Multidisciplinary Ophthalmic Imaging

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Artificial Intelligence March 2025

Retinal Microvascular Biomarker Assessment With Automated Algorithm and Semiautomated Software in the Montrachet Dataset

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Pétra Eid; Abderrahmane Bourredjem; Atif Anwer; Catherine Creuzot-Garcher; Pearse Andrew Keane; Yukun Zhou; Siegfried Wagner; Fabrice Meriaudeau; Louis Arnould
TAGS: biological markers, datasets, fundus photography, retinal imaging, software
Trans. Vis. Sci. Tech.. 2025; 14(3):13. https://doi.org/10.1167/tvst.14.3.13

Includes: Supplemental Content

Review March 2025

Advances in OCT Angiography

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Tristan T. Hormel; David Huang; Yali Jia
TAGS: angiogram, artifacts, diagnostic imaging, deep learning, fluid flow, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(3):6. https://doi.org/10.1167/tvst.14.3.6

Artificial Intelligence March 2025

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

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Bo Zheng; Chen Wang; Maotao Zhang; Shaojun Zhu; Maonian Wu; Tao Wu; Weihua Yang; Lu Chen
TAGS: learning, macular disorders, fundus photography, color, datasets
Trans. Vis. Sci. Tech.. 2025; 14(3):4. https://doi.org/10.1167/tvst.14.3.4

Includes: Supplemental Content

Retina February 2025

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

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Hiroyuki Takahashi; Yunchan Hwang; Jungeun Won; Muhammad Usman Jamil; Antonio Yaghy; Michelle C. Liang; Caroline R. Baumal; Andre J. Witkin; Kyoko Ohno-Matsui; Jay S. Duker; James G. Fujimoto; Nadia K. Waheed
TAGS: diabetic retinal microaneurysm, diabetic retinopathy, fluid flow, macrophage activation syndrome, meconium aspiration syndrome, retinal microaneurysm, vascular flow, blood capillaries
Trans. Vis. Sci. Tech.. 2025; 14(2):27. https://doi.org/10.1167/tvst.14.2.27

Multidisciplinary Ophthalmic Imaging February 2025

Retinal Arteriovenous Information Improves the Prediction Accuracy of Deep Learning–Based baPWV Index From Color Fundus Photographs

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Michiyuki Saito; Mizuho Mitamura; Kanae Fukutsu; Dong Zhenyu; Ryo Ando; Satoru Kase; Satoshi Katsuta; Susumu Ishida
TAGS: attention, color, deep learning, fundus photography, training
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):63. https://doi.org/10.1167/iovs.66.2.63

Includes: Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Multidisciplinary Ophthalmic Imaging February 2025

Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency

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Ye He; Pearl Heumann; Melissa Weilin Song; Shin Kadomoto; Srinivas R. Sadda; Ilina D. Pluym; Irena Tsui
TAGS: angiogram, optical coherence tomography, placental insufficiency, pregnancy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):36. https://doi.org/10.1167/iovs.66.2.36

Retina February 2025

Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7

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Stefan Futterknecht; Philipp Anders; Julia Mai; Sophie Riedl; Ursula Hall; Chrysoula Gabrani; Kristina Pfau; Martin J. Menten; Daniel Rueckert; A. Toby Prevost; Hrvoje Bogunovic; Lars G. Fritsche; Ursula Schmidt-Erfurth; Sobha Sivaprasad; Andrew Lotery; Hendrik P. N. Scholl; Maximilian Pfau
TAGS: drusen, study report, vision, eye, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):6. https://doi.org/10.1167/iovs.66.2.6

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging January 2025

Preferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease

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Oscar Otero-Marquez; Affan Haq; Luis Muncharaz Duran; Jordan Bellis; Sarah McCuskee; Sofia Ahsanuddin; Richard B. Rosen; Jeffrey Glassberg; Toco Y. P. Chui
TAGS: blood capillaries, sickle cell anemia, perfusion
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):57. https://doi.org/10.1167/iovs.66.1.57

Includes: Multimedia, Supplemental Content

Retina January 2025

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

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Christine A. Curcio; Jeffrey D. Messinger; Andreas Berlin; Kenneth R. Sloan; D. Scott McLeod; Malia M. Edwards; Jacques Bijon; K. Bailey Freund
TAGS: age-related macular degeneration, age-related macular degeneration, nonexudative, atrophic condition of skin, atrophy, autofluorescence, drusen, fundus autofluorescence imaging, histology, pathology, clinical, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):49. https://doi.org/10.1167/iovs.66.1.49

