Pharmacology

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Articles February 2020

Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy

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Xiang Ji; Tom Wright; Cynthia VandenHoven; Leslie MacKeen; Michelle McFarlane; Henry Liu; Annie Dupuis; Carol Westall
TAGS: child, childhood epilepsy, mobile devices, optical coherence tomography, reliability, retinal nerve fiber layer, vigabatrin
Trans. Vis. Sci. Tech.. 2020; 9(3):9. doi: https://doi.org/10.1167/tvst.9.3.9

Articles December 2019

Ability of Nonswelling Polyethylene Glycol-Based Vitreous Hydrogel to Maintain Transparency in the Presence of Vitreous Hemorrhage

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Sujin Hoshi; Fumiki Okamoto; Tomoya Murakami; Takamasa Sakai; Yuko Shinohara; Tomohiko Fujii; Masayoshi Nakatani; Tetsuro Oshika
TAGS: glycols, hydrogel, polyethylene, transparency, vitreous body, vitreous hemorrhage, gel, blood groups
Trans. Vis. Sci. Tech.. 2019; 8(6):33. doi: https://doi.org/10.1167/tvst.8.6.33

Articles November 2019

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

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Susan R. Crowell; Kathryn Wang; Amin Famili; Whitney Shatz; Kelly M. Loyet; Vincent Chang; Yanqiu Liu; Saileta Prabhu; Amrita V. Kamath; Robert F. Kelley
TAGS: hydrophobicity, molecule, ranibizumab, vitreous body, pharmacokinetics, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2019; 8(6):1. doi: https://doi.org/10.1167/tvst.8.6.1

Includes: Supplemental Content

Articles November 2019

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

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Pasquale Aragona; Peter A. Simmons; Hongpeng Wang; Tao Wang
TAGS: hyaluronic acid, mass or substance concentration per volume, ocular lubricants, viscosity, sodium, osmolality
Trans. Vis. Sci. Tech.. 2019; 8(6):2. doi: https://doi.org/10.1167/tvst.8.6.2

Articles October 2019

Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314

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Alan G. Woodruff; Claudia M. Santamaria; Manisha Mehta; Grant L. Pemberton; Kathleen Cullion; Daniel S. Kohane
TAGS: cornea, lidocaine, qx-314
Trans. Vis. Sci. Tech.. 2019; 8(5):28. doi: https://doi.org/10.1167/tvst.8.5.28

Articles September 2019

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

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Wayne Heaselgrave; Anas Hamad; Steven Coles; Scott Hau
TAGS: acanthamoeba, cysts, ophthalmic agents, trophozoite, bronchioloalveolar carcinoma, toxic effect
Trans. Vis. Sci. Tech.. 2019; 8(5):17. doi: https://doi.org/10.1167/tvst.8.5.17

Articles September 2019

Δ 9 -Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

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Pranjal S. Taskar; Akash Patil; Prit Lakhani; Eman Ashour; Waseem Gul; Mahmoud A. ElSohly; Brian Murphy; Soumyajit Majumdar
TAGS: tetrahydrocannabinol, intraocular pressure, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2019; 8(5):15. doi: https://doi.org/10.1167/tvst.8.5.15

Editorial August 2019

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

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Marco Zarbin
TAGS: peer review, science
Trans. Vis. Sci. Tech.. 2019; 8(4):r. doi: https://doi.org/10.1167/tvst.8.4.r

New Developments in Vision Research June 2019

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

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Ananya Datta; Mark Willcox; Fiona Stapleton
TAGS: antimicrobials, contact lens storage case, disinfection, silver, contact lenses
Trans. Vis. Sci. Tech.. 2019; 8(3):52. doi: https://doi.org/10.1167/tvst.8.3.52

Articles June 2019

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

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Emily Dosmar; Wenqiang Liu; Geeya Patel; Alison Rogozinski; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: endophthalmitis, hydrogel, vancomycin, infection, postoperative care, prevention, injections, saline solutions
Trans. Vis. Sci. Tech.. 2019; 8(3):53. doi: https://doi.org/10.1167/tvst.8.3.53

Review June 2019

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

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Colm D. Andrews; Russell G. Foster; Iona Alexander; Sridhar Vasudevan; Susan M. Downes; Carl Heneghan; Annette Plüddemann
TAGS: eye diseases, melatonin, pharmacy (field), sleep, systematic reviews, tasimelteon
Trans. Vis. Sci. Tech.. 2019; 8(3):49. doi: https://doi.org/10.1167/tvst.8.3.49

Includes: Supplemental Content

Articles June 2019

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

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Jing Shen; Qingfeng Liang; Guanyu Su; Yang Zhang; Zhiqun Wang; Christophe Baudouin; Antoine Labbé
TAGS: antimicrobials, chemotherapy regimen, infection, mass or substance concentration per volume, staphylococcus aureus, staphylococcus epidermidis, tolonium chloride, bacteria, anti-bacterial agents, photosensitizing agents
Trans. Vis. Sci. Tech.. 2019; 8(3):45. doi: https://doi.org/10.1167/tvst.8.3.45

Clinical Trials June 2019

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

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Katarzyna Konieczka; Simone Koch; Daniela Hauenstein; Thomas Navin Chackathayil; Tatjana Binggeli; Andreas Schoetzau; Josef Flammer
TAGS: brimonidine, latanoprost, antiglaucoma medications, cornea, temperature
Trans. Vis. Sci. Tech.. 2019; 8(3):47. doi: https://doi.org/10.1167/tvst.8.3.47

