Pharmacology

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Physiology and Pharmacology June 2025

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

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Jessica R. Crawshaw; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Antonello Caruso
TAGS: aqueous humor, ranibizumab, vascular endothelial growth factor a, pharmacodynamics, eye diseases, pharmacokinetics, mathematical model
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):20. https://doi.org/10.1167/iovs.66.6.20

Includes: Supplemental Content

Retina June 2025

Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model

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Assaf Ben-Arzi; Itay Spector; Yariv Keshet; Orly Gal-Or; Irit Bahar; Assaf Dotan
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, drug clearance, ranibizumab, intravitreal injections, bevacizumab, choroidal neovascularization, mass or substance concentration per volume, eye, antibodies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):1. https://doi.org/10.1167/iovs.66.6.1

Glaucoma June 2025

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
TAGS: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2025; 14(6):6. https://doi.org/10.1167/tvst.14.6.6

Includes: Supplemental Content

Low Vision Rehabilitation May 2025

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

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Junxian He; Shrinivas Pundlik; Gang Luo
TAGS: chatgpt, datasets, gait, walking (activity)
Trans. Vis. Sci. Tech.. 2025; 14(5):28. https://doi.org/10.1167/tvst.14.5.28

Retina May 2025

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

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Terhi Ollila; Ashwini Joshi; Sangita Kulathinal; Ilkka Immonen
TAGS: area under curve, cohort studies, exudative age-related macular degeneration, finnish, visual acuity
Trans. Vis. Sci. Tech.. 2025; 14(5):23. https://doi.org/10.1167/tvst.14.5.23

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Retina April 2025

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

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Ssu-Yu Pan; Chien-Hsiang Weng; Shang-Feng Tsai; Hui-Ju Lin; Jun-Fu Lin; Ching-Heng Lin; I-Jong Wang; Chien-Chih Chou
TAGS: age-related macular degeneration, diabetes mellitus, type 2, dipeptidyl-peptidase iv inhibitors, sodium-glucose transporter 2 inhibitors, diabetes mellitus, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):58. https://doi.org/10.1167/iovs.66.4.58

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Glaucoma April 2025

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

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Janne Frömmichen; Emma Bungert; Jeanne Ströble; Moritz Gläser; Charlotte Gottwald; Kosovare Zeqiri; Thomas Reinhard; Jan Lübke; Günther Schlunck; Cornelius Jakob Wiedenmann
TAGS: fibroblasts, fibrosis, fluid flow, interstitial fluid, verteporfin, actins, cell transdifferentiation, connective tissue growth factor
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):17. https://doi.org/10.1167/iovs.66.4.17

Retina April 2025

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

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Dante J. Pieramici; Peter A. Campochiaro; Margaret Chang; Ian Pearce; Carl D. Regillo; Shamika Gune; Nancy Holekamp; Carlos Quezada-Ruiz; Shrirang V. Ranade; Natasha Singh; Geoffrey Wise; Joshua Horvath
TAGS: implants, needles
Trans. Vis. Sci. Tech.. 2025; 14(4):8. https://doi.org/10.1167/tvst.14.4.8

Includes: Multimedia, Supplemental Content

Retina March 2025

Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

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Sergio Li Calzi; Ayaka Fujihashi; Dibyendu Chakraborty; Yvonne Adu-Rutledge; Ram Prasad; Edgar L. V. Ready; Sarbodeep Paul; Srikanth Kakumanu; Xiaoping Qi; Michael E. Boulton; Alan J. Franklin; Bob H. Katz; Maria B. Grant
TAGS: aflibercept, choroidal neovascularization, implants, lasers, oryctolagus cuniculus, polymers, retinal diseases, intravitreal injections, mice, injections
Trans. Vis. Sci. Tech.. 2025; 14(3):21. https://doi.org/10.1167/tvst.14.3.21

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Cornea March 2025

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

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David Diaz; Joseph W. Sassani; Ian S. Zagon; Patricia J. McLaughlin
TAGS: cornea, diabetes mellitus, dry eye syndromes, naltrexone, opioid receptor, rats, corneal epithelium, trigeminal ganglion
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):24. https://doi.org/10.1167/iovs.66.3.24

Includes: Supplemental Content

Letters to the Editor March 2025

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Patricia Barreto; Claudia Farinha; Rita Coimbra; Rufino Silva
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):3. https://doi.org/10.1167/iovs.66.3.3

Retina February 2025

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

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Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Yuto Hashimoto; Hana Yoshida; Hironori Takahashi; Yujiro Fujino; Kenichi Aizawa; Hidetoshi Kawashima; Yasuo Yanagi
TAGS: aflibercept, aqueous humor, bodily secretions, eyedrops, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):21. https://doi.org/10.1167/tvst.14.2.21

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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Lujue Wang; Yuan Li; Tongxin Niu; Jing Deng; Yuxian Shi; Yating Liu; Boding Tong; Xin Qi; Dan Cao; Yongguang Tao; Yunping Li
TAGS: ferroptosis, graves' ophthalmopathy, simvastatin, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):56. https://doi.org/10.1167/iovs.66.1.56

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

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Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

Use of SGLT2 Inhibitors Versus DPP-4 Inhibitors and Age-Related Macular Degeneration in Patients WithType 2 Diabetes: A Multinational Cohort Study

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

Effects of Verteporfin on Interstitial Fluid Flow-Induced Fibrotic Transdifferentiation of Human Tenon Fibroblasts

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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