Pharmacology

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Articles March 2021

Pharmacokinetics of Intravitreal Vancomycin and Ceftazidime in Silicone Oil-Filled Macaque Eyes

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Taku Imamura; Masashi Kakinoki; Daiki Hira; Tomoya Kitagawa; Satoshi Ueshima; Mikio Kakumoto; Tomohiro Terada; Ikuo Kawamoto; Mitsuru Murase; Masahito Ohji
TAGS: antibiotics, ceftazidime, eye, macaca, pharmacokinetics, silicone oils, silicones, vancomycin, aqueous humor
Trans. Vis. Sci. Tech.. 2021; 10(3):1. doi: https://doi.org/10.1167/tvst.10.3.1

Articles January 2021

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

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Szilárd Kiss; Kristina Oresic Bender; Ruslan N. Grishanin; Kelly M. Hanna; Julio D. Nieves; Pallavi Sharma; Aivan T. Nguyen; Romeo J. Rosario; Judith S. Greengard; Claire M. Gelfman; Mehdi Gasmi
TAGS: aflibercept, anti-vascular endothelial growth factor therapy, gene therapy, safety, eye, primates, retina, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(1):34. doi: https://doi.org/10.1167/tvst.10.1.34

Includes: Supplemental Content

Articles October 2020

VEGF Trap R1R2 Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis

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Viet Nhat Hung Le; Deniz Hos; Yanhong Hou; Madlen Witt; Mikhail Barkovskiy; Felix Bock; Claus Cursiefen
TAGS: aflibercept, cornea, corneal neovascularization, lymphangiogenesis, alkanes, cd40 ligand, thyroid hormone associated protein complex
Trans. Vis. Sci. Tech.. 2020; 9(11):15. doi: https://doi.org/10.1167/tvst.9.11.15

Articles October 2020

Treatment Efficacy and Biocompatibility of a Biodegradable Aflibercept-Loaded Microsphere-Hydrogel Drug Delivery System

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Wenqiang Liu; Anessa Puskar Tawakol; Kayla M. Rudeen; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: aflibercept, biocompatibility, choroidal neovascularization, drug delivery systems, hydrogel, injections, microspheres, treatment effectiveness, electroretinography, histopathology tests
Trans. Vis. Sci. Tech.. 2020; 9(11):13. doi: https://doi.org/10.1167/tvst.9.11.13

Articles October 2020

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

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Atsushi Ichio; Masahiko Sugimoto; Hisashi Matsubara; Daiki Mochida; Kumiko Kato; Mineo Kondo
TAGS: aflibercept, diabetic retinopathy, eye, macrophage activation syndrome, macular edema, meconium aspiration syndrome, electroretinography, injections, photopsia
Trans. Vis. Sci. Tech.. 2020; 9(11):2. doi: https://doi.org/10.1167/tvst.9.11.2

Articles August 2020

Effect of Paracentesis on Retinal Function Associated With Changes in Intraocular Pressure Caused by Intravitreal Injections

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Kazuma Kitsu; Kei Shinoda; Yoshinobu Mizuno; Kazuma Yagura; Gaku Terauchi; Celso Soiti Matsumoto; Masato Ochi; Atsushi Mizota
TAGS: intraocular pressure, intravitreal injections, paracentesis, surgical procedures, operative, anterior chamber paracentesis
Trans. Vis. Sci. Tech.. 2020; 9(9):10. doi: https://doi.org/10.1167/tvst.9.9.10

Articles August 2020

DS-7080a, a Selective Anti-ROBO4 Antibody, Shows Anti-Angiogenic Efficacy with Distinctly Different Profiles from Anti-VEGF Agents

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Yoshitaka Isumi; Shinko Hayashi; Tatsuya Inoue; Yasushi Yoshigae; Toshiyuki Sato; Jun Hasegawa; Toshinori Agatsuma
TAGS: angiogenesis, antibodies, anti-vascular endothelial growth factor therapy, choroidal neovascularization, lasers, eye, ranibizumab, macaca fascicularis
Trans. Vis. Sci. Tech.. 2020; 9(9):7. doi: https://doi.org/10.1167/tvst.9.9.7

Includes: Supplemental Content

Articles July 2020

Ranibizumab Population Pharmacokinetics and Free VEGF Pharmacodynamics in Preterm Infants With Retinopathy of Prematurity in the RAINBOW Trial

