Nanotechnology and Regenerative Medicine

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Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. doi: https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles April 2021

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

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María Jesús Muniesa; Iván Benítez; Juan Ezpeleta; Manuel Sánchez de la Torre; Marta Pazos; Elena Millà; Ferrán Barbé
TAGS: contact lenses, continuous positive airway pressure, intraocular pressure, obstructive sleep apnea, sensor, night time
Trans. Vis. Sci. Tech.. 2021; 10(4):10. doi: https://doi.org/10.1167/tvst.10.4.10

Articles April 2021

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

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Fumihito Hikage; Yosuke Ida; Yuika Ouchi; Megumi Watanabe; Hiroshi Ohguro
TAGS: agonists, fibroblasts, organoids, prostaglandins
Trans. Vis. Sci. Tech.. 2021; 10(4):6. doi: https://doi.org/10.1167/tvst.10.4.6

Includes: Supplemental Content

Review April 2021

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

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Ying Kai Chan; Andrew D. Dick; Sara Mary Hall; Thomas Langmann; Curtis L. Scribner; Brian C. Mansfield; for the Ocular Gene Therapy Inflammation Working Group
TAGS: blindness, gene therapy, inflammation, spatial vectors, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(4):3. doi: https://doi.org/10.1167/tvst.10.4.3

Articles January 2021

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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Szilárd Kiss; Kristina Oresic Bender; Ruslan N. Grishanin; Kelly M. Hanna; Julio D. Nieves; Pallavi Sharma; Aivan T. Nguyen; Romeo J. Rosario; Judith S. Greengard; Claire M. Gelfman; Mehdi Gasmi
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, gene therapy, safety, eye, primates, retina, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(1):34. doi: https://doi.org/10.1167/tvst.10.1.34

Includes: Supplemental Content

Articles September 2020

Semi-Automated Approach for Retinal Tissue Differentiation

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Evgenii Kegeles; Tatiana Perepelkina; Petr Baranov
TAGS: body tissue, liquids, organoids, mice, retinal ganglion cells, fluorescence, stem cells
Trans. Vis. Sci. Tech.. 2020; 9(10):24. doi: https://doi.org/10.1167/tvst.9.10.24

Includes: Supplemental Content

Special Issue August 2020

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

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Juan P. Vigueras-Guillén; Jeroen van Rooij; Angela Engel; Hans G. Lemij; Lucas J. van Vliet; Koenraad A. Vermeer
TAGS: corneal endothelium, deep learning, descemet stripping endothelial keratoplasty, surgical procedures, operative, gold standard, endothelium, datasets, software
Trans. Vis. Sci. Tech.. 2020; 9(2):49. doi: https://doi.org/10.1167/tvst.9.2.49

Special Issue August 2020

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

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Friso G. Heslinga; Mark Alberti; Josien P. W. Pluim; Javier Cabrerizo; Mitko Veta
TAGS: convolutional neural networks, descemet membrane endothelial keratoplasty, descemet's membrane, endothelium, keratoplasty, sclera, tissue transplants, pixel
Trans. Vis. Sci. Tech.. 2020; 9(2):48. doi: https://doi.org/10.1167/tvst.9.2.48

Special Issue August 2020

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

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Lutfiah Al Turk; Su Wang; Paul Krause; James Wawrzynski; George M. Saleh; Hend Alsawadi; Abdulrahman Zaid Alshamrani; Tunde Peto; Andrew Bastawrous; Jingren Li; Hongying Lilian Tang
TAGS: daphnia, datasets, evidence-based practice, software, screening, china, kenya, saudi arabia
Trans. Vis. Sci. Tech.. 2020; 9(2):44. doi: https://doi.org/10.1167/tvst.9.2.44

Articles June 2020

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

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Kyoung Woo Kim; Jin Suk Ryu; Jun Yeob Kim; Mee Kum Kim
TAGS: cornea, inflammation, oryctolagus cuniculus, sclera, tissue transplants, transplantation, wound healing, keratoplasty, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2020; 9(7):38. doi: https://doi.org/10.1167/tvst.9.7.38

Includes: Supplemental Content

Articles June 2020

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

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Ying V. Liu; Simrat K. Sodhi; Gilbert Xue; Derek Teng; Dzhalal Agakishiev; Minda M. McNally; Sarah Harris-Bookman; Caitlin McBride; Gregory J. Konar; Mandeep S. Singh
TAGS: biological markers, diagnostic imaging, photoreceptors, transplantation, tissue transplants, cell therapy, eye
Trans. Vis. Sci. Tech.. 2020; 9(7):5. doi: https://doi.org/10.1167/tvst.9.7.5

Articles May 2020

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

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Hyeong Min Kim; Seungmin Ha; Hye Kyoung Hong; Yoonha Hwang; Pilhan Kim; Eunsol Yang; Jae Yong Chung; Sunyoung Park; Young Joo Park; Kyu Hyung Park; Hyuncheol Kim; Se Joon Woo
TAGS: antibodies, eye, kinetics, molecule, nanoparticles, oryctolagus cuniculus, vitreous body, fluorescence, immunoglobulin g, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(6):20. doi: https://doi.org/10.1167/tvst.9.6.20

