Translational Research

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Articles December 2019

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

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Nicola K. Cassels; John M. Wild; Tom H. Margrain; Chris Blyth; Victor Chong; Jennifer H. Acton
TAGS: age-related macular degeneration, color, evidence-based practice
Trans. Vis. Sci. Tech.. 2019; 8(6):48. doi: https://doi.org/10.1167/tvst.8.6.48

Includes: Supplemental Content

Articles December 2019

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

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Krunoslav T. Stingl; Laura Kuehlewein; Nicole Weisschuh; Saskia Biskup; Frans P. M. Cremers; M. Imran Khan; Carina Kelbsch; Tobias Peters; Marius Ueffing; Barbara Wilhelm; Eberhart Zrenner; Katarina Stingl
TAGS: eye, illness length, mutation, pupil reaction, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2019; 8(6):45. doi: https://doi.org/10.1167/tvst.8.6.45

Articles December 2019

Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4 -Related Retinopathy

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Philipp L. Müller; Johannes Birtel; Philipp Herrmann; Frank G. Holz; Peter Charbel Issa; Martin Gliem
TAGS: fundus autofluorescence imaging, retinal diseases, eye, diagnostic imaging
Trans. Vis. Sci. Tech.. 2019; 8(6):46. doi: https://doi.org/10.1167/tvst.8.6.46

Includes: Supplemental Content

Articles December 2019

Topical Trabodenoson Is Neuroprotective in a Rodent Model of Anterior Ischemic Optic Neuropathy (rNAION)

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Yan Guo; Zara Mehrabian; Mary A. Johnson; David S. Albers; Cadmus C. Rich; Rudolf A. Baumgartner; Steven L. Bernstein
TAGS: anterior ischemic optic neuropathy, astrocytes, edema, eye, inflammation, ischemia, optic disk, retina, rodentia, neuroprotection
Trans. Vis. Sci. Tech.. 2019; 8(6):47. doi: https://doi.org/10.1167/tvst.8.6.47

Articles December 2019

Remote Tool-Based Adjudication for Grading Diabetic Retinopathy

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Mike Schaekermann; Naama Hammel; Michael Terry; Tayyeba K. Ali; Yun Liu; Brian Basham; Bilson Campana; William Chen; Xiang Ji; Jonathan Krause; Greg S. Corrado; Lily Peng; Dale R. Webster; Edith Law; Rory Sayres
TAGS: diabetic retinopathy, participation in ward rounds, reliability, reference standards
Trans. Vis. Sci. Tech.. 2019; 8(6):40. doi: https://doi.org/10.1167/tvst.8.6.40

Includes: Supplemental Content

Articles December 2019

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

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Marina Green-Gomez; Paul S. Bernstein; Christine A. Curcio; Rachel Moran; Warren Roche; John M. Nolan
TAGS: autofluorescence, macular pigment, carotenoids
Trans. Vis. Sci. Tech.. 2019; 8(6):41. doi: https://doi.org/10.1167/tvst.8.6.41

Letters to the Editor December 2019

Heteroplasmy Rates of the m.14495A>G variant in MT-ND6 May Not Predict the Phenotype of LHON

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Josef Finsterer; Rahim Aliyev
TAGS: heteroplasmia, optic atrophy, hereditary, leber, phenotype
Trans. Vis. Sci. Tech.. 2019; 8(6):42. doi: https://doi.org/10.1167/tvst.8.6.42

Articles December 2019

Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy

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Arul J. Duraisamy; Rakesh Radhakrishnan; Berhane Seyoum; Gary W. Abrams; Renu A. Kowluru
TAGS: biological markers, diabetes mellitus, diabetic retinopathy, dna, dna methylation, dna, mitochondrial, epigenetics, methylation, genes, dna (cytosine-5-)-methyltransferase 1
Trans. Vis. Sci. Tech.. 2019; 8(6):43. doi: https://doi.org/10.1167/tvst.8.6.43

