Pharmacology

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Neuro-ophthalmology August 2024

Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

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Simin Wang; Yu Liu; Dehuan Xu; Kaifan Pei; Haiyan Jiang; Li Gong; Wen Zeng; Yimei Liu; Shengzhou Wu
TAGS: choroidal neovascularization, eyedrops, fluorescein, lasers, mice, serine, vascular diseases, bevacizumab
Trans. Vis. Sci. Tech.. 2024; 13(8):24. https://doi.org/10.1167/tvst.13.8.24

Includes: Supplemental Content

Cornea & External Disease August 2024

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

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Valeria Villabona Martinez; Barbara Araujo Lima Dutra; Marcony R. Santhiago; Steven E. Wilson
TAGS: cornea, fibrosis, losartan, oryctolagus cuniculus
Trans. Vis. Sci. Tech.. 2024; 13(8):22. https://doi.org/10.1167/tvst.13.8.22

Retina August 2024

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

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Sheng Gao; Ge Ge; Yun Zhang; Meixia Zhang
TAGS: central serous chorioretinopathy, lasers, spironolactone
Trans. Vis. Sci. Tech.. 2024; 13(8):19. https://doi.org/10.1167/tvst.13.8.19

Includes: Supplemental Content

Retina July 2024

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

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Xia Zhang; Heng Wang; Kai Zhang; Jin Ma; Huijing He; Shuang Song; Enhua Shao; Bo Chen; Jingyuan Yang; Xinyu Zhao; Wenda Sui; Meng Wang; Sihua Liu; Xiaopeng Guo; Huijuan Zhu; Yong Yao; Yong Zhong; Bing Xing
TAGS: acromegaly, blood glucose, diabetes mellitus, diabetes mellitus, type 2, insulin-like growth factor i, diabetic retinopathy, antidepressive agents, tricyclic, trichloroacetic acid
Trans. Vis. Sci. Tech.. 2024; 13(7):20. https://doi.org/10.1167/tvst.13.7.20

Includes: Supplemental Content

Retina July 2024

Long-Term Effects of Intravitreal Ranibizumab Compared With Panretinal Photocoagulation on Optical Coherence Tomography Measured Choroidal Thickness and Vascularity

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Brian Lee; Kristin Josic; Muneeswar G. Nittala; Swetha B. Velaga; Ayesha Karamat; Sowmya Srinivas; Federico Corvi; Gagan Singh; Srinivas Sadda; Jennifer K. Sun; Michael Ip; for the DRCR Retina Network
TAGS: optical coherence tomography, panretinal photocoagulation, ranibizumab, cortical blindness, eye, cardiovascular imaging, significance
Trans. Vis. Sci. Tech.. 2024; 13(7):19. https://doi.org/10.1167/tvst.13.7.19

Includes: Supplemental Content

Retina July 2024

Real-World Use of Off-Label MVASI in the Treatment of Patients With Neovascular AMD and DME

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Marco Lombardo; Filippo Missiroli; Luca Cerri; Roberto P. Sorge; Massimo Cesareo; Federico Ricci
TAGS: bevacizumab, bevacizumab-awwb, exudative age-related macular degeneration, off-label use, biosimilar pharmaceuticals, injections
Trans. Vis. Sci. Tech.. 2024; 13(7):17. https://doi.org/10.1167/tvst.13.7.17

Retina July 2024

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

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Cheri Z. Chambers; Gillian L. Soo; Abbi L. Engel; Ian A. Glass; the Birth Defects Research Laboratory (BDRL); Andrea Frassetto; Paolo G. V. Martini; Timothy J. Cherry
TAGS: lipid nanoparticles, mice, retina, rna, messenger, lipids, body tissue
Trans. Vis. Sci. Tech.. 2024; 13(7):7. https://doi.org/10.1167/tvst.13.7.7

Includes: Supplemental Content

Retina July 2024

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

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Maximilian Hammer; Marcel Muuss; Lorenz Herbster; Jonathan Herth; Alexander Scheuerle; Ramin Khoramnia; Grzegorz Łabuz; Philipp Uhl; Gerd Uwe Auffarth
TAGS: aging, gel, hydrogels, injections, optics, silicone oils, suidae, surgical procedures, operative, vitreous body, tetracycline
Trans. Vis. Sci. Tech.. 2024; 13(7):5. https://doi.org/10.1167/tvst.13.7.5

