Pharmacology

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Editorial December 2024

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TAGS: bsnd gene, gangs, happiness, laparoscopic uterosacral nerve ablation, reading (activity), tolnaftate, acetylcholine, achondroplasia, camurati-engelmann syndrome, e-selectin
Trans. Vis. Sci. Tech.. 2024; 13(12):38. https://doi.org/10.1167/tvst.13.12.38

Retina December 2024

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

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Masahiko Shimura; Shotaro Sasaki; Ryota Nonaka; Ikumi Kashiwagi; Kanako Yasuda; Hidetaka Noma; Hitoshi Takagi
TAGS: angiopoietins, cytokine, diabetic macular edema, faricimab, injections, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2024; 13(12):35. https://doi.org/10.1167/tvst.13.12.35

Retina December 2024

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

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David S. Boyer; Nathan C. Steinle; Joel A. Pearlman; Cameron M. Stone; Courtney Crawford; Sunil Gupta; Pravin U. Dugel; Megan E. Baldwin; Ian M. Leitch
TAGS: aflibercept, diabetic macular edema, vascular endothelial growth factor a, vascular endothelial growth factor c, vascular endothelial growth factors
Trans. Vis. Sci. Tech.. 2024; 13(12):32. https://doi.org/10.1167/tvst.13.12.32

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

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Cheikh Diack; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Jacques Gaudreault; Katrijn Bogman; Valerie Cosson
TAGS: faricimab, intravitreal injections, retinal diseases, pharmacokinetics, hypertension, plasma
Trans. Vis. Sci. Tech.. 2024; 13(11):14. https://doi.org/10.1167/tvst.13.11.14

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

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Cheikh Diack; Robert L. Avery; Chui Ming Gemmy Cheung; Karl G. Csaky; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Denise Sickert; Ivo Stoilov; Valerie Cosson; Katrijn Bogman
TAGS: diabetic macular edema, exudative age-related macular degeneration, faricimab, hypertension, vascular endothelial growth factor a, pharmacodynamics
Trans. Vis. Sci. Tech.. 2024; 13(11):13. https://doi.org/10.1167/tvst.13.11.13

Includes: Supplemental Content

Glaucoma November 2024

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

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Kenzo Yamamura; Hidetoshi Mano; Masahiro Fuwa; Ryo Iwamura; Noriko Odani-Kawabata
TAGS: cercopithecidae, drug or chemical tissue distribution, macaca fascicularis, omidenepag, oryctolagus cuniculus, radioactivity, cornea, eye, aqueous humor, administration, topical
Trans. Vis. Sci. Tech.. 2024; 13(11):6. https://doi.org/10.1167/tvst.13.11.6

Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

Retina October 2024

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

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Faran Sabeti; Kate Thomson; Ted Maddess; Cindy Karouta; Myra Leung; Nicola Anstice; Tina Jong; Regan Ashby
TAGS: eye, levodopa, retina, administration, topical, carbidopa, young adult, perimetry, placebos
Trans. Vis. Sci. Tech.. 2024; 13(10):12. https://doi.org/10.1167/tvst.13.10.12

Includes: Supplemental Content

Neuro-ophthalmology September 2024

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

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Alex Kwok; Brahim Chaqour; Reas S. Khan; Puya Aravand; Kimberly Dine; Ahmara G. Ross; Kenneth S. Shindler
TAGS: mice, traumatic brain injuries, protein overexpression, optic nerve injuries, attenuation, pharmacology, vision
Trans. Vis. Sci. Tech.. 2024; 13(9):27. https://doi.org/10.1167/tvst.13.9.27

Neuro-ophthalmology August 2024

Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

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Simin Wang; Yu Liu; Dehuan Xu; Kaifan Pei; Haiyan Jiang; Li Gong; Wen Zeng; Yimei Liu; Shengzhou Wu
TAGS: choroidal neovascularization, eyedrops, fluorescein, lasers, mice, serine, vascular diseases, bevacizumab
Trans. Vis. Sci. Tech.. 2024; 13(8):24. https://doi.org/10.1167/tvst.13.8.24