Articles December 2019

Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging

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Elisa Castaldi; Guido Marco Cicchini; Benedetto Falsini; Paola Binda; Maria Concetta Morrone
TAGS: functional magnetic resonance imaging, retinitis pigmentosa, psychophysics, magnetic resonance imaging, photopsia, blood oxygen level dependent, primary visual cortex, evoked potentials, visual, visual impairment, electroretinography
Trans. Vis. Sci. Tech.. 2019; 8(6):44. doi: https://doi.org/10.1167/tvst.8.6.44

Articles December 2019

A Deep Learning Approach for Meibomian Gland Atrophy Evaluation in Meibography Images

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Jiayun Wang; Thao N. Yeh; Rudrasis Chakraborty; Stella X. Yu; Meng C. Lin
TAGS: atrophy, deep learning, meibomian gland
Trans. Vis. Sci. Tech.. 2019; 8(6):37. doi: https://doi.org/10.1167/tvst.8.6.37

Articles December 2019

Noninvasive Imaging and Correlative Histology of Cone Photoreceptor Structure in the Pig Retina

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Alison L. Huckenpahler; Joseph Carroll; Alexander E. Salmon; Benjamin S. Sajdak; Rebecca R. Mastey; Kenneth P. Allen; Henry J. Kaplan; Maureen A. McCall
TAGS: diagnostic imaging, histology, retina, retinal cone, suidae
Trans. Vis. Sci. Tech.. 2019; 8(6):38. doi: https://doi.org/10.1167/tvst.8.6.38

Includes: Supplemental Content

Articles December 2019

Confocal and Histological Features After Poly(Ethylene Glycol) Diacrylate Corneal Inlay Implantation

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Aritz Bidaguren; Javier Mendicute; Iratxe Madarieta; Nerea Garagorri
TAGS: cornea, ethylene glycol, implantation procedure, implants, hydrogel, microscopy, confocal, oryctolagus cuniculus, histology, follow-up
Trans. Vis. Sci. Tech.. 2019; 8(6):39. doi: https://doi.org/10.1167/tvst.8.6.39

Articles December 2019

Nonlinear Optical Corneal Crosslinking, Mechanical Stiffening, and Corneal Flattening Using Amplified Femtosecond Pulses

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Samantha Bradford; Eric Mikula; Sun Woong Kim; Yilu Xie; Tibor Juhasz; Donald J. Brown; James V. Jester
TAGS: cornea, corneal collagen cross-linking, optics, lasers
Trans. Vis. Sci. Tech.. 2019; 8(6):35. doi: https://doi.org/10.1167/tvst.8.6.35

Articles December 2019

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

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Francisco J. Valiente-Soriano; Arturo Ortín-Martínez; Johnny Di Pierdomenico; Diego García-Ayuso; Alejandro Gallego-Ortega; Juan A. Miralles de Imperial-Ollero; Manuel Jiménez-López; María Paz Villegas-Pérez; Larry A. Wheeler; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, brimonidine, ciliary neurotrophic factor, fibroblast growth factor 2, lip, phototoxicity, retina, retinal cone, opsin, mice
Trans. Vis. Sci. Tech.. 2019; 8(6):36. doi: https://doi.org/10.1167/tvst.8.6.36

Articles December 2019

Impact of Pupil Diameter on Objective Refraction Determination and Predicted Visual Acuity

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Heather A. Anderson; Ayeswarya Ravikumar; Julia S. Benoit; Jason D. Marsack
TAGS: diameter, pupil, refraction, visual acuity, eye
Trans. Vis. Sci. Tech.. 2019; 8(6):32. doi: https://doi.org/10.1167/tvst.8.6.32

Articles December 2019

Ability of Nonswelling Polyethylene Glycol-Based Vitreous Hydrogel to Maintain Transparency in the Presence of Vitreous Hemorrhage

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Sujin Hoshi; Fumiki Okamoto; Tomoya Murakami; Takamasa Sakai; Yuko Shinohara; Tomohiko Fujii; Masayoshi Nakatani; Tetsuro Oshika
TAGS: glycols, hydrogel, polyethylene, transparency, vitreous body, vitreous hemorrhage, gel, blood groups
Trans. Vis. Sci. Tech.. 2019; 8(6):33. doi: https://doi.org/10.1167/tvst.8.6.33

