Nanotechnology and Regenerative Medicine

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Articles February 2020

Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

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Sayena Jabbehdari; Ghasem Yazdanpanah; Levi N. Kanu; Khandaker N. Anwar; Xiang Shen; Behnam Rabiee; Ilham Putra; Medi Eslani; Mark I. Rosenblatt; Peiman Hematti; Ali R. Djalilian
TAGS: cornea, stem cell, mesenchymal, wound healing, epithelium, wounds and injuries
Trans. Vis. Sci. Tech.. 2020; 9(3):26. doi: https://doi.org/10.1167/tvst.9.3.26

Includes: Supplemental Content

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Articles December 2019

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

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Jan O. Pralits; Mark Alberti; Javier Cabrerizo
TAGS: descemet membrane endothelial keratoplasty, tissue transplants, eye
Trans. Vis. Sci. Tech.. 2019; 8(6):9. doi: https://doi.org/10.1167/tvst.8.6.9

Includes: Supplemental Content

Articles August 2019

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

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Hui Lin; Ying Liu; Samuel Yiu
TAGS: epithelium, lacrimal gland, stem cells
Trans. Vis. Sci. Tech.. 2019; 8(4):32. doi: https://doi.org/10.1167/tvst.8.4.32

Articles June 2019

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

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Trevor J. McGill; Linda Osborne; Bin Lu; Jonathan Stoddard; Stephen Huhn; Ann Tsukamoto; Alexandra Capela
TAGS: bromodeoxyuridine, central nervous system, retinal pigment cell, retinal pigment epithelium, stem cells, tissue transplants, transplantation, ki-67 antigen, retina, eye
Trans. Vis. Sci. Tech.. 2019; 8(3):43. doi: https://doi.org/10.1167/tvst.8.3.43

Articles May 2019

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

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Henri Lorach; Seungbum Kang; Mohajeet B. Bhuckory; Alix Trouillet; Roopa Dalal; Michael Marmor; Daniel Palanker
TAGS: photoreceptors, retinal degeneration, rodentia, tissue transplants, retina, transplantation
Trans. Vis. Sci. Tech.. 2019; 8(3):30. doi: https://doi.org/10.1167/tvst.8.3.30

Includes: Multimedia, Supplemental Content

Articles April 2019

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

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Suhwan Lee; Im Kyeung Kang; Ji Hyun Kim; Bok Kyoung Jung; Keerang Park; Heesoon Chang; Joo Yong Lee; Heuiran Lee
TAGS: gene therapy, vitreous body, adeno-associated virus, neutralizing antibodies, serotype
Trans. Vis. Sci. Tech.. 2019; 8(2):14. doi: https://doi.org/10.1167/tvst.8.2.14

Includes: Supplemental Content

Articles November 2018

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

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Sota Nishisako; Dai Aoki; Chiaki Sasaki; Kazunari Higa; Jun Shimazaki
TAGS: endothelial cells, anterior chamber of eye, keratoplasty, endothelium, tissue transplants, cornea, pressure-physical agent, significance, descemet stripping endothelial keratoplasty, donors
Trans. Vis. Sci. Tech.. 2018; 7(6):11. doi: https://doi.org/10.1167/tvst.7.6.11

Articles November 2018

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

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Ian Pitha; Ericka Oglesby; Amanda Chow; Elizabeth Kimball; Mary Ellen Pease; Julie Schaub; Harry Quigley
TAGS: fibroblasts, glaucoma, collagen, patient isolation, phosphotransferases, transforming growth factors, eye, intraocular pressure, sclera, myofibroblasts
Trans. Vis. Sci. Tech.. 2018; 7(6):6. doi: https://doi.org/10.1167/tvst.7.6.6

Includes: Supplemental Content

Articles October 2018

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

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Juan Yang; Jung Woo Park; Dejin Zheng; Ren-He Xu
TAGS: immunohistochemistry, embryonic stem cells, epithelium, cornea, eye, mice
Trans. Vis. Sci. Tech.. 2018; 7(5):23. doi: https://doi.org/10.1167/tvst.7.5.23

Includes: Supplemental Content

New Developments in Vision Research September 2018

Translational Retinal Research and Therapies

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Alison J. Hardcastle; Paul A. Sieving; José-Alain Sahel; Samuel G. Jacobson; Artur V. Cideciyan; John G. Flannery; William A. Beltran; Gustavo D. Aguirre
TAGS: gene therapy, mutation, blindness, retinal cone, dog, domestic, genes, genome, animal model, photoreceptors, retinal degeneration
Trans. Vis. Sci. Tech.. 2018; 7(5):8. doi: https://doi.org/10.1167/tvst.7.5.8

Articles April 2018

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

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Duri Kim; Ushasree Pattamatta; Elizabeth Kelly; Paul R. Healey; Nicole Carnt; Hans Zoellner; Andrew J. R. White
TAGS: angiotensins, irbesartan, cell culture techniques, receptor, angiotensin ii, angiotensin ii, fibroblasts, cell count, reactive oxygen species
Trans. Vis. Sci. Tech.. 2018; 7(2):20. doi: https://doi.org/10.1167/tvst.7.2.20

