Translational Research

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Cornea & External Disease July 2025

Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

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Jianqi Chen; Xiaohua Zhuo; Yuyao Ling; Yingting Zhu; Yangyang Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Zhidong Li
TAGS: allergic conjunctivitis, mendelian randomization analysis, proteins, proteome, cd36 antigens
Trans. Vis. Sci. Tech.. 2025; 14(7):6. https://doi.org/10.1167/tvst.14.7.6

Includes: Supplemental Content

Glaucoma July 2025

Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

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Xueming Yao; Yuhan Jiang; Hongxi Yang; Ju Guo; Xiaohong Wang; Andrzej Grzybowski; Mulin Jun Li; Hua Yan
TAGS: depressive disorders, glaucoma, cohort studies, uk biobank, genetics
Trans. Vis. Sci. Tech.. 2025; 14(7):5. https://doi.org/10.1167/tvst.14.7.5

Includes: Supplemental Content

Cornea & External Disease July 2025

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

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Dan Wang; Yueni Ma; Mengyu Zhang; Fei Li; Ning Gao; Yuanyuan Qi; Zhenying Shang; Ruibo Yang
TAGS: autonomic dysfunction, depressive disorders, dry eye syndromes, pathogenesis, apoptosis, rats, bodily secretions, oxidative stress, sympathectomy
Trans. Vis. Sci. Tech.. 2025; 14(7):4. https://doi.org/10.1167/tvst.14.7.4

Includes: Supplemental Content

Retina July 2025

A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation

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Anthony E. Felder; Giri Balasubramanian; Aldo Arroyo; Jason C. Park; Mahnaz Shahidi; J. Jason McAnany
TAGS: photopsia
Trans. Vis. Sci. Tech.. 2025; 14(7):3. https://doi.org/10.1167/tvst.14.7.3

Retina July 2025

The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis

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Janika Shah; Shinji Kakihara; Anna Busza; Amani A. Fawzi
TAGS: diabetic retinopathy, hypertension, perfusion, eye
Trans. Vis. Sci. Tech.. 2025; 14(7):2. https://doi.org/10.1167/tvst.14.7.2

Artificial Intelligence July 2025

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

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Min Shi; Muhammad Muneeb Afzal; Hao Huang; Congcong Wen; Yan Luo; Muhammad Osama Khan; Yu Tian; Leo Kim; Yi Fang; Mengyu Wang
TAGS: datasets, deep learning, diabetic retinopathy, retinal imaging, health disparity, color, scanning laser ophthalmoscopy, gender
Trans. Vis. Sci. Tech.. 2025; 14(7):1. https://doi.org/10.1167/tvst.14.7.1

Includes: Supplemental Content

Glaucoma June 2025

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

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Li-Hua Chen; Hai-Jiang Zhang; Qing-Ao Xiao
TAGS: methylation, mitochondria, mitochondrial diseases, open-angle glaucoma, pathogenesis, pathophysiology, multiomics, genes
Trans. Vis. Sci. Tech.. 2025; 14(6):37. https://doi.org/10.1167/tvst.14.6.37

Includes: Supplemental Content

Lens June 2025

Assessment of Diffractive Intraocular Lenses Using Near-Infrared Light: A Critical Evaluation

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Ricardo Elsner; Mario Gerlach; Sebastian Bohn; Jan Sievers; Heinrich Stolz; Rudolf F. Guthoff; Oliver Stachs; Karsten Sperlich
TAGS: eye, immunoglobulins, thyroid-stimulating, intraocular lens implant device, intraocular lens implantation procedure, lens (device), optics, wavelength, lens, crystalline, pupil, vision
Trans. Vis. Sci. Tech.. 2025; 14(6):36. https://doi.org/10.1167/tvst.14.6.36

Includes: Supplemental Content

Retina June 2025

Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion

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Yukiko Miyoshi; Yuki Nakano; Yuta Koyama; Rie Osaka; Junichiro Akimitsu; Aki Booka; Kiyoshi Suzuma
TAGS: aflibercept, central retinal vein occlusion, oxygen saturation measurement, vascular flow
Trans. Vis. Sci. Tech.. 2025; 14(6):35. https://doi.org/10.1167/tvst.14.6.35

Neuro-ophthalmology June 2025

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

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Yipao Li; Lu Chen; Shaokai Lin; Wei An; Linfeng Miao; Minghui Wan; Binjun Zhang
TAGS: gastrointestinal microbiome, graves' ophthalmopathy, idiopathic pneumonia syndrome, mendelian randomization analysis, proteins
Trans. Vis. Sci. Tech.. 2025; 14(6):34. https://doi.org/10.1167/tvst.14.6.34

