Translational Research

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Cornea & External Disease April 2025

A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

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Mark Dibbs; Mitchelle Matesva; Despoina Theotoka; Christina Jayaraj; Beruk Metiku; Patrick Demkowicz; Jacob S. Heng; Yvonne Wang; Christine Y. Bakhoum; Jessica Chow; Mathieu F. Bakhoum
TAGS: bacteria, corneal ulcer, nanopore sequencing, pathogenic organism, ulcer, eye, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):19. https://doi.org/10.1167/tvst.14.4.19

Includes: Supplemental Content

Cornea & External Disease April 2025

A Novel Approach to Fabricate Early Keratoconus Phantom Models

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Hui Tong; Mingjue Wu; Jianqiang Han; Lin Li; Haixia Zhang
TAGS: cornea, keratoconus, phantoms, imaging, silicones
Trans. Vis. Sci. Tech.. 2025; 14(4):18. https://doi.org/10.1167/tvst.14.4.18

Glaucoma April 2025

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

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Aliah McCalla; Mengyu Wang; Mohammad Eslami; Saber Kazeminasab; Yan Luo; Hannah Rana; Sajib Saha; Min Shi; Yu Tian; Nazlee Zebardast; Tobias Elze
TAGS: glaucoma, clinicians, optic disk
Trans. Vis. Sci. Tech.. 2025; 14(4):17. https://doi.org/10.1167/tvst.14.4.17

Includes: Supplemental Content

Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Cornea & External Disease April 2025

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

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Shuaiyi Li; Yiping Liu; Bao Yang; Sulei Lv; Xiulan Zou; Liqun Tang; Licheng Zhou; Zhenyu Jiang; Zejia Liu
TAGS: catabolism, cornea, corneal edema, monte carlo method, transparency, fibril
Trans. Vis. Sci. Tech.. 2025; 14(4):15. https://doi.org/10.1167/tvst.14.4.15

Cornea & External Disease April 2025

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

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Xiru Yang; Xinyao Yu; Shan Gao; Pinghui Wei; Guoge Han
TAGS: extrinsic asthma, hypersensitivity, keratoconus, mendelian randomization analysis, atopic dermatitis, urticaria
Trans. Vis. Sci. Tech.. 2025; 14(4):14. https://doi.org/10.1167/tvst.14.4.14

Cornea & External Disease April 2025

Hyperbaric Oxygenation Increases Available Oxygen and Resistance to Enzymatic Digestion in Accelerated Corneal Collagen Crosslinking

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Johannes Menzel-Severing; Theresa Streit; Jule Schmiedel; Sven Dreyer; Theo G. Seiler; Joana Witt; Gerd Geerling
TAGS: corneal collagen cross-linking, digestion, hyperbaric oxygenation, oxygen, cornea
Trans. Vis. Sci. Tech.. 2025; 14(4):13. https://doi.org/10.1167/tvst.14.4.13

Cornea & External Disease April 2025

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

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Xiang Cao; Zijiao Xu; Boyang Zhang; Qingyu Li; Zhixin Jiang; Xiaoyong Yuan
TAGS: allergic conjunctivitis, biological markers, mendelian randomization analysis, modified barium swallow, proteins
Trans. Vis. Sci. Tech.. 2025; 14(4):12. https://doi.org/10.1167/tvst.14.4.12

Includes: Supplemental Content

Letters to the Editor April 2025

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

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James Lin; Ting-Wan Kao
TAGS: artificial intelligence, biological markers, diabetic nephropathy, perfusion, screening
Trans. Vis. Sci. Tech.. 2025; 14(4):11. https://doi.org/10.1167/tvst.14.4.11

Letters to the Editor April 2025

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

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Qinling Jiang; Lin Mou
TAGS: amino acids, branched-chain, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2025; 14(4):10. https://doi.org/10.1167/tvst.14.4.10

Glaucoma April 2025

Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

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Nana Takahashi; Yukihiro Shiga; Naoki Kiyota; Masayuki Yasuda; Naoki Takahashi; Kota Sato; Ryutaro Arita; Akiko Kikuchi; Shin Takayama; Tadashi Ishii; Toru Nakazawa
TAGS: common cold, open-angle glaucoma, optic disk, vascular flow, cold sensation, cold temperature, eye, glaucoma
Trans. Vis. Sci. Tech.. 2025; 14(4):9. https://doi.org/10.1167/tvst.14.4.9

Includes: Supplemental Content

Retina April 2025

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

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Dante J. Pieramici; Peter A. Campochiaro; Margaret Chang; Ian Pearce; Carl D. Regillo; Shamika Gune; Nancy Holekamp; Carlos Quezada-Ruiz; Shrirang V. Ranade; Natasha Singh; Geoffrey Wise; Joshua Horvath
TAGS: implants, needles
Trans. Vis. Sci. Tech.. 2025; 14(4):8. https://doi.org/10.1167/tvst.14.4.8

