Nanotechnology and Regenerative Medicine

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Cornea March 2023

Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

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Ruixing Liu; Jingguo Li; Zhihua Guo; Dandan Chu; Chengcheng Li; Liuqi Shi; Junjie Zhang; Lei Zhu; Zhanrong Li
TAGS: cornea, descemet stripping endothelial keratoplasty, fibrosis, signal transduction, proteins, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2023; 64(3):9. doi: https://doi.org/10.1167/iovs.64.3.9

Glaucoma February 2023

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts

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Jack E. Teplitsky; Anastasiya Vinokurtseva; James J. Armstrong; James Denstedt; Hong Liu; Cindy M. L. Hutnik
TAGS: cicatrix, collagen, cytotoxicity, fibroblasts, glaucoma surgery, mitomycin, proteins, tenon's capsule, fibrosis
Trans. Vis. Sci. Tech.. 2023; 12(2):31. doi: https://doi.org/10.1167/tvst.12.2.31

Includes: Supplemental Content

Artificial Intelligence February 2023

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

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Naomi Joseph; Beth Ann Benetz; Prathyush Chirra; Harry Menegay; Silke Oellerich; Lamis Baydoun; Gerrit R. J. Melles; Jonathan H. Lass; David L. Wilson
TAGS: diagnostic imaging, endothelial cells, machine learning, rejection (psychology), transplant rejection, eye, descemet membrane endothelial keratoplasty, datasets
Trans. Vis. Sci. Tech.. 2023; 12(2):22. doi: https://doi.org/10.1167/tvst.12.2.22

Includes: Supplemental Content

Cornea January 2023

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

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Bofeng Wang; Huizhen Guo; Dongmei Liu; Siqi Wu; Jiafeng Liu; Xihong Lan; Huaxing Huang; Fengjiao An; Jin Zhu; Jianping Ji; Li Wang; Hong Ouyang; Mingsen Li
TAGS: epithelial stem cells, genes, hmga2 protein, chromatin immunoprecipitation sequencing, epithelium, protein overexpression, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2023; 64(1):12. doi: https://doi.org/10.1167/iovs.64.1.12

Includes: Supplemental Content

Cornea & External Disease December 2022

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

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Alfonso Iovieno; Luigi Fontana; Marco Coassin; Dario Bovio; Caterina Salito
TAGS: keratoplasty, tissue dissection
Trans. Vis. Sci. Tech.. 2022; 11(12):17. doi: https://doi.org/10.1167/tvst.11.12.17

Includes: Multimedia, Supplemental Content

Cornea December 2022

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

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Wei Zhang; Alfrun Schönberg; Fiona Bassett; Karina Hadrian; Deniz Hos; Martina Becker; Felix Bock; Claus Cursiefen
TAGS: cornea, keratoplasty, wounds and injuries, mice, angiogenesis, lymph, alkalies, burns, sutures, inflammatory cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(13):18. doi: https://doi.org/10.1167/iovs.63.13.18

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit November 2022

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

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John P. M. Wood; Glyn Chidlow; Luke A. Halliday; Robert J. Casson; Dinesh Selva; Michelle Sun
TAGS: body tissue, langer-giedion syndrome, engineering
Trans. Vis. Sci. Tech.. 2022; 11(11):10. doi: https://doi.org/10.1167/tvst.11.11.10

Includes: Supplemental Content

Retina October 2022

A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury

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Pratheepa Kumari Rasiah; Kumar Abhiram Jha; Jordy Gentry; Nobel A. Del Mar; Tanisha Townsend; Kwame E. Torgbe; Anton Reiner; Rajashekhar Gangaraju
TAGS: ambulatory surgery center, blast injuries, eye, intravitreal injections, mice, safety, secretome, stem cells, traumatic brain injuries, saline solutions
Trans. Vis. Sci. Tech.. 2022; 11(10):1. doi: https://doi.org/10.1167/tvst.11.10.1

Includes: Supplemental Content

Cornea & External Disease September 2022

Carbon Nanostructures for Ocular Tissue Reinforcement

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Joaquin Silvestre; Shihao Chen; Zheng Zheng; Alfredo Vega; Tong Chen; Francisco Rodríguez-Reinoso; Pin Zhu; Shuang Zeng; Yaru Zheng; Fangjun Bao; Yong Liu; Jorge L. Alió
TAGS: carbon, cornea, nanostructures, body tissue, ophthalmology, reinforcement, nanotechnology
Trans. Vis. Sci. Tech.. 2022; 11(9):1. doi: https://doi.org/10.1167/tvst.11.9.1

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2022

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

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Jiale Diao; Xinxin Chen; Pei Mou; Xiaoye Ma; Ruili Wei
TAGS: berberine, fibroblasts, fibrosis, graves' ophthalmopathy, tissue remodeling, inflammation, western blotting, proteins, enzyme-linked immunosorbent assay, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2022; 63(10):6. doi: https://doi.org/10.1167/iovs.63.10.6

Includes: Supplemental Content

Cornea July 2022

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

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Kirill E. Zhurenkov; Elga I. Alexander-Sinkler; Ilya O. Gavrilyik; Natalia M. Yartseva; Svetlana A. Aleksandrova; Tatiana V. Mashel; Julia I. Khorolskaya; Miralda I. Blinova; Alexei N. Kulikov; Sergei V. Churashov; Valery F. Chernysh; Natalia A. Mikhailova
TAGS: cornea, epithelium, lip, mucous membrane, oryctolagus cuniculus, patient isolation, reconstructive surgical procedures, social isolation, stem cells, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2022; 63(8):16. doi: https://doi.org/10.1167/iovs.63.8.16