Includes: Multimedia, Supplemental Content

Review January 2025

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

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Julia Foust; Morgan McCloud; Amit Narawane; Robert M. Trout; Xi Chen; Al-Hafeez Dhalla; Jianwei D. Li; Christian Viehland; Mark Draelos; Lejla Vajzovic; Ryan P. McNabb; Anthony N. Kuo; Cynthia A. Toth
TAGS: eye, intraoperative care, robotics, surgical procedures, operative, diagnostic imaging, mobile devices
Trans. Vis. Sci. Tech.. 2025; 14(1):14. https://doi.org/10.1167/tvst.14.1.14

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

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Brandon D. Anderson; Brent A. Bell; Ying Song; Timothy T. Lee; Tan Wang; Joshua L. Dunaief
TAGS: age-related macular degeneration, nonexudative, atrophy, injections, iodates, sodium, mice, diagnostic imaging, retina
Trans. Vis. Sci. Tech.. 2025; 14(1):9. https://doi.org/10.1167/tvst.14.1.9

Includes: Supplemental Content

Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging January 2025

Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy

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Sara Oliveira; Pedro Guimarães; Elisa Julião Campos; Rosa Fernandes; João Martins; Miguel Castelo-Branco; Pedro Serranho; Paulo Matafome; Rui Bernardes; António Francisco Ambrósio
TAGS: biological markers, diabetes mellitus, diabetes mellitus, type 1, diabetic retinopathy, early diagnosis, retina, streptozocin, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):7. https://doi.org/10.1167/iovs.66.1.7

Includes: Supplemental Content

Retina December 2024

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

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Lukas Goerdt; Jose Luis Rodriguez Garcia; Sandrine H. Künzel; Kristina Pfau; Kristin Raming; Simone Tzaridis; Matthias Schmid; Frank G. Holz; Ben Isselmann; Leonie Weinhold; Sarah Thiele
TAGS: patient prognosis, telangiectasis, spectral domain-optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):36. https://doi.org/10.1167/iovs.65.14.36

Cornea & External Disease December 2024

In Vivo Contactless, Cellular-Resolution Imaging of the Healthy and Pathological Human Limbus With 250-kHz Point-Scanning SD-OCT

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Kostadinka Bizheva; Zohreh Hosseinaee; Kirsten Carter; Denise Hileeto; Brian G. Ballios; Luigina Sorbara; Hall F. Chew
TAGS: body tissue, diagnostic imaging, spectral domain-optical coherence tomography, eye, cicatrix
Trans. Vis. Sci. Tech.. 2024; 13(12):29. https://doi.org/10.1167/tvst.13.12.29

Retina December 2024

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

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Farhan E. Hiya; Yuxuan Cheng; Mengxi Shen; Jianqing Li; Alessandro Berni; Sandy Wenting Zhou; Gissel Herrera; Robert C. O'Brien; Giovanni Gregori; Ruikang K. Wang; Philip J. Rosenfeld
TAGS: chief complaint, drusen, eye, perfusion, reliability, diagnostic imaging, coronary arteriosclerosis, masks, computer assisted diagnosis, computer-aided detection systems
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):5. https://doi.org/10.1167/iovs.65.14.5

Retina December 2024

Characterization of the Retinal Circulation of the Mouse

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Fei Shang,; Jesse Schallek
TAGS: mice, retina circulation, vasculature, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):3. https://doi.org/10.1167/iovs.65.14.3

Includes: Multimedia, Supplemental Content

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Retinal Microvascular Biomarker Assessment With Automated Algorithm and Semiautomated Software in the Montrachet Dataset

Advances in OCT Angiography

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

Retinal Arteriovenous Information Improves the Prediction Accuracy of Deep Learning–Based baPWV Index From Color Fundus Photographs

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency

Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7

Preferential Sites of Retinal Capillary Occlusion in Sickle Cell Disease

Fundus Autofluorescence Variation in Geographic Atrophy of Age-Related Macular Degeneration: A Clinicopathologic Correlation

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Retinal OCT-Derived Texture Features as Potential Biomarkers for Early Diagnosis and Progression of Diabetic Retinopathy

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

In Vivo Contactless, Cellular-Resolution Imaging of the Healthy and Pathological Human Limbus With 250-kHz Point-Scanning SD-OCT

A Novel Grid Strategy for Correlating Focal Macular Anatomic Changes With Focal Changes in Choriocapillaris Perfusion

Characterization of the Retinal Circulation of the Mouse

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