Pharmacology

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Retina March 2025

Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

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Sergio Li Calzi; Ayaka Fujihashi; Dibyendu Chakraborty; Yvonne Adu-Rutledge; Ram Prasad; Edgar L. V. Ready; Sarbodeep Paul; Srikanth Kakumanu; Xiaoping Qi; Michael E. Boulton; Alan J. Franklin; Bob H. Katz; Maria B. Grant
TAGS: aflibercept, choroidal neovascularization, implants, lasers, oryctolagus cuniculus, polymers, retinal diseases, intravitreal injections, mice, injections
Trans. Vis. Sci. Tech.. 2025; 14(3):21. https://doi.org/10.1167/tvst.14.3.21

Clinical and Epidemiologic Research March 2025

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

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Joseph Magagnoli; Tammy Cummings; James W. Hardin; S. Scott Sutton; Jayakrishna Ambati
TAGS: age-related macular degeneration, bisphosphonates, nlr family, pyrin domain-containing 3 protein
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):32. https://doi.org/10.1167/iovs.66.3.32

Includes: Supplemental Content

Cornea March 2025

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

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David Diaz; Joseph W. Sassani; Ian S. Zagon; Patricia J. McLaughlin
TAGS: cornea, diabetes mellitus, dry eye syndromes, naltrexone, opioid receptor, rats, corneal epithelium, trigeminal ganglion
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):24. https://doi.org/10.1167/iovs.66.3.24

Includes: Supplemental Content

Letters to the Editor March 2025

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Patricia Barreto; Claudia Farinha; Rita Coimbra; Rufino Silva
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):3. https://doi.org/10.1167/iovs.66.3.3

Retina February 2025

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

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Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Yuto Hashimoto; Hana Yoshida; Hironori Takahashi; Yujiro Fujino; Kenichi Aizawa; Hidetoshi Kawashima; Yasuo Yanagi
TAGS: aflibercept, aqueous humor, bodily secretions, eyedrops, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):21. https://doi.org/10.1167/tvst.14.2.21

Includes: Supplemental Content

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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Lujue Wang; Yuan Li; Tongxin Niu; Jing Deng; Yuxian Shi; Yating Liu; Boding Tong; Xin Qi; Dan Cao; Yongguang Tao; Yunping Li
TAGS: ferroptosis, graves' ophthalmopathy, simvastatin, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):56. https://doi.org/10.1167/iovs.66.1.56

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Anatomy and Pathology/Oncology January 2025

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

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Xiaoting Pei; Mengru Ba; Tingting Yang; Shuting Xuan; Duliurui Huang; Di Qi; Dingli Lu; Shenzhen Huang; Zhijie Li
TAGS: diabetes mellitus, diabetes mellitus, type 2, insulin, mice, langer-giedion syndrome, circadian rhythms, dry eye syndromes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):19. https://doi.org/10.1167/iovs.66.1.19

Includes: Supplemental Content

Immunology and Microbiology January 2025

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

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Shira Merzbach; Adi Schumacher-Klinger; Michal Klazas; Amnon Hoffman; Philip Lazarovici; Chaim Gilon; Gabriel Nussbaum; Radgonde Amer
TAGS: anti-inflammatory agents, autoimmunity, cyclic peptides, epitopes, mice, uveitis, mice, inbred c57bl, cd45 antigens, cytokine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):13. https://doi.org/10.1167/iovs.66.1.13

Retina December 2024

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

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Kim Lien Huber; Heiko Stino; Irene Steiner; Philipp Fuchs; Felix Goldbach; Julia Mai; Bianca S. Gerendas; Katharina Kriechbaum; Ursula Schmidt-Erfurth; Andreas Pollreisz
TAGS: aflibercept, diabetic macular edema, eye, faricimab, injections, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):46. https://doi.org/10.1167/iovs.65.14.46

Includes: Supplemental Content

Editorial December 2024

Reviewers

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TAGS: bsnd gene, gangs, happiness, laparoscopic uterosacral nerve ablation, reading (activity), tolnaftate, acetylcholine, achondroplasia, camurati-engelmann syndrome, e-selectin
Trans. Vis. Sci. Tech.. 2024; 13(12):38. https://doi.org/10.1167/tvst.13.12.38

