Nanotechnology and Regenerative Medicine

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Articles January 2021

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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Szilárd Kiss; Kristina Oresic Bender; Ruslan N. Grishanin; Kelly M. Hanna; Julio D. Nieves; Pallavi Sharma; Aivan T. Nguyen; Romeo J. Rosario; Judith S. Greengard; Claire M. Gelfman; Mehdi Gasmi
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, gene therapy, safety, eye, primates, retina, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(1):34. doi: https://doi.org/10.1167/tvst.10.1.34

Includes: Supplemental Content

Articles September 2020

Semi-Automated Approach for Retinal Tissue Differentiation

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Evgenii Kegeles; Tatiana Perepelkina; Petr Baranov
TAGS: body tissue, liquids, organoids, mice, retinal ganglion cells, fluorescence, stem cells
Trans. Vis. Sci. Tech.. 2020; 9(10):24. doi: https://doi.org/10.1167/tvst.9.10.24

Includes: Supplemental Content

Special Issue August 2020

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

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Juan P. Vigueras-Guillén; Jeroen van Rooij; Angela Engel; Hans G. Lemij; Lucas J. van Vliet; Koenraad A. Vermeer
TAGS: corneal endothelium, deep learning, descemet stripping endothelial keratoplasty, surgical procedures, operative, gold standard, endothelium, datasets, software
Trans. Vis. Sci. Tech.. 2020; 9(2):49. doi: https://doi.org/10.1167/tvst.9.2.49

Special Issue August 2020

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

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Friso G. Heslinga; Mark Alberti; Josien P. W. Pluim; Javier Cabrerizo; Mitko Veta
TAGS: convolutional neural networks, descemet membrane endothelial keratoplasty, descemet's membrane, endothelium, keratoplasty, sclera, tissue transplants, pixel
Trans. Vis. Sci. Tech.. 2020; 9(2):48. doi: https://doi.org/10.1167/tvst.9.2.48

Special Issue August 2020

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

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Lutfiah Al Turk; Su Wang; Paul Krause; James Wawrzynski; George M. Saleh; Hend Alsawadi; Abdulrahman Zaid Alshamrani; Tunde Peto; Andrew Bastawrous; Jingren Li; Hongying Lilian Tang
TAGS: daphnia, datasets, evidence-based practice, software, screening, china, kenya, saudi arabia
Trans. Vis. Sci. Tech.. 2020; 9(2):44. doi: https://doi.org/10.1167/tvst.9.2.44

Articles June 2020

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

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Kyoung Woo Kim; Jin Suk Ryu; Jun Yeob Kim; Mee Kum Kim
TAGS: cornea, inflammation, oryctolagus cuniculus, sclera, tissue transplants, transplantation, wound healing, keratoplasty, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2020; 9(7):38. doi: https://doi.org/10.1167/tvst.9.7.38

Includes: Supplemental Content

Articles June 2020

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

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Ying V. Liu; Simrat K. Sodhi; Gilbert Xue; Derek Teng; Dzhalal Agakishiev; Minda M. McNally; Sarah Harris-Bookman; Caitlin McBride; Gregory J. Konar; Mandeep S. Singh
TAGS: biological markers, diagnostic imaging, photoreceptors, transplantation, tissue transplants, cell therapy, eye
Trans. Vis. Sci. Tech.. 2020; 9(7):5. doi: https://doi.org/10.1167/tvst.9.7.5

Articles May 2020

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

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Hyeong Min Kim; Seungmin Ha; Hye Kyoung Hong; Yoonha Hwang; Pilhan Kim; Eunsol Yang; Jae Yong Chung; Sunyoung Park; Young Joo Park; Kyu Hyung Park; Hyuncheol Kim; Se Joon Woo
TAGS: antibodies, eye, kinetics, molecule, nanoparticles, oryctolagus cuniculus, vitreous body, fluorescence, immunoglobulin g, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(6):20. doi: https://doi.org/10.1167/tvst.9.6.20

Includes: Supplemental Content

Review April 2020

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

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Heather Machin; Karl Brown; Gerard Sutton; Paul Baird
TAGS: australia, body tissue, transplantation, research personnel
Trans. Vis. Sci. Tech.. 2020; 9(5):4. doi: https://doi.org/10.1167/tvst.9.5.4

Articles March 2020

In Vitro Culture of Human Corneal Endothelium on Non-Mulberry Silk Fibroin Films for Tissue Regeneration

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Charanya Ramachandran; Prerak Gupta; Swatilekha Hazra; Biman B. Mandal
TAGS: corneal endothelium, fibroins, tissue regeneration, catabolism, personal integrity, edema, refractive index, proteins, cornea, transparency
Trans. Vis. Sci. Tech.. 2020; 9(4):12. doi: https://doi.org/10.1167/tvst.9.4.12

