Pharmacology

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Articles May 2022

Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases

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Carina M. Weigelt; Nina Zippel; Holger Fuchs; Anna-Kaisa Rimpelä; Tanja Schönberger; Birgit Stierstorfer; Remko A. Bakker; Norbert H. Redemann
TAGS: golimumab, inflammation, mice, retinal diseases, tumor necrosis factors
Trans. Vis. Sci. Tech.. 2022; 11(5):18. doi: https://doi.org/10.1167/tvst.11.5.18

Includes: Supplemental Content

Articles May 2022

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

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Jannatul Fardous; Yuuta Inoue; Kozue Yoshida; Fumiyasu Ono; Akihiro Higuchi; Hiroyuki Ijima
TAGS: biocompatibility, drug delivery systems, gel, hydrophobicity, nanogels, particle size, permeability, water, sterilization, sexual, chemical surfactants
Trans. Vis. Sci. Tech.. 2022; 11(5):16. doi: https://doi.org/10.1167/tvst.11.5.16

Includes: Supplemental Content

Articles May 2022

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses

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Danielle P. Clasky; Louise Meunier; Laura A. Wells
TAGS: choroid, drug clearance, drug release, drug transport, eye, fluid flow, intraocular lens implant device, mass or substance concentration per volume, steady state, vascular flow
Trans. Vis. Sci. Tech.. 2022; 11(5):14. doi: https://doi.org/10.1167/tvst.11.5.14

Includes: Supplemental Content

Articles March 2022

The Effect of Topical Anesthetics on 16S Ribosomal Ribonucleic Acid Amplicon Sequencing Results in Ocular Surface Microbiome Research

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Heleen Delbeke; Ingele Casteels; Marie Joossens
TAGS: anesthetics, microbiome, ocular surfaces, ribosomal rna, topical anesthetics
Trans. Vis. Sci. Tech.. 2022; 11(3):2. doi: https://doi.org/10.1167/tvst.11.3.2

Articles March 2022

Shear-Thinning and Temperature-Dependent Viscosity Relationships of Contemporary Ocular Lubricants

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Wasim Kapadia; Ning Qin; Pei Zhao; Chau-Minh Phan; Lacey Haines; Lyndon Jones; Carolyn L. Ren
TAGS: eyedrops, ocular lubricants, temperature, viscosity
Trans. Vis. Sci. Tech.. 2022; 11(3):1. doi: https://doi.org/10.1167/tvst.11.3.1

Articles February 2022

PNP Hydrogel Prevents Formation of Symblephara in Mice After Ocular Alkali Injury

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Aditi Swarup; Abigail K. Grosskopf; Lindsay M. Stapleton; Varun R. Subramaniam; BaoXiang Li; Irving L. Weissman; Eric A. Appel; Albert Y. Wu
TAGS: alkalies, hydrogel, mice, wounds and injuries
Trans. Vis. Sci. Tech.. 2022; 11(2):31. doi: https://doi.org/10.1167/tvst.11.2.31

Articles February 2022

Bleb Analysis Using Anterior Segment Optical Coherence Tomography and Surgical Predictors of XEN Gel Stent

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Yuri Kim; Su-Ho Lim; Seungsoo Rho
TAGS: blister, gel, surgical procedures, operative, stents, optical coherence tomography
Trans. Vis. Sci. Tech.. 2022; 11(2):26. doi: https://doi.org/10.1167/tvst.11.2.26

Articles February 2022

Retinal Oxygen Delivery and Extraction in Ophthalmologically Healthy Subjects With Different Blood Pressure Status

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Konstantinos Pappelis; Nomdo M. Jansonius
TAGS: blood pressure, did not receive therapy or drug, hypotension, oxygen delivery, eye, oxygen saturation measurement
Trans. Vis. Sci. Tech.. 2022; 11(2):9. doi: https://doi.org/10.1167/tvst.11.2.9

Includes: Supplemental Content

Articles February 2022

Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

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Maximilian Hammer; Sonja Schickhardt; Donald J. Munro; Alexander Scheuerle; Christian S. Mayer; Gerd U. Auffarth
TAGS: emulsions, silicone oils, viscosity, surface tension
Trans. Vis. Sci. Tech.. 2022; 11(2):3. doi: https://doi.org/10.1167/tvst.11.2.3