Articles December 2019

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

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Marco Pellegrini; Federico Bernabei; Fabiana Moscardelli; Aldo Vagge; Riccardo Scotto; Cristina Bovone; Vincenzo Scorcia; Giuseppe Giannaccare
TAGS: cornea, digital image analysis, dry eye syndromes, fluorescein stain method, reliability
Trans. Vis. Sci. Tech.. 2019; 8(6):34. doi: https://doi.org/10.1167/tvst.8.6.34

Articles December 2019

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

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Chulbul M. Ahmed; Brian T. Dwyer; Alla Romashko; Steve Van Adestine; Eun-Hee Park; Zhen Lou; Devin Welty; Serene Josiah; Anneli Savinainen; Bohong Zhang; Alfred S. Lewin
TAGS: molecular chaperones, opsin, rhodopsin, animal model, retinitis pigmentosa, pharmacology, mice, photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(6):30. doi: https://doi.org/10.1167/tvst.8.6.30

Includes: Supplemental Content

Articles December 2019

Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics

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Edwin H. Yau; Robert T. Taggart; Mohammed Zuber; Alexandria J. Trujillo; Zahra S. Fayazi; Mark C. Butler; Lowell G. Sheflin; Jennifer B. Breen; Dian Yu; Jack M. Sullivan
TAGS: catalytic rna, opsin, rna, rna interference, rna, messenger, screening, therapeutics, cytokinesis, superior epigastric artery perforator flap, mutation
Trans. Vis. Sci. Tech.. 2019; 8(6):28. doi: https://doi.org/10.1167/tvst.8.6.28

Includes: Supplemental Content

Articles December 2019

Validation of Computerized Quantification of Ocular Redness

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Ekaterina Sirazitdinova; Marlies Gijs; Christian J. F. Bertens; Tos T. J. M. Berendschot; Rudy M. M. A. Nuijts; Thomas M. Deserno
TAGS: automation, color, conjunctiva, eye, machine learning, reliability, sclera, software, pixel, frequency distribution
Trans. Vis. Sci. Tech.. 2019; 8(6):31. doi: https://doi.org/10.1167/tvst.8.6.31

Includes: Supplemental Content

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Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

Functional Relevance and Structural Correlates of Near Infrared and Short Wavelength Fundus Autofluorescence Imaging in ABCA4 -Related Retinopathy

Topical Trabodenoson Is Neuroprotective in a Rodent Model of Anterior Ischemic Optic Neuropathy (rNAION)

Remote Tool-Based Adjudication for Grading Diabetic Retinopathy

Standardizing the Assessment of Macular Pigment Using a Dual-Wavelength Autofluorescence Technique

Heteroplasmy Rates of the m.14495A>G variant in MT-ND6 May Not Predict the Phenotype of LHON

Epigenetic Modifications in Peripheral Blood as Potential Noninvasive Biomarker of Diabetic Retinopathy

Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging

A Deep Learning Approach for Meibomian Gland Atrophy Evaluation in Meibography Images

Noninvasive Imaging and Correlative Histology of Cone Photoreceptor Structure in the Pig Retina

Confocal and Histological Features After Poly(Ethylene Glycol) Diacrylate Corneal Inlay Implantation

Nonlinear Optical Corneal Crosslinking, Mechanical Stiffening, and Corneal Flattening Using Amplified Femtosecond Pulses

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

Impact of Pupil Diameter on Objective Refraction Determination and Predicted Visual Acuity

Ability of Nonswelling Polyethylene Glycol-Based Vitreous Hydrogel to Maintain Transparency in the Presence of Vitreous Hemorrhage

Assessment of Corneal Fluorescein Staining in Different Dry Eye Subtypes Using Digital Image Analysis

SRD005825 Acts as a Pharmacologic Chaperone of Opsin and Promotes Survival of Photoreceptors in an Animal Model of Autosomal Dominant Retinitis Pigmentosa

Systematic Screening, Rational Development, and Initial Optimization of Efficacious RNA Silencing Agents for Human Rod Opsin Therapeutics

Validation of Computerized Quantification of Ocular Redness

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