Retina June 2024

Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide

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Ian L. McAllister; Sarojini Vijayasekaran; Samuel McLenachan; Riyaz Bhikoo; Fred K. Chen; Dan Zhang; Emily Kanagalingam; Dao-Yi Yu
TAGS: bevacizumab, cytokine, did not receive therapy or drug, eye, genes, proteins, rna, messenger, triamcinolone acetonide, vascular endothelial growth factor a, venous retinal branch occlusion
Trans. Vis. Sci. Tech.. 2024; 13(6):13. https://doi.org/10.1167/tvst.13.6.13

Cornea & External Disease June 2024

Development and Characterization of a Photocrosslinkable, Chitosan-Based, Nerve Growth Factor–Eluting Hydrogel for the Ocular Surface

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Levi N. Kanu; Amy E. Ross; Wissam Farhat; Sushma V. Mudigunda; Nikolay Boychev; Liangju Kuang; Audrey E. K. Hutcheon; Joseph B. Ciolino
TAGS: cenegermin, chitosan, hydrogel, hydrogels, nerve growth factors, ocular surfaces, drug release
Trans. Vis. Sci. Tech.. 2024; 13(6):12. https://doi.org/10.1167/tvst.13.6.12

Artificial Intelligence June 2024

Deep Neural Networks for Automated Outer Plexiform Layer Subsidence Detection on Retinal OCT of Patients With Intermediate AMD

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Guilherme Aresta; Teresa Araujo; Gregor S. Reiter; Julia Mai; Sophie Riedl; Christoph Grechenig; Robyn H. Guymer; Zhichao Wu; Ursula Schmidt-Erfurth; Hrvoje Bogunovic
TAGS: biological markers, datasets, lead, volume, eye, deep learning
Trans. Vis. Sci. Tech.. 2024; 13(6):7. https://doi.org/10.1167/tvst.13.6.7

Lens June 2024

A New Method to Minimize the Standard Deviation and Root Mean Square of the Prediction Error of Single-Optimized IOL Power Formulas

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Damien Gatinel; Guillaume Debellemanière; Alain Saad; Radhika Rampat; Avi Wallerstein; Mathieu Gauvin; Jacques Malet
TAGS: datasets, elastin-like polypeptides, eye, lens (device), lens, crystalline, precision, postoperative care
Trans. Vis. Sci. Tech.. 2024; 13(6):2. https://doi.org/10.1167/tvst.13.6.2

Retina April 2024

Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits

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Claus von der Burchard; Christopher Kren; Jan-Erik Fleger; Dirk Theisen-Kunde; Veit Danicke; Hossam S. Abbas; Viktoria Kleyman; Johann Roider; Ralf Brinkmann
TAGS: body temperature, lasers, oryctolagus cuniculus, temperature
Trans. Vis. Sci. Tech.. 2024; 13(4):26. https://doi.org/10.1167/tvst.13.4.26

Includes: Supplemental Content

Refractive Intervention April 2024

Differential Impact of 0.01% and 0.05% Atropine Eyedrops on Ocular Surface in Young Adults

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Yifan Luo; Ziang Yin; Jiali Zhang; Weijia Wang; Yingying Huang; Xue Li; Hao Chen; Fan Lu; Jinhua Bao
TAGS: atropine, eyedrops, ocular surfaces, young adult
Trans. Vis. Sci. Tech.. 2024; 13(4):22. https://doi.org/10.1167/tvst.13.4.22

Cornea & External Disease February 2024

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

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Filippo Bonelli; Fabiola Campestre; Romina Mayra Lasagni Vitar; Ibrahim Halil Demirsoy; Philippe Fonteyne; Giulio Ferrari
TAGS: aprepitant, cornea, pain, signs and symptoms, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(2):9. https://doi.org/10.1167/tvst.13.2.9

Includes: Supplemental Content

Retina December 2023

Intravitreal Brolucizumab for Pachychoroid Neovasculopathy Associated With Chronic Central Serous Chorioretinopathy

