Glaucoma

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Glaucoma March 2025

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

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Kunal Kanwar; Rithambara Ramachandran; Joshua D. Stein; Chris A. Andrews; Azraa S. Chaudhury; Maryam Ige; Xueqing Zhou; Shikha Marwah; Yang Li; Charlesnika T. Evans; Abel N. Kho; Paul J. Bryar; Dustin D. French; on behalf of the Sight Outcomes Research Collaborative (SOURCE) Consortium
TAGS: open-angle glaucoma, optic nerve, disease progression
Trans. Vis. Sci. Tech.. 2025; 14(3):15. https://doi.org/10.1167/tvst.14.3.15

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

Glaucoma March 2025

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina

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Susannah Waxman; Hannah Schilpp; Ashley Linton; Tatjana C. Jakobs; Ian A. Sigal
TAGS: astrocytes, language morphology, morphology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):1. https://doi.org/10.1167/iovs.66.3.1

Includes: Supplemental Content

Glaucoma February 2025

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

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Haiyan Li; Devon H. Harvey; Jiannong Dai; Steven P. Swingle; Anthony M. Compton; Chenna Kesavulu Sugali; Kamesh Dhamodaran; Jing Yao; Tsai-Yu Lin; Todd Sulchek; Taeyoon Kim; C. Ross Ethier; Weiming Mao
TAGS: actins, adhesions, computer simulation, trabecular meshwork, cell nucleus, green fluorescent proteins, diagnostic imaging, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):65. https://doi.org/10.1167/iovs.66.2.65

Includes: Multimedia, Supplemental Content

Glaucoma February 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta
TAGS: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):24. https://doi.org/10.1167/tvst.14.2.24

Includes: Supplemental Content

Glaucoma February 2025

Mettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia–Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy

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Feiyan Zhu; Jiazhen Feng; Yiji Pan; Lingyi Ouyang; Tao He; Yiqiao Xing
TAGS: acute erythroblastic leukemia, autophagy, forkhead box protein o1, glaucoma, pathophysiology, reperfusion injury, retinal ischemia, wounds and injuries, ganglia, methylation
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):58. https://doi.org/10.1167/iovs.66.2.58

Genetics February 2025

Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

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Jihye Kim; Jae H. Kang; Janey L. Wiggs; Hetince Zhao; Keva Li; Nazlee Zebardast; Ayellet Segrè; David S. Friedman; Ron Do; Anthony P. Khawaja; Hugues Aschard; Louis R. Pasquale
TAGS: glaucoma, uk biobank, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):57. https://doi.org/10.1167/iovs.66.2.57

Includes: Supplemental Content

Glaucoma February 2025

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

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Jun Yu; Yuzhou Zhang; Ka Wai Kam; Mary Ho; Alvin L. Young; Chi Pui Pang; Clement C. Tham; Jason C. Yam; Li Jia Chen
TAGS: glaucoma, pulmonary function, pulmonary function tests, respiratory physiology, uk biobank, biological markers
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):48. https://doi.org/10.1167/iovs.66.2.48

Includes: Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Glaucoma February 2025

Objective Grading of Tonography Tracings for the Measurement of Outflow Facility

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Arthur J. Sit; Carol B. Toris; Vikas Gulati; Arash Kazemi; Jesse Gilbert; Shan Fan; David M. Reed; David O. Hodge; Sayoko E. Moroi
TAGS: aqueous humor, intraocular pressure, eye, bland-altman plot
Trans. Vis. Sci. Tech.. 2025; 14(2):10. https://doi.org/10.1167/tvst.14.2.10

Glaucoma February 2025

Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

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Jingyu Wang; Natalie Sadlak; Marissa G. Fiorello; Manishi Desai; Ji Yi
TAGS: glaucoma, optical coherence tomography, oximetry, oxygen saturation measurement, pilot projects, somalia, visible light, eye, antistreptolysin o, arteriosclerosis obliterans
Trans. Vis. Sci. Tech.. 2025; 14(2):12. https://doi.org/10.1167/tvst.14.2.12

Includes: Supplemental Content

Glaucoma February 2025

Detecting and Quantifying Glaucomatous Visual Function Loss With Continuous Visual Stimulus Tracking: A Case-Control Study