Editorial December 2024

Reviewers

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TAGS: angiotensin receptor-neprilysin inhibitors, basil, cataract-alopecia-sclerodactyly syndrome, chad, chin, christianity, happiness, ilex, iris, love
Journal of Vision. 2024; 24(13):16. https://doi.org/10.1167/jov.24.13.16

Editorial December 2024

Reviewers

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TAGS: acetylcholine, achondroplasia, arthritis, juvenile rheumatoid, betula, christianity, encephalomyelitis, acute disseminated, esters, gastroesophageal reflux disease, glycogen storage disease type iv, krypton
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):42. https://doi.org/10.1167/iovs.65.14.42

Retina December 2024

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

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Masahiko Shimura; Shotaro Sasaki; Ryota Nonaka; Ikumi Kashiwagi; Kanako Yasuda; Hidetaka Noma; Hitoshi Takagi
TAGS: angiopoietins, cytokine, diabetic macular edema, faricimab, injections, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2024; 13(12):35. https://doi.org/10.1167/tvst.13.12.35

Retina December 2024

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

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David S. Boyer; Nathan C. Steinle; Joel A. Pearlman; Cameron M. Stone; Courtney Crawford; Sunil Gupta; Pravin U. Dugel; Megan E. Baldwin; Ian M. Leitch
TAGS: aflibercept, diabetic macular edema, vascular endothelial growth factor a, vascular endothelial growth factor c, vascular endothelial growth factors
Trans. Vis. Sci. Tech.. 2024; 13(12):32. https://doi.org/10.1167/tvst.13.12.32

Lens December 2024

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

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Yu Yang; Cong Fan; Yue Zhang; Tianyi Kang; Jian Jiang
TAGS: diabetes mellitus, lens (device), lens, crystalline, metabolites, mice, retina, streptozocin, metabolic disturbance, lipocalin-2 protein, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):19. https://doi.org/10.1167/iovs.65.14.19

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2024

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

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María Belen Cancela; Ursula Winter; Santiago Zugbi; Milagros Dinardi; Daniela Alves da Quinta; Rosario Aschero; Daiana Ganiewich; Claudia Sampor; Mariana Sgroi; Eduardo Lagomarsino; Adriana Fandiño; Andrea S. Llera; Guillermo Chantada; Angel M. Carcaboso; Paula Schaiquevich
TAGS: melphalan, retinoblastoma, topotecan, parent, membrane transport proteins, inhibitory concentration 50
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):14. https://doi.org/10.1167/iovs.65.14.14

Includes: Supplemental Content

Clinical and Epidemiologic Research December 2024

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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Panagiotis Laspas; Alica Hartmann; Ida Scholz; Esther Maria Hoffmann; Anthony P. Khawaja; Karl Johannes Lackner; Thomas Münzel; Jasmin Ghaemi Kerahrodi; Irene Schmidtmann; Oliver Tüscher; Jörn Markus Schattenberg; Norbert Pfeiffer; Stavros Konstantinides; Philipp Sebastian Wild; Alexander Karl-Georg Schuster
TAGS: intraocular pressure, pharmaceutical preparations, health, beta-blockers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):4. https://doi.org/10.1167/iovs.65.14.4

Includes: Supplemental Content

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Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

NLRP3 Activation With Bisphosphonate Use and the Risk of Incident Age-Related Macular Degeneration

Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways

Author Response: Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Leptin Receptor Deficiency–Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome

Anti-Inflammatory Effects of Clarstatin, a Shared-Epitope–Antagonistic Cyclic Peptide, on Experimental Autoimmune Uveitis in Mice

Real-World Outcomes After Switch From Aflibercept to Faricimab in Eyes With Diabetic Macular Edema

Reviewers

Reviewers

Reviewers

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

Change in Systemic Medication and its Influence on Intraocular Pressure – Results From the Gutenberg Health Study

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