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Matthew Fidler; Brian W. Fleck; Andreas Stahl; Neil Marlow; James E. Chastain; Jun Li; Domenico Lepore; James D. Reynolds; Michael F. Chiang; Alistair R. Fielder; on behalf of the RAINBOW study group
TAGS: infant, ranibizumab, vascular endothelial growth factor a, infant, premature, retinopathy of prematurity, pharmacodynamics
Trans. Vis. Sci. Tech.. 2020; 9(8):43. doi: https://doi.org/10.1167/tvst.9.8.43

Includes: Supplemental Content

Articles July 2020

Short-Term Changes in Tear Lipid Layer Thickness After Instillation of Lipid Containing Eye Drops

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Phoebe Lim; Tun Aung Han; Louis Tong
TAGS: eyedrops, lipids
Trans. Vis. Sci. Tech.. 2020; 9(8):29. doi: https://doi.org/10.1167/tvst.9.8.29

Includes: Supplemental Content

Articles July 2020

Intravitreal Injection with a Conjunctival Injection Device: A Single-Center Experience

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Yu Qiang Soh; Nathalie Pei Yu Chiam; Andrew Shih Hsiang Tsai; Gemmy Chui Ming Cheung; Tien Yin Wong; Ian Yew San Yeo; Edmund Yick Mun Wong; Anna Cheng Sim Tan
TAGS: conjunctival injection, injections, intravitreal injections, surgeons
Trans. Vis. Sci. Tech.. 2020; 9(8):28. doi: https://doi.org/10.1167/tvst.9.8.28

Articles July 2020

Benzalkonium Chloride Resistance in Staphylococcus epidermidis on the Ocular Surface of Glaucoma Patients Under Long-Term Administration of Eye Drops

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Jinhee Lee; Takuya Iwasaki; Shinichiro Ohtani; Hidehito Matsui; Ryohei Nejima; Yosai Mori; Fumie Kagaya; Akiko Yagi; Akiko Yoshimura; Hideaki Hanaki; Makoto Aihara; Kazunori Miyata
TAGS: bacterial artificial chromosomes, benzalkonium chloride, blood alcohol concentration, bronchioloalveolar carcinoma, eyedrops, genes, glaucoma, staphylococcus epidermidis, polymerase chain reaction
Trans. Vis. Sci. Tech.. 2020; 9(8):9. doi: https://doi.org/10.1167/tvst.9.8.9

Includes: Supplemental Content

Articles July 2020

Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye

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Chengxin Zhou; Arushi Singh; Grace Qian; Natalie Wolkow; Claes H. Dohlman; Demetrios G. Vavvas; James Chodosh; Eleftherios I. Paschalis
TAGS: anti-vascular endothelial growth factor therapy, cornea, eye, drug delivery systems
Trans. Vis. Sci. Tech.. 2020; 9(8):5. doi: https://doi.org/10.1167/tvst.9.8.5

Includes: Supplemental Content

Articles July 2020

Antimycotic Activity of Ozonized Oil in Liposome Eye Drops against Candida spp.

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Giuseppe Celenza; Roberto Iorio; Salvatore Cracchiolo; Sabrina Petricca; Ciro Costagliola; Benedetta Cinque; Bernardetta Segatore; Gianfranco Amicosante; Pierangelo Bellio
TAGS: antifungal agents, candida, candida albicans, eyedrops, liposomes, depolarization, lipid peroxidation
Trans. Vis. Sci. Tech.. 2020; 9(8):4. doi: https://doi.org/10.1167/tvst.9.8.4

Includes: Supplemental Content

Articles July 2020

Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

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Kazuhisa Yamada; Hiroki Kaneko; Hideyuki Shimizu; Ayana Suzumura; Rina Namba; Kei Takayama; Seina Ito; Masataka Sugimoto; Hiroko Terasaki
TAGS: aging, rna, tissue degeneration, lamivudine, interleukin-18, retinal pigment cell, anti-inflammatory agents, retinal pigment epithelium
Trans. Vis. Sci. Tech.. 2020; 9(8):1. doi: https://doi.org/10.1167/tvst.9.8.1

Articles June 2020

Development and Optimization of Freeze-Dried Eye Drops Derived From Plasma Rich in Growth Factors Technology

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Eduardo Anitua; María de la Fuente; Ignacio Alcalde; Cristina Sanchez; Jesús Merayo-Lloves; Francisco Muruzabal
TAGS: eyedrops, freeze drying, growth factor, plasma
Trans. Vis. Sci. Tech.. 2020; 9(7):35. doi: https://doi.org/10.1167/tvst.9.7.35

