Nanotechnology and Regenerative Medicine

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Articles May 2022

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

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Jannatul Fardous; Yuuta Inoue; Kozue Yoshida; Fumiyasu Ono; Akihiro Higuchi; Hiroyuki Ijima
TAGS: biocompatibility, drug delivery systems, gel, hydrophobicity, nanogels, particle size, permeability, water, sterilization, sexual, chemical surfactants
Trans. Vis. Sci. Tech.. 2022; 11(5):16. doi: https://doi.org/10.1167/tvst.11.5.16

Includes: Supplemental Content

Articles May 2022

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

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Tianhui Zhu; Xiaosheng Huang; Shiming Peng; Ye Ye; Jun Zhao
TAGS: glaucoma, microbubbles, optic nerve injuries, oryctolagus cuniculus, transplantation, ultrasonography
Trans. Vis. Sci. Tech.. 2022; 11(5):12. doi: https://doi.org/10.1167/tvst.11.5.12

Articles May 2022

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

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Wei Zhang; Alfrun Schönberg; Felix Bock; Claus Cursiefen
TAGS: cd40 ligand, cornea, eye, eyedrops, keratoplasty, rejection (psychology), telomeric repeat amplification protocol, thyroid hormone associated protein complex, allografting, transplantation
Trans. Vis. Sci. Tech.. 2022; 11(5):6. doi: https://doi.org/10.1167/tvst.11.5.6

Includes: Supplemental Content

Articles February 2022

Measurement Properties of the Attitudes to Gene Therapy for the Eye (AGT-Eye) Instrument for People With Inherited Retinal Diseases

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Myra B. McGuinness; Alexis Ceecee Britten-Jones; Lauren N. Ayton; Robert P. Finger; Fred K. Chen; John Grigg; Heather G. Mack
TAGS: attitude, eye, gene therapy, retinal diseases, perception
Trans. Vis. Sci. Tech.. 2022; 11(2):14. doi: https://doi.org/10.1167/tvst.11.2.14

Includes: Supplemental Content

Articles December 2021

A Loop-mediated Isothermal Amplification With a Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Pseudomonas aeruginosa in Endophthalmitis

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Kui Dong; ZhiMing Kang; Xuan Ji; Xinxin Zhang; PeiNi Cheng; Bin Sun
TAGS: amplification, endophthalmitis, lights, manufactured, bacterial endophthalmitis, fluid flow, pseudomonas aeruginosa, nanoparticles
Trans. Vis. Sci. Tech.. 2021; 10(14):26. doi: https://doi.org/10.1167/tvst.10.14.26

Special Issue November 2021

Outer Retinal Cell Replacement: Putting the Pieces Together

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Allison L. Ludwig; David M. Gamm
TAGS: cell therapy, donors, transplantation, transfer technique, safety, retina, cell transplantation, animal model
Trans. Vis. Sci. Tech.. 2021; 10(10):15. doi: https://doi.org/10.1167/tvst.10.10.15

Includes: Supplemental Content

Articles October 2021

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

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Atsuhiko Fukuto; Soohyun Kim; Jennifer Kang; Brooke L. Gates; Maggie W. Chang; Kent E. Pinkerton; Laura S. Van Winkle; Yoshiaki Kiuchi; Christopher J. Murphy; Brian C. Leonard; Sara M. Thomasy
TAGS: cornea, fibroblasts, metals, myofibroblasts, nanostructures, oryctolagus cuniculus, oxides, proteins, cell survival, rna, messenger
Trans. Vis. Sci. Tech.. 2021; 10(12):23. doi: https://doi.org/10.1167/tvst.10.12.23

Includes: Supplemental Content

Articles October 2021

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

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Albert Y. Cheung; Andrew Kalina; Alex Im; Andrew R. Davis; Medi Eslani; Raymond L. Hogge; Elizabeth Yeu
TAGS: dehiscence, densitometry, descemet membrane endothelial keratoplasty, optical coherence tomography, cornea
Trans. Vis. Sci. Tech.. 2021; 10(12):6. doi: https://doi.org/10.1167/tvst.10.12.6

Articles September 2021

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

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Yuki Kusano; Takefumi Yamaguchi; Sota Nishisako; Takehiro Matsumura; Masaki Fukui; Kazunari Higa; Toshihiro Inoue; Jun Shimazaki
TAGS: cytokine, descemet stripping endothelial keratoplasty, isolated tumor cells, peripheral anterior synechiae, protein measurement, total, eye
Trans. Vis. Sci. Tech.. 2021; 10(11):12. doi: https://doi.org/10.1167/tvst.10.11.12

Includes: Supplemental Content

Special Issue September 2021

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

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Van Phuc Nguyen; Yanxiu Li; Jessica Henry; Thomas Qian; Wei Zhang; Xueding Wang; Yannis M. Paulus
TAGS: diagnostic imaging, fluorescence, indocyanine green, injections, optical coherence tomography, cell tracking, regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):10. doi: https://doi.org/10.1167/tvst.10.10.10

