Pharmacology

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Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics, clinical trial protocol document, body temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: 10.1167/tvst.8.3.40

Articles June 2019

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

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Anup Kumar Ghosh; Shivaprakash Mandya Rudramurthy; Amit Gupta; Hansraj Choudhary; Shreya Singh; Anchal Thakur; Manu Jatana
TAGS: amphotericin b, antifungal agents, cornea, did not receive therapy or drug, fungal keratitis, liposomes, oryctolagus cuniculus, keratitis
Trans. Vis. Sci. Tech.. 2019; 8(3):35. doi: 10.1167/tvst.8.3.35

Articles June 2019

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

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Hung-Yin Lai; Ming-Tse Kuo; Po-Chiung Fang; Chi-Chang Lin; Chun-Chih Chien; Wan-Hua Cho; Alexander Chen; Ing-Chou Lai
TAGS: homeostasis, cornea, tear film finding, liposomal amikacin for inhalation
Trans. Vis. Sci. Tech.. 2019; 8(3):32. doi: 10.1167/tvst.8.3.32

Includes: Multimedia, Supplemental Content

Articles May 2019

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

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Dirk-Henning Menz; Nicolas Feltgen; Thorsten Lechner; Helge Menz; Bernd-Kristof Müller; Joachim Dresp; Hans Hoerauf
TAGS: olive oil, heart failure, patent foramen ovale, hydrofluoric acid, gas chromatography-mass spectrometry, body tissue, toxic effect, retinal toxicity, catabolism, perfluorooctane
Trans. Vis. Sci. Tech.. 2019; 8(3):24. doi: 10.1167/tvst.8.3.24

Retina May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic, somatostatin, brimonidine, retinal vascular caliber
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2257-2262. doi: 10.1167/iovs.18-26487

Retina May 2019

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

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Stephanie K. Lynch; Kyungmoo Lee; Zhi Chen; James C. Folk; Ursula Schmidt-Erfurth; Bianca S. Gerendas; Andreas Wahle; Charles C. Wykoff; Michael D. Abràmoff
TAGS: diabetes mellitus, fluocinolone acetonide, nerve degeneration, left ventricular area fractional change, cyclophosphamide/doxorubicin/fluorouracil protocol, right ventricular fractional area change
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2134-2139. doi: 10.1167/iovs.18-24643

Clinical Trials May 2019

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain
TAGS: deoxyribonuclease i, deoxyribonucleases, dry eye syndromes, placebos, eyedrops
Trans. Vis. Sci. Tech.. 2019; 8(3):10. doi: 10.1167/tvst.8.3.10

Retinal Cell Biology April 2019

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

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Adam Thompson; Martin Berry; Ann Logan; Zubair Ahmed
TAGS: rapamycin, peptides, neuronal outgrowth, rna, messenger, retinal ganglion cells, axon, neurites
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1748-1759. doi: 10.1167/iovs.18-26449

Visual Neuroscience April 2019

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

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Run-Ze Cui; Lu Wang; Sheng-Nan Qiao; Yong-Chen Wang; Xin Wang; Fei Yuan; Shi-Jun Weng; Xiong-Li Yang; Yong-Mei Zhong
TAGS: diabetes mellitus, streptozocin, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1644-1656. doi: 10.1167/iovs.18-26359

Retina April 2019

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

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Bruce A. Berkowitz; Robert H. Podolsky; Karen M. Lins-Childers; Yichao Li; Haohua Qian
TAGS: oxidative stress, diltiazem, mice, apraxia of speech, aneurysms-osteoarthritis syndrome, saline solutions
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1566-1570. doi: 10.1167/iovs.18-26164

Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: metformin, age-related macular degeneration, antidiabetics
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: 10.1167/iovs.18-26422

Physiology and Pharmacology April 2019

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

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Krisztina Kovacs; Alexandra Vaczy; Katalin Fekete; Petra Kovari; Tamas Atlasz; Dora Reglodi; Robert Gabriel; Ferenc Gallyas; Balazs Sumegi
TAGS: hypoxia, retina, retinal injuries, poly(adp-ribose) polymerase inhibitors, olaparib, hypoxia chronic
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1478-1490. doi: 10.1167/iovs.18-25936

