Visual Neuroscience

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Expression of Concern July 2025

Expression of Concern for: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo

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TAGS: apoptosis, glaucoma, glutamate, glutamates, neuroprotective effect, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):34. https://doi.org/10.1167/iovs.66.9.34

Glaucoma July 2025

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

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Tingting Liu; Ya Xing Wang; Jost B. Jonas; Quan V. Hoang; Michaël J. A. Girard; Xiaofei Wang
TAGS: eye, gaze, myopia, optic disk, eye movement, sclera, adduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):21. https://doi.org/10.1167/iovs.66.9.21

Includes: Supplemental Content

Article July 2025

Function over form: The temporal evolution of affordance-based scene categorization

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Michelle R. Greene; Bruce C. Hansen
TAGS: electroencephalography, triplets, generalization (psychology), reaction time, perception
Journal of Vision. 2025; 25(8):10. https://doi.org/10.1167/jov.25.8.10

Retinal Cell Biology July 2025

Activation of Sigma 1 Receptor Preserves Visual Function After Optic Nerve Injury

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Jing Wang; Zhimin Xu; Ruth Caldwell
TAGS: mice, optic nerve injuries, retina, vision, wounds and injuries, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):13. https://doi.org/10.1167/iovs.66.9.13

Includes: Supplemental Content

Cornea July 2025

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

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Elwin D. Clutter; Wending Yang; Jacob Han; Nihal Kaplan; Han Peng
TAGS: akt signaling pathway, cell motility, dna, epithelial cells, proto-oncogene proteins c-akt, signal transduction, wound healing, wounds and injuries, cornea, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(9):2. https://doi.org/10.1167/iovs.66.9.2

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Maraviroc Prevents Optic Nerve Injury-Induced Retinal Ganglion Cell Apoptosis by Modulating the CCL5/CCR5/CTSS Axis

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Jingqiu Huang; Zhaohui Chang; Lian Liu; Cheng Lai; Xizhi Deng; Bin Jiang; Min Ke
TAGS: apoptosis, chemokine (c-c motif) receptor 5, maraviroc, optic nerve, rantes, wounds and injuries, neuroprotective effect
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):77. https://doi.org/10.1167/iovs.66.6.77

Includes: Supplemental Content

Artificial Intelligence June 2025

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
TAGS: artificial intelligence, datasets, glaucoma, optic cup, optic disk, optical coherence tomography, training, electronic medical records
Trans. Vis. Sci. Tech.. 2025; 14(6):30. https://doi.org/10.1167/tvst.14.6.30

Includes: Supplemental Content

Clinical and Epidemiologic Research June 2025

Interplay Between γ-Zone Peripapillary Atrophy and Optic Disc Parameters in Central Visual Field Impairment in Highly Myopic Eyes

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Nan Zhou; Takeshi Yoshida; Keigo Sugisawa; Sota Yoshimoto; Kyoko Ohno-Matsui
TAGS: atrophy, eye, myopia, optic disk, visual field defects, risk factors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):74. https://doi.org/10.1167/iovs.66.6.74

Retina June 2025

Small-Molecule Inhibition of the Hippo Pathway Induces Regeneration of Retinal Pigment Epithelium

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Erik A. Souverein; Sanyukta Oak; Zachary Fouladian; Mark W. Reid; G. Esteban Fernandez; Andrew Salas; Jennifer G. Aparicio; Aaron Nagiel; Ksenia Gnedeva
TAGS: cell proliferation, hippo signaling pathway, lasers, long-acting thyroid stimulator, phosphotransferases, retinal pigment epithelium, small molecule, wound healing, wounds and injuries, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):69. https://doi.org/10.1167/iovs.66.6.69

Includes: Supplemental Content

Physiology and Pharmacology June 2025

The Effects of Delayed Visual Feedback on Dynamic Postural Control

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Nora Pourhashemi; Kayton Jaksic; Behrang Keshavarz; Taylor W. Cleworth
TAGS: regulation of posture, vision, visual feedback, electromyography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):68. https://doi.org/10.1167/iovs.66.6.68

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study

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Jost B. Jonas; Songhomitra Panda-Jonas; Dan Milea; Cédric Lamirel; Jie Xu; Rahul A. Jonas; Ya Xing Wang
TAGS: adult, beijing, eye, prevalence, optic disk
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):63. https://doi.org/10.1167/iovs.66.6.63

Biochemistry and Molecular Biology June 2025

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

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Nemanja Milićević; Cristina Sandu; Etienne Challet; Teemu O. Ihalainen; Soile Nymark; Marie-Paule Felder-Schmittbuhl
TAGS: bioluminescence, body tissue, circadian rhythms, mice, sclera, rhythm, pectoral compartment nerve block type 1, picture exchange communication system, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):62. https://doi.org/10.1167/iovs.66.6.62

Includes: Supplemental Content

Lens June 2025

Hyperopic Eyes Are Structurally More Dynamic Than Myopic Eyes During Accommodation: An In Vivo Investigation

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Tuyishime Didier Fidele Uwacu; Saugat Bhattacharyya; Kathryn J. Saunders; Julie-Anne Little
TAGS: eye, visual accommodation, refractive errors, lens, crystalline, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):51. https://doi.org/10.1167/iovs.66.6.51

Includes: Multimedia, Supplemental Content

Genetics June 2025

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

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Rola Ba-Abbad; Igor V. Peshenko; Malena Daich Varela; Siying Lin; Gavin Arno; Omar A. Mahroo; Catherine Egan; Anthony G. Robson; Elena V. Olshevskaya; Alexander M. Dizhoor; Andrew R. Webster
TAGS: alleles, night blindness, retinal cone, electroretinography, rod photoreceptors, phenotype, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):22. https://doi.org/10.1167/iovs.66.6.22