Articles June 2019

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

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Young Hyun Kim; Andrew D. Graham; Wing Li; Clayton J. Radke; Meng C. Lin
TAGS: evaporation, eye, heterogeneity of variance, loa, sample size, tear production, dry eye syndromes, humidity, reading (activity), anesthetics
Trans. Vis. Sci. Tech.. 2019; 8(3):40. doi: https://doi.org/10.1167/tvst.8.3.40

Articles June 2019

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

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Anup Kumar Ghosh; Shivaprakash Mandya Rudramurthy; Amit Gupta; Hansraj Choudhary; Shreya Singh; Anchal Thakur; Manu Jatana
TAGS: amphotericin b, antifungal agents, cornea, did not receive therapy or drug, fungal keratitis, liposomes, oryctolagus cuniculus, keratitis
Trans. Vis. Sci. Tech.. 2019; 8(3):35. doi: https://doi.org/10.1167/tvst.8.3.35

Articles June 2019

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

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Hung-Yin Lai; Ming-Tse Kuo; Po-Chiung Fang; Chi-Chang Lin; Chun-Chih Chien; Wan-Hua Cho; Alexander Chen; Ing-Chou Lai
TAGS: homeostasis, cornea, tear film finding, liposomal amikacin for inhalation
Trans. Vis. Sci. Tech.. 2019; 8(3):32. doi: https://doi.org/10.1167/tvst.8.3.32

Includes: Multimedia, Supplemental Content

Articles May 2019

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

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Dirk-Henning Menz; Nicolas Feltgen; Thorsten Lechner; Helge Menz; Bernd-Kristof Müller; Joachim Dresp; Hans Hoerauf
TAGS: olive oil, heart failure, patent foramen ovale, hydrofluoric acid, gas chromatography-mass spectrometry, body tissue, toxic effect, retinal toxicity, catabolism, perfluorooctane
Trans. Vis. Sci. Tech.. 2019; 8(3):24. doi: https://doi.org/10.1167/tvst.8.3.24

Clinical Trials May 2019

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

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Christine Mun; Shilpa Gulati; Sapna Tibrewal; Yi-Fan Chen; Seungwon An; Bayasgalan Surenkhuu; Ilangovan Raju; Morgan Buwick; Anna Ahn; Ji-Eun Kwon; Nour Atassi; Anubhav Pradeep; Damiano Rondelli; Sandeep Jain
TAGS: deoxyribonuclease i, deoxyribonucleases, dry eye syndromes, placebos, eyedrops
Trans. Vis. Sci. Tech.. 2019; 8(3):10. doi: https://doi.org/10.1167/tvst.8.3.10

Articles January 2019

Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost

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Susan S. Lee; Alexandra Almazan; Sherri Decker; Yan Zhong; Alazar N. Ghebremeskel; Patrick Hughes; Michael R. Robinson; James A. Burke; Robert N. Weinreb
TAGS: intraocular pressure, pharmacokinetics, bimatoprost
Trans. Vis. Sci. Tech.. 2019; 8(1):15. doi: https://doi.org/10.1167/tvst.8.1.15

Articles January 2019

Characterization of Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Ranibizumab

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Wenqiang Liu; Marta Arias Borrell; David C. Venerus; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: hydrogel, hydrogels, edema, temperature, ranibizumab, body temperature, drug delivery systems, microspheres
Trans. Vis. Sci. Tech.. 2019; 8(1):12. doi: https://doi.org/10.1167/tvst.8.1.12

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Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy

Ability of Nonswelling Polyethylene Glycol-Based Vitreous Hydrogel to Maintain Transparency in the Presence of Vitreous Hemorrhage

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules

Physicochemical Properties of Hyaluronic Acid–Based Lubricant Eye Drops

Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability

Δ 9 -Tetrahydrocannabinol Derivative-Loaded Nanoformulation Lowers Intraocular Pressure in Normotensive Rabbits

The Elusive Nature of Truth in Scientific Studies and the Importance of Peer Review

In Vitro Antimicrobial Efficacy of Silver Lens Cases Used With a Multipurpose Disinfecting Solution

Controlled Release of Vancomycin From a Thermoresponsive Hydrogel System for the Prophylactic Treatment of Postoperative Acute Endophthalmitis

Sleep–Wake Disturbance Related to Ocular Disease: A Systematic Review of Phase-Shifting Pharmaceutical Therapies

In Vitro Effect of Toluidine Blue Antimicrobial Photodynamic Chemotherapy on Staphylococcus epidermidis and Staphylococcus aureus Isolated from Ocular Surface Infection

Effects of the Glaucoma Drugs Latanoprost and Brimonidine on Corneal Temperature

Human Lacrimal Production Rate and Wetted Length of Modified Schirmer's Tear Test Strips

Evaluation of Liposomal and Conventional Amphotericin B in Experimental Fungal Keratitis Rabbit Model

Tracking the Reflective Light Particles Spreading on the Cornea: An Emerging Assessment for Tear Film Homeostasis

Hydrofluoric Acid and Other Impurities in Toxic Perfluorooctane Batches

A Phase I/II Placebo-Controlled Randomized Pilot Clinical Trial of Recombinant Deoxyribonuclease (DNase) Eye Drops Use in Patients With Dry Eye Disease

Intraocular Pressure Effects and Mechanism of Action of Topical Versus Sustained-Release Bimatoprost

Characterization of Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Ranibizumab

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