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Articles February 2020

Generation of a Retina Reporter hiPSC Line to Label Progenitor, Ganglion, and Photoreceptor Cell Types

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Phuong T. Lam; Christian Gutierrez; Katia Del Rio-Tsonis; Michael L. Robinson
TAGS: ganglia, organoids, photoreceptors, retina
Trans. Vis. Sci. Tech.. 2020; 9(3):21. doi: https://doi.org/10.1167/tvst.9.3.21

Includes: Multimedia, Supplemental Content

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Articles February 2020

Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach

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Janika Nättinen; Ulla Aapola; Antti Jylhä; Anu Vaajanen; Hannu Uusitalo
TAGS: blood capillaries, datasets, libraries, proteins, proteomics, sampling method
Trans. Vis. Sci. Tech.. 2020; 9(3):16. doi: https://doi.org/10.1167/tvst.9.3.16

Includes: Supplemental Content

Special Issue February 2020

How Artificial Intelligence Can Transform Randomized Controlled Trials

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Cecilia S. Lee; Aaron Y. Lee
TAGS: artificial intelligence, randomized controlled trial
Trans. Vis. Sci. Tech.. 2020; 9(2):9. doi: https://doi.org/10.1167/tvst.9.2.9

Articles February 2020

PTEN Inhibition Facilitates Diabetic Corneal Epithelial Regeneration by Reactivating Akt Signaling Pathway

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Jing Li; Xia Qi; Xiaochuan Wang; Weina Li; Ya Li; Qingjun Zhou
TAGS: cornea, diabetes mellitus, epithelium, pten gene, mice, akt signaling pathway
Trans. Vis. Sci. Tech.. 2020; 9(3):5. doi: https://doi.org/10.1167/tvst.9.3.5

Articles December 2019

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

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Krunoslav T. Stingl; Laura Kuehlewein; Nicole Weisschuh; Saskia Biskup; Frans P. M. Cremers; M. Imran Khan; Carina Kelbsch; Tobias Peters; Marius Ueffing; Barbara Wilhelm; Eberhart Zrenner; Katarina Stingl
TAGS: eye, illness length, mutation, pupil reaction, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2019; 8(6):45. doi: https://doi.org/10.1167/tvst.8.6.45

Letters to the Editor December 2019

Heteroplasmy Rates of the m.14495A>G variant in MT-ND6 May Not Predict the Phenotype of LHON

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Josef Finsterer; Rahim Aliyev
TAGS: heteroplasmia, optic atrophy, hereditary, leber, phenotype
Trans. Vis. Sci. Tech.. 2019; 8(6):42. doi: https://doi.org/10.1167/tvst.8.6.42

Articles December 2019

Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy

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Arul J. Duraisamy; Rakesh Radhakrishnan; Berhane Seyoum; Gary W. Abrams; Renu A. Kowluru
TAGS: biological markers, diabetes mellitus, diabetic retinopathy, dna, dna methylation, dna, mitochondrial, epigenetics, methylation, genes, dna (cytosine-5-)-methyltransferase 1
Trans. Vis. Sci. Tech.. 2019; 8(6):43. doi: https://doi.org/10.1167/tvst.8.6.43

Articles December 2019

Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging

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Elisa Castaldi; Guido Marco Cicchini; Benedetto Falsini; Paola Binda; Maria Concetta Morrone
TAGS: functional magnetic resonance imaging, retinitis pigmentosa, psychophysics, magnetic resonance imaging, photopsia, blood oxygen level dependent, primary visual cortex, evoked potentials, visual, visual impairment, electroretinography
Trans. Vis. Sci. Tech.. 2019; 8(6):44. doi: https://doi.org/10.1167/tvst.8.6.44

Articles December 2019

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

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Francisco J. Valiente-Soriano; Arturo Ortín-Martínez; Johnny Di Pierdomenico; Diego García-Ayuso; Alejandro Gallego-Ortega; Juan A. Miralles de Imperial-Ollero; Manuel Jiménez-López; María Paz Villegas-Pérez; Larry A. Wheeler; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, brimonidine, ciliary neurotrophic factor, fibroblast growth factor 2, lip, phototoxicity, retina, retinal cone, opsin, mice
Trans. Vis. Sci. Tech.. 2019; 8(6):36. doi: https://doi.org/10.1167/tvst.8.6.36

Articles December 2019

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

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Chulbul M. Ahmed; Brian T. Dwyer; Alla Romashko; Steve Van Adestine; Eun-Hee Park; Zhen Lou; Devin Welty; Serene Josiah; Anneli Savinainen; Bohong Zhang; Alfred S. Lewin
TAGS: molecular chaperones, opsin, rhodopsin, animal model, retinitis pigmentosa, pharmacology, mice, photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(6):30. doi: https://doi.org/10.1167/tvst.8.6.30