Includes: Supplemental Content

Retina June 2025

Systemic Hypoxia Increases Retinal Blood Flow but Reduces the Oxygen Saturation Less in Peripheral Than in Macular Vessels in Normal Persons

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Jacob Drachmann; Line Petersen; Signe Krejberg Jeppesen; Toke Bek
TAGS: hypoxia, oxygen saturation measurement, vascular flow, venule, arteriole
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):43. https://doi.org/10.1167/iovs.66.6.43

Retina June 2025

Minimizing Pupil Size Dependence in Flicker ERG Using Stiles–Crawford Compensation

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Kumiko Kato; C. Quentin Davis; Nooshin Zeinali; Asako Sugawara; Hisashi Matsubara; Masahiko Sugimoto; Yuzen Kashima; Keitaro Mizumoto; Hidetaka Kudo; Eiichiro Nagasaka; Daphne L. McCulloch; Mineo Kondo
TAGS: electroretinography, photopsia, pupil size, pupil, luminance
Trans. Vis. Sci. Tech.. 2025; 14(6):23. https://doi.org/10.1167/tvst.14.6.23

Includes: Supplemental Content

Neuro-ophthalmology June 2025

Aquaporin-4 Peptide Injection in Mice Induces Retinal and Optic Nerve Alterations That Simulate Those of Neuromyelitis Optica Spectrum Disorder

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Mina Okuda-Arai; Sotaro Mori; Yoshichika Katsura; Shota Miyake; Kenichi Serizawa; Makoto Nakamura
TAGS: immunization, mice, neuromyelitis optica, optic nerve, optic neuritis, peptides, water channels, injections
Trans. Vis. Sci. Tech.. 2025; 14(6):21. https://doi.org/10.1167/tvst.14.6.21

Includes: Supplemental Content

Retina June 2025

An Analysis of Scotopic Microperimetry in Healthy Adults

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Daniel A. O. Adeyoju; Amandeep S. Josan; Laura J. Taylor; Robert E. MacLaren
TAGS: adult, eye, reliability, rod photoreceptors, eye diseases, vision, perimetry, age-related macular degeneration, retinal diseases
Trans. Vis. Sci. Tech.. 2025; 14(6):18. https://doi.org/10.1167/tvst.14.6.18

Retina June 2025

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

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Brett G. Jeffrey; Xueyang Yin; Christina Appleman; Sobany Suy; Anna Papadogiannis; Daniel Claus; Brian P. Brooks; Marisa Boyle; Laryssa A. Huryn; Wadih M. Zein
TAGS: electroretinography, erg protein, human, reference values
Trans. Vis. Sci. Tech.. 2025; 14(6):13. https://doi.org/10.1167/tvst.14.6.13

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

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Neringa Jurkute; Heiko Brennenstuhl; Monika Kustermann; Lindsey Van Haute; Christian D. Mutti; Enrico Bugiardini; Takayuki Handa; Masaru Shimura; Axel Petzold; James Acheson; Anthony G. Robson; William L. Macken; Michael G. Hanna; Robert D. S. Pitceathly; Ashirwad Merve; Urania Kotzaeridou; Stefan Kölker; Michael Freilinger; Marcus Erdler; Reginald E. Bittner; Johannes A. Mayr; Yasushi Okazaki; Kei Murayama; Holger Prokisch; Andrew R. Webster; Michal Minczuk; Gavin Arno; Berthold Pemp; Georg F. Hoffmann; Wolfgang M. Schmidt; Patrick Yu-Wai-Man
TAGS: family, mitochondrial diseases, optic atrophy, phenotype, mitochondria, optic nerve disorders, respiratory chain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):17. https://doi.org/10.1167/iovs.66.6.17

Includes: Supplemental Content

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Expression of Concern for: Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo

Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length

Function over form: The temporal evolution of affordance-based scene categorization

Activation of Sigma 1 Receptor Preserves Visual Function After Optic Nerve Injury

Inhibitor of DNA-Binding 3 Is a Novel Regulator of Limbal Epithelial Cell Migration Via the EphA2/Akt Signaling Pathway

Maraviroc Prevents Optic Nerve Injury-Induced Retinal Ganglion Cell Apoptosis by Modulating the CCL5/CCR5/CTSS Axis

Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements

Interplay Between γ-Zone Peripapillary Atrophy and Optic Disc Parameters in Central Visual Field Impairment in Highly Myopic Eyes

Small-Molecule Inhibition of the Hippo Pathway Induces Regeneration of Retinal Pigment Epithelium

The Effects of Delayed Visual Feedback on Dynamic Postural Control

Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study

Circadian Rhythms in Murine Ocular Tissues Including Sclera Are Affected by Neurobasal A Medium Preincubation and Mouse Strain, but Not Sex

Hyperopic Eyes Are Structurally More Dynamic Than Myopic Eyes During Accommodation: An In Vivo Investigation

Clinical and Biochemical Characterization of Specific GUCY2D Alleles Associated With a Rare Form of Night Blindness

Systemic Hypoxia Increases Retinal Blood Flow but Reduces the Oxygen Saturation Less in Peripheral Than in Macular Vessels in Normal Persons

Minimizing Pupil Size Dependence in Flicker ERG Using Stiles–Crawford Compensation

Aquaporin-4 Peptide Injection in Mice Induces Retinal and Optic Nerve Alterations That Simulate Those of Neuromyelitis Optica Spectrum Disorder

An Analysis of Scotopic Microperimetry in Healthy Adults

Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

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