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2022

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

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Bo Yi Kim; Soo Hyun Choi; Ji-Young Kim; JaeSang Ko; Jong In Yook; Hyun Sil Kim; Eun Jig Lee; Don O. Kikkawa; Jin Sook Yoon
TAGS: body tissue, bone morphogenetic proteins, fibroblasts, molecule, pathogenesis, proteins, tumor necrosis factors, western blotting, cytokine, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):7. doi: https://doi.org/10.1167/iovs.63.6.7

Includes: Supplemental Content

Glaucoma June 2022

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes

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Hotaka Nemoto; Megumi Honjo; Michiaki Okamoto; Koichiro Sugimoto; Makoto Aihara
TAGS: cardiac progenitor cells, ciliary body, eye, intraocular pressure, lasers, oryctolagus cuniculus, photocoagulation of ciliary body, fibronectins, sclera
Invest. Ophthalmol. Vis. Sci.. 2022; 63(6):3. doi: https://doi.org/10.1167/iovs.63.6.3

Articles May 2022

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

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Jannatul Fardous; Yuuta Inoue; Kozue Yoshida; Fumiyasu Ono; Akihiro Higuchi; Hiroyuki Ijima
TAGS: biocompatibility, drug delivery systems, gel, hydrophobicity, nanogels, particle size, permeability, water, sterilization, sexual, chemical surfactants
Trans. Vis. Sci. Tech.. 2022; 11(5):16. doi: https://doi.org/10.1167/tvst.11.5.16

Includes: Supplemental Content

Articles May 2022

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

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Tianhui Zhu; Xiaosheng Huang; Shiming Peng; Ye Ye; Jun Zhao
TAGS: glaucoma, microbubbles, optic nerve injuries, oryctolagus cuniculus, transplantation, ultrasonography
Trans. Vis. Sci. Tech.. 2022; 11(5):12. doi: https://doi.org/10.1167/tvst.11.5.12

Articles May 2022

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

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Wei Zhang; Alfrun Schönberg; Felix Bock; Claus Cursiefen
TAGS: cd40 ligand, cornea, eye, eyedrops, keratoplasty, rejection (psychology), telomeric repeat amplification protocol, thyroid hormone associated protein complex, allografting, transplantation
Trans. Vis. Sci. Tech.. 2022; 11(5):6. doi: https://doi.org/10.1167/tvst.11.5.6

Includes: Supplemental Content

Retinal Cell Biology April 2022

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

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Ricardo Usategui-Martín; Kevin Puertas-Neyra; Nadia Galindo-Cabello; Leticia A. Hernández-Rodríguez; Fernando González-Pérez; José Carlos Rodríguez-Cabello; Rogelio González-Sarmiento; José Carlos Pastor; Ivan Fernandez-Bueno
TAGS: apoptosis, autophagy, genes, necroptosis, nerve degeneration, neuroprotective effect, oxidative stress, proteins, rna, messenger, secretome
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):27. doi: https://doi.org/10.1167/iovs.63.4.27

Includes: Supplemental Content

Retinal Cell Biology April 2022

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

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Taku Wakabayashi; Hisamichi Naito; Tomohiro Iba; Kohji Nishida; Nobuyuki Takakura
TAGS: cell separation, choroid, endothelium, fluorescence, mice, retina, stem cells, electroconvulsive therapy, cd31 antigens, epidural cortical stimulation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):5. doi: https://doi.org/10.1167/iovs.63.4.5

Includes: Supplemental Content

Cornea April 2022

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

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Kye-Im Jeon; Ankita Kumar; Kaitlin T. Wozniak; Keith Nehrke; Krystel R. Huxlin
TAGS: cornea, fibroblasts, fibrosis, mitochondria, myofibroblasts, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):2. doi: https://doi.org/10.1167/iovs.63.4.2

Includes: Supplemental Content

Retina March 2022

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

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Xinye Qian; Hehe Liu; Shangyi Fu; Jiaxiong Lu; Yu-Ting Hung; Cassidy Turner; Haiwei Gu; Rui Chen
TAGS: gene therapy, mice, phenotype, photoreceptors, retinal degeneration, mice, knockout, retina, ceramides, tissue degeneration, injections
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):11. doi: https://doi.org/10.1167/iovs.63.3.11

Includes: Supplemental Content

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Celastrol Alleviates Corneal Stromal Fibrosis by Inhibiting TGF-β1/Smad2/3-YAP/TAZ Signaling After Descemet Stripping Endothelial Keratoplasty

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

ETS1–HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation

Ex Vivo Evaluation of a Pressure-Sensitive Device to Aid Big Bubble Intrastromal Dissection in Deep Anterior Lamellar Keratoplasty

Different Murine High-Risk Corneal Transplant Settings Vary Significantly in Their (Lymph)angiogenic and Inflammatory Cell Signatures

Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies

A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury

Carbon Nanostructures for Ocular Tissue Reinforcement

Potential Therapeutic Activity of Berberine in Thyroid-Associated Ophthalmopathy: Inhibitory Effects on Tissue Remodeling in Orbital Fibroblasts

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction

Potential Therapeutic Role of Bone Morphogenic Protein 7 (BMP7) in the Pathogenesis of Graves’ Orbitopathy

Potential Mechanisms of Intraocular Pressure Reduction by Micropulse Transscleral Cyclophotocoagulation in Rabbit Eyes

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death

Identification of CD157-Positive Vascular Endothelial Stem Cells in Mouse Retinal and Choroidal Vessels: Fluorescence-Activated Cell Sorting Analysis

Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation

AAV8 -Mediated Gene Therapy Rescues Retinal Degeneration Phenotype in a Tlcd3b Knockout Mouse Model

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