Includes: Supplemental Content

Articles December 2019

Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics

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Edwin H. Yau; Robert T. Taggart; Mohammed Zuber; Alexandria J. Trujillo; Zahra S. Fayazi; Mark C. Butler; Lowell G. Sheflin; Jennifer B. Breen; Dian Yu; Jack M. Sullivan
TAGS: catalytic rna, opsin, rna, rna interference, rna, messenger, screening, therapeutics, cytokinesis, superior epigastric artery perforator flap, mutation
Trans. Vis. Sci. Tech.. 2019; 8(6):28. doi: https://doi.org/10.1167/tvst.8.6.28

Includes: Supplemental Content

Articles December 2019

Biomechanical and Morphologic Effects of Collagen Cross-Linking in Human Tarsus

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Shoaib Ugradar; Alan Le; Michael Lesgart; Robert A. Goldberg; Daniel Rootman; Joseph L. Demer
TAGS: ankle, body tissue, corneal collagen cross-linking, cross-linking, tarsal bones, microscopes, transmission electron, riboflavin, collagen, ultraviolet a radiation, radiation
Trans. Vis. Sci. Tech.. 2019; 8(6):25. doi: https://doi.org/10.1167/tvst.8.6.25

Articles December 2019

OCTA-Based Identification of Different Vascular Patterns in Stargardt Disease

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Alessandro Arrigo; Francesco Romano; Emanuela Aragona; Carlo di Nunzio; Andrea Sperti; Francesco Bandello; Maurizio Battaglia Parodi
TAGS: stargardt's disease
Trans. Vis. Sci. Tech.. 2019; 8(6):26. doi: https://doi.org/10.1167/tvst.8.6.26

Review November 2019

Corneal Endothelial Cells Over the Past Decade: Are We Missing the Mark(er)?

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Bert Van den Bogerd; Nadia Zakaria; Bianca Adam; Steffi Matthyssen; Carina Koppen; Sorcha Ní Dhubhghaill
TAGS: cornea, endothelial cells, endothelium, adenosine triphosphatases, phenotype, genotype
Trans. Vis. Sci. Tech.. 2019; 8(6):13. doi: https://doi.org/10.1167/tvst.8.6.13

Includes: Supplemental Content

Articles November 2019

Impact of Bleaching on Photoreceptors in Different Intermediate AMD Phenotypes

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Enrico Borrelli; Eliana Costanzo; Mariacristina Parravano; Pasquale Viggiano; Monica Varano; Paola Giorno; Alessandro Marchese; Riccardo Sacconi; Leonardo Mastropasqua; Francesco Bandello; Giuseppe Querques
TAGS: phenotype, photoreceptors, volume, eye, diagnostic imaging
Trans. Vis. Sci. Tech.. 2019; 8(6):5. doi: https://doi.org/10.1167/tvst.8.6.5

Articles October 2019

Fully Automated Estimation of Spacing and Density for Retinal Mosaics

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Robert F. Cooper; Geoffrey K. Aguirre; Jessica I. W. Morgan
TAGS: mosaicism, retinal cone, photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(5):26. doi: https://doi.org/10.1167/tvst.8.5.26

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: https://doi.org/10.1167/tvst.8.5.17

Articles August 2019

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

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Hui Lin; Ying Liu; Samuel Yiu
TAGS: epithelium, lacrimal gland, stem cells
Trans. Vis. Sci. Tech.. 2019; 8(4):32. doi: https://doi.org/10.1167/tvst.8.4.32

Articles August 2019

Long-Term Follow-Up of Retinal Degenerations Associated With LRAT Mutations and Their Comparability to Phenotypes Associated With RPE65 Mutations

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Mays Talib; Mary J. van Schooneveld; Roos J. G. van Duuren; Caroline Van Cauwenbergh; Jacoline B. ten Brink; Elfride De Baere; Ralph J. Florijn; Nicoline E. Schalij-Delfos; Bart P. Leroy; Arthur A. Bergen; Camiel J. F. Boon
TAGS: follow-up, genetics, mutation, phenotype, retinal degeneration, respiratory distress syndrome, newborn, eye, visual impairment
Trans. Vis. Sci. Tech.. 2019; 8(4):24. doi: https://doi.org/10.1167/tvst.8.4.24

Includes: Supplemental Content

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Generation of a Retina Reporter hiPSC Line to Label Progenitor, Ganglion, and Photoreceptor Cell Types

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach

How Artificial Intelligence Can Transform Randomized Controlled Trials

PTEN Inhibition Facilitates Diabetic Corneal Epithelial Regeneration by Reactivating Akt Signaling Pathway

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

Heteroplasmy Rates of the m.14495A>G variant in MT-ND6 May Not Predict the Phenotype of LHON

Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy

Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics

Biomechanical and Morphologic Effects of Collagen Cross-Linking in Human Tarsus

OCTA-Based Identification of Different Vascular Patterns in Stargardt Disease

Corneal Endothelial Cells Over the Past Decade: Are We Missing the Mark(er)?

Impact of Bleaching on Photoreceptors in Different Intermediate AMD Phenotypes

Fully Automated Estimation of Spacing and Density for Retinal Mosaics

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

Long-Term Follow-Up of Retinal Degenerations Associated With LRAT Mutations and Their Comparability to Phenotypes Associated With RPE65 Mutations

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