Includes: Supplemental Content

Cornea & External Disease August 2024

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

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Valeria Villabona Martinez; Barbara Araujo Lima Dutra; Marcony R. Santhiago; Steven E. Wilson
TAGS: cornea, fibrosis, losartan, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2024; 13(8):22. https://doi.org/10.1167/tvst.13.8.22

Retina August 2024

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

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Sheng Gao; Ge Ge; Yun Zhang; Meixia Zhang
TAGS: central serous chorioretinopathy, lasers, spironolactone
Trans. Vis. Sci. Tech.. 2024; 13(8):19. https://doi.org/10.1167/tvst.13.8.19

Includes: Supplemental Content

Retina July 2024

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

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Xia Zhang; Heng Wang; Kai Zhang; Jin Ma; Huijing He; Shuang Song; Enhua Shao; Bo Chen; Jingyuan Yang; Xinyu Zhao; Wenda Sui; Meng Wang; Sihua Liu; Xiaopeng Guo; Huijuan Zhu; Yong Yao; Yong Zhong; Bing Xing
TAGS: acromegaly, blood glucose, diabetes mellitus, diabetes mellitus, type 2, insulin-like growth factor i, diabetic retinopathy, antidepressive agents, tricyclic, trichloroacetic acid
Trans. Vis. Sci. Tech.. 2024; 13(7):20. https://doi.org/10.1167/tvst.13.7.20

Includes: Supplemental Content

Retina July 2024

Long-Term Effects of Intravitreal Ranibizumab Compared With Panretinal Photocoagulation on Optical Coherence Tomography Measured Choroidal Thickness and Vascularity

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Brian Lee; Kristin Josic; Muneeswar G. Nittala; Swetha B. Velaga; Ayesha Karamat; Sowmya Srinivas; Federico Corvi; Gagan Singh; Srinivas Sadda; Jennifer K. Sun; Michael Ip; for the DRCR Retina Network
TAGS: optical coherence tomography, panretinal photocoagulation, ranibizumab, cortical blindness, eye, cardiovascular imaging, significance
Trans. Vis. Sci. Tech.. 2024; 13(7):19. https://doi.org/10.1167/tvst.13.7.19

Includes: Supplemental Content

Retina July 2024

Real-World Use of Off-Label MVASI in the Treatment of Patients With Neovascular AMD and DME

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Marco Lombardo; Filippo Missiroli; Luca Cerri; Roberto P. Sorge; Massimo Cesareo; Federico Ricci
TAGS: bevacizumab, bevacizumab-awwb, exudative age-related macular degeneration, off-label use, biosimilar pharmaceuticals, injections
Trans. Vis. Sci. Tech.. 2024; 13(7):17. https://doi.org/10.1167/tvst.13.7.17

Retina July 2024

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

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Cheri Z. Chambers; Gillian L. Soo; Abbi L. Engel; Ian A. Glass; the Birth Defects Research Laboratory (BDRL); Andrea Frassetto; Paolo G. V. Martini; Timothy J. Cherry
TAGS: lipid nanoparticles, mice, retina, rna, messenger, lipids, body tissue
Trans. Vis. Sci. Tech.. 2024; 13(7):7. https://doi.org/10.1167/tvst.13.7.7

Includes: Supplemental Content

Retina July 2024

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

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Maximilian Hammer; Marcel Muuss; Lorenz Herbster; Jonathan Herth; Alexander Scheuerle; Ramin Khoramnia; Grzegorz Łabuz; Philipp Uhl; Gerd Uwe Auffarth
TAGS: aging, gel, hydrogels, injections, optics, silicone oils, suidae, surgical procedures, operative, vitreous body, tetracycline
Trans. Vis. Sci. Tech.. 2024; 13(7):5. https://doi.org/10.1167/tvst.13.7.5

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Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

Long-Term Effects of Intravitreal Ranibizumab Compared With Panretinal Photocoagulation on Optical Coherence Tomography Measured Choroidal Thickness and Vascularity

Real-World Use of Off-Label MVASI in the Treatment of Patients With Neovascular AMD and DME

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

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