Special Issue August 2021

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

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Hannah Cobb; Silvia Aparicio-Domingo; M. Valeria Canto-Soler
TAGS: cyclic gmp, good manufacturing practice, organoids, transplantation
Trans. Vis. Sci. Tech.. 2021; 10(10):9. doi: https://doi.org/10.1167/tvst.10.10.9

Special Issue August 2021

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

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Ilham Putra; Xiang Shen; Khandaker N. Anwar; Behnam Rabiee; Ravand Samaeekia; Enmar Almazyad; Pushpanjali Giri; Sayena Jabbehdari; Mohammed R. Hayat; Abdelrahman M. Elhusseiny; Mahmood Ghassemi; Nadim Mahmud; Deepak P. Edward; Charlotte E. Joslin; Mark I. Rosenblatt; Reza Dana; Medi Eslani; Peiman Hematti; Ali R. Djalilian
TAGS: bone marrow, cornea, cryopreservation, injections, safety, stem cell, mesenchymal, wound healing, eye, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2021; 10(10):3. doi: https://doi.org/10.1167/tvst.10.10.3

Includes: Supplemental Content

Special Issue August 2021

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

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Steven M. Becker; Santa J. Tumminia; Michael F. Chiang
TAGS: regenerative medicine
Trans. Vis. Sci. Tech.. 2021; 10(10):2. doi: https://doi.org/10.1167/tvst.10.10.2

Articles August 2021

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

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Jing-Yan Yang; Bin Lu; Qiang Feng; Jorge S. Alfaro; Po-Hsuen Chen; Joseph Loscalzo; Wen-Bin Wei; Ying-Yi Zhang; Shi-Jiang Lu; Shaomei Wang
TAGS: ciliary neurotrophic factor, nerve growth factors, retinal degeneration, neuroprotection
Trans. Vis. Sci. Tech.. 2021; 10(9):6. doi: https://doi.org/10.1167/tvst.10.9.6

Articles July 2021

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

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Shuo Jia; Fushun Chen; Huogang Wang; Gandhervin Kesavamoorthy; Jimmy Shiu-Ming Lai; Ian Yat-Hing Wong; Kin Chiu; Jonathan Cheuk-Hung Chan
TAGS: cholecalciferol, fibroblasts, glaucoma, pterygium, vitamin d3 24-hydroxylase, rna-seq, cell survival
Trans. Vis. Sci. Tech.. 2021; 10(8):7. doi: https://doi.org/10.1167/tvst.10.8.7

Includes: Supplemental Content

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Articles January 2021

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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Szilárd Kiss; Kristina Oresic Bender; Ruslan N. Grishanin; Kelly M. Hanna; Julio D. Nieves; Pallavi Sharma; Aivan T. Nguyen; Romeo J. Rosario; Judith S. Greengard; Claire M. Gelfman; Mehdi Gasmi
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, gene therapy, safety, eye, primates, retina, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(1):34. doi: https://doi.org/10.1167/tvst.10.1.34

Includes: Supplemental Content

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Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

Ultrasound Targeted Microbubble Destruction Promotes the Therapeutic Effect of HUMSC Transplantation on Glaucoma-Caused Optic Nerve Injury in Rabbits

Posttransplant VEGFR1R2 Trap Eye Drops Inhibit Corneal (Lymph)angiogenesis and Improve Corneal Allograft Survival in Eyes at High Risk of Rejection

Measurement Properties of the Attitudes to Gene Therapy for the Eye (AGT-Eye) Instrument for People With Inherited Retinal Diseases

A Loop-mediated Isothermal Amplification With a Nanoparticle-Based Lateral Flow Biosensor Assay to Detect Pseudomonas aeruginosa in Endophthalmitis

Outer Retinal Cell Replacement: Putting the Pieces Together

Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation

Region of Interest Densitometry Analysis of Descemet Membrane Endothelial Keratoplasty Dehiscence on Anterior Segment Optical Coherence Tomography

Aqueous Cytokine Levels Are Associated With Progression of Peripheral Anterior Synechiae After Descemet Stripping Automated Endothelial Keratoplasty

In Vivo Subretinal ARPE-19 Cell Tracking Using Indocyanine Green Contrast-Enhanced Multimodality Photoacoustic Microscopy, Optical Coherence Tomography, and Fluorescence Imaging for Regenerative Medicine

Transitioning into GMP-Compliance: Alternative Methods for Producing Retinal Organoids for Transplantation

Preclinical Evaluation of the Safety and Efficacy of Cryopreserved Bone Marrow Mesenchymal Stromal Cells for Corneal Repair

The NEI Audacious Goals Initiative: Advancing the Frontier of Regenerative Medicine

Retinal Protection by Sustained Nanoparticle Delivery of Oncostatin M and Ciliary Neurotrophic Factor Into Rodent Models of Retinal Degeneration

Effect of Vitamin D3 on Regulating Human Tenon's Fibroblasts Activity

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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