Pharmacology

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Glaucoma June 2025

Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
TAGS: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2025; 14(6):6. https://doi.org/10.1167/tvst.14.6.6

Includes: Supplemental Content

Low Vision Rehabilitation May 2025

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

PDF

Junxian He; Shrinivas Pundlik; Gang Luo
TAGS: chatgpt, datasets, gait, walking (activity)
Trans. Vis. Sci. Tech.. 2025; 14(5):28. https://doi.org/10.1167/tvst.14.5.28

Retina May 2025

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

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Terhi Ollila; Ashwini Joshi; Sangita Kulathinal; Ilkka Immonen
TAGS: area under curve, cohort studies, exudative age-related macular degeneration, finnish, visual acuity
Trans. Vis. Sci. Tech.. 2025; 14(5):23. https://doi.org/10.1167/tvst.14.5.23

Retina April 2025

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

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Dante J. Pieramici; Peter A. Campochiaro; Margaret Chang; Ian Pearce; Carl D. Regillo; Shamika Gune; Nancy Holekamp; Carlos Quezada-Ruiz; Shrirang V. Ranade; Natasha Singh; Geoffrey Wise; Joshua Horvath
TAGS: implants, needles
Trans. Vis. Sci. Tech.. 2025; 14(4):8. https://doi.org/10.1167/tvst.14.4.8

Includes: Multimedia, Supplemental Content

Retina March 2025

Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

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Sergio Li Calzi; Ayaka Fujihashi; Dibyendu Chakraborty; Yvonne Adu-Rutledge; Ram Prasad; Edgar L. V. Ready; Sarbodeep Paul; Srikanth Kakumanu; Xiaoping Qi; Michael E. Boulton; Alan J. Franklin; Bob H. Katz; Maria B. Grant
TAGS: aflibercept, choroidal neovascularization, implants, lasers, oryctolagus cuniculus, polymers, retinal diseases, intravitreal injections, mice, injections
Trans. Vis. Sci. Tech.. 2025; 14(3):21. https://doi.org/10.1167/tvst.14.3.21

Retina February 2025

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

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Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Yuto Hashimoto; Hana Yoshida; Hironori Takahashi; Yujiro Fujino; Kenichi Aizawa; Hidetoshi Kawashima; Yasuo Yanagi
TAGS: aflibercept, aqueous humor, bodily secretions, eyedrops, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):21. https://doi.org/10.1167/tvst.14.2.21

Includes: Supplemental Content

Editorial December 2024

Reviewers

PDF

TAGS: bsnd gene, gangs, happiness, laparoscopic uterosacral nerve ablation, reading (activity), tolnaftate, acetylcholine, achondroplasia, camurati-engelmann syndrome, e-selectin
Trans. Vis. Sci. Tech.. 2024; 13(12):38. https://doi.org/10.1167/tvst.13.12.38

Retina December 2024

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

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Masahiko Shimura; Shotaro Sasaki; Ryota Nonaka; Ikumi Kashiwagi; Kanako Yasuda; Hidetaka Noma; Hitoshi Takagi
TAGS: angiopoietins, cytokine, diabetic macular edema, faricimab, injections, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2024; 13(12):35. https://doi.org/10.1167/tvst.13.12.35

Retina December 2024

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

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David S. Boyer; Nathan C. Steinle; Joel A. Pearlman; Cameron M. Stone; Courtney Crawford; Sunil Gupta; Pravin U. Dugel; Megan E. Baldwin; Ian M. Leitch
TAGS: aflibercept, diabetic macular edema, vascular endothelial growth factor a, vascular endothelial growth factor c, vascular endothelial growth factors
Trans. Vis. Sci. Tech.. 2024; 13(12):32. https://doi.org/10.1167/tvst.13.12.32

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Cornea & External Disease November 2024

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

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Carol Beatty; Amy Estes; Hongyan Xu; Yutao Liu
TAGS: estrogen, keratoconus, pharmaceutical preparations, risk factors, obesity, medical history, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(11):18. https://doi.org/10.1167/tvst.13.11.18

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

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Cheikh Diack; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Jacques Gaudreault; Katrijn Bogman; Valerie Cosson
TAGS: faricimab, intravitreal injections, retinal diseases, pharmacokinetics, hypertension, plasma
Trans. Vis. Sci. Tech.. 2024; 13(11):14. https://doi.org/10.1167/tvst.13.11.14

