https://doi.org/10.1167/iovs.66.4.74

Includes: Supplemental Content

Article April 2025

Violated predictions enhance the representational fidelity of visual features in perception

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Reuben Rideaux; Phuong Dang; Luke Jackel-David; Zak Buhmann; Dragan Rangelov; Jason B. Mattingley
TAGS: perception, precision, reaction time
Journal of Vision. 2025; 25(4):14. https://doi.org/10.1167/jov.25.4.14

Includes: Supplemental Content

Glaucoma April 2025

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

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Julia V. Stingl; Cordula Braun; Sara Walter; Jasmin Rezapour; Felix M. Wagner; Lucy Shen; Alicja Strzalkowska; Irene Schmidtmann; Alexander K. Schuster; Esther M. Hoffmann
TAGS: bruch's basal membrane, child, optics, glaucoma, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):24. https://doi.org/10.1167/tvst.14.4.24

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Retina April 2025

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

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Xingyu Xiao; Jianchun Zhao; Shiqun Lin; Yajie Yang; Wenhui Li; Yan Zhou; Xiao Zhang; Rongping Dai
TAGS: diabetes mellitus, nonproliferative diabetic retinopathy, retinal vessels, renal function, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):72. https://doi.org/10.1167/iovs.66.4.72

Retina April 2025

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

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Toshiaki Abe; Reiko Daigaku; Xie Yuting; Yasukazu Daigaku; Nobuhiro Nagai; Hirokazu Kaji; Aya Katsuyama; Yuki Katsukura; Yasuko Izumida; Atsuko Suzuki; Shinji Yamada; Yao-Wen Chang; Keiko Terada; Sei-ichi Ishiguro; Noriko Osumi; Hiroshi Kunikata; Toru Nakazawa
TAGS: hmgn1 protein, mice, proteins, mobility, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):70. https://doi.org/10.1167/iovs.66.4.70

Includes: Supplemental Content

Retina April 2025

Structure-Function Associations Between Quantitative Contrast Sensitivity Function And Peripapillary Optical Coherence Tomography Angiography in Diabetic Retinopathy

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Sierra K. Ha; Xinyi Ding; Francesco Romano; Katherine M. Overbey; Filippos Vingopoulos; Itika Garg; Cade F. Bennett; Isabella Stettler; Ioanna Ploumi; Grace Baldwin; Matthew J. Finn; Peyman Razavi; Demetrios G. Vavvas; Deeba Husain; Nimesh A. Patel; Leo A. Kim; John B. Miller
TAGS: angiogram, contrast sensitivity, diabetic retinopathy, optical coherence tomography, blood capillaries, perfusion, retinal nerve fiber layer, cultural formulation interview, visual acuity, microvascular network
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):69. https://doi.org/10.1167/iovs.66.4.69

Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Retina April 2025

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

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Jie Xu; Yi Li; Xiangyu Li; Xuan Tan; Lihua Liu; Lining Cao; Hui Xu
TAGS: interleukin-6, retina, zebrafish, microglia, signal transduction, stat3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):67. https://doi.org/10.1167/iovs.66.4.67

Includes: Supplemental Content

Retina April 2025

Radiomics-Based OCT Analysis of Choroid Reveals Biomarkers of Central Serous Chorioretinopathy

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Ryan Chace Williamson; Kiran Kumar Vupparaboina; Sandeep Chandra Bollepalli; Mohammed Nasar Ibrahim; Nicola Valsecchi; Arman Zarnegar; José-Alain Sahel; Jay Chhablani
TAGS: biological markers, central serous chorioretinopathy, choroid, eye, radiomics, face
Trans. Vis. Sci. Tech.. 2025; 14(4):23. https://doi.org/10.1167/tvst.14.4.23

Glaucoma April 2025

Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma

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Davina A. Malek; Alberto Diniz-Filho; Erwin R. Boer; Felipe A. Medeiros
TAGS: blindness, glaucoma, reaction time, divided attention, visual fields
Trans. Vis. Sci. Tech.. 2025; 14(4):21. https://doi.org/10.1167/tvst.14.4.21

Includes: Supplemental Content

Article April 2025

Warm versus cool colors and their relation to color perception

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Jake Manalansan; Lorne A. Whitehead; Michael A. Webster
TAGS: color, color perception, comedone, closed, retinal cone
Journal of Vision. 2025; 25(4):13. https://doi.org/10.1167/jov.25.4.13

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Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

Supporting Effective Peer Review at Investigative Ophthalmology & Visual Science

Distinctive pupil and microsaccade-rate signatures in self-recognition

Gaze behavioral patterns during table tennis forehand rallies

Segmental Uveoscleral Outflow and its Relationship With Trabecular Outflow in Monkey Eyes

Multiterminal En Plaque Motor Endplates in Extraocular Muscles Are Conserved Across Vertebrate Species

A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

Violated predictions enhance the representational fidelity of visual features in perception

New Threshold for Large Optic Discs in Children Using Bruch's Membrane Opening Area

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

Relationships Between Retinal Vascular Characteristics and Systemic Indicators in Patients With Diabetes Mellitus

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

Structure-Function Associations Between Quantitative Contrast Sensitivity Function And Peripapillary Optical Coherence Tomography Angiography in Diabetic Retinopathy

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Radiomics-Based OCT Analysis of Choroid Reveals Biomarkers of Central Serous Chorioretinopathy

Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma

Warm versus cool colors and their relation to color perception

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