Nanotechnology and Regenerative Medicine

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Articles September 2021

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

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Yuki Kusano; Takefumi Yamaguchi; Sota Nishisako; Takehiro Matsumura; Masaki Fukui; Kazunari Higa; Toshihiro Inoue; Jun Shimazaki
TAGS: cytokine, descemet stripping endothelial keratoplasty, isolated tumor cells, peripheral anterior synechiae, protein measurement, total, eye
Trans. Vis. Sci. Tech.. 2021; 10(11):12. doi: https://doi.org/10.1167/tvst.10.11.12

Includes: Supplemental Content

Special Issue September 2021

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

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Van Phuc Nguyen; Yanxiu Li; Jessica Henry; Thomas Qian; Wei Zhang; Xueding Wang; Yannis M. Paulus
TAGS: diagnostic imaging, fluorescence, indocyanine green, injections, optical coherence tomography, cell tracking, regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):10. doi: https://doi.org/10.1167/tvst.10.10.10

Special Issue August 2021

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

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Hannah Cobb; Silvia Aparicio-Domingo; M. Valeria Canto-Soler
TAGS: cyclic gmp, good manufacturing practice, organoids, transplantation
Trans. Vis. Sci. Tech.. 2021; 10(10):9. doi: https://doi.org/10.1167/tvst.10.10.9

Special Issue August 2021

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

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Ilham Putra; Xiang Shen; Khandaker N. Anwar; Behnam Rabiee; Ravand Samaeekia; Enmar Almazyad; Pushpanjali Giri; Sayena Jabbehdari; Mohammed R. Hayat; Abdelrahman M. Elhusseiny; Mahmood Ghassemi; Nadim Mahmud; Deepak P. Edward; Charlotte E. Joslin; Mark I. Rosenblatt; Reza Dana; Medi Eslani; Peiman Hematti; Ali R. Djalilian
TAGS: bone marrow, cornea, cryopreservation, injections, safety, stem cell, mesenchymal, wound healing, eye, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2021; 10(10):3. doi: https://doi.org/10.1167/tvst.10.10.3

Includes: Supplemental Content

Special Issue August 2021

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

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Steven M. Becker; Santa J. Tumminia; Michael F. Chiang
TAGS: regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):2. doi: https://doi.org/10.1167/tvst.10.10.2

Articles August 2021

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

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Jing-Yan Yang; Bin Lu; Qiang Feng; Jorge S. Alfaro; Po-Hsuen Chen; Joseph Loscalzo; Wen-Bin Wei; Ying-Yi Zhang; Shi-Jiang Lu; Shaomei Wang
TAGS: ciliary neurotrophic factor, nerve growth factors, retinal degeneration, neuroprotection
Trans. Vis. Sci. Tech.. 2021; 10(9):6. doi: https://doi.org/10.1167/tvst.10.9.6

Articles July 2021

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

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Shuo Jia; Fushun Chen; Huogang Wang; Gandhervin Kesavamoorthy; Jimmy Shiu-Ming Lai; Ian Yat-Hing Wong; Kin Chiu; Jonathan Cheuk-Hung Chan
TAGS: cholecalciferol, fibroblasts, glaucoma, pterygium, vitamin d3 24-hydroxylase, rna-seq, cell survival
Trans. Vis. Sci. Tech.. 2021; 10(8):7. doi: https://doi.org/10.1167/tvst.10.8.7

Includes: Supplemental Content

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Articles January 2021

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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Szilárd Kiss; Kristina Oresic Bender; Ruslan N. Grishanin; Kelly M. Hanna; Julio D. Nieves; Pallavi Sharma; Aivan T. Nguyen; Romeo J. Rosario; Judith S. Greengard; Claire M. Gelfman; Mehdi Gasmi
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, gene therapy, safety, eye, primates, retina, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(1):34. doi: https://doi.org/10.1167/tvst.10.1.34

Includes: Supplemental Content

Articles September 2020

Semi-Automated Approach for Retinal Tissue Differentiation

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Evgenii Kegeles; Tatiana Perepelkina; Petr Baranov
TAGS: body tissue, liquids, organoids, mice, retinal ganglion cells, fluorescence, stem cells
Trans. Vis. Sci. Tech.. 2020; 9(10):24. doi: https://doi.org/10.1167/tvst.9.10.24

Includes: Supplemental Content

Special Issue August 2020

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

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Juan P. Vigueras-Guillén; Jeroen van Rooij; Angela Engel; Hans G. Lemij; Lucas J. van Vliet; Koenraad A. Vermeer
TAGS: corneal endothelium, deep learning, descemet stripping endothelial keratoplasty, surgical procedures, operative, gold standard, endothelium, datasets, software
Trans. Vis. Sci. Tech.. 2020; 9(2):49. doi: https://doi.org/10.1167/tvst.9.2.49

Special Issue August 2020

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

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Friso G. Heslinga; Mark Alberti; Josien P. W. Pluim; Javier Cabrerizo; Mitko Veta
TAGS: convolutional neural networks, descemet membrane endothelial keratoplasty, descemet's membrane, endothelium, keratoplasty, sclera, tissue transplants, pixel
Trans. Vis. Sci. Tech.. 2020; 9(2):48. doi: https://doi.org/10.1167/tvst.9.2.48

Special Issue August 2020

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

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Lutfiah Al Turk; Su Wang; Paul Krause; James Wawrzynski; George M. Saleh; Hend Alsawadi; Abdulrahman Zaid Alshamrani; Tunde Peto; Andrew Bastawrous; Jingren Li; Hongying Lilian Tang
TAGS: daphnia, datasets, evidence-based practice, software, screening, china, kenya, saudi arabia
Trans. Vis. Sci. Tech.. 2020; 9(2):44. doi: https://doi.org/10.1167/tvst.9.2.44

Articles June 2020

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

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Kyoung Woo Kim; Jin Suk Ryu; Jun Yeob Kim; Mee Kum Kim
TAGS: cornea, inflammation, oryctolagus cuniculus, sclera, tissue transplants, transplantation, wound healing, keratoplasty, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2020; 9(7):38. doi: https://doi.org/10.1167/tvst.9.7.38

Includes: Supplemental Content

Articles June 2020

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

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Ying V. Liu; Simrat K. Sodhi; Gilbert Xue; Derek Teng; Dzhalal Agakishiev; Minda M. McNally; Sarah Harris-Bookman; Caitlin McBride; Gregory J. Konar; Mandeep S. Singh
TAGS: biological markers, diagnostic imaging, photoreceptors, transplantation, tissue transplants, cell therapy, eye
Trans. Vis. Sci. Tech.. 2020; 9(7):5. doi: https://doi.org/10.1167/tvst.9.7.5

Articles May 2020

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

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Hyeong Min Kim; Seungmin Ha; Hye Kyoung Hong; Yoonha Hwang; Pilhan Kim; Eunsol Yang; Jae Yong Chung; Sunyoung Park; Young Joo Park; Kyu Hyung Park; Hyuncheol Kim; Se Joon Woo
TAGS: antibodies, eye, kinetics, molecule, nanoparticles, oryctolagus cuniculus, vitreous body, fluorescence, immunoglobulin g, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(6):20. doi: https://doi.org/10.1167/tvst.9.6.20

Includes: Supplemental Content

Review April 2020

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

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Heather Machin; Karl Brown; Gerard Sutton; Paul Baird
TAGS: australia, body tissue, transplantation, research personnel
Trans. Vis. Sci. Tech.. 2020; 9(5):4. doi: https://doi.org/10.1167/tvst.9.5.4

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Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

Semi-Automated Approach for Retinal Tissue Differentiation

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

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