Includes: Supplemental Content

Retina November 2024

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

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Cheikh Diack; Robert L. Avery; Chui Ming Gemmy Cheung; Karl G. Csaky; Leonid Gibiansky; Felix Jaminion; Ekaterina Gibiansky; Denise Sickert; Ivo Stoilov; Valerie Cosson; Katrijn Bogman
TAGS: diabetic macular edema, exudative age-related macular degeneration, faricimab, hypertension, vascular endothelial growth factor a, pharmacodynamics
Trans. Vis. Sci. Tech.. 2024; 13(11):13. https://doi.org/10.1167/tvst.13.11.13

Includes: Supplemental Content

Glaucoma November 2024

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

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Kenzo Yamamura; Hidetoshi Mano; Masahiro Fuwa; Ryo Iwamura; Noriko Odani-Kawabata
TAGS: cercopithecidae, drug or chemical tissue distribution, macaca fascicularis, omidenepag, oryctolagus cuniculus, radioactivity, cornea, eye, aqueous humor, administration, topical
Trans. Vis. Sci. Tech.. 2024; 13(11):6. https://doi.org/10.1167/tvst.13.11.6

Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

Retina October 2024

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

PDF

Faran Sabeti; Kate Thomson; Ted Maddess; Cindy Karouta; Myra Leung; Nicola Anstice; Tina Jong; Regan Ashby
TAGS: eye, levodopa, retina, administration, topical, carbidopa, young adult, perimetry, placebos
Trans. Vis. Sci. Tech.. 2024; 13(10):12. https://doi.org/10.1167/tvst.13.10.12

Includes: Supplemental Content

Neuro-ophthalmology September 2024

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

PDF

Alex Kwok; Brahim Chaqour; Reas S. Khan; Puya Aravand; Kimberly Dine; Ahmara G. Ross; Kenneth S. Shindler
TAGS: mice, traumatic brain injuries, protein overexpression, optic nerve injuries, attenuation, pharmacology, vision
Trans. Vis. Sci. Tech.. 2024; 13(9):27. https://doi.org/10.1167/tvst.13.9.27

Neuro-ophthalmology August 2024

Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

PDF

Simin Wang; Yu Liu; Dehuan Xu; Kaifan Pei; Haiyan Jiang; Li Gong; Wen Zeng; Yimei Liu; Shengzhou Wu
TAGS: choroidal neovascularization, eyedrops, fluorescein, lasers, mice, serine, vascular diseases, bevacizumab
Trans. Vis. Sci. Tech.. 2024; 13(8):24. https://doi.org/10.1167/tvst.13.8.24

Includes: Supplemental Content

Cornea & External Disease August 2024

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

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Valeria Villabona Martinez; Barbara Araujo Lima Dutra; Marcony R. Santhiago; Steven E. Wilson
TAGS: cornea, fibrosis, losartan, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2024; 13(8):22. https://doi.org/10.1167/tvst.13.8.22

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Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery

Using ChatGPT To Generate Walking Directions—Could It Potentially Help Visually Impaired With Micronavigation?

Area Under the Curve Analysis in a Real-World Cohort of Finnish Patients Treated for Neovascular Age-Related Macular Degeneration

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

Carboxyamidotriazole Complexed to PLGA Is Safe, Effective, and Durable in Models of Neovascular Retinal Disease

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis

Reviewers

Changes in Aqueous Angiopoietin-1/2 Concentrations During the Induction Phase of Intravitreal Faricimab Injections for Diabetic Macular Edema

Phase 1b Dose Escalation Study of Sozinibercept Inhibition of Vascular Endothelial Growth Factors C and D With Aflibercept for Diabetic Macular Edema

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Exploring New Links Among Keratoconus, Hormonal Factors, and Medications: Insights From a Case–Control Study Utilizing the All of Us Database

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

Ocular Pharmacokinetics of Faricimab Following Intravitreal Administration in Patients With Retinal Disease

Ocular Pharmacodynamics of Intravitreal Faricimab in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema

Ocular Tissue Distribution of Omidenepag Isopropyl in Rabbits and Cynomolgus Monkeys

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye

Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact

Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

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