Includes: Supplemental Content

Articles February 2020

Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

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Sayena Jabbehdari; Ghasem Yazdanpanah; Levi N. Kanu; Khandaker N. Anwar; Xiang Shen; Behnam Rabiee; Ilham Putra; Medi Eslani; Mark I. Rosenblatt; Peiman Hematti; Ali R. Djalilian
TAGS: cornea, stem cell, mesenchymal, wound healing, epithelium, wounds and injuries
Trans. Vis. Sci. Tech.. 2020; 9(3):26. doi: https://doi.org/10.1167/tvst.9.3.26

Includes: Supplemental Content

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Articles December 2019

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

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Jan O. Pralits; Mark Alberti; Javier Cabrerizo
TAGS: descemet membrane endothelial keratoplasty, tissue transplants, eye
Trans. Vis. Sci. Tech.. 2019; 8(6):9. doi: https://doi.org/10.1167/tvst.8.6.9

Includes: Supplemental Content

Articles August 2019

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

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Hui Lin; Ying Liu; Samuel Yiu
TAGS: epithelium, lacrimal gland, stem cells
Trans. Vis. Sci. Tech.. 2019; 8(4):32. doi: https://doi.org/10.1167/tvst.8.4.32

Articles June 2019

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

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Trevor J. McGill; Linda Osborne; Bin Lu; Jonathan Stoddard; Stephen Huhn; Ann Tsukamoto; Alexandra Capela
TAGS: bromodeoxyuridine, central nervous system, retinal pigment cell, retinal pigment epithelium, stem cells, tissue transplants, transplantation, ki-67 antigen, retina, eye
Trans. Vis. Sci. Tech.. 2019; 8(3):43. doi: https://doi.org/10.1167/tvst.8.3.43

Articles May 2019

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

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Henri Lorach; Seungbum Kang; Mohajeet B. Bhuckory; Alix Trouillet; Roopa Dalal; Michael Marmor; Daniel Palanker
TAGS: photoreceptors, retinal degeneration, transplantation, retina, rodentia, tissue transplants
Trans. Vis. Sci. Tech.. 2019; 8(3):30. doi: https://doi.org/10.1167/tvst.8.3.30

Includes: Multimedia, Supplemental Content

Articles April 2019

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

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Suhwan Lee; Im Kyeung Kang; Ji Hyun Kim; Bok Kyoung Jung; Keerang Park; Heesoon Chang; Joo Yong Lee; Heuiran Lee
TAGS: adeno-associated virus, gene therapy, neutralizing antibodies, vitreous body, serotype
Trans. Vis. Sci. Tech.. 2019; 8(2):14. doi: https://doi.org/10.1167/tvst.8.2.14

Includes: Supplemental Content

Articles November 2018

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

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Sota Nishisako; Dai Aoki; Chiaki Sasaki; Kazunari Higa; Jun Shimazaki
TAGS: anterior chamber of eye, cornea, donors, endothelial cells, endothelium, keratoplasty, pressure-physical agent, tissue transplants, descemet stripping endothelial keratoplasty, significance
Trans. Vis. Sci. Tech.. 2018; 7(6):11. doi: https://doi.org/10.1167/tvst.7.6.11

Articles November 2018

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

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Ian Pitha; Ericka Oglesby; Amanda Chow; Elizabeth Kimball; Mary Ellen Pease; Julie Schaub; Harry Quigley
TAGS: fibroblasts, glaucoma, myofibroblasts, phosphotransferases, sclera, transforming growth factors, intraocular pressure, patient isolation, eye, collagen
Trans. Vis. Sci. Tech.. 2018; 7(6):6. doi: https://doi.org/10.1167/tvst.7.6.6

Includes: Supplemental Content

Articles October 2018

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

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Juan Yang; Jung Woo Park; Dejin Zheng; Ren-He Xu
TAGS: cornea, embryonic stem cells, epithelium, mice, immunohistochemistry, eye
Trans. Vis. Sci. Tech.. 2018; 7(5):23. doi: https://doi.org/10.1167/tvst.7.5.23

Includes: Supplemental Content

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Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

Semi-Automated Approach for Retinal Tissue Differentiation

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

In Vitro Culture of Human Corneal Endothelium on Non-Mulberry Silk Fibroin Films for Tissue Regeneration

Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

Relationship Between Neutralizing Antibodies Against Adeno-Associated Virus in the Vitreous and Serum: Effects on Retinal Gene Therapy

Comparison of Artificial Anterior Chamber Internal Pressures and Cutting Systems for Descemet's Stripping Automated Endothelial Keratoplasty

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma

Universal Corneal Epithelial-Like Cells Derived from Human Embryonic Stem Cells for Cellularization of a Corneal Scaffold

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