Includes: Multimedia, Supplemental Content

Cornea & External Disease April 2025

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

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Jad F. Assaf; Jiachi Hong; Yan Li; David Huang
TAGS: cornea, incidence, optical coherence tomography, body tissue
Trans. Vis. Sci. Tech.. 2025; 14(4):7. https://doi.org/10.1167/tvst.14.4.7

Glaucoma April 2025

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

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Taiga Inooka; Ryo Tomita; Taro Kominami; Marie Mochizuki; Koji M. Nishiguchi; Kenya Yuki
TAGS: glaucoma, open-angle glaucoma, eye, reliability
Trans. Vis. Sci. Tech.. 2025; 14(4):6. https://doi.org/10.1167/tvst.14.4.6

Refractive Intervention April 2025

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

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Hou-Ren Tsai; Jeng-Hung Wang; Cheng-Jen Chiu
TAGS: cornea, orthokeratology, prospective studies, lens (device), lens, crystalline
Trans. Vis. Sci. Tech.. 2025; 14(4):5. https://doi.org/10.1167/tvst.14.4.5

Includes: Supplemental Content

Review April 2025

An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis

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Megha Gautam; Babu Lal; Smita Patel; Rajiv R. Mohan; Arivarasan Barathi; Nikita Yadav; Sunil Kumar Verma; Richa Nyodu; Ananyan Sampath; Darshna Koshti; Bhavana Sharma
TAGS: fungal keratitis, meta-analysis, prevalence, systematic reviews, atypical, keratitis, treatment outcome, risk factors
Trans. Vis. Sci. Tech.. 2025; 14(4):4. https://doi.org/10.1167/tvst.14.4.4

Includes: Supplemental Content

Glaucoma April 2025

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

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Samantha Sze-Yee Lee; Gareth Lingham; Alex W. Hewitt; David A. Mackey
TAGS: intraocular pressure, retinal nerve fiber layer, young adult, eye, ophthalmic examination and evaluation
Trans. Vis. Sci. Tech.. 2025; 14(4):3. https://doi.org/10.1167/tvst.14.4.3

Includes: Supplemental Content

Uveitis April 2025

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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Hui Liu; Suo Guo; Yaning Liu; Guannan Su; Peizeng Yang
TAGS: chinese (other dialects), signs and symptoms, uveitis, anterior, chinese people, cytomegalovirus, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(4):2. https://doi.org/10.1167/tvst.14.4.2

Includes: Supplemental Content

Lens April 2025

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

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Yuti Liu; Jiazhen Yao; Mingxue Ren; Lingxia Ye; An-Peng Pan; Xu Xu
TAGS: cataract, fluorocarbons, prevalence, national health and nutrition examination survey, adult
Trans. Vis. Sci. Tech.. 2025; 14(4):1. https://doi.org/10.1167/tvst.14.4.1

Includes: Supplemental Content

Artificial Intelligence March 2025

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

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Abigail Koornwinder; Youchen Zhang; Rohith Ravindranath; Robert T. Chang; Isaac A. Bernstein; Sophia Y. Wang
TAGS: artificial intelligence, electronic medical records, glaucoma, retinal nerve fiber layer, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):27. https://doi.org/10.1167/tvst.14.3.27

Includes: Supplemental Content

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A Tear-Based Approach for Rapid Identification of Bacterial Pathogens in Corneal Ulcers Using Nanopore Sequencing

A Novel Approach to Fabricate Early Keratoconus Phantom Models

Association Between Cup-to-Disc Ratio and Structural and Functional Damage Parameters in Glaucoma: Insights From Multiparametric Modeling

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

Causal Relationship Between Common Allergic Diseases and Keratoconus: A Two-Sample Mendelian Randomization Study

Hyperbaric Oxygenation Increases Available Oxygen and Resistance to Enzymatic Digestion in Accelerated Corneal Collagen Crosslinking

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study

Comments on Xie et al.’s Study on Artificial Intelligence–Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

Risk Score Predicting Primary Open-Angle Glaucoma Patients With Vascular Predisposition

Structural Updates to the Implant and Refill Needle of the Port Delivery Platform

Characterization of Directional Reflectance in Corneal Tissue: A Comprehensive Optical Coherence Tomography Analysis

Comparison of the Humphrey Field Analyzer and MP-3 Microperimeter in Patients With Glaucoma, Classified by Severity and Misalignment of Test Points

Assessment of Corneal Biomechanical Changes After Discontinuation of Long-Term Orthokeratology: A 2-Year Prospective Study

An Emerging Global Threat of Mycotic Keratitis Caused by Uncommon Fungal Species: A Systematic Review and Meta-Analysis

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Intraocular Pressure in Young Adults

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

Multimodal Artificial Intelligence Models Predicting Glaucoma Progression Using Electronic Health Records and Retinal Nerve Fiber Layer Scans

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