Oncology

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Neuro-ophthalmology June 2025

Aquaporin-4 Peptide Injection in Mice Induces Retinal and Optic Nerve Alterations That Simulate Those of Neuromyelitis Optica Spectrum Disorder

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Mina Okuda-Arai; Sotaro Mori; Yoshichika Katsura; Shota Miyake; Kenichi Serizawa; Makoto Nakamura
TAGS: immunization, mice, neuromyelitis optica, optic nerve, optic neuritis, peptides, water channels, injections
Trans. Vis. Sci. Tech.. 2025; 14(6):21. https://doi.org/10.1167/tvst.14.6.21

Includes: Supplemental Content

Retina July 2024

Optical Coherence Tomography Angiography–Navigated Laser Photocoagulation of Retinal Hemangioblastomas in Patients With von Hippel–Lindau Disease

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Yannik Laich; Navid Farassat; Viviane Grewing; Daniel Boehringer; Felicitas Bucher; Peter M. Maloca; Thomas Reinhard; Stefan J. Lang; Hansjuergen Agostini; Michael Reich
TAGS: laser therapy, lasers, light coagulation, retinal hemangioblastoma, von hippel-lindau syndrome, angiogram, optical coherence tomography, tumor size
Trans. Vis. Sci. Tech.. 2024; 13(7):8. https://doi.org/10.1167/tvst.13.7.8

Includes: Supplemental Content

Refractive Intervention July 2024

Accelerometer-Measured Daily Behaviors That Mediate the Association Between Refractive Status and Depressive Disorders

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Zijing Du; Shan Wang; Gabriella Bulloch; Feng Zhang; Yaxin Wang; Chunran Lai; Zhiyong Zhuo; Yu Huang; Xianwen Shang; Ying Fang; Zhuoting Zhu; Yijun Hu; Xiayin Zhang; Honghua Yu
TAGS: accelerometers, depressive disorders
Trans. Vis. Sci. Tech.. 2024; 13(7):3. https://doi.org/10.1167/tvst.13.7.3

Includes: Supplemental Content

Retina February 2024

ZEISS PLEX Elite 9000 Widefield Optical Coherence Tomography Angiography as Screening Method for Early Detection of Retinal Hemangioblastomas in von Hippel–Lindau Disease

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Stefan J. Lang; Michelle Dreesbach; Yannik Laich; Andreas Glatz; Daniel Boehringer; Viviane Grewing; Marianne Fritz; Felicitas Bucher; Wolf A. Lagrèze; Peter M. Maloca; Thomas Reinhard; Clemens Lange; Hansjuergen Agostini; Michael Reich
TAGS: angiogram, early diagnosis, ophthalmoscopy, optical coherence tomography, retinal hemangioblastoma, screening, von hippel-lindau syndrome, retina, tumor size
Trans. Vis. Sci. Tech.. 2024; 13(2):8. https://doi.org/10.1167/tvst.13.2.8

Editorial March 2023

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin; Roy Chuck
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2023; 12(3):10. https://doi.org/10.1167/tvst.12.3.10

Lacrimal Apparatus, Eyelids, Orbit February 2023

Integrated Whole-Exome and Transcriptome Sequencing Indicated Dysregulation of Cholesterol Metabolism in Eyelid Sebaceous Gland Carcinoma

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Yuchuan Wang; Jun Li; Peng Hao; Jing Li; Ruifang Han; Jinyong Lin; Xuan Li
TAGS: cancer, cholesterol metabolism, exome, eyelid, sebaceous adenocarcinoma, spinal cord stimulation, genes, proteins
Trans. Vis. Sci. Tech.. 2023; 12(2):4. https://doi.org/10.1167/tvst.12.2.4

Includes: Supplemental Content

Ocular Oncology December 2022

Investigating the Role of DUSP4 in Uveal Melanoma

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Karen Aughton; Dorota Sabat-Pośpiech; Samantha Barlow; Sarah E. Coupland; Helen Kalirai
TAGS: cell lines, doxorubicin, intraocular melanoma, proteins, selumetinib, rna, small interfering, mitogen-activated protein kinases, immunohistochemistry, phosphoric monoester hydrolases, bap1 gene
Trans. Vis. Sci. Tech.. 2022; 11(12):13. https://doi.org/10.1167/tvst.11.12.13

Includes: Supplemental Content

Artificial Intelligence October 2022

Synthetic OCT Data Generation to Enhance the Performance of Diagnostic Models for Neurodegenerative Diseases