Articles February 2022

Hydrodynamic Interaction Between Tear Film and Air Puff From Noncontact Tonometry

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Atieh Yousefi; Yanhui Ma; Cynthia J. Roberts; Sayoko E. Moroi; Matthew A. Reilly
TAGS: eyedrops, non-contact tonometry, tear film finding
Trans. Vis. Sci. Tech.. 2022; 11(2):2. doi: https://doi.org/10.1167/tvst.11.2.2

Includes: Multimedia, Supplemental Content

Articles February 2022

Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging

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Tim J. Enz; Mario Bittner; James R. Tribble; Pete A. Williams; Michael A. Thiel; Martin K. Schmid; Lucas M. Bachmann; Frank Bochmann
TAGS: blood flow velocity, brimonidine, brinzolamide ophthalmic suspension, diagnostic imaging, intraocular pressure, eye
Trans. Vis. Sci. Tech.. 2022; 11(2):1. doi: https://doi.org/10.1167/tvst.11.2.1

Includes: Supplemental Content

Articles January 2022

Rose Bengal and Riboflavin Mediated Photodynamic Antimicrobial Therapy Against Selected South Florida Nocardia Keratitis Isolates

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Ethan Adre; Heather Durkee; Alejandro Arboleda; Karam Alawa; Jorge Maestre; Keenan J. Mintz; Roger M. Leblanc; Guillermo Amescua; Jean–Marie Parel; Darlene Miller
TAGS: antimicrobials, florida, keratitis, nocardia, riboflavin, rose bengal, photosensitizing agents
Trans. Vis. Sci. Tech.. 2022; 11(1):29. doi: https://doi.org/10.1167/tvst.11.1.29

Articles January 2022

Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration

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Joo Youn Shin; Jonghyun Lee; Jinkyu Park; Min Kim; Hyewon Chung; Suk Ho Byeon
TAGS: age-related macular degeneration, cytokeratin 8, exudative age-related macular degeneration, hypertension, ranibizumab, treatment outcome, aqueous humor, injections
Trans. Vis. Sci. Tech.. 2022; 11(1):26. doi: https://doi.org/10.1167/tvst.11.1.26

Includes: Supplemental Content

Articles January 2022

Wide Corneal Epithelial Thickness Mapping in Eyes With Topical Antiglaucoma Therapy Using Optical Coherence Tomography

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Yiming Ye; Yunzhi Xu; Yangfan Yang; Yanmei Fan; Pingping Liu; Keming Yu; Minbin Yu
TAGS: antiglaucoma agents, cornea, epithelium, eye, optical coherence tomography, glaucoma, duration of treatment
Trans. Vis. Sci. Tech.. 2022; 11(1):4. doi: https://doi.org/10.1167/tvst.11.1.4

Includes: Supplemental Content

Articles December 2021

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

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Tomohiro Nizawa; Imran A. Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia M. Edwards; Gerard A. Lutty
TAGS: atrophy, choroid, electroretinography, eyedrops, gel, hydrogel, ketotifen, mast cell degranulation, mast-cell sarcoma, minimally conscious state
Trans. Vis. Sci. Tech.. 2021; 10(14):37. doi: https://doi.org/10.1167/tvst.10.14.37

Includes: Supplemental Content

Articles December 2021

Novel Dual-Targeting Antibody Fragment IDB0062 Overcomes Anti–Vascular Endothelial Growth Factor Drug Limitations in Age-Related Macular Degeneration

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Seongbeom Kim; Gihong Min; Bomin Kim; Doseop Lee; Myongjae Lee; Jong-Hee Ko; Hyuk-Sang Kwon
TAGS: aflibercept, age-related macular degeneration, anti-vascular endothelial growth factor therapy, choroidal neovascularization, drug resistance, immunoglobulin fragments, mice, neuropilin-1, ranibizumab, vascular endothelial growth factor a
Trans. Vis. Sci. Tech.. 2021; 10(14):35. doi: https://doi.org/10.1167/tvst.10.14.35

Includes: Supplemental Content

Clinical Trials December 2021

Safety and Tolerability of Intravitreal Carotuximab (DE-122) in Patients With Persistent Exudative Age-Related Macular Degeneration: A Phase I Study

