Glaucoma

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Glaucoma July 2025

Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

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Xueming Yao; Yuhan Jiang; Hongxi Yang; Ju Guo; Xiaohong Wang; Andrzej Grzybowski; Mulin Jun Li; Hua Yan
TAGS: depressive disorders, glaucoma, cohort studies, uk biobank, genetics
Trans. Vis. Sci. Tech.. 2025; 14(7):5. https://doi.org/10.1167/tvst.14.7.5

Includes: Supplemental Content

Glaucoma July 2025

Natural Course and Risk Factors of Glaucoma Development in the Untreated Fellow Eye in Unilateral Normal-Tension Glaucoma

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Eun Jung Lee; Do Young Park; Changwon Kee; Jong Chul Han
TAGS: did not receive therapy or drug, eye, glaucoma, intraocular pressure, low tension glaucoma, risk factors, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):16. https://doi.org/10.1167/iovs.66.9.16

Includes: Supplemental Content

Glaucoma July 2025

The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma

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Victor A. de Vries; Karin A. van Garderen; Caroline C. W. Klaver; Daniel Bos; Maryam Kavousi; Wishal D. Ramdas
TAGS: carotid atherosclerosis, carotid intima-media thickness, glaucoma, open-angle glaucoma, intraocular pressure, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):9. https://doi.org/10.1167/iovs.66.9.9

Glaucoma July 2025

Polygenic Risk Prediction for Normal-Tension Glaucoma

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Maryam Marzban; Santiago Diaz Torres; Regina Yu; Weixiong He; David A. Mackey; Ayellet V. Segrè; Janey Wiggs; Stuart MacGregor; Puya Gharahkhani; on behalf of the International Glaucoma Genetics Consortium
TAGS: datasets, low tension glaucoma, polygenic risk score, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):4. https://doi.org/10.1167/iovs.66.9.4

Includes: Supplemental Content

Glaucoma June 2025

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

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Li-Hua Chen; Hai-Jiang Zhang; Qing-Ao Xiao
TAGS: methylation, mitochondria, mitochondrial diseases, open-angle glaucoma, pathogenesis, pathophysiology, multiomics, genes
Trans. Vis. Sci. Tech.. 2025; 14(6):37. https://doi.org/10.1167/tvst.14.6.37

Includes: Supplemental Content

Glaucoma June 2025

Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation

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Shunsuke Nakakura; Ryo Asaoka; Etsuko Terao; Yasuko Fujisawa; Satomi Oogi; Kanae Ueda
TAGS: blister, implantation procedure, intraocular pressure, postoperative care, language morphology, morphology
Trans. Vis. Sci. Tech.. 2025; 14(6):32. https://doi.org/10.1167/tvst.14.6.32

Artificial Intelligence June 2025

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
TAGS: artificial intelligence, datasets, glaucoma, optic cup, optic disk, optical coherence tomography, training, electronic medical records
Trans. Vis. Sci. Tech.. 2025; 14(6):30. https://doi.org/10.1167/tvst.14.6.30

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Interplay Between γ-Zone Peripapillary Atrophy and Optic Disc Parameters in Central Visual Field Impairment in Highly Myopic Eyes

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Nan Zhou; Takeshi Yoshida; Keigo Sugisawa; Sota Yoshimoto; Kyoko Ohno-Matsui
TAGS: atrophy, eye, myopia, optic disk, visual field defects, risk factors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):74. https://doi.org/10.1167/iovs.66.6.74

Genetics June 2025

Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging

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Emily Tran; Mohan Rakesh; Gisele Li; Ellen E. Freeman; Marie-Hélène Roy-Gagnon
TAGS: aging, cognitive ability, cognitive impairment, eye diseases, genetic risk, hospitals, longitudinal studies, mental processes, montreal, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):71. https://doi.org/10.1167/iovs.66.6.71

Includes: Supplemental Content

Glaucoma June 2025

The Association of Muscle-Related Factors With Glaucoma and Related Traits in a Large United Kingdom Population