Includes: Supplemental Content

Cornea & External Disease June 2025

In Vivo Stability of Electronic Intraocular Lens Implant for Corneal Blindness

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Ibraim V. Vieira; Victoria H. Fan; Michael W. Wiemer; Brian E. Lemoff; Kishan S. Sood; Maria Julia Mussa; Charles Q. Yu
TAGS: blindness, cornea, implants, intraocular lens implant device, eye, oryctolagus cuniculus, implantation procedure
Trans. Vis. Sci. Tech.. 2025; 14(6):33. https://doi.org/10.1167/tvst.14.6.33

Glaucoma June 2025

Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation

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Shunsuke Nakakura; Ryo Asaoka; Etsuko Terao; Yasuko Fujisawa; Satomi Oogi; Kanae Ueda
TAGS: blister, implantation procedure, intraocular pressure, postoperative care, language morphology, morphology
Trans. Vis. Sci. Tech.. 2025; 14(6):32. https://doi.org/10.1167/tvst.14.6.32

Lens June 2025

Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children

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Na Li; Luodian Luobu; Bei Du; Weiping Lin; Ruihua Wei
TAGS: child, lens (device), lens, crystalline, myopia, orthokeratology contact lenses
Trans. Vis. Sci. Tech.. 2025; 14(6):27. https://doi.org/10.1167/tvst.14.6.27

Retina June 2025

Treatment Efficacy of a Dual Release of Aflibercept and Dexamethasone From a Single Hydrogel Drug Delivery System in a Rodent Model

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Kayla M. Rudeen; Chryssa M. Maloney; Katherine L. Lydon; Leandro B. C. Teixeria; William F. Mieler; Jennifer J. Kang-Mieler
TAGS: aflibercept, choroidal neovascularization, dexamethasone, drug delivery systems, hydrogel, rodentia, treatment effectiveness, electroretinography, lasers, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(6):31. https://doi.org/10.1167/tvst.14.6.31

Artificial Intelligence June 2025

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
TAGS: artificial intelligence, datasets, glaucoma, optic cup, optic disk, optical coherence tomography, training, electronic medical records
Trans. Vis. Sci. Tech.. 2025; 14(6):30. https://doi.org/10.1167/tvst.14.6.30

Includes: Supplemental Content

Artificial Intelligence June 2025

Challenges for Opticians in Evaluating Small Pigmented Choroidal Lesions: Potential Support From the Mel AI noma Deep Learning Algorithm

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Shiva Sabazade; Marco A. Lumia Michalski; Sara Wittskog; Mats Holmström; Maria Nilsson; Gustav Stålhammar
TAGS: deep learning, noma, opticians, optometrists, melanoma, patient referral, nevus
Trans. Vis. Sci. Tech.. 2025; 14(6):29. https://doi.org/10.1167/tvst.14.6.29

Letters to the Editor June 2025

Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection

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Jessica Galvan; Mariana Gouveia Bastos Meirelles; Ricardo Luz Leitão Guerra
TAGS: optics, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(6):28. https://doi.org/10.1167/tvst.14.6.28

Lens June 2025

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
TAGS: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(6):26. https://doi.org/10.1167/tvst.14.6.26

Artificial Intelligence June 2025

Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

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Yining Wang; Changyu Chen; Ziye Wang; Yijin Wu; Hongshuang Lu; Jianping Xiong; Keigo Sugisawa; Koju Kamoi; Kyoko Ohno-Matsui
TAGS: datasets, deep learning, eye, staphyloma, retina, specialism
Trans. Vis. Sci. Tech.. 2025; 14(6):25. https://doi.org/10.1167/tvst.14.6.25

Includes: Supplemental Content

Cornea & External Disease June 2025

A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking

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Ana R. Arizcuren; Alejandra Consejo
TAGS: cornea, pixel
Trans. Vis. Sci. Tech.. 2025; 14(6):24. https://doi.org/10.1167/tvst.14.6.24

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Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis

Exploring the Mechanisms Linking Depression and Glaucoma: A Cohort Study of UK Biobank

Investigating the Role of Autonomic Dysfunction in the Pathogenesis of Depression-Related Dry Eye

A Method to Evaluate the Frequency Dependence of Retinal Vascular and Neural Metrics to Stimulus Modulation

The Impact of Hypertension on Macular Perfusion in Patients With Referable Diabetic Retinopathy: An OCTA Analysis

Equitable Deep Learning for Diabetic Retinopathy Detection Using Multidimensional Retinal Imaging With Fair Adaptive Scaling

Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma

Assessment of Diffractive Intraocular Lenses Using Near-Infrared Light: A Critical Evaluation

Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study

In Vivo Stability of Electronic Intraocular Lens Implant for Corneal Blindness

Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation

Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children

Treatment Efficacy of a Dual Release of Aflibercept and Dexamethasone From a Single Hydrogel Drug Delivery System in a Rodent Model

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

Challenges for Opticians in Evaluating Small Pigmented Choroidal Lesions: Potential Support From the Mel AI noma Deep Learning Algorithm

Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features

Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images

A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking

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