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Victor H. Gonzalez; Brian Berger; Roger Goldberg; Carmelina M. Gordon; Rahul N. Khurana; Raymund Angeles; Naveed Shams
TAGS: anti-vascular endothelial growth factor therapy, exudative age-related macular degeneration, persistence, phase 1 clinical trials, safety, intravitreal injections, cohort studies, endoglin, eye
Trans. Vis. Sci. Tech.. 2021; 10(14):27. doi: https://doi.org/10.1167/tvst.10.14.27

Includes: Supplemental Content

Articles December 2021

Effects of Gelatin Methacrylate Hydrogel on Corneal Repair and Regeneration in Rats

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Yun Chen; Lina Dong; Bin Kong; Yu Huang; Suyi Zhong; Che Connon; Jiaqi Tan; Siming Yang; Wei Sun; Shengli Mi
TAGS: cornea, gelatin, hydrogel, methacrylates, rats
Trans. Vis. Sci. Tech.. 2021; 10(14):25. doi: https://doi.org/10.1167/tvst.10.14.25

Includes: Supplemental Content

Articles December 2021

A Novel Eye Drop Formulation for Potential Treatment of Neovascular Age-Related Macular Degeneration

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Wen-Chia Huang; Felice Cheng; Chia-Ching Chen; Po-Hsien Kuo; Yen-Jen Wang; Shao-Chan Yin; Chia-Mu Tu; Ming-Hsi Wu; Wen-Yu Wang; Sung-En Chen
TAGS: eyedrops, drug delivery systems, exudative age-related macular degeneration, oryctolagus cuniculus, choroidal neovascularization
Trans. Vis. Sci. Tech.. 2021; 10(14):23. doi: https://doi.org/10.1167/tvst.10.14.23

Articles December 2021

Effect of Pharmacological Pupil Dilation on Dark-Adapted Perimetric Sensitivity in Healthy Subjects Using an Octopus 900 Perimeter

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Austin D. Igelman; Cristy Ku; Sam Mershon; Mariana Matioli da Palma; J. Jason McAnany; Robert A. Hyde; Jason C. Park; Paul Yang; Mark E. Pennesi
TAGS: color, dilatation, pathologic, mydriasis, perimetry, pharmacology, pupil dilation, octopus
Trans. Vis. Sci. Tech.. 2021; 10(14):18. doi: https://doi.org/10.1167/tvst.10.14.18

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Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases

Delivery of Hydrophobic Drugs to the Posterior Ocular Region by Gel-in-Water Nanoemulsion

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses

The Effect of Topical Anesthetics on 16S Ribosomal Ribonucleic Acid Amplicon Sequencing Results in Ocular Surface Microbiome Research

Shear-Thinning and Temperature-Dependent Viscosity Relationships of Contemporary Ocular Lubricants

PNP Hydrogel Prevents Formation of Symblephara in Mice After Ocular Alkali Injury

Bleb Analysis Using Anterior Segment Optical Coherence Tomography and Surgical Predictors of XEN Gel Stent

Retinal Oxygen Delivery and Extraction in Ophthalmologically Healthy Subjects With Different Blood Pressure Status

Physicochemical Properties of Explanted Silicone Oil After Use as an Intraocular Tamponade

Hydrodynamic Interaction Between Tear Film and Air Puff From Noncontact Tonometry

Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging

Rose Bengal and Riboflavin Mediated Photodynamic Antimicrobial Therapy Against Selected South Florida Nocardia Keratitis Isolates

Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration

Wide Corneal Epithelial Thickness Mapping in Eyes With Topical Antiglaucoma Therapy Using Optical Coherence Tomography

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

Novel Dual-Targeting Antibody Fragment IDB0062 Overcomes Anti–Vascular Endothelial Growth Factor Drug Limitations in Age-Related Macular Degeneration

Safety and Tolerability of Intravitreal Carotuximab (DE-122) in Patients With Persistent Exudative Age-Related Macular Degeneration: A Phase I Study

Effects of Gelatin Methacrylate Hydrogel on Corneal Repair and Regeneration in Rats

A Novel Eye Drop Formulation for Potential Treatment of Neovascular Age-Related Macular Degeneration

Effect of Pharmacological Pupil Dilation on Dark-Adapted Perimetric Sensitivity in Healthy Subjects Using an Octopus 900 Perimeter

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