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Kian M. Madjedi; Kelsey V. Stuart; Grace S. Yin; Robert N. Luben; Zihan Sun; Mahantesh Biradar; Ruiqi Hu; Paul J. Foster; Peng T. Khaw; Katharina C. Bell; Jonathan G. Crowston; Anthony P. Khawaja; on behalf of the UK Biobank Eye and Vision Consortium
TAGS: glaucoma, muscle, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):66. https://doi.org/10.1167/iovs.66.6.66

Glaucoma June 2025

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

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Xiaowei Yu; Hanxue Zhao; Yan Gao; Tao Zhou; Lin Deng; Miao Zhang; Hongyu Zhong; Feng Mei; Zhijun Li; Longyan Sun; Tianrui Zhang; Yan Shi; Zhigang Fan
TAGS: angle closure glaucoma, chinese (other dialects), chinese people, cohort studies, genetics, genotype, microphthalmos, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):9. https://doi.org/10.1167/iovs.66.6.9

Includes: Supplemental Content

Glaucoma June 2025

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

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Yumeng Zhang; Hanwen Huang; Huimin Zhong; Yang Zhang; Siqi He; Yanzhi Guo; Yiwei Wang; Ping Huang; Shouyue Huang; Yisheng Zhong
TAGS: aging, mice, older adult, signal transduction, retinal ganglion cells, western blotting, hypoxia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):8. https://doi.org/10.1167/iovs.66.6.8

Includes: Supplemental Content

Glaucoma June 2025

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

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Jianqi Chen; Xiaohua Zhuo; Yangjiani Li; Yingting Zhu; Zhidong Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Lei Lei
TAGS: body tissue, genes, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):7. https://doi.org/10.1167/iovs.66.6.7

Includes: Supplemental Content

Glaucoma June 2025

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
TAGS: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(6):7. https://doi.org/10.1167/tvst.14.6.7

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations

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Charis Y. N. Chiang; Xiaofei Wang; Stuart K. Gardiner; Martin Buist; Michaël J. A. Girard
TAGS: exophthalmos, eye, glaucoma, optic nerve, orbit, retinal ganglion cells, retinal nerve fiber layer, magnetic resonance imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):4. https://doi.org/10.1167/iovs.66.6.4

Includes: Supplemental Content

Glaucoma June 2025

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
TAGS: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2025; 14(6):6. https://doi.org/10.1167/tvst.14.6.6

Includes: Supplemental Content

Glaucoma June 2025

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

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Jie Wang; Karine D. Bojikian; Aiyin Chen; Ping Wei; Liang Liu; Yali Jia; David Huang
TAGS: angiogram, ganglia, optical coherence tomography, nerve fibers
Trans. Vis. Sci. Tech.. 2025; 14(6):5. https://doi.org/10.1167/tvst.14.6.5

Artificial Intelligence June 2025

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift

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Homa Rashidisabet; R. V. Paul Chan; Yannek I. Leiderman; Thasarat Sutabutr Vajaranant; Darvin Yi
TAGS: datasets, glaucoma
Trans. Vis. Sci. Tech.. 2025; 14(6):3. https://doi.org/10.1167/tvst.14.6.3

Includes: Supplemental Content

Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Glaucoma May 2025

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

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Royston K. Y. Tan; Tin A. Tun; Fabian A. Braeu; Shamira A. Perera; Michaël J. A. Girard
TAGS: iris, biomechanics, dilatation, pathologic, permeability
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):36. https://doi.org/10.1167/iovs.66.5.36

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Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

Natural Course and Risk Factors of Glaucoma Development in the Untreated Fellow Eye in Unilateral Normal-Tension Glaucoma

The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma

Polygenic Risk Prediction for Normal-Tension Glaucoma

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

Interplay Between γ-Zone Peripapillary Atrophy and Optic Disc Parameters in Central Visual Field Impairment in Highly Myopic Eyes

Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging

The Association of Muscle-Related Factors With Glaucoma and Related Traits in a Large United Kingdom Population

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

PRMT5 Regulates Senescence in Retinal Ganglion Cells by Targeting the Wnt/β-Catenin Signaling Cascade

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study

Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Iris Crypts Could Reduce the Chance of Angle Closure: A Computational Biomechanics Study Derived From Clinical and Human Iris Data

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