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Hajar Danesh; David H. Steel; Jeffry Hogg; Fereshteh Ashtari; Will Innes; Jaume Bacardit; Anya Hurlbert; Jenny C. A. Read; Rahele Kafieh
TAGS: maps, neurodegenerative disorders, neuromyelitis optica, training, histogram
Trans. Vis. Sci. Tech.. 2022; 11(10):10. https://doi.org/10.1167/tvst.11.10.10

Includes: Supplemental Content

Ocular Oncology September 2022

Germline RB1 Mutation in Retinoblastoma Patients: Detection Methods and Implication in Tumor Focality

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Duangnate Rojanaporn; Sermsiri Chitphuk; Nareenart Iemwimangsa; Takol Chareonsirisuthigul; Duangporn Saengwimol; Rangsima Aroonroch; Usanarat Anurathathapan; Suradej Hongeng; Rossukon Kaewkhaw
TAGS: massively-parallel genome sequencing, mutation, neoplasms, retinoblastoma, exons
Trans. Vis. Sci. Tech.. 2022; 11(9):30. https://doi.org/10.1167/tvst.11.9.30

Includes: Supplemental Content

Artificial Intelligence September 2022

Feasibility of Automated Segmentation of Pigmented Choroidal Lesions in OCT Data With Deep Learning

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Philippe Valmaggia; Philipp Friedli; Beat Hörmann; Pascal Kaiser; Hendrik P. N. Scholl; Philippe C. Cattin; Robin Sandkühler; Peter M. Maloca
TAGS: deep learning, posterior cruciate ligament, ptsd checklist
Trans. Vis. Sci. Tech.. 2022; 11(9):25. https://doi.org/10.1167/tvst.11.9.25

Includes: Supplemental Content

Articles May 2022

Development and Validation of a Novel Metabolic Signature-Based Prognostic Model for Uveal Melanoma

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Ke Shi; Xinxin Li; Jingfa Zhang; Xiaodong Sun
TAGS: genes, intraocular melanoma, metabolism, patient prognosis
Trans. Vis. Sci. Tech.. 2022; 11(5):9. https://doi.org/10.1167/tvst.11.5.9

Includes: Supplemental Content

Articles March 2022

Vascular Lakes in Uveal Melanoma and Their Association With Outcome

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Hayley Jones; Helen Kalirai; Azzam Taktak; Ke Chen; Sarah E. Coupland
TAGS: intraocular melanoma, patient prognosis, neoplasms
Trans. Vis. Sci. Tech.. 2022; 11(3):32. https://doi.org/10.1167/tvst.11.3.32

Articles March 2022

Safety Evaluation of Photoacoustic Tomography System for Intraocular Tumors

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Guan Xu; Naheed Khan; Ahmed Almazroa; Mercy Pawar; Cagri Besirli; Yannis M. Paulus; Xueding Wang; Hakan Demirci
TAGS: electroretinography, eye, eye neoplasms, histology, lasers, light, lighting, safety, sclera, tomography
Trans. Vis. Sci. Tech.. 2022; 11(3):30. https://doi.org/10.1167/tvst.11.3.30

Editorial March 2022

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2022; 11(3):25. https://doi.org/10.1167/tvst.11.3.25

Articles September 2021

In Vivo Efficacy of Imatinib Mesylate, a Tyrosine Kinase Inhibitor, in the Treatment of Chemically Induced Dry Eye in Animal Models

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Yi-Yong Baek; Bokyung Sung; Jun-Sub Choi; Hyeon-Kyu Go; Do-Hyung Kim; Joon Young Hyon; Ji Chang You
TAGS: animal model, dry eye syndromes, imatinib mesylate, protein-tyrosine kinase inhibitor, bronchioloalveolar carcinoma, blood alcohol concentration
Trans. Vis. Sci. Tech.. 2021; 10(11):14. https://doi.org/10.1167/tvst.10.11.14

Articles September 2021

Efficacy, Toxicity, and Pharmacokinetics of Intra-Arterial Chemotherapy Versus Intravenous Chemotherapy for Retinoblastoma in Animal Models and Patients

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Anthony B. Daniels; Michael T. Froehler; Jessica V. Kaczmarek; Carley M. Bogan; Pranav R. Santapuram; Janene M. Pierce; Sheau-Chiann Chen; Emma A. Schremp; Kelli L. Boyd; Yuankai K. Tao; Marion W. Calcutt; Tatsuki Koyama; Ann Richmond; Debra L. Friedman
TAGS: chemotherapy regimen, oryctolagus cuniculus, pharmacokinetics, toxic effect, chemotherapy, intravenous, retinoblastoma, animal model, melphalan
Trans. Vis. Sci. Tech.. 2021; 10(11):10. https://doi.org/10.1167/tvst.10.11.10