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: gene therapy, cell survival, dyes, injection of therapeutic agent, surgical procedures, operative, toxic effect, spatial vectors
Trans. Vis. Sci. Tech.. 2017; 6(4):4. doi: https://doi.org/10.1167/tvst.6.4.4

Includes: Supplemental Content

Articles June 2017

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

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Jimmy Chammas; Arnaud Sauer; Joëlle Pizzuto; Fabienne Pouthier; David Gaucher; Jacques Marescaux; Didier Mutter; Tristan Bourcier
TAGS: keratoplasty, penetrating, ophthalmologic surgical procedures, surgical procedures, operative, sutures, cornea, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2017; 6(3):21. doi: https://doi.org/10.1167/tvst.6.3.21

Articles June 2017

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

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Trevor J. McGill; Osnat Bohana-Kashtan; Jonathan W. Stoddard; Michael D. Andrews; Neelay Pandit; Lior R. Rosenberg-Belmaker; Ofer Wiser; Limor Matzrafi; Eyal Banin; Benjamin Reubinoff; Nir Netzer; Charles Irving
TAGS: photoreceptors, eye, retina, transplantation, good manufacturing practice, retinal pigment cell
Trans. Vis. Sci. Tech.. 2017; 6(3):17. doi: https://doi.org/10.1167/tvst.6.3.17

Articles May 2017

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

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Jennifer R. Chao; Deepak A. Lamba; Todd R. Klesert; Anna La Torre; Akina Hoshino; Russell J. Taylor; Anu Jayabalu; Abbi L. Engel; Thomas H. Khuu; Ruikang K. Wang; Maureen Neitz; Jay Neitz; Thomas A. Reh
TAGS: embryo, primates, diagnostic imaging, eye, optic nerve, retina, transplantation
Trans. Vis. Sci. Tech.. 2017; 6(3):4. doi: https://doi.org/10.1167/tvst.6.3.4

Articles January 2017

Retinoic Acid Enhances the Differentiation of Adipose-Derived Stem Cells to Keratocytes In Vitro

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Amy P. Lynch; Mark Ahearne
TAGS: western blotting, cell proliferation, stem cells, tretinoin, keratocytes
Trans. Vis. Sci. Tech.. 2017; 6(1):6. doi: https://doi.org/10.1167/tvst.6.1.6

Includes: Supplemental Content

Articles November 2016

ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell–Derived Retinal Pigmented Epithelium

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Roxanne H. Croze; William J. Thi; Dennis O. Clegg
TAGS: embryonic stem cells, epithelium, wounds and injuries, wound closure
Trans. Vis. Sci. Tech.. 2016; 5(6):7. doi: https://doi.org/10.1167/tvst.5.6.7

Includes: Supplemental Content

Articles October 2016

Test–Retest Variability of Functional and Structural Parameters in Patients with Stargardt Disease Participating in the SAR422459 Gene Therapy Trial

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Maria A. Parker; Dongseok Choi; Laura R. Erker; Mark E. Pennesi; Paul Yang; Elvira N. Chegarnov; Peter N. Steinkamp; Catherine L. Schlechter; Claire-Marie Dhaenens; Saddek Mohand-Said; Isabelle Audo; Jose Sahel; Richard G. Weleber; David J. Wilson
TAGS: gene therapy, perimetry, visual acuity, visual fields, eye, stargardt's disease, spectral-domain optical coherence tomography
Trans. Vis. Sci. Tech.. 2016; 5(5):10. doi: https://doi.org/10.1167/tvst.5.5.10

Includes: Supplemental Content

Articles July 2016

Efficacy and Safety of Human Retinal Progenitor Cells

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Ma'ayan Semo; Nasrin Haamedi; Lara Stevanato; David Carter; Gary Brooke; Michael Young; Peter Coffey; John Sinden; Sara Patel; Anthony Vugler
TAGS: dexamethasone, stem cells, injection of therapeutic agent, safety, vision, eye, rats, transplantation, prostate cancer, hormone-refractory
Trans. Vis. Sci. Tech.. 2016; 5(4):6. doi: https://doi.org/10.1167/tvst.5.4.6

Includes: Supplemental Content

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Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

Translational Retinal Research and Therapies

Inhibitory Effects of Angiotensin II Receptor Blockade on Human Tenon Fibroblast Migration and Reactive Oxygen Species Production in Cell Culture

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate

Retinoic Acid Enhances the Differentiation of Adipose-Derived Stem Cells to Keratocytes In Vitro

ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell–Derived Retinal Pigmented Epithelium

Test–Retest Variability of Functional and Structural Parameters in Patients with Stargardt Disease Participating in the SAR422459 Gene Therapy Trial

Efficacy and Safety of Human Retinal Progenitor Cells

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