Articles June 2020

Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model

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Johanna H. Meyer; Janine Marx; Claudine Strack; Frank G. Holz; Steffen Schmitz-Valckenberg
TAGS: aflibercept, angiogram, animal model, choroidal neovascularization, diagnostic imaging, endothelial growth factors, lasers, optical coherence tomography, sodium chloride, laser therapy
Trans. Vis. Sci. Tech.. 2020; 9(7):29. doi: https://doi.org/10.1167/tvst.9.7.29

Includes: Supplemental Content

Articles June 2020

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

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Hongman Song; Yong Zeng; Sheik Pran Babu Sardar Pasha; Ronald A. Bush; Camasamudram Vijayasarathy; Haohua Qian; Lisa Wei; Henry E. Wiley; Zhijian Wu; Paul A. Sieving
TAGS: eye, retina, spatial vectors, transfer technique, oryctolagus cuniculus, mice, fibroblast growth factor 2, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(7):28. doi: https://doi.org/10.1167/tvst.9.7.28

Articles June 2020

Presbyopia Treatment With Eye Drops: An Eight Year Retrospective Study

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Giovanna Benozzi; Cristian Perez; Juliana Leiro; Sonia Facal; Betina Orman
TAGS: eyedrops, presbyopia, retrospective studies, follow-up
Trans. Vis. Sci. Tech.. 2020; 9(7):25. doi: https://doi.org/10.1167/tvst.9.7.25

Articles June 2020

Microbial Cross-contamination in Multidose Eyedrops: The Impact of Instillation Angle and Bottle Geometry

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Alexandre Xavier da Costa; Maria Cecilia Zorat Yu; Denise de Freitas; Priscila Cardoso Cristovam; Lauren C. LaMonica; Vagner Rogerio dos Santos; José Alvaro Pereira Gomes
TAGS: eyedrops
Trans. Vis. Sci. Tech.. 2020; 9(7):7. doi: https://doi.org/10.1167/tvst.9.7.7

Includes: Supplemental Content

Articles June 2020

A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells

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Alison Heffer; Victor Wang; Jayanth Sridhar; Steven E. Feldon; Richard T. Libby; Collynn F. Woeller; Ajay E. Kuriyan
TAGS: injections, intravitreal injections, mice, retinal pigment cell, vitreoretinopathy, proliferative, eye, vitreous body, retina, tissue membrane
Trans. Vis. Sci. Tech.. 2020; 9(7):9. doi: https://doi.org/10.1167/tvst.9.7.9

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Pharmacokinetics of Intravitreal Vancomycin and Ceftazidime in Silicone Oil-Filled Macaque Eyes

Long-Term Safety Evaluation of Continuous Intraocular Delivery of Aflibercept by the Intravitreal Gene Therapy Candidate ADVM-022 in Nonhuman Primates

VEGF Trap R1R2 Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis

Treatment Efficacy and Biocompatibility of a Biodegradable Aflibercept-Loaded Microsphere-Hydrogel Drug Delivery System

Effects of Intravitreal Aflibercept on Retinal Function and Improvement of Macular Edema Associated With Diabetic Retinopathy

Effect of Paracentesis on Retinal Function Associated With Changes in Intraocular Pressure Caused by Intravitreal Injections

DS-7080a, a Selective Anti-ROBO4 Antibody, Shows Anti-Angiogenic Efficacy with Distinctly Different Profiles from Anti-VEGF Agents

Ranibizumab Population Pharmacokinetics and Free VEGF Pharmacodynamics in Preterm Infants With Retinopathy of Prematurity in the RAINBOW Trial

Short-Term Changes in Tear Lipid Layer Thickness After Instillation of Lipid Containing Eye Drops

Intravitreal Injection with a Conjunctival Injection Device: A Single-Center Experience

Benzalkonium Chloride Resistance in Staphylococcus epidermidis on the Ocular Surface of Glaucoma Patients Under Long-Term Administration of Eye Drops

Microporous Drug Delivery System for Sustained Anti-VEGF Delivery to the Eye

Antimycotic Activity of Ozonized Oil in Liposome Eye Drops against Candida spp.

Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities

Development and Optimization of Freeze-Dried Eye Drops Derived From Plasma Rich in Growth Factors Technology

Imaging of Therapeutic Effects of Anti-Vascular Endothelial Growth Factor Inhibitors by Optical Coherence Tomography Angiography in a Rat Model

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

Presbyopia Treatment With Eye Drops: An Eight Year Retrospective Study

Microbial Cross-contamination in Multidose Eyedrops: The Impact of Instillation Angle and Bottle Geometry

A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells

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