Includes: Supplemental Content

Review April 2020

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

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Heather Machin; Karl Brown; Gerard Sutton; Paul Baird
TAGS: australia, body tissue, transplantation, research personnel
Trans. Vis. Sci. Tech.. 2020; 9(5):4. doi: https://doi.org/10.1167/tvst.9.5.4

Articles March 2020

In Vitro Culture of Human Corneal Endothelium on Non-Mulberry Silk Fibroin Films for Tissue Regeneration

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Charanya Ramachandran; Prerak Gupta; Swatilekha Hazra; Biman B. Mandal
TAGS: corneal endothelium, fibroins, tissue regeneration, catabolism, personal integrity, edema, refractive index, proteins, cornea, transparency
Trans. Vis. Sci. Tech.. 2020; 9(4):12. doi: https://doi.org/10.1167/tvst.9.4.12

Includes: Supplemental Content

Articles February 2020

Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

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Sayena Jabbehdari; Ghasem Yazdanpanah; Levi N. Kanu; Khandaker N. Anwar; Xiang Shen; Behnam Rabiee; Ilham Putra; Medi Eslani; Mark I. Rosenblatt; Peiman Hematti; Ali R. Djalilian
TAGS: cornea, stem cell, mesenchymal, wound healing, epithelium, wounds and injuries
Trans. Vis. Sci. Tech.. 2020; 9(3):26. doi: https://doi.org/10.1167/tvst.9.3.26

Includes: Supplemental Content

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Articles December 2019

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

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Jan O. Pralits; Mark Alberti; Javier Cabrerizo
TAGS: descemet membrane endothelial keratoplasty, tissue transplants, eye
Trans. Vis. Sci. Tech.. 2019; 8(6):9. doi: https://doi.org/10.1167/tvst.8.6.9

Includes: Supplemental Content

Articles August 2019

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

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Hui Lin; Ying Liu; Samuel Yiu
TAGS: epithelium, lacrimal gland, stem cells
Trans. Vis. Sci. Tech.. 2019; 8(4):32. doi: https://doi.org/10.1167/tvst.8.4.32

Articles June 2019

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

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Trevor J. McGill; Linda Osborne; Bin Lu; Jonathan Stoddard; Stephen Huhn; Ann Tsukamoto; Alexandra Capela
TAGS: bromodeoxyuridine, central nervous system, retinal pigment cell, retinal pigment epithelium, stem cells, tissue transplants, transplantation, ki-67 antigen, retina, eye
Trans. Vis. Sci. Tech.. 2019; 8(3):43. doi: https://doi.org/10.1167/tvst.8.3.43

Articles May 2019

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

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Henri Lorach; Seungbum Kang; Mohajeet B. Bhuckory; Alix Trouillet; Roopa Dalal; Michael Marmor; Daniel Palanker
TAGS: photoreceptors, retinal degeneration, transplantation, retina, rodentia, tissue transplants
Trans. Vis. Sci. Tech.. 2019; 8(3):30. doi: https://doi.org/10.1167/tvst.8.3.30

Includes: Multimedia, Supplemental Content

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Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Effect of CPAP Therapy on 24-Hour Intraocular Pressure-Related Pattern From Contact Lens Sensors in Obstructive Sleep Apnea Syndrome

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts

Inflammation in Viral Vector-Mediated Ocular Gene Therapy: A Review and Report From a Workshop Hosted by the Foundation Fighting Blindness, 9/2020

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

Semi-Automated Approach for Retinal Tissue Differentiation

Deep Learning for Assessing the Corneal Endothelium from Specular Microscopy Images up to 1 Year after Ultrathin-DSAEK Surgery

Quantifying Graft Detachment after Descemet's Membrane Endothelial Keratoplasty with Deep Convolutional Neural Networks

Evidence Based Prediction and Progression Monitoring on Retinal Images from Three Nations

Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model

Quantifiable In Vivo Imaging Biomarkers of Retinal Regeneration by Photoreceptor Cell Transplantation

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Ocular Tissue for Research in Australia: Strategies for Potential Research Utility of Surplus and Transplant-Ineligible Deceased Donations

In Vitro Culture of Human Corneal Endothelium on Non-Mulberry Silk Fibroin Films for Tissue Regeneration

Reproducible Derivation and Expansion of Corneal Mesenchymal Stromal Cells for Therapeutic Applications

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Gas-Graft Coverage After DMEK: A Clinically Validated Numeric Study

Three Dimensional Culture of Potential Epithelial Progenitor Cells in Human Lacrimal Gland

Subretinal Transplantation of Human Central Nervous System Stem Cells Stimulates Controlled Proliferation of Endogenous Retinal Pigment Epithelium

Transplantation of Mature Photoreceptors in Rodents With Retinal Degeneration

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