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Anne C. L. Vrijling; Minke J. de Boer; Remco J. Renken; Jan-Bernard C. Marsman; Joost Heutink; Frans W. Cornelissen; Nomdo M. Jansonius
TAGS: glaucoma, vision, learning
Trans. Vis. Sci. Tech.. 2025; 14(2):3. https://doi.org/10.1167/tvst.14.2.3

Includes: Supplemental Content

Glaucoma January 2025

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

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Qian Ying; Hongdou Luo; Zhi Xie; Yi Huang; Haijian Hu; Ming Jin; Ke Xu; Yulian Pang; Yuning Song; Xu Zhang
TAGS: glutamate, glutamates, mitochondria, neuroglia, optic atrophy, autosomal dominant, proteins, retina, wounds and injuries, n-methylaspartate, retinal injuries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):62. https://doi.org/10.1167/iovs.66.1.62

Glaucoma January 2025

Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty

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Min Seok Kim; Heesuk Kim; Hyung Keun Lee; Chan Yun Kim; Wungrak Choi
TAGS: artificial intelligence, descemet's membrane endothelial keratoplasty, ocular hypertension, survival analysis, preoperative care, risk factors, tissue transplants, glaucoma, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):61. https://doi.org/10.1167/iovs.66.1.61

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma

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Takashi Nishida; Takuhei Shoji; Robert N. Weinreb; Saori Yamaguchi; Izumi Mine; Akane Kosaka; Kei Shinoda
TAGS: eye movement, gaze, glaucoma, adduction, optic disk, eye, abduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):59. https://doi.org/10.1167/iovs.66.1.59

Review January 2025

Artificial Intelligence for Optical Coherence Tomography in Glaucoma

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Mak B. Djulbegovic; Henry Bair; David J. Taylor Gonzalez; Hiroshi Ishikawa; Gadi Wollstein; Joel S. Schuman
TAGS: glaucoma, optical coherence tomography, artificial intelligence
Trans. Vis. Sci. Tech.. 2025; 14(1):27. https://doi.org/10.1167/tvst.14.1.27

Artificial Intelligence January 2025

Explainable Deep Learning for Glaucomatous Visual Field Prediction: Artifact Correction Enhances Transformer Models

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Kornchanok Sriwatana; Chanon Puttanawarut; Yanin Suwan; Titipat Achakulvisut
TAGS: artifacts, datasets, glaucoma, visual fields
Trans. Vis. Sci. Tech.. 2025; 14(1):22. https://doi.org/10.1167/tvst.14.1.22

Includes: Supplemental Content

Glaucoma January 2025

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

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Faycal Moujane; Chi Zhang; Robert Knight; John Y. Lee; Sophie X. Deng; Jie J. Zheng
TAGS: attenuation, cornea, extracellular vesicles, glaucoma, myoc gene, trabecular meshwork, culture media, conditioned, dexamethasone, genes, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(1):21. https://doi.org/10.1167/tvst.14.1.21

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

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Joseph L. Demer; Robert A. Clark; Soh Youn Suh; JoAnn A. Giaconi; Kouros Nouri-Mahdavi; Simon K. Law; Laura Bonelli; Anthony C. Arnold; Peter Quiros; Anne L. Coleman; Joseph Caprioli
TAGS: adduction, cerebrospinal fluid, eye, eye movement, magnetic resonance imaging, open-angle glaucoma, optic nerve, optic nerve disorders, subarachnoid space, volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):53. https://doi.org/10.1167/iovs.66.1.53

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The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

Morphological Comparison of Astrocytes in the Lamina Cribrosa and Glial Lamina

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

Mettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia–Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy

Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?

Lung Function as a Biomarker for Glaucoma: The UK Biobank Study

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

Objective Grading of Tonography Tracings for the Measurement of Outflow Facility

Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study

Detecting and Quantifying Glaucomatous Visual Function Loss With Continuous Visual Stimulus Tracking: A Case-Control Study

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression

Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty

Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma

Artificial Intelligence for Optical Coherence Tomography in Glaucoma

Explainable Deep Learning for Glaucomatous Visual Field Prediction: Artifact Correction Enhances Transformer Models

Corneal Stromal Stem Cell-Derived Extracellular Vesicles Attenuate ANGPTL7 Expression in the Human Trabecular Meshwork

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

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