Cornea March 2019

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

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Bum-Joo Cho; Jin Sun Hwang; Young Joo Shin; Jeong Won Kim; Tae-Young Chung; Joon Young Hyon
TAGS: inflammation, rapamycin, dry eye syndromes, endoplasmic reticulum, mice, stress
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1254-1264. doi: 10.1167/iovs.18-25583

Biochemistry and Molecular Biology March 2019

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

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Kailin Chen; Kairan Lai; Xiaobo Zhang; Zhenwei Qin; Qiuli Fu; Chenqi Luo; Xiuming Jin; Jianghua Hu; Siyu Liu; Ke Yao
TAGS: fibroblasts, conjunctiva, pterygium, proto-oncogene proteins c-akt, bromfenac, hpfs trial
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1156-1164. doi: 10.1167/iovs.18-24743

Includes: Supplemental Content

Cornea March 2019

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

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Hyesook Lee; Sangwon Jeon; Chae Eun Kim; Young-Joon Park; Jaewook Yang
TAGS: dry eye syndromes, cornea, eye, stress, mucins, dosage forms, desiccation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1076-1087. doi: 10.1167/iovs.18-24935

Retina February 2019

Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

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Jurgen Sergeys; Isabelle Etienne; Inge Van Hove; Evy Lefevere; Ingeborg Stalmans; Jean H. M. Feyen; Lieve Moons; Tine Van Bergen
TAGS: diabetes mellitus, streptozocin, mice
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):807-822. doi: 10.1167/iovs.18-25372

Includes: Supplemental Content

Retina February 2019

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina

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Mark K. Webster; Betty J. Barnett; Megan L. Stanchfield; Joshua R. Paris; Sarah E. Webster; Cynthia A. Cooley-Themm; Edward M. Levine; Deborah C. Otteson; Cindy L. Linn
TAGS: cell cycle, adult, bromodeoxyuridine, mammals, neuroglia, neurons, mice, retina, agonists, eyedrops, reentry, neural development, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):570-579. doi: 10.1167/iovs.18-25722

Articles January 2019

Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost

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Susan S. Lee; Alexandra Almazan; Sherri Decker; Yan Zhong; Alazar N. Ghebremeskel; Patrick Hughes; Michael R. Robinson; James A. Burke; Robert N. Weinreb
TAGS: intraocular pressure, pharmacokinetics, bimatoprost
Trans. Vis. Sci. Tech.. 2019; 8(1):15. doi: 10.1167/tvst.8.1.15

Articles January 2019

Characterization of Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Ranibizumab

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Wenqiang Liu; Marta Arias Borrell; David C. Venerus; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: hydrogel, hydrogels, edema, temperature, ranibizumab, body temperature, drug delivery systems, microspheres
Trans. Vis. Sci. Tech.. 2019; 8(1):12. doi: 10.1167/tvst.8.1.12

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Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

Activation of the BMP4/Smad1 Pathway Promotes Retinal Ganglion Cell Survival and Axon Regeneration

ON-Type Retinal Ganglion Cells are Preferentially Affected in STZ-Induced Diabetic Mice

Outer Retinal Oxidative Stress Measured In Vivo Using QUEnch-assiSTed (QUEST) OCT

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

Rapamycin Rescues Endoplasmic Reticulum Stress–Induced Dry Eye Syndrome in Mice

Bromfenac Inhibits TGF-β1–Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts

A New Ophthalmic Pharmaceutical Formulation, Topical Sulglycotide, Enhances the Ocular Mucin Secretion in Desiccation Stress-Mediated Dry Eye Disease

Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses

Stimulation of Retinal Pigment Epithelium With an α7 nAChR Agonist Leads to Müller Glia Dependent Neurogenesis in the Adult Mammalian Retina

Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost

Characterization of Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Ranibizumab

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