Editorial July 2021

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2021; 10(8):3. https://doi.org/10.1167/tvst.10.8.3

Articles February 2021

White Paper on Ophthalmic Imaging for Choroidal Nevus Identification and Transformation into Melanoma

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Carol L. Shields; Sara E. Lally; Lauren A. Dalvin; Mandeep S. Sagoo; Marco Pellegrini; Swathi Kaliki; Ahmet Kaan Gündüz; Minoru Furuta; Prithvi Mruthyunjaya; Adrian T. Fung; Jay S. Duker; Sara M. Selig; Antonio Yaghy; Sandor R. Ferenczy; Malvina B. Eydelman; Mark S. Blumenkranz
TAGS: melanoma, nevus, nevus of choroid, ophthalmic imaging
Trans. Vis. Sci. Tech.. 2021; 10(2):24. https://doi.org/10.1167/tvst.10.2.24

Articles January 2021

Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species

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Michael Byrne; Vinod Vathipadiekal; Luciano Apponi; Naoki Iwamoto; Pachamuthu Kandasamy; Kenneth Longo; Fangjun Liu; Richard Looby; Lauren Norwood; Anee Shah; Juili Dilip Shelke; Chikdu Shivalila; Hailin Yang; Yuan Yin; Lankai Guo; Keith Bowman; Chandra Vargeese
TAGS: antisense oligonucleotides, eye, mice, oligonucleotides, rna
Trans. Vis. Sci. Tech.. 2021; 10(1):23. https://doi.org/10.1167/tvst.10.1.23

Includes: Supplemental Content

Articles January 2021

A Cross-Sectional Study of Sub-Basal Corneal Nerve Reduction Following Neurotoxic Chemotherapy

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Jeremy Chung Bo Chiang; David Goldstein; Terry Trinh; Kimberley Au; David Mizrahi; Mark Muhlmann; Philip Crowe; Siobhan O'Neill; Katie Edwards; Susanna B. Park; Arun V. Krishnan; Maria Markoulli
TAGS: chemotherapy regimen, cornea, neurons, paclitaxel, oxaliplatin, cancer, microscopy, confocal
Trans. Vis. Sci. Tech.. 2021; 10(1):24. https://doi.org/10.1167/tvst.10.1.24

Includes: Supplemental Content

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Aquaporin-4 Peptide Injection in Mice Induces Retinal and Optic Nerve Alterations That Simulate Those of Neuromyelitis Optica Spectrum Disorder

Optical Coherence Tomography Angiography–Navigated Laser Photocoagulation of Retinal Hemangioblastomas in Patients With von Hippel–Lindau Disease

Accelerometer-Measured Daily Behaviors That Mediate the Association Between Refractive Status and Depressive Disorders

ZEISS PLEX Elite 9000 Widefield Optical Coherence Tomography Angiography as Screening Method for Early Detection of Retinal Hemangioblastomas in von Hippel–Lindau Disease

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

Integrated Whole-Exome and Transcriptome Sequencing Indicated Dysregulation of Cholesterol Metabolism in Eyelid Sebaceous Gland Carcinoma

Investigating the Role of DUSP4 in Uveal Melanoma

Synthetic OCT Data Generation to Enhance the Performance of Diagnostic Models for Neurodegenerative Diseases

Germline RB1 Mutation in Retinoblastoma Patients: Detection Methods and Implication in Tumor Focality

Feasibility of Automated Segmentation of Pigmented Choroidal Lesions in OCT Data With Deep Learning

Development and Validation of a Novel Metabolic Signature-Based Prognostic Model for Uveal Melanoma

Vascular Lakes in Uveal Melanoma and Their Association With Outcome

Safety Evaluation of Photoacoustic Tomography System for Intraocular Tumors

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

In Vivo Efficacy of Imatinib Mesylate, a Tyrosine Kinase Inhibitor, in the Treatment of Chemically Induced Dry Eye in Animal Models

Efficacy, Toxicity, and Pharmacokinetics of Intra-Arterial Chemotherapy Versus Intravenous Chemotherapy for Retinoblastoma in Animal Models and Patients

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

White Paper on Ophthalmic Imaging for Choroidal Nevus Identification and Transformation into Melanoma

Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species

A Cross-Sectional Study of Sub-Basal Corneal Nerve Reduction Following Neurotoxic Chemotherapy

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