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Marianna Carosielli; Adriano Carnevali; Matteo Fallico; Enza Pirozzi; Flavia Chiosi; Argyrios Chronopoulos; Pasquale Cucciniello; Marzia Affatato; Giuseppe Rapino; Roberto dell'Omo; on behalf of the BROCS study group, BROCS (BROlucizumab for the treatment of Central Serous chorioretinopathy) study group†
TAGS: brolucizumab, central serous chorioretinopathy, eye, injections, anti-vascular endothelial growth factor therapy
Trans. Vis. Sci. Tech.. 2023; 12(12):17. https://doi.org/10.1167/tvst.12.12.17

Retina December 2023

Minocycline and Diacetyl Minocycline Eye Drops Reduce Ocular Neovascularization in Mice

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Joshua O. Willms; Kelly Mitchell; Mayank Shashtri; Olof Sundin; Xiaobo Liu; Praneetha Panthagani; Phat Tran; Stephany Navarro; Colton Sniegowski; Abdul A. Shaik; Tristin Chaudhury; Ted W. Reid; Susan E. Bergeson
TAGS: choroidal neovascularization, eyedrops, mice, minocycline, neovascularization, pathologic, diacetyl
Trans. Vis. Sci. Tech.. 2023; 12(12):10. https://doi.org/10.1167/tvst.12.12.10

Includes: Multimedia, Supplemental Content

Glaucoma December 2023

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

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Tilahun Ayane Debele; Zachary F. Mount; Yong Yuan; Winston W.-Y. Kao; Yoonjee C. Park
TAGS: actins, collagen, cytotoxicity, dexamethasone, gel, glaucoma, permeability, phenotype, prevention, trabecular meshwork
Trans. Vis. Sci. Tech.. 2023; 12(12):4. https://doi.org/10.1167/tvst.12.12.4

Includes: Supplemental Content

Glaucoma November 2023

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

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Xiaofeng Zhu; Bei Zeng; Caiqing Wu; Zidong Chen; Minbin Yu; Yangfan Yang
TAGS: fibrosis, intraocular pressure, mice, pirfenidone, trabecular meshwork, western blotting, cytoskeleton
Trans. Vis. Sci. Tech.. 2023; 12(11):21. https://doi.org/10.1167/tvst.12.11.21

Cornea & External Disease October 2023

Establishing a Mouse Model of Chlorpromazine-Induced Corneal Trigeminal Denervation

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Xiongshi Lin; Peipei Xu; Ying Tian; Haiqi Xiao; Xing Dong; Shuangyong Wang
TAGS: chlorpromazine, cornea, denervation, mice
Trans. Vis. Sci. Tech.. 2023; 12(10):21. https://doi.org/10.1167/tvst.12.10.21

Includes: Supplemental Content

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Effects of Topic Delivery of an Inhibitor of Serine Racemase on Laser-Induced Choroidal Vasculopathy

Effect of Topical Losartan in the Treatment of Established Corneal Fibrosis in Rabbits

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

Long-Term Effects of Intravitreal Ranibizumab Compared With Panretinal Photocoagulation on Optical Coherence Tomography Measured Choroidal Thickness and Vascularity

Real-World Use of Off-Label MVASI in the Treatment of Patients With Neovascular AMD and DME

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

Viscoelastic, Optical, and Surgical Properties of Vitreous Body Replacement Hydrogels After Aging Compared to Porcine Vitreous Bodies And Silicone Oils

Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide

Development and Characterization of a Photocrosslinkable, Chitosan-Based, Nerve Growth Factor–Eluting Hydrogel for the Ocular Surface

Deep Neural Networks for Automated Outer Plexiform Layer Subsidence Detection on Retinal OCT of Patients With Intermediate AMD

A New Method to Minimize the Standard Deviation and Root Mean Square of the Prediction Error of Single-Optimized IOL Power Formulas

Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits

Differential Impact of 0.01% and 0.05% Atropine Eyedrops on Ocular Surface in Young Adults

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

Intravitreal Brolucizumab for Pachychoroid Neovasculopathy Associated With Chronic Central Serous Chorioretinopathy

Minocycline and Diacetyl Minocycline Eye Drops Reduce Ocular Neovascularization in Mice

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

Establishing a Mouse Model of Chlorpromazine-Induced Corneal Trigeminal Denervation

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